Details for: GAS6

Gene ID: 2621

Symbol: GAS6

Ensembl ID: ENSG00000183087

Description: growth arrest specific 6

Associated with

  • Cell surface interactions at the vascular wall
    (R-HSA-202733)
  • Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
    (R-HSA-159854)
  • Gamma-carboxylation of protein precursors
    (R-HSA-159740)
  • Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
    (R-HSA-163841)
  • Hemostasis
    (R-HSA-109582)
  • Metabolism of proteins
    (R-HSA-392499)
  • Platelet activation, signaling and aggregation
    (R-HSA-76002)
  • Platelet degranulation
    (R-HSA-114608)
  • Post-translational protein modification
    (R-HSA-597592)
  • Post-translational protein phosphorylation
    (R-HSA-8957275)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-HSA-381426)
  • Removal of aminoterminal propeptides from gamma-carboxylated proteins
    (R-HSA-159782)
  • Response to elevated platelet cytosolic ca2+
    (R-HSA-76005)
  • Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the golgi apparatus
    (R-HSA-159763)
  • Activation of protein kinase b activity
    (GO:0032148)
  • Animal organ regeneration
    (GO:0031100)
  • Apoptotic cell clearance
    (GO:0043277)
  • B cell chemotaxis
    (GO:0035754)
  • Blood coagulation
    (GO:0007596)
  • Calcium ion binding
    (GO:0005509)
  • Calcium ion transmembrane transport
    (GO:0070588)
  • Cell-substrate adhesion
    (GO:0031589)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Cellular response to glucose stimulus
    (GO:0071333)
  • Cellular response to growth factor stimulus
    (GO:0071363)
  • Cellular response to interferon-alpha
    (GO:0035457)
  • Cellular response to starvation
    (GO:0009267)
  • Cellular response to vitamin k
    (GO:0071307)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
    (GO:0043027)
  • Cytoplasm
    (GO:0005737)
  • Dendritic cell differentiation
    (GO:0097028)
  • Endoplasmic reticulum lumen
    (GO:0005788)
  • Enzyme-linked receptor protein signaling pathway
    (GO:0007167)
  • Extracellular exosome
    (GO:0070062)
  • Extracellular matrix assembly
    (GO:0085029)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Fibroblast apoptotic process
    (GO:0044346)
  • Fusion of virus membrane with host plasma membrane
    (GO:0019064)
  • Golgi lumen
    (GO:0005796)
  • Hematopoietic stem cell migration to bone marrow
    (GO:0097241)
  • Myeloid cell apoptotic process
    (GO:0033028)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of biomineral tissue development
    (GO:0070168)
  • Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043154)
  • Negative regulation of dendritic cell apoptotic process
    (GO:2000669)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of fibroblast apoptotic process
    (GO:2000270)
  • Negative regulation of interleukin-1 production
    (GO:0032692)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of myeloid cell apoptotic process
    (GO:0033033)
  • Negative regulation of oligodendrocyte apoptotic process
    (GO:1900142)
  • Negative regulation of renal albumin absorption
    (GO:2000533)
  • Negative regulation of tumor necrosis factor-mediated signaling pathway
    (GO:0010804)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Neuron migration
    (GO:0001764)
  • Phagocytosis
    (GO:0006909)
  • Phosphatidylserine binding
    (GO:0001786)
  • Platelet alpha granule lumen
    (GO:0031093)
  • Positive regulation of cytokine-mediated signaling pathway
    (GO:0001961)
  • Positive regulation of dendritic cell chemotaxis
    (GO:2000510)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glomerular filtration
    (GO:0003104)
  • Positive regulation of natural killer cell differentiation
    (GO:0032825)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein export from nucleus
    (GO:0046827)
  • Positive regulation of protein kinase activity
    (GO:0045860)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of tor signaling
    (GO:0032008)
  • Protein-macromolecule adaptor activity
    (GO:0030674)
  • Protein binding
    (GO:0005515)
  • Protein localization to plasma membrane
    (GO:0072659)
  • Protein phosphorylation
    (GO:0006468)
  • Receptor-mediated virion attachment to host cell
    (GO:0046813)
  • Receptor ligand activity
    (GO:0048018)
  • Receptor tyrosine kinase binding
    (GO:0030971)
  • Signaling receptor binding
    (GO:0005102)
  • Signal transduction
    (GO:0007165)
  • Symbiont entry into host cell
    (GO:0046718)
  • Viral genome replication
    (GO:0019079)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 246.8735
    Cell Significance Index: -38.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 152.2610
    Cell Significance Index: -38.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 79.1108
    Cell Significance Index: -37.3500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 56.2426
    Cell Significance Index: -37.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.5488
    Cell Significance Index: -33.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.1690
    Cell Significance Index: -38.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.6032
    Cell Significance Index: -39.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.9346
    Cell Significance Index: -26.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 11.8456
    Cell Significance Index: 190.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.4195
    Cell Significance Index: -37.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 6.3497
    Cell Significance Index: 146.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.6092
    Cell Significance Index: 156.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.2859
    Cell Significance Index: 120.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9034
    Cell Significance Index: 51.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4987
    Cell Significance Index: 67.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2740
    Cell Significance Index: 174.9500
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 1.1806
    Cell Significance Index: 4.4000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.1707
    Cell Significance Index: 14.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1550
    Cell Significance Index: 30.3700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.0979
    Cell Significance Index: 9.0800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0053
    Cell Significance Index: 17.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8913
    Cell Significance Index: 68.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8910
    Cell Significance Index: 114.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8695
    Cell Significance Index: 785.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8286
    Cell Significance Index: 166.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7651
    Cell Significance Index: 22.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7535
    Cell Significance Index: 21.6000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.7291
    Cell Significance Index: 11.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7144
    Cell Significance Index: 315.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6024
    Cell Significance Index: 13.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5283
    Cell Significance Index: 189.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3877
    Cell Significance Index: 5.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3489
    Cell Significance Index: 6.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3432
    Cell Significance Index: 9.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3363
    Cell Significance Index: 54.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3008
    Cell Significance Index: 29.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2932
    Cell Significance Index: 13.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2572
    Cell Significance Index: 6.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2250
    Cell Significance Index: 42.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1935
    Cell Significance Index: 105.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1855
    Cell Significance Index: 13.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1530
    Cell Significance Index: 105.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1123
    Cell Significance Index: 71.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0927
    Cell Significance Index: 2.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0885
    Cell Significance Index: 3.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0637
    Cell Significance Index: 0.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0598
    Cell Significance Index: 112.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0524
    Cell Significance Index: 0.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0380
    Cell Significance Index: 1.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0294
    Cell Significance Index: 3.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0261
    Cell Significance Index: 19.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0088
    Cell Significance Index: 13.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0081
    Cell Significance Index: 3.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0027
    Cell Significance Index: 0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0024
    Cell Significance Index: -4.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0209
    Cell Significance Index: -28.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0289
    Cell Significance Index: -5.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0304
    Cell Significance Index: -22.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0398
    Cell Significance Index: -7.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0558
    Cell Significance Index: -41.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0634
    Cell Significance Index: -8.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0675
    Cell Significance Index: -42.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0700
    Cell Significance Index: -39.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0701
    Cell Significance Index: -7.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1010
    Cell Significance Index: -17.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1109
    Cell Significance Index: -31.9200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1140
    Cell Significance Index: -1.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1430
    Cell Significance Index: -20.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1519
    Cell Significance Index: -17.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1521
    Cell Significance Index: -17.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1523
    Cell Significance Index: -9.3600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1640
    Cell Significance Index: -2.3000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1640
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1996
    Cell Significance Index: -42.0400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2502
    Cell Significance Index: -2.0400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2845
    Cell Significance Index: -2.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2871
    Cell Significance Index: -21.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2929
    Cell Significance Index: -6.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3037
    Cell Significance Index: -31.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3236
    Cell Significance Index: -38.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3406
    Cell Significance Index: -22.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3477
    Cell Significance Index: -18.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3710
    Cell Significance Index: -16.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3785
    Cell Significance Index: -9.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4324
    Cell Significance Index: -34.2500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4398
    Cell Significance Index: -2.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4574
    Cell Significance Index: -17.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4718
    Cell Significance Index: -24.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4763
    Cell Significance Index: -26.7300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4932
    Cell Significance Index: -6.1500
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.5040
    Cell Significance Index: -1.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5775
    Cell Significance Index: -36.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5846
    Cell Significance Index: -29.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5865
    Cell Significance Index: -37.8400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6086
    Cell Significance Index: -6.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6188
    Cell Significance Index: -37.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6435
    Cell Significance Index: -7.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6780
    Cell Significance Index: -14.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6808
    Cell Significance Index: -14.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7131
    Cell Significance Index: -22.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GAS6 is a secreted protein that belongs to the immunoglobulin superfamily. It is composed of four immunoglobulin-like domains and one fibronectin type III-like domain. GAS6 is expressed in various tissues, including the lungs, kidneys, and the gastrointestinal tract, and is involved in the regulation of cell-cell interactions, cell adhesion, and signaling pathways. **Pathways and Functions:** GAS6 binds to the AXL receptor tyrosine kinase, triggering a signaling cascade that regulates various cellular processes. The GAS6-AXL interaction has been implicated in the regulation of: 1. **Apoptosis**: GAS6 can induce apoptosis in certain cell types, while also inhibiting apoptosis in others. 2. **Cell proliferation**: GAS6 can promote cell proliferation by activating the AXL receptor tyrosine kinase. 3. **Cell migration**: GAS6 can regulate cell migration by modulating the expression of adhesion molecules. 4. **Immune regulation**: GAS6 has been implicated in the regulation of immune cells, including dendritic cells, T cells, and B cells. 5. **Tumor growth**: GAS6 has been shown to promote tumor growth by activating the AXL receptor tyrosine kinase. **Clinical Significance:** GAS6 has been implicated in various diseases, including: 1. **Cancer**: GAS6 has been shown to promote tumor growth and metastasis in various cancer types, including breast, lung, and colon cancer. 2. **Autoimmune diseases**: GAS6 has been implicated in the regulation of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Inflammatory disorders**: GAS6 has been shown to regulate inflammatory responses in diseases such as asthma and chronic obstructive pulmonary disease (COPD). 4. **Neurological disorders**: GAS6 has been implicated in the regulation of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, GAS6 is a multifaceted protein that plays a crucial role in various cellular processes, including cell signaling, apoptosis, and immune regulation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of GAS6 and its potential therapeutic applications. **Recommendations:** 1. **Further research**: Investigate the mechanisms of GAS6 signaling and its role in different diseases. 2. **Therapeutic targeting**: Develop therapeutic strategies that target GAS6-AXL interactions to treat diseases such as cancer and autoimmune disorders. 3. **Diagnostic biomarkers**: Identify GAS6 as a potential biomarker for diseases such as cancer and autoimmune disorders. By understanding the complex role of GAS6 in immune regulation and beyond, we can uncover new therapeutic targets and develop novel treatments for various diseases.

Genular Protein ID: 2481651301

Symbol: GAS6_HUMAN

Name: AXL receptor tyrosine kinase ligand

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8336730

Title: The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.

PubMed ID: 8336730

DOI: 10.1128/mcb.13.8.4976-4985.1993

PubMed ID: 15108283

Title: Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke.

PubMed ID: 15108283

DOI: 10.1002/humu.20025

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7854420

Title: Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6.

PubMed ID: 7854420

DOI: 10.1038/373623a0

PubMed ID: 7867073

Title: The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases.

PubMed ID: 7867073

DOI: 10.1016/0092-8674(95)90520-0

PubMed ID: 9326368

Title: Identification and tissue expression of a splice variant for the growth arrest-specific gene gas6.

PubMed ID: 9326368

DOI: 10.1016/s0014-5793(97)01094-6

PubMed ID: 8939948

Title: Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases.

PubMed ID: 8939948

DOI: 10.1074/jbc.271.47.30022

PubMed ID: 9326369

Title: The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation.

PubMed ID: 9326369

DOI: 10.1016/s0014-5793(97)01093-4

PubMed ID: 12364394

Title: Acidification prevents endothelial cell apoptosis by Axl activation.

PubMed ID: 12364394

DOI: 10.1161/01.res.0000036753.50601.e9

PubMed ID: 18840707

Title: The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development.

PubMed ID: 18840707

DOI: 10.1182/blood-2008-05-157073

PubMed ID: 21501828

Title: The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry.

PubMed ID: 21501828

DOI: 10.1016/j.chom.2011.03.012

PubMed ID: 23084921

Title: The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry.

PubMed ID: 23084921

DOI: 10.1016/j.chom.2012.08.009

PubMed ID: 17005688

Title: Tyro3 family-mediated cell entry of Ebola and Marburg viruses.

PubMed ID: 17005688

DOI: 10.1128/jvi.01157-06

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 8621659

Title: Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl.

PubMed ID: 8621659

DOI: 10.1074/jbc.271.16.9785

PubMed ID: 16362042

Title: Structural basis for Gas6-Axl signalling.

PubMed ID: 16362042

DOI: 10.1038/sj.emboj.7600912

Sequence Information:

  • Length: 678
  • Mass: 74925
  • Checksum: BB6D8AB0F6C48EA9
  • Sequence:
  • MAPSLSPGPA ALRRAPQLLL LLLAAECALA ALLPAREATQ FLRPRQRRAF QVFEEAKQGH 
    LERECVEELC SREEAREVFE NDPETDYFYP RYLDCINKYG SPYTKNSGFA TCVQNLPDQC 
    TPNPCDRKGT QACQDLMGNF FCLCKAGWGG RLCDKDVNEC SQENGGCLQI CHNKPGSFHC 
    SCHSGFELSS DGRTCQDIDE CADSEACGEA RCKNLPGSYS CLCDEGFAYS SQEKACRDVD 
    ECLQGRCEQV CVNSPGSYTC HCDGRGGLKL SQDMDTCEDI LPCVPFSVAK SVKSLYLGRM 
    FSGTPVIRLR FKRLQPTRLV AEFDFRTFDP EGILLFAGGH QDSTWIVLAL RAGRLELQLR 
    YNGVGRVTSS GPVINHGMWQ TISVEELARN LVIKVNRDAV MKIAVAGDLF QPERGLYHLN 
    LTVGGIPFHE KDLVQPINPR LDGCMRSWNW LNGEDTTIQE TVKVNTRMQC FSVTERGSFY 
    PGSGFAFYSL DYMRTPLDVG TESTWEVEVV AHIRPAADTG VLFALWAPDL RAVPLSVALV 
    DYHSTKKLKK QLVVLAVEHT ALALMEIKVC DGQEHVVTVS LRDGEATLEV DGTRGQSEVS 
    AAQLQERLAV LERHLRSPVL TFAGGLPDVP VTSAPVTAFY RGCMTLEVNR RLLDLDEAAY 
    KHSDITAHSC PPVEPAAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.