FYN | ENSG00000010810 | NCBI 2534

Details for: FYN

Gene ID: 2534

Symbol: FYN

Ensembl ID: ENSG00000010810

Description: FYN proto-oncogene, Src family tyrosine kinase

Associated with

Activated ntrk2 signals through fyn
(R-HSA-9032500)
Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Axon guidance
(R-HSA-422475)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cd28 co-stimulation
(R-HSA-389356)
Cd28 dependent pi3k/akt signaling
(R-HSA-389357)
Cd28 dependent vav1 pathway
(R-HSA-389359)
Cd209 (dc-sign) signaling
(R-HSA-5621575)
Cell-cell communication
(R-HSA-1500931)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Costimulation by the cd28 family
(R-HSA-388841)
Crmps in sema3a signaling
(R-HSA-399956)
Ctla4 inhibitory signaling
(R-HSA-389513)
Cytokine signaling in immune system
(R-HSA-1280215)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Dcc mediated attractive signaling
(R-HSA-418885)
Dectin-2 family
(R-HSA-5621480)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Epha-mediated growth cone collapse
(R-HSA-3928663)
Ephb-mediated forward signaling
(R-HSA-3928662)
Ephrin signaling
(R-HSA-3928664)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Flt3 signaling
(R-HSA-9607240)
Flt3 signaling through src family kinases
(R-HSA-9706374)
Gpvi-mediated activation cascade
(R-HSA-114604)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Intracellular signaling by second messengers
(R-HSA-9006925)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Ncam signaling for neurite out-growth
(R-HSA-375165)
Nef and signal transduction
(R-HSA-164944)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nephrin family interactions
(R-HSA-373753)
Nervous system development
(R-HSA-9675108)
Netrin-1 signaling
(R-HSA-373752)
Ntrk2 activates rac1
(R-HSA-9032759)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Pecam1 interactions
(R-HSA-210990)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet adhesion to exposed collagen
(R-HSA-75892)
Raf/map kinase cascade
(R-HSA-5673001)
Reelin signalling pathway
(R-HSA-8866376)
Regulation of kit signaling
(R-HSA-1433559)
Regulation of signaling by cbl
(R-HSA-912631)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Sema3a-plexin repulsion signaling by inhibiting integrin adhesion
(R-HSA-399955)
Sema3a pak dependent axon repulsion
(R-HSA-399954)
Semaphorin interactions
(R-HSA-373755)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by erbb2
(R-HSA-1227986)
Signaling by interleukins
(R-HSA-449147)
Signaling by kit in disease
(R-HSA-9669938)
Signaling by ntrk2 (trkb)
(R-HSA-9006115)
Signaling by ntrks
(R-HSA-166520)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain kit mutants
(R-HSA-9670439)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by scf-kit
(R-HSA-1433557)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Viral infection pathways
(R-HSA-9824446)
G protein-coupled receptor binding
(GO:0001664)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Protein tyrosine kinase activity
(GO:0004713)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 533.6551
Cell Significance Index: -83.0100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 324.3530
Cell Significance Index: -82.2700
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 194.9884
Cell Significance Index: -80.3300
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 178.2984
Cell Significance Index: -72.4400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 160.0551
Cell Significance Index: -82.3300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 76.3347
Cell Significance Index: -72.8800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 67.4598
Cell Significance Index: -83.1800
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 23.4489
Cell Significance Index: -51.3200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 22.3528
Cell Significance Index: -59.8800
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 21.9798
Cell Significance Index: -67.5100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 21.1883
Cell Significance Index: -83.6100
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 13.7819
Cell Significance Index: 36.9200
Cell Name: preadipocyte (CL0002334)
Fold Change: 5.4598
Cell Significance Index: 106.5600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 4.0442
Cell Significance Index: 226.9400
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 3.8431
Cell Significance Index: 53.7400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 3.1052
Cell Significance Index: 190.8600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.8608
Cell Significance Index: 1026.1300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.4620
Cell Significance Index: 493.8700
Cell Name: cortical interneuron (CL0008031)
Fold Change: 2.3309
Cell Significance Index: 55.9000
Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.0405
Cell Significance Index: 44.6800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.5824
Cell Significance Index: 106.4000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.0665
Cell Significance Index: 737.6000
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 1.0051
Cell Significance Index: 10.4700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.9344
Cell Significance Index: 41.3300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.8139
Cell Significance Index: 30.8200
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.6224
Cell Significance Index: 17.7600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.5583
Cell Significance Index: 29.0800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5060
Cell Significance Index: 14.5800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4450
Cell Significance Index: 61.1100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4307
Cell Significance Index: 388.8900
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.3974
Cell Significance Index: 6.8100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.3924
Cell Significance Index: 604.0700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3595
Cell Significance Index: 71.3400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3151
Cell Significance Index: 172.0900
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.3035
Cell Significance Index: 4.3700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3032
Cell Significance Index: 23.2700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.2299
Cell Significance Index: 4.9200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2262
Cell Significance Index: 43.0400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1950
Cell Significance Index: 123.8400
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1828
Cell Significance Index: 337.2000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1474
Cell Significance Index: 200.3700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0605
Cell Significance Index: 5.9900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0541
Cell Significance Index: 101.8500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0470
Cell Significance Index: 1.6500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0340
Cell Significance Index: 5.5300
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0132
Cell Significance Index: 1.6900
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.0745
Cell Significance Index: -1.0700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0764
Cell Significance Index: -34.6800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0977
Cell Significance Index: -72.3600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1063
Cell Significance Index: -77.9400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1147
Cell Significance Index: -86.8500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1243
Cell Significance Index: -18.0800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.1281
Cell Significance Index: -56.6400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1469
Cell Significance Index: -91.7600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1478
Cell Significance Index: -83.3400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.1488
Cell Significance Index: -16.1900
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2201
Cell Significance Index: -1.3300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2553
Cell Significance Index: -73.4500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.2868
Cell Significance Index: -51.7000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3021
Cell Significance Index: -35.2100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4227
Cell Significance Index: -49.8500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4280
Cell Significance Index: -90.1400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.4406
Cell Significance Index: -19.9700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.4501
Cell Significance Index: -55.3500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.4653
Cell Significance Index: -27.9400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.4861
Cell Significance Index: -33.6200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.5202
Cell Significance Index: -88.8200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.5705
Cell Significance Index: -12.3600
Cell Name: lactocyte (CL0002325)
Fold Change: -0.6115
Cell Significance Index: -79.0100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.7023
Cell Significance Index: -80.4600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.7026
Cell Significance Index: -71.7700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.7093
Cell Significance Index: -37.2400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.7287
Cell Significance Index: -75.8800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7498
Cell Significance Index: -24.0200
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.7997
Cell Significance Index: -51.6000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.8125
Cell Significance Index: -23.2900
Cell Name: peg cell (CL4033014)
Fold Change: -0.8440
Cell Significance Index: -19.5000
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.8719
Cell Significance Index: -21.8000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8752
Cell Significance Index: -53.6600
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.9328
Cell Significance Index: -6.3200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.9373
Cell Significance Index: -44.0500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.9777
Cell Significance Index: -77.4300
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -1.0717
Cell Significance Index: -18.5300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -1.0782
Cell Significance Index: -80.3600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -1.0995
Cell Significance Index: -77.7600
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.2335
Cell Significance Index: -26.1800
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -1.2443
Cell Significance Index: -31.0300
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -1.2490
Cell Significance Index: -15.5800
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.2655
Cell Significance Index: -32.5300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.3638
Cell Significance Index: -47.3900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.3837
Cell Significance Index: -44.0700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.3903
Cell Significance Index: -45.5200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.4380
Cell Significance Index: -42.3600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.4448
Cell Significance Index: -91.0600
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -1.4920
Cell Significance Index: -30.9500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.5017
Cell Significance Index: -78.0100
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -1.5202
Cell Significance Index: -30.0600
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.5765
Cell Significance Index: -31.6500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.6549
Cell Significance Index: -46.2500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.6659
Cell Significance Index: -27.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Tyrosine Kinase Activity**: FYN is a non-receptor tyrosine kinase that phosphorylates tyrosine residues on target proteins, leading to the activation of downstream signaling pathways. 2. **Src Family Kinase**: FYN is a member of the Src family of kinases, which are characterized by their ability to phosphorylate and regulate the activity of various signaling proteins. 3. **Cell Surface Expression**: FYN is predominantly expressed on the surface of cells, where it interacts with ligands and other signaling molecules to regulate cellular responses. 4. **Regulatory Interactions**: FYN interacts with various regulatory proteins, including adaptor proteins, phosphatases, and other kinases, to modulate its activity and signaling outcomes. **Pathways and Functions** 1. **Immune Response**: FYN plays a critical role in the regulation of immune cell responses, including the activation of T cells, B cells, and natural killer cells. 2. **Cell Signaling**: FYN is involved in various signaling pathways, including the PI3K/AKT, MAPK, and JAK/STAT pathways, which regulate cellular processes such as proliferation, differentiation, and survival. 3. **Neurotransmission**: FYN is expressed in neurons and is involved in the regulation of neurotransmitter release and synaptic plasticity. 4. **Developmental Biology**: FYN is required for the development and maintenance of various tissues, including the immune system, nervous system, and cardiovascular system. 5. **Cancer**: FYN is often overexpressed in cancer cells, where it contributes to the development and progression of tumors by promoting cell proliferation, survival, and metastasis. **Clinical Significance** 1. **Cancer**: FYN overexpression has been implicated in various types of cancer, including breast, lung, and colon cancer, where it contributes to tumor progression and metastasis. 2. **Infectious Diseases**: FYN is involved in the regulation of immune responses to infectious diseases, including HIV, Leishmania, and other parasites. 3. **Autoimmune Disorders**: FYN dysregulation has been implicated in autoimmune disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. 4. **Neurological Disorders**: FYN is involved in the regulation of neurotransmission and synaptic plasticity, and dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the FYN proto-oncogene plays a critical role in various cellular processes, including cell signaling, immune response, and development. Its dysregulation has been implicated in various diseases, including cancer, infectious diseases, and autoimmune disorders. Further research is needed to fully understand the mechanisms by which FYN regulates cellular processes and to identify potential therapeutic targets for the treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Tyrosine-protein kinase Fyn

Genular Protein ID: 3205760051

Symbol: FYN_HUMAN

Name: Tyrosine-protein kinase Fyn

UniProtKB Accession Codes:

P06241 B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7

Database IDs:

Citations:

PubMed ID: 3099169

Title: Isolation and oncogenic potential of a novel human src-like gene.

PubMed ID: 3099169

DOI: 10.1128/mcb.6.12.4195-4201.1986

PubMed ID: 3526330

Title: Yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.

PubMed ID: 3526330

DOI: 10.1073/pnas.83.15.5459

PubMed ID: 7822789

Title: Human p59fyn(T) regulates OKT3-induced calcium influx by a mechanism distinct from PIP2 hydrolysis in Jurkat T cells.

PubMed ID: 7822789

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1699196

Title: In vivo phosphorylation and membrane association of the fyn proto-oncogene product in IM-9 human lymphoblasts.

PubMed ID: 1699196

PubMed ID: 1533589

Title: Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase.

PubMed ID: 1533589

DOI: 10.1002/eji.1830220510

PubMed ID: 8394019

Title: Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.

PubMed ID: 8394019

DOI: 10.1073/pnas.90.15.7366

PubMed ID: 8206991

Title: Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization.

PubMed ID: 8206991

DOI: 10.1016/s0021-9258(19)89447-4

PubMed ID: 7568038

Title: p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

PubMed ID: 7568038

DOI: 10.1073/pnas.92.19.8891

PubMed ID: 9038210

Title: Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.

PubMed ID: 9038210

DOI: 10.1074/jbc.272.9.5915

PubMed ID: 9360983

Title: Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.

PubMed ID: 9360983

DOI: 10.1074/jbc.272.46.29083

PubMed ID: 9207119

Title: Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.

PubMed ID: 9207119

DOI: 10.1073/pnas.94.14.7493

PubMed ID: 9741627

Title: A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth.

PubMed ID: 9741627

DOI: 10.1016/s0092-8674(00)81604-9

PubMed ID: 10196263

Title: Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines.

PubMed ID: 10196263

DOI: 10.1128/jvi.73.5.3709-3717.1999

PubMed ID: 10498895

Title: Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.

PubMed ID: 10498895

DOI: 10.1038/sj.onc.1202917

PubMed ID: 10790433

Title: Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.

PubMed ID: 10790433

DOI: 10.1084/jem.191.9.1591

PubMed ID: 11005864

Title: T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase.

PubMed ID: 11005864

DOI: 10.1073/pnas.97.20.10923

PubMed ID: 11162638

Title: Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.

PubMed ID: 11162638

DOI: 10.1006/bbrc.2000.4253

PubMed ID: 11518702

Title: The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.

PubMed ID: 11518702

DOI: 10.1074/jbc.m101546200

PubMed ID: 11536198

Title: Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation.

PubMed ID: 11536198

DOI: 10.1002/neu.1066

PubMed ID: 12218089

Title: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.

PubMed ID: 12218089

DOI: 10.4049/jimmunol.169.6.2813

PubMed ID: 12788081

Title: p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn.

PubMed ID: 12788081

DOI: 10.1016/s0006-291x(03)00923-9

PubMed ID: 14761972

Title: Regulation of TRPC6 channel activity by tyrosine phosphorylation.

PubMed ID: 14761972

DOI: 10.1074/jbc.m311274200

PubMed ID: 15557120

Title: Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance.

PubMed ID: 15557120

DOI: 10.1083/jcb.200405053

PubMed ID: 14707117

Title: Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation.

PubMed ID: 14707117

DOI: 10.1084/jem.20030976

PubMed ID: 14757743

Title: Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.

PubMed ID: 14757743

DOI: 10.1084/jem.20030589

PubMed ID: 15489916

Title: Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.

PubMed ID: 15489916

DOI: 10.1038/sj.onc.1208074

PubMed ID: 15536091

Title: Fyn phosphorylates human MAP-2c on tyrosine 67.

PubMed ID: 15536091

DOI: 10.1074/jbc.m411380200

PubMed ID: 15537652

Title: Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase.

PubMed ID: 15537652

DOI: 10.1074/jbc.m402053200

PubMed ID: 16387660

Title: Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation.

PubMed ID: 16387660

DOI: 10.1016/j.molcel.2005.11.014

PubMed ID: 16841086

Title: Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival.

PubMed ID: 16841086

DOI: 10.1038/sj.cdd.4402011

PubMed ID: 17925405

Title: Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.

PubMed ID: 17925405

DOI: 10.1074/jbc.m704650200

PubMed ID: 17194753

Title: Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA.

PubMed ID: 17194753

DOI: 10.1128/mcb.01974-06

PubMed ID: 18056706

Title: Regulation of FynT function by dual domain docking on PAG/Cbp.

PubMed ID: 18056706

DOI: 10.1074/jbc.m705215200

PubMed ID: 18258597

Title: Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.

PubMed ID: 18258597

DOI: 10.1074/jbc.m707247200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19179337

Title: Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-{gamma}1.

PubMed ID: 19179337

DOI: 10.1074/jbc.m806851200

PubMed ID: 19652227

Title: Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.

PubMed ID: 19652227

DOI: 10.1074/jbc.m109.000240

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20028775

Title: The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems.

PubMed ID: 20028775

DOI: 10.1189/jlb.0409227

PubMed ID: 20100835

Title: Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.

PubMed ID: 20100835

DOI: 10.1074/jbc.m109.071381

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22080863

Title: T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.

PubMed ID: 22080863

DOI: 10.1172/jci59492

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27335501

Title: ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion.

PubMed ID: 27335501

DOI: 10.4049/jimmunol.1501913

PubMed ID: 7687536

Title: Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin.

PubMed ID: 7687536

DOI: 10.2210/pdb1shf/pdb

PubMed ID: 7664083

Title: High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.

PubMed ID: 7664083

DOI: 10.1038/nsb0894-546

PubMed ID: 8961927

Title: Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.

PubMed ID: 8961927

DOI: 10.1021/bi9620969

PubMed ID: 8681387

Title: Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.

PubMed ID: 8681387

DOI: 10.1016/s0092-8674(00)81276-3

PubMed ID: 8805554

Title: Solution structure and peptide binding of the SH3 domain from human Fyn.

PubMed ID: 8805554

DOI: 10.1016/s0969-2126(96)00076-7

PubMed ID: 9351806

Title: The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.

PubMed ID: 9351806

DOI: 10.1016/s0969-2126(97)00283-9

PubMed ID: 12545174

Title: SAP couples Fyn to SLAM immune receptors.

PubMed ID: 12545174

DOI: 10.1038/ncb920

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 537
Mass: 60762
Checksum: 4A1E443A4B5A0977
Sequence:

MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG 
LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 
EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET 
TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC 
RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT 
LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR 
ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY 
TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE 
RGYRMPCPQD CPISLHELMI HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FYN

Associated with

Cells (max top 100)

Other Information

Isolation and oncogenic potential of a novel human src-like gene. PubMed ID: 3099169

Yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. PubMed ID: 3526330

Human p59fyn(T) regulates OKT3-induced calcium influx by a mechanism distinct from PIP2 hydrolysis in Jurkat T cells. PubMed ID: 7822789

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

In vivo phosphorylation and membrane association of the fyn proto-oncogene product in IM-9 human lymphoblasts. PubMed ID: 1699196

Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase. PubMed ID: 1533589

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells. PubMed ID: 8394019

Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization. PubMed ID: 8206991

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation. PubMed ID: 7568038

Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. PubMed ID: 9038210

Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates. PubMed ID: 9360983

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. PubMed ID: 9207119

A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. PubMed ID: 9741627

Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines. PubMed ID: 10196263

Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. PubMed ID: 10498895

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. PubMed ID: 10790433

T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase. PubMed ID: 11005864

Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125. PubMed ID: 11162638

The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK. PubMed ID: 11518702

Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation. PubMed ID: 11536198

Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells. PubMed ID: 12218089

p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. PubMed ID: 12788081

Regulation of TRPC6 channel activity by tyrosine phosphorylation. PubMed ID: 14761972

Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance. PubMed ID: 15557120

Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation. PubMed ID: 14707117

Unc119, a novel activator of Lck/Fyn, is essential for T cell activation. PubMed ID: 14757743

Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. PubMed ID: 15489916

Fyn phosphorylates human MAP-2c on tyrosine 67. PubMed ID: 15536091

Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase. PubMed ID: 15537652

Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation. PubMed ID: 16387660

Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. PubMed ID: 16841086

Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. PubMed ID: 17925405

Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA. PubMed ID: 17194753

Regulation of FynT function by dual domain docking on PAG/Cbp. PubMed ID: 18056706

Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2. PubMed ID: 18258597

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. PubMed ID: 19807924

Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-{gamma}1. PubMed ID: 19179337

Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32. PubMed ID: 19652227

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems. PubMed ID: 20028775

Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. PubMed ID: 20100835

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice. PubMed ID: 22080863

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion. PubMed ID: 27335501

Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin. PubMed ID: 7687536

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides. PubMed ID: 7664083

Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase. PubMed ID: 8961927

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. PubMed ID: 8681387

Solution structure and peptide binding of the SH3 domain from human Fyn. PubMed ID: 8805554

The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity. PubMed ID: 9351806

SAP couples Fyn to SLAM immune receptors. PubMed ID: 12545174

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846