Details for: FYN

Gene ID: 2534

Symbol: FYN

Ensembl ID: ENSG00000010810

Description: FYN proto-oncogene, Src family tyrosine kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.81
    Marker Score: 162313.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 4.35
    Marker Score: 2862
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.23
    Marker Score: 22196
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.69
    Marker Score: 19844
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.6
    Marker Score: 10095
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.48
    Marker Score: 4897
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.21
    Marker Score: 68602
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.13
    Marker Score: 10507.5
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.03
    Marker Score: 1757
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.81
    Marker Score: 3504
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.74
    Marker Score: 20680
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.72
    Marker Score: 1173
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.66
    Marker Score: 3067
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.65
    Marker Score: 1484
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.65
    Marker Score: 2227
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.63
    Marker Score: 3179
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.57
    Marker Score: 6155
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.51
    Marker Score: 2789
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.47
    Marker Score: 1189
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.47
    Marker Score: 767
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.44
    Marker Score: 24130
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.43
    Marker Score: 36375
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.4
    Marker Score: 2076
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.39
    Marker Score: 90623.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.39
    Marker Score: 6588.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.37
    Marker Score: 1718
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.36
    Marker Score: 7454
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.35
    Marker Score: 9726
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.32
    Marker Score: 17765
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.3
    Marker Score: 990
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.3
    Marker Score: 1371
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.28
    Marker Score: 1170
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.27
    Marker Score: 10508
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.23
    Marker Score: 3240
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.21
    Marker Score: 849
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.21
    Marker Score: 1291
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.2
    Marker Score: 43851.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.19
    Marker Score: 8452
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.18
    Marker Score: 807
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.18
    Marker Score: 80401.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.17
    Marker Score: 2679
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 2.15
    Marker Score: 772
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.13
    Marker Score: 694
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.12
    Marker Score: 6176
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.11
    Marker Score: 640
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.11
    Marker Score: 883
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.09
    Marker Score: 1956
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.05
    Marker Score: 2828
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.01
    Marker Score: 1159
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2
    Marker Score: 1318.5
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2
    Marker Score: 659
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.99
    Marker Score: 1100
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.99
    Marker Score: 695
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.98
    Marker Score: 18624
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.97
    Marker Score: 984
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.95
    Marker Score: 119990.5
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.93
    Marker Score: 1456
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.9
    Marker Score: 2792
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.89
    Marker Score: 19477
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.88
    Marker Score: 4310
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.85
    Marker Score: 5272
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.84
    Marker Score: 7681
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.83
    Marker Score: 474
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.82
    Marker Score: 7410
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.81
    Marker Score: 1614
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.8
    Marker Score: 2425.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.79
    Marker Score: 561
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.77
    Marker Score: 2204
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.77
    Marker Score: 16773
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.76
    Marker Score: 2122
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.75
    Marker Score: 1329
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.75
    Marker Score: 555
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.74
    Marker Score: 1023
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.74
    Marker Score: 3347
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.74
    Marker Score: 908
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.7
    Marker Score: 14615.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.69
    Marker Score: 89410
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.69
    Marker Score: 1088
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.69
    Marker Score: 1819
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.67
    Marker Score: 2809
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.64
    Marker Score: 1394.5
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.62
    Marker Score: 1169
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.61
    Marker Score: 779
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.6
    Marker Score: 3898.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.59
    Marker Score: 955
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.58
    Marker Score: 1391.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.57
    Marker Score: 1518
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.57
    Marker Score: 458
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.55
    Marker Score: 1744
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.53
    Marker Score: 2357
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.5
    Marker Score: 3534
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.49
    Marker Score: 408
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.48
    Marker Score: 3758
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.48
    Marker Score: 1227
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.47
    Marker Score: 905
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.46
    Marker Score: 756
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.45
    Marker Score: 2490
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.42
    Marker Score: 2304
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.42
    Marker Score: 349.5
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.41
    Marker Score: 1479

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Other Information

**Key characteristics:** - FYN is a transmembrane protein with a kinase domain that is responsible for protein tyrosine phosphorylation. - It is a member of the Src family of tyrosine kinases, which are involved in a variety of cellular processes, including cell growth, differentiation, and signaling. - FYN is a key regulator of the adaptive immune system. It is expressed in high levels in dendritic cells and macrophages, which are critical for the initiation and regulation of adaptive immune responses. - It is also expressed in endothelial cells, which are important for the formation and maintenance of blood-brain barrier. **Pathways and functions:** - FYN is involved in the regulation of adaptive immune responses by phosphorylating key proteins involved in immune cell activation, such as CD28 and CD80. - It also plays a role in cell-cell communication, as it is expressed in both immune cells and endothelial cells. - Through these interactions, FYN helps to regulate the migration, adhesion, and activation of immune cells. - It is also involved in the regulation of inflammation and cell survival. **Clinical significance:** - Mutations in FYN have been linked to several human diseases, including cancer, autoimmune disorders, and inflammatory diseases. - Targeting FYN has emerged as a potential therapeutic strategy for these diseases. **Other notes:** - FYN is a highly conserved protein, with similar sequences found in organisms from yeast to humans. - It is a promising target for cancer immunotherapy due to its expression in cancer cells and its role in immune regulation.

Genular Protein ID: 3205760051

Symbol: FYN_HUMAN

Name: Tyrosine-protein kinase Fyn

UniProtKB Accession Codes:

P06241 B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CORUM 1 CPTAC 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 ELM 1 EMBL 12 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 90 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 54 PDBsum 48 PIR 1 PRINTS 3 PRO 1 PROSITE 5 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 43 RefSeq 10 Rhea 3 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3099169

Title: Isolation and oncogenic potential of a novel human src-like gene.

PubMed ID: 3099169

DOI: 10.1128/mcb.6.12.4195-4201.1986

PubMed ID: 3526330

Title: Yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.

PubMed ID: 3526330

DOI: 10.1073/pnas.83.15.5459

PubMed ID: 7822789

Title: Human p59fyn(T) regulates OKT3-induced calcium influx by a mechanism distinct from PIP2 hydrolysis in Jurkat T cells.

PubMed ID: 7822789

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1699196

Title: In vivo phosphorylation and membrane association of the fyn proto-oncogene product in IM-9 human lymphoblasts.

PubMed ID: 1699196

PubMed ID: 1533589

Title: Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase.

PubMed ID: 1533589

DOI: 10.1002/eji.1830220510

PubMed ID: 8394019

Title: Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.

PubMed ID: 8394019

DOI: 10.1073/pnas.90.15.7366

PubMed ID: 8206991

Title: Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization.

PubMed ID: 8206991

DOI: 10.1016/s0021-9258(19)89447-4

PubMed ID: 7568038

Title: p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

PubMed ID: 7568038

DOI: 10.1073/pnas.92.19.8891

PubMed ID: 9038210

Title: Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.

PubMed ID: 9038210

DOI: 10.1074/jbc.272.9.5915

PubMed ID: 9360983

Title: Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.

PubMed ID: 9360983

DOI: 10.1074/jbc.272.46.29083

PubMed ID: 9207119

Title: Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.

PubMed ID: 9207119

DOI: 10.1073/pnas.94.14.7493

PubMed ID: 9741627

Title: A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth.

PubMed ID: 9741627

DOI: 10.1016/s0092-8674(00)81604-9

PubMed ID: 10196263

Title: Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines.

PubMed ID: 10196263

DOI: 10.1128/jvi.73.5.3709-3717.1999

PubMed ID: 10498895

Title: Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.

PubMed ID: 10498895

DOI: 10.1038/sj.onc.1202917

PubMed ID: 10790433

Title: Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.

PubMed ID: 10790433

DOI: 10.1084/jem.191.9.1591

PubMed ID: 11005864

Title: T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase.

PubMed ID: 11005864

DOI: 10.1073/pnas.97.20.10923

PubMed ID: 11162638

Title: Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.

PubMed ID: 11162638

DOI: 10.1006/bbrc.2000.4253

PubMed ID: 11518702

Title: The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.

PubMed ID: 11518702

DOI: 10.1074/jbc.m101546200

PubMed ID: 11536198

Title: Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation.

PubMed ID: 11536198

DOI: 10.1002/neu.1066

PubMed ID: 12218089

Title: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.

PubMed ID: 12218089

DOI: 10.4049/jimmunol.169.6.2813

PubMed ID: 12788081

Title: p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn.

PubMed ID: 12788081

DOI: 10.1016/s0006-291x(03)00923-9

PubMed ID: 14761972

Title: Regulation of TRPC6 channel activity by tyrosine phosphorylation.

PubMed ID: 14761972

DOI: 10.1074/jbc.m311274200

PubMed ID: 15557120

Title: Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance.

PubMed ID: 15557120

DOI: 10.1083/jcb.200405053

PubMed ID: 14707117

Title: Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation.

PubMed ID: 14707117

DOI: 10.1084/jem.20030976

PubMed ID: 14757743

Title: Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.

PubMed ID: 14757743

DOI: 10.1084/jem.20030589

PubMed ID: 15489916

Title: Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.

PubMed ID: 15489916

DOI: 10.1038/sj.onc.1208074

PubMed ID: 15536091

Title: Fyn phosphorylates human MAP-2c on tyrosine 67.

PubMed ID: 15536091

DOI: 10.1074/jbc.m411380200

PubMed ID: 15537652

Title: Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase.

PubMed ID: 15537652

DOI: 10.1074/jbc.m402053200

PubMed ID: 16387660

Title: Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation.

PubMed ID: 16387660

DOI: 10.1016/j.molcel.2005.11.014

PubMed ID: 16841086

Title: Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival.

PubMed ID: 16841086

DOI: 10.1038/sj.cdd.4402011

PubMed ID: 17925405

Title: Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.

PubMed ID: 17925405

DOI: 10.1074/jbc.m704650200

PubMed ID: 17194753

Title: Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA.

PubMed ID: 17194753

DOI: 10.1128/mcb.01974-06

PubMed ID: 18056706

Title: Regulation of FynT function by dual domain docking on PAG/Cbp.

PubMed ID: 18056706

DOI: 10.1074/jbc.m705215200

PubMed ID: 18258597

Title: Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.

PubMed ID: 18258597

DOI: 10.1074/jbc.m707247200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19179337

Title: Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-{gamma}1.

PubMed ID: 19179337

DOI: 10.1074/jbc.m806851200

PubMed ID: 19652227

Title: Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.

PubMed ID: 19652227

DOI: 10.1074/jbc.m109.000240

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20028775

Title: The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems.

PubMed ID: 20028775

DOI: 10.1189/jlb.0409227

PubMed ID: 20100835

Title: Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.

PubMed ID: 20100835

DOI: 10.1074/jbc.m109.071381

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22080863

Title: T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.

PubMed ID: 22080863

DOI: 10.1172/jci59492

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27335501

Title: ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion.

PubMed ID: 27335501

DOI: 10.4049/jimmunol.1501913

PubMed ID: 7687536

Title: Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin.

PubMed ID: 7687536

DOI: 10.2210/pdb1shf/pdb

PubMed ID: 7664083

Title: High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.

PubMed ID: 7664083

DOI: 10.1038/nsb0894-546

PubMed ID: 8961927

Title: Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.

PubMed ID: 8961927

DOI: 10.1021/bi9620969

PubMed ID: 8681387

Title: Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.

PubMed ID: 8681387

DOI: 10.1016/s0092-8674(00)81276-3

PubMed ID: 8805554

Title: Solution structure and peptide binding of the SH3 domain from human Fyn.

PubMed ID: 8805554

DOI: 10.1016/s0969-2126(96)00076-7

PubMed ID: 9351806

Title: The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.

PubMed ID: 9351806

DOI: 10.1016/s0969-2126(97)00283-9

PubMed ID: 12545174

Title: SAP couples Fyn to SLAM immune receptors.

PubMed ID: 12545174

DOI: 10.1038/ncb920

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 537
  • Mass: 60762
  • Checksum: 4A1E443A4B5A0977
  • Sequence:
    • MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG 
LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 
EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET 
TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC 
RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT 
LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR 
ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY 
TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE 
RGYRMPCPQD CPISLHELMI HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.