Details for: GAS6
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 246.8735
Cell Significance Index: -38.4000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 152.2610
Cell Significance Index: -38.6200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 79.1108
Cell Significance Index: -37.3500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 56.2426
Cell Significance Index: -37.7400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 35.5488
Cell Significance Index: -33.9400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 31.1690
Cell Significance Index: -38.4300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.6032
Cell Significance Index: -39.1200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 11.9346
Cell Significance Index: -26.1200 - Cell Name: decidual cell (CL2000002)
Fold Change: 11.8456
Cell Significance Index: 190.0500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.4195
Cell Significance Index: -37.1700 - Cell Name: peg cell (CL4033014)
Fold Change: 6.3497
Cell Significance Index: 146.7000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.6092
Cell Significance Index: 156.6400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.2859
Cell Significance Index: 120.0200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.9034
Cell Significance Index: 51.8100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.4987
Cell Significance Index: 67.9300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.2740
Cell Significance Index: 174.9500 - Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 1.1806
Cell Significance Index: 4.4000 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.1707
Cell Significance Index: 14.5200 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.1550
Cell Significance Index: 30.3700 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.0979
Cell Significance Index: 9.0800 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.0053
Cell Significance Index: 17.7700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.8913
Cell Significance Index: 68.4000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.8910
Cell Significance Index: 114.2200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8695
Cell Significance Index: 785.1300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8286
Cell Significance Index: 166.2100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7651
Cell Significance Index: 22.0500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.7535
Cell Significance Index: 21.6000 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.7291
Cell Significance Index: 11.2800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7144
Cell Significance Index: 315.8600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6024
Cell Significance Index: 13.0500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5283
Cell Significance Index: 189.4900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.3877
Cell Significance Index: 5.2900 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.3489
Cell Significance Index: 6.8100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3432
Cell Significance Index: 9.5900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3363
Cell Significance Index: 54.7000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3008
Cell Significance Index: 29.7600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2932
Cell Significance Index: 13.6700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2572
Cell Significance Index: 6.4300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2250
Cell Significance Index: 42.8200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1935
Cell Significance Index: 105.6600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1855
Cell Significance Index: 13.1200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1530
Cell Significance Index: 105.8100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1123
Cell Significance Index: 71.3100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0927
Cell Significance Index: 2.9700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0885
Cell Significance Index: 3.1100 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.0637
Cell Significance Index: 0.9400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0598
Cell Significance Index: 112.6800 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0524
Cell Significance Index: 0.7900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0380
Cell Significance Index: 1.7900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0294
Cell Significance Index: 3.6200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0261
Cell Significance Index: 19.1700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0088
Cell Significance Index: 13.5400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0081
Cell Significance Index: 3.6900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0027
Cell Significance Index: 0.1900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0024
Cell Significance Index: -4.4600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0209
Cell Significance Index: -28.4100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0289
Cell Significance Index: -5.7300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0304
Cell Significance Index: -22.9800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0398
Cell Significance Index: -7.1800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0558
Cell Significance Index: -41.3000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0634
Cell Significance Index: -8.1900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0675
Cell Significance Index: -42.1700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0700
Cell Significance Index: -39.5000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0701
Cell Significance Index: -7.1600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1010
Cell Significance Index: -17.2500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1109
Cell Significance Index: -31.9200 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.1140
Cell Significance Index: -1.4100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1430
Cell Significance Index: -20.7900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1519
Cell Significance Index: -17.4000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1521
Cell Significance Index: -17.7200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1523
Cell Significance Index: -9.3600 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1640
Cell Significance Index: -2.3000 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.1640
Cell Significance Index: -2.1000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1996
Cell Significance Index: -42.0400 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2502
Cell Significance Index: -2.0400 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2845
Cell Significance Index: -2.3900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2871
Cell Significance Index: -21.4000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2929
Cell Significance Index: -6.1300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3037
Cell Significance Index: -31.6300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3236
Cell Significance Index: -38.1600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3406
Cell Significance Index: -22.9000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3477
Cell Significance Index: -18.1100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3710
Cell Significance Index: -16.4100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3785
Cell Significance Index: -9.7300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4324
Cell Significance Index: -34.2500 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.4398
Cell Significance Index: -2.9800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4574
Cell Significance Index: -17.3200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4718
Cell Significance Index: -24.5100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4763
Cell Significance Index: -26.7300 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.4932
Cell Significance Index: -6.1500 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: -0.5040
Cell Significance Index: -1.9300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5775
Cell Significance Index: -36.4000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.5846
Cell Significance Index: -29.5400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.5865
Cell Significance Index: -37.8400 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.6086
Cell Significance Index: -6.3000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6188
Cell Significance Index: -37.9400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.6435
Cell Significance Index: -7.3100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.6780
Cell Significance Index: -14.4400 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.6808
Cell Significance Index: -14.4500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7131
Cell Significance Index: -22.7100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2481651301
Symbol: GAS6_HUMAN
Name: AXL receptor tyrosine kinase ligand
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8336730
Title: The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.
PubMed ID: 8336730
PubMed ID: 15108283
Title: Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke.
PubMed ID: 15108283
DOI: 10.1002/humu.20025
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7854420
Title: Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6.
PubMed ID: 7854420
DOI: 10.1038/373623a0
PubMed ID: 7867073
Title: The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases.
PubMed ID: 7867073
PubMed ID: 9326368
Title: Identification and tissue expression of a splice variant for the growth arrest-specific gene gas6.
PubMed ID: 9326368
PubMed ID: 8939948
Title: Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases.
PubMed ID: 8939948
PubMed ID: 9326369
Title: The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation.
PubMed ID: 9326369
PubMed ID: 12364394
Title: Acidification prevents endothelial cell apoptosis by Axl activation.
PubMed ID: 12364394
PubMed ID: 18840707
Title: The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development.
PubMed ID: 18840707
PubMed ID: 21501828
Title: The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry.
PubMed ID: 21501828
PubMed ID: 23084921
Title: The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry.
PubMed ID: 23084921
PubMed ID: 17005688
Title: Tyro3 family-mediated cell entry of Ebola and Marburg viruses.
PubMed ID: 17005688
DOI: 10.1128/jvi.01157-06
PubMed ID: 26091039
Title: A single kinase generates the majority of the secreted phosphoproteome.
PubMed ID: 26091039
PubMed ID: 8621659
Title: Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl.
PubMed ID: 8621659
PubMed ID: 16362042
Sequence Information:
- Length: 678
- Mass: 74925
- Checksum: BB6D8AB0F6C48EA9
- Sequence:
MAPSLSPGPA ALRRAPQLLL LLLAAECALA ALLPAREATQ FLRPRQRRAF QVFEEAKQGH LERECVEELC SREEAREVFE NDPETDYFYP RYLDCINKYG SPYTKNSGFA TCVQNLPDQC TPNPCDRKGT QACQDLMGNF FCLCKAGWGG RLCDKDVNEC SQENGGCLQI CHNKPGSFHC SCHSGFELSS DGRTCQDIDE CADSEACGEA RCKNLPGSYS CLCDEGFAYS SQEKACRDVD ECLQGRCEQV CVNSPGSYTC HCDGRGGLKL SQDMDTCEDI LPCVPFSVAK SVKSLYLGRM FSGTPVIRLR FKRLQPTRLV AEFDFRTFDP EGILLFAGGH QDSTWIVLAL RAGRLELQLR YNGVGRVTSS GPVINHGMWQ TISVEELARN LVIKVNRDAV MKIAVAGDLF QPERGLYHLN LTVGGIPFHE KDLVQPINPR LDGCMRSWNW LNGEDTTIQE TVKVNTRMQC FSVTERGSFY PGSGFAFYSL DYMRTPLDVG TESTWEVEVV AHIRPAADTG VLFALWAPDL RAVPLSVALV DYHSTKKLKK QLVVLAVEHT ALALMEIKVC DGQEHVVTVS LRDGEATLEV DGTRGQSEVS AAQLQERLAV LERHLRSPVL TFAGGLPDVP VTSAPVTAFY RGCMTLEVNR RLLDLDEAAY KHSDITAHSC PPVEPAAA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.