FYN | ENSG00000010810 | NCBI 2534

Details for: FYN

Associated with

Activated ntrk2 signals through fyn
(R-HSA-9032500)
Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cd28 co-stimulation
(R-HSA-389356)
Cd28 dependent pi3k/akt signaling
(R-HSA-389357)
Cd28 dependent vav1 pathway
(R-HSA-389359)
Cd209 (dc-sign) signaling
(R-HSA-5621575)
Cell-cell communication
(R-HSA-1500931)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Costimulation by the cd28 family
(R-HSA-388841)
Crmps in sema3a signaling
(R-HSA-399956)
Ctla4 inhibitory signaling
(R-HSA-389513)
Cytokine signaling in immune system
(R-HSA-1280215)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Dcc mediated attractive signaling
(R-HSA-418885)
Dectin-2 family
(R-HSA-5621480)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Epha-mediated growth cone collapse
(R-HSA-3928663)
Ephb-mediated forward signaling
(R-HSA-3928662)
Ephrin signaling
(R-HSA-3928664)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Flt3 signaling
(R-HSA-9607240)
Flt3 signaling through src family kinases
(R-HSA-9706374)
Gpvi-mediated activation cascade
(R-HSA-114604)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Intracellular signaling by second messengers
(R-HSA-9006925)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Ncam signaling for neurite out-growth
(R-HSA-375165)
Nef and signal transduction
(R-HSA-164944)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nephrin family interactions
(R-HSA-373753)
Nervous system development
(R-HSA-9675108)
Netrin-1 signaling
(R-HSA-373752)
Ntrk2 activates rac1
(R-HSA-9032759)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Pecam1 interactions
(R-HSA-210990)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet adhesion to exposed collagen
(R-HSA-75892)
Raf/map kinase cascade
(R-HSA-5673001)
Reelin signalling pathway
(R-HSA-8866376)
Regulation of kit signaling
(R-HSA-1433559)
Regulation of signaling by cbl
(R-HSA-912631)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Sema3a-plexin repulsion signaling by inhibiting integrin adhesion
(R-HSA-399955)
Sema3a pak dependent axon repulsion
(R-HSA-399954)
Semaphorin interactions
(R-HSA-373755)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by erbb2
(R-HSA-1227986)
Signaling by interleukins
(R-HSA-449147)
Signaling by kit in disease
(R-HSA-9669938)
Signaling by ntrk2 (trkb)
(R-HSA-9006115)
Signaling by ntrks
(R-HSA-166520)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain kit mutants
(R-HSA-9670439)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by scf-kit
(R-HSA-1433557)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Viral infection pathways
(R-HSA-9824446)
Actin filament
(GO:0005884)
Activated t cell proliferation
(GO:0050798)
Adaptive immune response
(GO:0002250)
Alpha-tubulin binding
(GO:0043014)
Atp binding
(GO:0005524)
Axon guidance
(GO:0007411)
Calcium ion transport
(GO:0006816)
Cell body
(GO:0044297)
Cell differentiation
(GO:0030154)
Cell surface receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Cellular response to amyloid-beta
(GO:1904646)
Cellular response to glycine
(GO:1905430)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to l-glutamate
(GO:1905232)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Dendrite morphogenesis
(GO:0048813)
Dendritic spine maintenance
(GO:0097062)
Detection of mechanical stimulus involved in sensory perception of pain
(GO:0050966)
Disordered domain specific binding
(GO:0097718)
Endosome
(GO:0005768)
Enzyme binding
(GO:0019899)
Ephrin receptor binding
(GO:0046875)
Ephrin receptor signaling pathway
(GO:0048013)
Fc-gamma receptor signaling pathway involved in phagocytosis
(GO:0038096)
Feeding behavior
(GO:0007631)
Forebrain development
(GO:0030900)
Gene expression
(GO:0010467)
Glial cell projection
(GO:0097386)
G protein-coupled glutamate receptor signaling pathway
(GO:0007216)
G protein-coupled receptor binding
(GO:0001664)
Growth factor receptor binding
(GO:0070851)
Heart process
(GO:0003015)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Intracellular signal transduction
(GO:0035556)
Learning
(GO:0007612)
Leukocyte migration
(GO:0050900)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Modulation of chemical synaptic transmission
(GO:0050804)
Natural killer cell activation
(GO:0030101)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of dendritic spine maintenance
(GO:1902951)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of hydrogen peroxide biosynthetic process
(GO:0010730)
Negative regulation of inflammatory response to antigenic stimulus
(GO:0002862)
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
(GO:1902176)
Negative regulation of protein catabolic process
(GO:0042177)
Negative regulation of protein ubiquitination
(GO:0031397)
Neuron migration
(GO:0001764)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nucleus
(GO:0005634)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Perikaryon
(GO:0043204)
Perinuclear endoplasmic reticulum
(GO:0097038)
Perinuclear region of cytoplasm
(GO:0048471)
Phospholipase activator activity
(GO:0016004)
Phospholipase binding
(GO:0043274)
Plasma membrane
(GO:0005886)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of protein localization to membrane
(GO:1905477)
Positive regulation of protein localization to nucleus
(GO:1900182)
Positive regulation of protein targeting to membrane
(GO:0090314)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Protein ubiquitination
(GO:0016567)
Reelin-mediated signaling pathway
(GO:0038026)
Regulation of calcium ion import across plasma membrane
(GO:1905664)
Regulation of cell shape
(GO:0008360)
Regulation of glutamate receptor signaling pathway
(GO:1900449)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)
Response to amyloid-beta
(GO:1904645)
Response to ethanol
(GO:0045471)
Response to singlet oxygen
(GO:0000304)
Scaffold protein binding
(GO:0097110)
Schaffer collateral - ca1 synapse
(GO:0098685)
Signaling receptor binding
(GO:0005102)
Stimulatory c-type lectin receptor signaling pathway
(GO:0002223)
Tau-protein kinase activity
(GO:0050321)
Tau protein binding
(GO:0048156)
T cell costimulation
(GO:0031295)
T cell receptor signaling pathway
(GO:0050852)
Transmembrane transporter binding
(GO:0044325)
Type 5 metabotropic glutamate receptor binding
(GO:0031802)
Vascular endothelial growth factor receptor signaling pathway
(GO:0048010)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

central memory CD8-positive, alpha-beta T cell CL0000907

CSI 74.6

rCSI 50.26%

PRS 70.61
Bergmann glial cell CL0000644

CSI 41.17

rCSI 56.33%

PRS 52.09
differentiation-committed oligodendrocyte precursor CL4023059

CSI 40.84

rCSI 74.21%

PRS 50.34
lamp5 GABAergic cortical interneuron CL4023011

CSI 40.27

rCSI 67.59%

PRS 40.05
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 37.74

rCSI 66.66%

PRS 39.08
astrocyte of the cerebral cortex CL0002605

CSI 36.46

rCSI 81.75%

PRS 40.79
enteroendocrine cell CL0000164

CSI 35.63

rCSI 48.68%

PRS 59.64
astrocyte CL0000127

CSI 34.43

rCSI 73.36%

PRS 29.82
oligodendrocyte precursor cell CL0002453

CSI 31.69

rCSI 69.72%

PRS 40.7
VIP GABAergic cortical interneuron CL4023016

CSI 30.55

rCSI 36.49%

PRS 39.89
sncg GABAergic cortical interneuron CL4023015

CSI 29.46

rCSI 47.38%

PRS 42.32
naive T cell CL0000898

CSI 29.16

rCSI 20.3%

PRS 72.69
myofibroblast cell CL0000186

CSI 27.75

rCSI 38.43%

PRS 59.68
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 27.71

rCSI 55.25%

PRS 75.69
T-helper 17 cell CL0000899

CSI 26.6

rCSI 21.12%

PRS 79.34
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 26.5

rCSI 32.11%

PRS 46.52
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 26.34

rCSI 64.02%

PRS 38.76
pvalb GABAergic cortical interneuron CL4023018

CSI 25.92

rCSI 32.24%

PRS 38.19
CD4-positive helper T cell CL0000492

CSI 25.32

rCSI 19.16%

PRS 71.38
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 24.89

rCSI 28.74%

PRS 51.28
mature B cell CL0000785

CSI 23.27

rCSI 20.23%

PRS 68.28
neuroblast (sensu Vertebrata) CL0000031

CSI 22.41

rCSI 28.76%

PRS 55.27
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 22.15

rCSI 69.29%

PRS 44.18
mature NK T cell CL0000814

CSI 22.05

rCSI 28.2%

PRS 80.86
effector CD8-positive, alpha-beta T cell CL0001050

CSI 21.54

rCSI 16.38%

PRS 70.54
fallopian tube secretory epithelial cell CL4030006

CSI 21

rCSI 20.21%

PRS 58.08
precursor B cell CL0000817

CSI 19.91

rCSI 17.44%

PRS 67.75
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 19.39

rCSI 12.92%

PRS 78.8
ciliated epithelial cell CL0000067

CSI 18.5

rCSI 16.27%

PRS 45.82
cerebral cortex GABAergic interneuron CL0010011

CSI 18.4

rCSI 54.3%

PRS 61.06
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 17.28

rCSI 62.19%

PRS 38.53
group 3 innate lymphoid cell CL0001071

CSI 16.52

rCSI 12.41%

PRS 62.73
retinal ganglion cell CL0000740

CSI 16.33

rCSI 36.08%

PRS 44.33
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 16.15

rCSI 12.11%

PRS 85.25
near-projecting glutamatergic cortical neuron CL4023012

CSI 16.1

rCSI 60.86%

PRS 40.92
CD14-positive monocyte CL0001054

CSI 15.56

rCSI 19.38%

PRS 68.65
CD4-positive, alpha-beta memory T cell CL0000897

CSI 15.23

rCSI 10.93%

PRS 72.04
neural crest cell CL0011012

CSI 15.21

rCSI 12.02%

PRS 44.77
L6b glutamatergic cortical neuron CL4023038

CSI 15.12

rCSI 47.24%

PRS 41.54
fibroblast of lung CL0002553

CSI 14.72

rCSI 13.7%

PRS 58
GABAergic amacrine cell CL4030027

CSI 14.54

rCSI 49.82%

PRS 47.27
sst GABAergic cortical interneuron CL4023017

CSI 14.19

rCSI 18.3%

PRS 41.23
cerebral cortex endothelial cell CL1001602

CSI 14.14

rCSI 24.46%

PRS 48
gamma-delta T cell CL0000798

CSI 14.02

rCSI 16.47%

PRS 85.67
neuron CL0000540

CSI 13.78

rCSI 36.71%

PRS 47.84
CD8-positive, alpha-beta memory T cell CL0000909

CSI 13.05

rCSI 13.63%

PRS 81.11
glioblast CL0000030

CSI 12.42

rCSI 19.81%

PRS 50.74
naive B cell CL0000788

CSI 12.16

rCSI 10.43%

PRS 65.95
melanocyte CL0000148

CSI 12

rCSI 8.89%

PRS 50.55
mucosal invariant T cell CL0000940

CSI 11.96

rCSI 9.66%

PRS 68.39
mesenchymal cell CL0008019

CSI 11.95

rCSI 30.36%

PRS 52.34
bronchus fibroblast of lung CL2000093

CSI 11.92

rCSI 9.68%

PRS 58.41
elicited macrophage CL0000861

CSI 11.78

rCSI 10.82%

PRS 66.47
neural cell CL0002319

CSI 11.68

rCSI 44.07%

PRS 45.1
platelet CL0000233

CSI 11.67

rCSI 48.41%

PRS 62.59
dopaminergic neuron CL0000700

CSI 11.46

rCSI 64.75%

PRS 43.28
early lymphoid progenitor CL0000936

CSI 11.03

rCSI 9.69%

PRS 63.03
adipocyte CL0000136

CSI 10.84

rCSI 13.92%

PRS 51.19
inhibitory interneuron CL0000498

CSI 10.74

rCSI 24.79%

PRS 47.48
pulmonary capillary endothelial cell CL4028001

CSI 10.72

rCSI 20.44%

PRS 73.28
enteric smooth muscle cell CL0002504

CSI 10.72

rCSI 15.29%

PRS 60.33
podocyte CL0000653

CSI 10.66

rCSI 47.36%

PRS 57.09
radial glial cell CL0000681

CSI 10.49

rCSI 14.57%

PRS 56.78
T follicular helper cell CL0002038

CSI 10.39

rCSI 7.78%

PRS 72.74
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 10.19

rCSI 7.16%

PRS 76.92
double negative thymocyte CL0002489

CSI 9.98

rCSI 6.94%

PRS 68.44
epicardial adipocyte CL1000309

CSI 9.87

rCSI 32.12%

PRS 58.92
activated CD8-positive, alpha-beta T cell CL0000906

CSI 9.8

rCSI 9.64%

PRS 80.2
regulatory T cell CL0000815

CSI 9.78

rCSI 11.33%

PRS 70.54
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 9.74

rCSI 57.35%

PRS 41.44
vascular leptomeningeal cell CL4023051

CSI 9.74

rCSI 17.07%

PRS 49.98
T cell CL0000084

CSI 9.6

rCSI 18.77%

PRS 89.62
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 9.57

rCSI 12.02%

PRS 85.65
peripheral nervous system neuron CL2000032

CSI 9.48

rCSI 12.92%

PRS 49.95
T-helper 1 cell CL0000545

CSI 9.42

rCSI 17%

PRS 80.43
flat midget bipolar cell CL4033033

CSI 9.38

rCSI 67.03%

PRS 51.72
myeloid dendritic cell CL0000782

CSI 9

rCSI 13.04%

PRS 73.83
keratocyte CL0002363

CSI 8.9

rCSI 21.39%

PRS 66.05
ependymal cell CL0000065

CSI 8.47

rCSI 17.18%

PRS 37.88
mature T cell CL0002419

CSI 8.42

rCSI 6.55%

PRS 75.72
CD4-positive, alpha-beta thymocyte CL0000810

CSI 8.31

rCSI 6.66%

PRS 78.5
CD14-low, CD16-positive monocyte CL0002396

CSI 8.23

rCSI 6.34%

PRS 57.8
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 8.22

rCSI 14.06%

PRS 76.32
rod bipolar cell CL0000751

CSI 8.15

rCSI 14.64%

PRS 50.89
skin fibroblast CL0002620

CSI 8.03

rCSI 6.92%

PRS 64.02
serotonergic neuron CL0000850

CSI 7.89

rCSI 35.27%

PRS 42.25
central nervous system neuron CL2000029

CSI 7.89

rCSI 58.02%

PRS 44.86
endothelial cell of placenta CL0009092

CSI 7.85

rCSI 38.68%

PRS 69.17
stromal cell of ovary CL0002132

CSI 7.83

rCSI 21.53%

PRS 71.19
interneuron CL0000099

CSI 7.83

rCSI 15.72%

PRS 47.05
Schwann cell CL0002573

CSI 7.68

rCSI 21.84%

PRS 56.18
cerebral cortex neuron CL0010012

CSI 7.5

rCSI 30.56%

PRS 53.01
midbrain dopaminergic neuron CL2000097

CSI 7.49

rCSI 47.95%

PRS 60.94
helper T cell CL0000912

CSI 7.34

rCSI 10.38%

PRS 63.8
intermediate monocyte CL0002393

CSI 7.32

rCSI 11.04%

PRS 61.39
mural cell CL0008034

CSI 7.27

rCSI 24.62%

PRS 50.89
activated CD4-positive, alpha-beta T cell CL0000896

CSI 7.27

rCSI 6.72%

PRS 77.48
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 7.25

rCSI 8.66%

PRS 77.56
parietal epithelial cell CL1000452

CSI 7.22

rCSI 19.28%

PRS 49.31
lung pericyte CL0009089

CSI 7.21

rCSI 19.02%

PRS 66.75

mesenchymal stem cell CL0000134

CSI 0.2

rCSI 2.0%

PRS 71.2%
enteric neuron CL0007011

CSI 0.3

rCSI 3.9%

PRS 74.0%
vein endothelial cell of respiratory system CL4033008

CSI 0.3

rCSI 2.4%

PRS 71.7%
decidual natural killer cell, human CL0002343

CSI 0.4

rCSI 4.0%

PRS 86.5%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 0.5

rCSI 5.4%

PRS 85.0%
fibroblast of breast CL4006000

CSI 0.5

rCSI 2.1%

PRS 72.4%
pancreatic ductal cell CL0002079

CSI 0.6

rCSI 1.1%

PRS 60.5%
endothelial cell of uterus CL0009095

CSI 0.6

rCSI 4.4%

PRS 76.0%
thymocyte CL0000893

CSI 0.7

rCSI 2.5%

PRS 88.5%
regular ventricular cardiac myocyte CL0002131

CSI 0.7

rCSI 4.5%

PRS 49.8%
diffuse bipolar 3a cell CL4033029

CSI 0.8

rCSI 5.2%

PRS 54.2%
double negative T regulatory cell CL0011024

CSI 0.8

rCSI 14.5%

PRS 89.0%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 0.8

rCSI 0.7%

PRS 54.6%
placental villous trophoblast CL2000060

CSI 0.8

rCSI 1.3%

PRS 55.9%
pancreatic stellate cell CL0002410

CSI 0.8

rCSI 4.8%

PRS 67.5%
stromal cell CL0000499

CSI 0.9

rCSI 2.4%

PRS 55.0%
cytotoxic T cell CL0000910

CSI 0.9

rCSI 5.4%

PRS 67.5%
mesangial cell CL0000650

CSI 0.9

rCSI 3.8%

PRS 69.8%
tissue-resident macrophage CL0000864

CSI 1.0

rCSI 4.7%

PRS 74.8%
promonocyte CL0000559

CSI 1.0

rCSI 1.8%

PRS 66.9%
pancreatic A cell CL0000171

CSI 1.1

rCSI 1.1%

PRS 61.3%
alveolar adventitial fibroblast CL4028006

CSI 1.1

rCSI 1.7%

PRS 59.8%
diffuse bipolar 4 cell CL4033031

CSI 1.2

rCSI 13.1%

PRS 49.4%
GABAergic interneuron CL0011005

CSI 1.2

rCSI 18.6%

PRS 62.8%
lung microvascular endothelial cell CL2000016

CSI 1.2

rCSI 22.9%

PRS 74.8%
neuroendocrine cell CL0000165

CSI 1.2

rCSI 4.7%

PRS 73.6%
type EC enteroendocrine cell CL0000577

CSI 1.3

rCSI 4.7%

PRS 67.6%
intrahepatic cholangiocyte CL0002538

CSI 1.4

rCSI 3.3%

PRS 69.6%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 1.4

rCSI 8.2%

PRS 77.7%
lung ciliated cell CL1000271

CSI 1.4

rCSI 1.6%

PRS 47.9%
type B pancreatic cell CL0000169

CSI 1.4

rCSI 3.2%

PRS 55.8%
blood vessel smooth muscle cell CL0019018

CSI 1.4

rCSI 11.7%

PRS 51.1%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 1.5

rCSI 2.0%

PRS 77.7%
endothelial cell of arteriole CL1000412

CSI 1.5

rCSI 8.2%

PRS 73.9%
stem cell CL0000034

CSI 1.5

rCSI 1.5%

PRS 48.3%
tendon cell CL0000388

CSI 1.5

rCSI 4.0%

PRS 75.0%
diffuse bipolar 6 cell CL4033032

CSI 1.6

rCSI 8.3%

PRS 53.0%
contractile cell CL0000183

CSI 1.8

rCSI 5.3%

PRS 56.6%
forebrain radial glial cell CL0013000

CSI 1.8

rCSI 5.8%

PRS 63.4%
cardiac muscle cell CL0000746

CSI 1.8

rCSI 2.6%

PRS 48.0%
H1 horizontal cell CL0004217

CSI 1.8

rCSI 7.2%

PRS 58.2%
erythroid lineage cell CL0000764

CSI 1.8

rCSI 11.8%

PRS 76.5%
skeletal muscle satellite cell CL0000594

CSI 1.9

rCSI 5.5%

PRS 81.7%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 1.9

rCSI 2.7%

PRS 54.2%
common myeloid progenitor CL0000049

CSI 1.9

rCSI 1.5%

PRS 59.1%
medium spiny neuron CL1001474

CSI 1.9

rCSI 16.6%

PRS 45.4%
renal interstitial pericyte CL1001318

CSI 2.0

rCSI 5.5%

PRS 53.7%
basophil CL0000767

CSI 2.0

rCSI 4.3%

PRS 76.4%
mesodermal cell CL0000222

CSI 2.1

rCSI 2.5%

PRS 55.8%
neuroplacodal cell CL0000032

CSI 2.1

rCSI 19.5%

PRS 69.6%
mesothelial cell CL0000077

CSI 2.2

rCSI 8.5%

PRS 34.9%
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 2.2

rCSI 5.3%

PRS 89.4%
diffuse bipolar 3b cell CL4033030

CSI 2.3

rCSI 14.9%

PRS 55.4%
basket cell CL0000118

CSI 2.3

rCSI 14.3%

PRS 40.5%
interstitial cell of Cajal CL0002088

CSI 2.3

rCSI 2.9%

PRS 64.1%
pancreatic D cell CL0000173

CSI 2.3

rCSI 2.3%

PRS 60.5%
BEST4+ enteroycte CL4030026

CSI 2.3

rCSI 2.9%

PRS 59.8%
myoepithelial cell CL0000185

CSI 2.4

rCSI 6.1%

PRS 66.4%
granulocyte monocyte progenitor cell CL0000557

CSI 2.4

rCSI 2.1%

PRS 62.6%
natural T-regulatory cell CL0000903

CSI 2.4

rCSI 4.6%

PRS 87.3%
megakaryocyte CL0000556

CSI 2.5

rCSI 10.9%

PRS 71.1%
hepatic pit cell CL2000054

CSI 2.6

rCSI 35.2%

PRS 86.0%
intraepithelial lymphocyte CL0002496

CSI 2.6

rCSI 7.0%

PRS 87.7%
lung endothelial cell CL1001567

CSI 2.7

rCSI 6.2%

PRS 77.3%
diffuse bipolar 2 cell CL4033028

CSI 2.7

rCSI 21.0%

PRS 54.9%
regular atrial cardiac myocyte CL0002129

CSI 2.8

rCSI 8.9%

PRS 56.6%
cerebellar granule cell CL0001031

CSI 2.8

rCSI 4.1%

PRS 52.0%
cerebral cortex pyramidal neuron CL4023111

CSI 2.8

rCSI 17.5%

PRS 73.9%
activated type II NK T cell CL0000931

CSI 2.9

rCSI 3.2%

PRS 74.1%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 2.9

rCSI 8.2%

PRS 77.3%
Kupffer cell CL0000091

CSI 2.9

rCSI 6.6%

PRS 57.6%
ON parasol ganglion cell CL4033052

CSI 3.0

rCSI 41.8%

PRS 49.6%
mature alpha-beta T cell CL0000791

CSI 3.0

rCSI 11.0%

PRS 77.3%
indirect pathway medium spiny neuron CL4023029

CSI 3.1

rCSI 73.5%

PRS 40.3%
direct pathway medium spiny neuron CL4023026

CSI 3.1

rCSI 73.6%

PRS 39.3%
diffuse bipolar 1 cell CL4033027

CSI 3.2

rCSI 23.8%

PRS 52.1%
ON midget ganglion cell CL4033046

CSI 3.2

rCSI 64.8%

PRS 49.2%
memory T cell CL0000813

CSI 3.2

rCSI 6.2%

PRS 84.4%
adventitial cell CL0002503

CSI 3.2

rCSI 7.7%

PRS 67.0%
conjunctival epithelial cell CL1000432

CSI 3.2

rCSI 4.9%

PRS 58.5%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 3.3

rCSI 16.3%

PRS 70.2%
cardiac endothelial cell CL0010008

CSI 3.3

rCSI 13.4%

PRS 56.5%
OFF midget ganglion cell CL4033047

CSI 3.3

rCSI 67.6%

PRS 50.5%
tracheobronchial smooth muscle cell CL0019019

CSI 3.3

rCSI 5.9%

PRS 66.5%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 3.3

rCSI 11.0%

PRS 45.3%
OFF-bipolar cell CL0000750

CSI 3.4

rCSI 4.6%

PRS 65.7%
lung neuroendocrine cell CL1000223

CSI 3.5

rCSI 5.1%

PRS 63.3%
endocardial cell CL0002350

CSI 3.5

rCSI 16.8%

PRS 57.0%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 3.6

rCSI 9.3%

PRS 53.0%
progenitor cell CL0011026

CSI 3.7

rCSI 7.9%

PRS 57.7%
amacrine cell CL0000561

CSI 3.7

rCSI 10.8%

PRS 47.9%
chondrocyte CL0000138

CSI 3.8

rCSI 6.0%

PRS 50.2%
GABAergic neuron CL0000617

CSI 3.8

rCSI 12.6%

PRS 43.7%
alveolar type 1 fibroblast cell CL4028004

CSI 3.8

rCSI 4.1%

PRS 61.9%
kidney interstitial alternatively activated macrophage CL1000695

CSI 3.8

rCSI 10.0%

PRS 57.5%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 3.8

rCSI 9.9%

PRS 84.2%
cardiac blood vessel endothelial cell CL0010006

CSI 3.9

rCSI 27.3%

PRS 50.0%
innate lymphoid cell CL0001065

CSI 3.9

rCSI 8.1%

PRS 60.5%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 3.9

rCSI 12.1%

PRS 67.4%
exhausted T cell CL0011025

CSI 4.0

rCSI 68.3%

PRS 81.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Node Color (Target Cell CSI, relative to current network):
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [FYN](/details-gene/2534) is a proto-oncogene located on chromosome 6q21 that encodes a non-receptor tyrosine kinase belonging to the Src family. As a critical intracellular signaling molecule, [FYN](/details-gene/2534) plays a multifaceted role in a wide range of cellular processes. Expression data reveals its prominent significance in both the adaptive immune system and the central nervous system. **Overall**, it is most significant in lymphocyte populations, particularly [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907), where it is integral to T-cell receptor signaling and activation. Concurrently, its high significance in various glial and neuronal cell types, including [Bergmann glial cell](/details-cell/CL0000644) and [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059), underscores its importance in neural development, axon guidance, and synaptic function. Its association with human disease is noted in OMIM ([137025](https://omim.org/entry/137025)). ## Cellular Roles and Expression Landscape The expression profile of [FYN](/details-gene/2534) highlights its dual specialization in the immune and nervous systems. **Overall**, its highest significance is observed in the adaptive immune compartment. It is a defining kinase in multiple T-cell subsets, including [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907), [naive T cell](/details-cell/CL0000898), [CD8-positive, CD28-negative, alpha-beta regulatory T cell](/details-cell/CL0000920), and [T-helper 17 cell](/details-cell/CL0000899). This pattern is consistent with its well-documented role in transducing signals from the T-cell receptor (TCR) and co-stimulatory molecules like CD28, which is critical for T-cell proliferation, differentiation, and effector function ([PubMed: 7822789](https://pubmed.ncbi.nlm.nih.gov/7822789/); [PubMed: 7568038](https://doi.org/10.1073/pnas.92.19.8891)). Simultaneously, [FYN](/details-gene/2534) demonstrates profound importance within the central nervous system. It shows high significance in various glial cells such as [Bergmann glial cell](/details-cell/CL0000644), [astrocyte of the cerebral cortex](/details-cell/CL0002605), and both [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059) and [oligodendrocyte precursor cell](/details-cell/CL0002453). Furthermore, its relevance extends to specific neuronal populations, including [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) and [caudal ganglionic eminence derived cortical interneuron](/details-cell/CL4023064). This broad neural expression pattern points to its involvement in key neurodevelopmental processes like myelination, neuronal migration, and dendrite morphogenesis. Beyond these primary domains, [FYN](/details-gene/2534) also shows moderate significance in other specialized cell types like [enteroendocrine cell](/details-cell/CL0000164) and [myofibroblast cell](/details-cell/CL0000186), suggesting a broader, context-specific role in tissue homeostasis and signaling across the body. ## Pathways and Molecular Function [FYN](/details-gene/2534)'s fundamental molecular function is as a '[Non-membrane spanning protein tyrosine kinase activity](/details-go/GO:0004715)', executing '[Peptidyl-tyrosine phosphorylation](/details-go/GO:0018108)' to regulate downstream signaling cascades. Its pathway involvements directly reflect its cellular expression profile. Consistent with its high significance in T-lymphocytes, [FYN](/details-gene/2534) is a central component of the '[Adaptive immune system](/details-reactome/R-HSA-1280218)'. It is explicitly implicated in the '[T cell receptor signaling pathway](/details-go/GO:0050852)', '[CD28 co-stimulation](/details-reactome/R-HSA-389356)', and '[Natural killer cell activation](/details-go/GO:0030101)'. It also participates in signaling from other immune receptors, such as in the '[Fc-gamma receptor signaling pathway involved in phagocytosis](/details-go/GO:0038096)' and '[C-type lectin receptors (clrs)](/details-reactome/R-HSA-5621481)'. Its role in the nervous system is supported by its involvement in '[Nervous system development](/details-reactome/R-HSA-9675108)', including processes like '[Axon guidance](/details-go/GO:0007411)', '[Dendrite morphogenesis](/details-go/GO:0048813)', and '[Ephrin receptor signaling pathway](/details-go/GO:0048013)'. Notably, it is also linked to neuropathological processes, as indicated by its participation in the '[Cellular response to amyloid-beta](/details-go/GO:1904646)' pathway. As a versatile kinase, [FYN](/details-gene/2534) also functions in more universal signaling pathways related to cell growth and adhesion, such as the '[Vascular endothelial growth factor receptor signaling pathway](/details-go/GO:0048010)' and '[Cell surface interactions at the vascular wall](/details-reactome/R-HSA-202733)'. ## Research Directions The dual prominence of [FYN](/details-gene/2534) in both the immune and central nervous systems presents intriguing questions, particularly at the intersection of these two systems in health and disease. ### Proposed Hypotheses: 1. **Role in Neuro-inflammation:** Given its high significance in both T-cells and glial cells (astrocytes and oligodendrocytes), [FYN](/details-gene/2534) may function as a critical signaling hub mediating the crosstalk between infiltrating immune cells and resident glial cells during neuro-inflammatory conditions like multiple sclerosis. It could regulate astrocyte reactivity or oligodendrocyte vulnerability in response to T-cell-derived signals. 2. **Regulation of T-cell Memory Formation:** The observation that [FYN](/details-gene/2534) shows the highest significance in [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) suggests a specific, non-redundant role in the establishment or maintenance of immunological memory. The precise level of [FYN](/details-gene/2534) kinase activity may act as a rheostat that determines whether an activated T-cell undergoes terminal differentiation into an effector cell versus differentiating into a long-lived memory cell. ### Key Experimental Approach: To test the first hypothesis regarding [FYN](/details-gene/2534)'s role in neuro-inflammation, a targeted in-vitro and in-vivo approach could be employed. Specifically, one could generate conditional knockout mice with [FYN](/details-gene/2534) deleted in either astrocytes (e.g., GFAP-Cre) or oligodendrocytes (e.g., Olig2-Cre). These mice could then be subjected to the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. Differences in disease severity, immune cell infiltration into the CNS, demyelination, and glial activation between knockout and wild-type mice would be assessed using histology, flow cytometry, and transcriptomic analysis of isolated CNS cells. This would directly test the cell-type-specific contribution of [FYN](/details-gene/2534) to neuro-inflammatory pathology. ### Therapeutic Potential: As a tyrosine kinase, [FYN](/details-gene/2534) belongs to a well-established class of druggable targets. Its role as a proto-oncogene and its involvement in T-cell activation make it a potential target for **inhibition**. In autoimmune diseases, a selective FYN inhibitor could dampen aberrant T-cell responses. In certain cancers, inhibiting [FYN](/details-gene/2534) might reduce proliferation and survival signals. However, its crucial roles in both the immune system and the CNS pose a significant therapeutic challenge. Systemic inhibition could lead to immunosuppression or neurological side effects. Therefore, the development of cell-type specific inhibitors, targeted delivery systems (e.g., antibody-drug conjugates), or therapies aimed at modulating specific protein-protein interactions downstream of [FYN](/details-gene/2534) may be required for a favorable therapeutic window.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Tyrosine-protein kinase Fyn

Genular Protein ID: 3205760051

Symbol: FYN_HUMAN

Name: Tyrosine-protein kinase Fyn

UniProtKB Accession Codes:

P06241 B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7

Database IDs:

Citations:

PubMed ID: 3099169

Title: Isolation and oncogenic potential of a novel human src-like gene.

PubMed ID: 3099169

DOI: 10.1128/mcb.6.12.4195-4201.1986

PubMed ID: 3526330

Title: Yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.

PubMed ID: 3526330

DOI: 10.1073/pnas.83.15.5459

PubMed ID: 7822789

Title: Human p59fyn(T) regulates OKT3-induced calcium influx by a mechanism distinct from PIP2 hydrolysis in Jurkat T cells.

PubMed ID: 7822789

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1699196

Title: In vivo phosphorylation and membrane association of the fyn proto-oncogene product in IM-9 human lymphoblasts.

PubMed ID: 1699196

PubMed ID: 1533589

Title: Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase.

PubMed ID: 1533589

DOI: 10.1002/eji.1830220510

PubMed ID: 8394019

Title: Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.

PubMed ID: 8394019

DOI: 10.1073/pnas.90.15.7366

PubMed ID: 8206991

Title: Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization.

PubMed ID: 8206991

DOI: 10.1016/s0021-9258(19)89447-4

PubMed ID: 7568038

Title: p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

PubMed ID: 7568038

DOI: 10.1073/pnas.92.19.8891

PubMed ID: 9038210

Title: Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.

PubMed ID: 9038210

DOI: 10.1074/jbc.272.9.5915

PubMed ID: 9360983

Title: Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.

PubMed ID: 9360983

DOI: 10.1074/jbc.272.46.29083

PubMed ID: 9207119

Title: Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.

PubMed ID: 9207119

DOI: 10.1073/pnas.94.14.7493

PubMed ID: 9741627

Title: A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth.

PubMed ID: 9741627

DOI: 10.1016/s0092-8674(00)81604-9

PubMed ID: 10196263

Title: Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines.

PubMed ID: 10196263

DOI: 10.1128/jvi.73.5.3709-3717.1999

PubMed ID: 10498895

Title: Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.

PubMed ID: 10498895

DOI: 10.1038/sj.onc.1202917

PubMed ID: 10790433

Title: Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.

PubMed ID: 10790433

DOI: 10.1084/jem.191.9.1591

PubMed ID: 11005864

Title: T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase.

PubMed ID: 11005864

DOI: 10.1073/pnas.97.20.10923

PubMed ID: 11162638

Title: Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.

PubMed ID: 11162638

DOI: 10.1006/bbrc.2000.4253

PubMed ID: 11518702

Title: The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.

PubMed ID: 11518702

DOI: 10.1074/jbc.m101546200

PubMed ID: 11536198

Title: Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation.

PubMed ID: 11536198

DOI: 10.1002/neu.1066

PubMed ID: 12218089

Title: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.

PubMed ID: 12218089

DOI: 10.4049/jimmunol.169.6.2813

PubMed ID: 12788081

Title: p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn.

PubMed ID: 12788081

DOI: 10.1016/s0006-291x(03)00923-9

PubMed ID: 14761972

Title: Regulation of TRPC6 channel activity by tyrosine phosphorylation.

PubMed ID: 14761972

DOI: 10.1074/jbc.m311274200

PubMed ID: 15557120

Title: Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance.

PubMed ID: 15557120

DOI: 10.1083/jcb.200405053

PubMed ID: 14707117

Title: Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation.

PubMed ID: 14707117

DOI: 10.1084/jem.20030976

PubMed ID: 14757743

Title: Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.

PubMed ID: 14757743

DOI: 10.1084/jem.20030589

PubMed ID: 15489916

Title: Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.

PubMed ID: 15489916

DOI: 10.1038/sj.onc.1208074

PubMed ID: 15536091

Title: Fyn phosphorylates human MAP-2c on tyrosine 67.

PubMed ID: 15536091

DOI: 10.1074/jbc.m411380200

PubMed ID: 15537652

Title: Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase.

PubMed ID: 15537652

DOI: 10.1074/jbc.m402053200

PubMed ID: 16387660

Title: Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation.

PubMed ID: 16387660

DOI: 10.1016/j.molcel.2005.11.014

PubMed ID: 16841086

Title: Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival.

PubMed ID: 16841086

DOI: 10.1038/sj.cdd.4402011

PubMed ID: 17925405

Title: Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.

PubMed ID: 17925405

DOI: 10.1074/jbc.m704650200

PubMed ID: 17194753

Title: Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA.

PubMed ID: 17194753

DOI: 10.1128/mcb.01974-06

PubMed ID: 18056706

Title: Regulation of FynT function by dual domain docking on PAG/Cbp.

PubMed ID: 18056706

DOI: 10.1074/jbc.m705215200

PubMed ID: 18258597

Title: Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.

PubMed ID: 18258597

DOI: 10.1074/jbc.m707247200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19179337

Title: Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-{gamma}1.

PubMed ID: 19179337

DOI: 10.1074/jbc.m806851200

PubMed ID: 19652227

Title: Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.

PubMed ID: 19652227

DOI: 10.1074/jbc.m109.000240

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20028775

Title: The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems.

PubMed ID: 20028775

DOI: 10.1189/jlb.0409227

PubMed ID: 20100835

Title: Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.

PubMed ID: 20100835

DOI: 10.1074/jbc.m109.071381

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22080863

Title: T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.

PubMed ID: 22080863

DOI: 10.1172/jci59492

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27335501

Title: ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion.

PubMed ID: 27335501

DOI: 10.4049/jimmunol.1501913

PubMed ID: 7687536

Title: Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin.

PubMed ID: 7687536

DOI: 10.2210/pdb1shf/pdb

PubMed ID: 7664083

Title: High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.

PubMed ID: 7664083

DOI: 10.1038/nsb0894-546

PubMed ID: 8961927

Title: Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.

PubMed ID: 8961927

DOI: 10.1021/bi9620969

PubMed ID: 8681387

Title: Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.

PubMed ID: 8681387

DOI: 10.1016/s0092-8674(00)81276-3

PubMed ID: 8805554

Title: Solution structure and peptide binding of the SH3 domain from human Fyn.

PubMed ID: 8805554

DOI: 10.1016/s0969-2126(96)00076-7

PubMed ID: 9351806

Title: The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.

PubMed ID: 9351806

DOI: 10.1016/s0969-2126(97)00283-9

PubMed ID: 12545174

Title: SAP couples Fyn to SLAM immune receptors.

PubMed ID: 12545174

DOI: 10.1038/ncb920

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 537
Mass: 60762
Checksum: 4A1E443A4B5A0977
Sequence:

MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG 
LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 
EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET 
TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC 
RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT 
LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR 
ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY 
TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE 
RGYRMPCPQD CPISLHELMI HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Atherosclerosis MONDO0005311
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Breast cancer UBERON0000310_MONDO0007254
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colonic epithelium UBERON0000397
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Entorhinal cortex UBERON0002728
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	\|— Frontal cortex Healthy UBERON0001870_PATO0000461
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileal epithelium UBERON0008345
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	\|— Lymph node Healthy UBERON0000029_PATO0000461
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	\|— Prefrontal cortex Healthy UBERON0000451_PATO0000461
	Primary motor cortex UBERON0001384
	\|— Primary motor cortex Healthy UBERON0001384_PATO0000461
	Primary visual cortex UBERON0002436
	\|— Primary visual cortex Healthy UBERON0002436_PATO0000461
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648

Details for: FYN

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Isolation and oncogenic potential of a novel human src-like gene. PubMed ID: 3099169

Yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. PubMed ID: 3526330

Human p59fyn(T) regulates OKT3-induced calcium influx by a mechanism distinct from PIP2 hydrolysis in Jurkat T cells. PubMed ID: 7822789

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

In vivo phosphorylation and membrane association of the fyn proto-oncogene product in IM-9 human lymphoblasts. PubMed ID: 1699196

Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase. PubMed ID: 1533589

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells. PubMed ID: 8394019

Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization. PubMed ID: 8206991

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation. PubMed ID: 7568038

Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. PubMed ID: 9038210

Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates. PubMed ID: 9360983

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. PubMed ID: 9207119

A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. PubMed ID: 9741627

Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines. PubMed ID: 10196263

Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. PubMed ID: 10498895

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. PubMed ID: 10790433

T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase. PubMed ID: 11005864

Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125. PubMed ID: 11162638

The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK. PubMed ID: 11518702

Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation. PubMed ID: 11536198

Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells. PubMed ID: 12218089

p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. PubMed ID: 12788081

Regulation of TRPC6 channel activity by tyrosine phosphorylation. PubMed ID: 14761972

Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance. PubMed ID: 15557120

Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation. PubMed ID: 14707117

Unc119, a novel activator of Lck/Fyn, is essential for T cell activation. PubMed ID: 14757743

Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. PubMed ID: 15489916

Fyn phosphorylates human MAP-2c on tyrosine 67. PubMed ID: 15536091

Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase. PubMed ID: 15537652

Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation. PubMed ID: 16387660

Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. PubMed ID: 16841086

Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. PubMed ID: 17925405

Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA. PubMed ID: 17194753

Regulation of FynT function by dual domain docking on PAG/Cbp. PubMed ID: 18056706

Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2. PubMed ID: 18258597

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. PubMed ID: 19807924

Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-{gamma}1. PubMed ID: 19179337

Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32. PubMed ID: 19652227

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems. PubMed ID: 20028775

Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. PubMed ID: 20100835

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice. PubMed ID: 22080863

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion. PubMed ID: 27335501

Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin. PubMed ID: 7687536

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides. PubMed ID: 7664083

Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase. PubMed ID: 8961927

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. PubMed ID: 8681387

Solution structure and peptide binding of the SH3 domain from human Fyn. PubMed ID: 8805554

The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity. PubMed ID: 9351806

SAP couples Fyn to SLAM immune receptors. PubMed ID: 12545174

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846