Details for: GAS6

Gene ID: 2621

Symbol: GAS6

Ensembl ID: ENSG00000183087

Description: growth arrest specific 6

Associated with

  • Cell surface interactions at the vascular wall
    (R-HSA-202733)
  • Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
    (R-HSA-159854)
  • Gamma-carboxylation of protein precursors
    (R-HSA-159740)
  • Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
    (R-HSA-163841)
  • Hemostasis
    (R-HSA-109582)
  • Metabolism of proteins
    (R-HSA-392499)
  • Platelet activation, signaling and aggregation
    (R-HSA-76002)
  • Platelet degranulation
    (R-HSA-114608)
  • Post-translational protein modification
    (R-HSA-597592)
  • Post-translational protein phosphorylation
    (R-HSA-8957275)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-HSA-381426)
  • Removal of aminoterminal propeptides from gamma-carboxylated proteins
    (R-HSA-159782)
  • Response to elevated platelet cytosolic ca2+
    (R-HSA-76005)
  • Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the golgi apparatus
    (R-HSA-159763)
  • Activation of protein kinase b activity
    (GO:0032148)
  • Animal organ regeneration
    (GO:0031100)
  • Apoptotic cell clearance
    (GO:0043277)
  • B cell chemotaxis
    (GO:0035754)
  • Blood coagulation
    (GO:0007596)
  • Calcium ion binding
    (GO:0005509)
  • Calcium ion transmembrane transport
    (GO:0070588)
  • Cell-substrate adhesion
    (GO:0031589)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Cellular response to glucose stimulus
    (GO:0071333)
  • Cellular response to growth factor stimulus
    (GO:0071363)
  • Cellular response to interferon-alpha
    (GO:0035457)
  • Cellular response to starvation
    (GO:0009267)
  • Cellular response to vitamin k
    (GO:0071307)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
    (GO:0043027)
  • Cytoplasm
    (GO:0005737)
  • Dendritic cell differentiation
    (GO:0097028)
  • Endoplasmic reticulum lumen
    (GO:0005788)
  • Enzyme-linked receptor protein signaling pathway
    (GO:0007167)
  • Extracellular exosome
    (GO:0070062)
  • Extracellular matrix assembly
    (GO:0085029)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Fibroblast apoptotic process
    (GO:0044346)
  • Fusion of virus membrane with host plasma membrane
    (GO:0019064)
  • Golgi lumen
    (GO:0005796)
  • Hematopoietic stem cell migration to bone marrow
    (GO:0097241)
  • Myeloid cell apoptotic process
    (GO:0033028)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of biomineral tissue development
    (GO:0070168)
  • Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043154)
  • Negative regulation of dendritic cell apoptotic process
    (GO:2000669)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of fibroblast apoptotic process
    (GO:2000270)
  • Negative regulation of interleukin-1 production
    (GO:0032692)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of myeloid cell apoptotic process
    (GO:0033033)
  • Negative regulation of oligodendrocyte apoptotic process
    (GO:1900142)
  • Negative regulation of renal albumin absorption
    (GO:2000533)
  • Negative regulation of tumor necrosis factor-mediated signaling pathway
    (GO:0010804)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Neuron migration
    (GO:0001764)
  • Phagocytosis
    (GO:0006909)
  • Phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0043491)
  • Phosphatidylserine binding
    (GO:0001786)
  • Platelet alpha granule lumen
    (GO:0031093)
  • Positive regulation of cytokine-mediated signaling pathway
    (GO:0001961)
  • Positive regulation of dendritic cell chemotaxis
    (GO:2000510)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glomerular filtration
    (GO:0003104)
  • Positive regulation of natural killer cell differentiation
    (GO:0032825)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein export from nucleus
    (GO:0046827)
  • Positive regulation of protein kinase activity
    (GO:0045860)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of tor signaling
    (GO:0032008)
  • Protein-macromolecule adaptor activity
    (GO:0030674)
  • Protein binding
    (GO:0005515)
  • Protein localization to plasma membrane
    (GO:0072659)
  • Protein phosphorylation
    (GO:0006468)
  • Receptor-mediated virion attachment to host cell
    (GO:0046813)
  • Receptor ligand activity
    (GO:0048018)
  • Receptor tyrosine kinase binding
    (GO:0030971)
  • Signaling receptor binding
    (GO:0005102)
  • Signal transduction
    (GO:0007165)
  • Symbiont entry into host cell
    (GO:0046718)
  • Viral genome replication
    (GO:0019079)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.84
    Marker Score: 3424.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.54
    Marker Score: 6464
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.46
    Marker Score: 4072
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.3
    Marker Score: 738
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.3
    Marker Score: 11292
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.22
    Marker Score: 8222
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.13
    Marker Score: 2260
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2
    Marker Score: 466
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.97
    Marker Score: 827
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.96
    Marker Score: 3682
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.95
    Marker Score: 620
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.9
    Marker Score: 1970
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.89
    Marker Score: 1042
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.66
    Marker Score: 1999
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.65
    Marker Score: 3350
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.64
    Marker Score: 1560
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.62
    Marker Score: 6968
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.61
    Marker Score: 371
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.6
    Marker Score: 4296
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.6
    Marker Score: 4191
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.6
    Marker Score: 1376
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.59
    Marker Score: 9434
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.56
    Marker Score: 1469
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.53
    Marker Score: 940
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.49
    Marker Score: 784
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.48
    Marker Score: 433
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.48
    Marker Score: 1591
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.47
    Marker Score: 6088
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.47
    Marker Score: 610
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.45
    Marker Score: 396
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.44
    Marker Score: 366
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.43
    Marker Score: 539
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.42
    Marker Score: 829
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.4
    Marker Score: 3823.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.4
    Marker Score: 996
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.4
    Marker Score: 1191
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.39
    Marker Score: 1250
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.39
    Marker Score: 3309
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.39
    Marker Score: 393
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.37
    Marker Score: 50664.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.34
    Marker Score: 476
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.34
    Marker Score: 2675
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.33
    Marker Score: 389
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.33
    Marker Score: 12595
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.32
    Marker Score: 871
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.32
    Marker Score: 12439
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.31
    Marker Score: 13530
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.31
    Marker Score: 1903
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.31
    Marker Score: 2020
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.3
    Marker Score: 408
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.28
    Marker Score: 1275
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.27
    Marker Score: 14264
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.26
    Marker Score: 42941
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.26
    Marker Score: 310
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.24
    Marker Score: 1261
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.24
    Marker Score: 1414
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.22
    Marker Score: 445
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.21
    Marker Score: 10383
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.21
    Marker Score: 1089
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18727
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.2
    Marker Score: 1286
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.19
    Marker Score: 532
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.17
    Marker Score: 11797
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.17
    Marker Score: 308
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.15
    Marker Score: 303
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.14
    Marker Score: 1102
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.14
    Marker Score: 70140
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.13
    Marker Score: 287
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.13
    Marker Score: 492
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.13
    Marker Score: 1593
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.12
    Marker Score: 1894
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.12
    Marker Score: 735.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.11
    Marker Score: 4297
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.11
    Marker Score: 1279
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.1
    Marker Score: 291
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.1
    Marker Score: 3454
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.1
    Marker Score: 1509
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.09
    Marker Score: 2671.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.09
    Marker Score: 7094
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.08
    Marker Score: 298
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.08
    Marker Score: 645
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.08
    Marker Score: 21407
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.07
    Marker Score: 40573
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.06
    Marker Score: 23726
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.06
    Marker Score: 1536
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.06
    Marker Score: 616
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.05
    Marker Score: 2308
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.03
    Marker Score: 257
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.02
    Marker Score: 257
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.01
    Marker Score: 1065
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1
    Marker Score: 630.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71718
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47940.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1
    Marker Score: 218
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30394
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.98
    Marker Score: 331
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.97
    Marker Score: 1550
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.97
    Marker Score: 219
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.96
    Marker Score: 1754

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Other Information

**Key characteristics:** * The GAS6 gene is located on chromosome 17p13.2. * It is a large gene with a length of approximately 2.5 million base pairs. * It contains 21 exons and 19 introns. * It is expressed in high levels in the lungs, kidneys, and skin. **Pathways and functions:** * GAS6 is a key regulator of platelet aggregation. * It is expressed in the endothelium of blood vessels and is important for the regulation of platelet aggregation. * It is also expressed in the lungs, where it is involved in the regulation of inflammation and immune responses. **Clinical significance:** * Mutations in the GAS6 gene have been linked to a number of human diseases, including asthma, hypertension, and cancer. * Gas6 inhibitors are being investigated as potential treatments for these diseases. **Additional information:** * The GAS6 gene was discovered in 1995 as a potential regulator of platelet aggregation. * It is a member of the Gas6 family of cell surface receptors, which are a large family of receptors that are involved in a variety of cellular processes, including cell adhesion, migration, and signaling. * Gas6 is a highly conserved protein, with a similar gene found in mice and rats.

Genular Protein ID: 2481651301

Symbol: GAS6_HUMAN

Name: AXL receptor tyrosine kinase ligand

UniProtKB Accession Codes:

Q14393 B3KRQ7 B3KVL4 E9PBL7 Q6IMN1 Q7Z7N3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 24 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 72 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 8 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8336730

Title: The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.

PubMed ID: 8336730

DOI: 10.1128/mcb.13.8.4976-4985.1993

PubMed ID: 15108283

Title: Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke.

PubMed ID: 15108283

DOI: 10.1002/humu.20025

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7854420

Title: Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6.

PubMed ID: 7854420

DOI: 10.1038/373623a0

PubMed ID: 7867073

Title: The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases.

PubMed ID: 7867073

DOI: 10.1016/0092-8674(95)90520-0

PubMed ID: 9326368

Title: Identification and tissue expression of a splice variant for the growth arrest-specific gene gas6.

PubMed ID: 9326368

DOI: 10.1016/s0014-5793(97)01094-6

PubMed ID: 8939948

Title: Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases.

PubMed ID: 8939948

DOI: 10.1074/jbc.271.47.30022

PubMed ID: 9326369

Title: The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation.

PubMed ID: 9326369

DOI: 10.1016/s0014-5793(97)01093-4

PubMed ID: 12364394

Title: Acidification prevents endothelial cell apoptosis by Axl activation.

PubMed ID: 12364394

DOI: 10.1161/01.res.0000036753.50601.e9

PubMed ID: 18840707

Title: The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development.

PubMed ID: 18840707

DOI: 10.1182/blood-2008-05-157073

PubMed ID: 21501828

Title: The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry.

PubMed ID: 21501828

DOI: 10.1016/j.chom.2011.03.012

PubMed ID: 23084921

Title: The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry.

PubMed ID: 23084921

DOI: 10.1016/j.chom.2012.08.009

PubMed ID: 17005688

Title: Tyro3 family-mediated cell entry of Ebola and Marburg viruses.

PubMed ID: 17005688

DOI: 10.1128/jvi.01157-06

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 8621659

Title: Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl.

PubMed ID: 8621659

DOI: 10.1074/jbc.271.16.9785

PubMed ID: 16362042

Title: Structural basis for Gas6-Axl signalling.

PubMed ID: 16362042

DOI: 10.1038/sj.emboj.7600912

Sequence Information:

  • Length: 678
  • Mass: 74925
  • Checksum: BB6D8AB0F6C48EA9
  • Sequence:
    • MAPSLSPGPA ALRRAPQLLL LLLAAECALA ALLPAREATQ FLRPRQRRAF QVFEEAKQGH 
LERECVEELC SREEAREVFE NDPETDYFYP RYLDCINKYG SPYTKNSGFA TCVQNLPDQC 
TPNPCDRKGT QACQDLMGNF FCLCKAGWGG RLCDKDVNEC SQENGGCLQI CHNKPGSFHC 
SCHSGFELSS DGRTCQDIDE CADSEACGEA RCKNLPGSYS CLCDEGFAYS SQEKACRDVD 
ECLQGRCEQV CVNSPGSYTC HCDGRGGLKL SQDMDTCEDI LPCVPFSVAK SVKSLYLGRM 
FSGTPVIRLR FKRLQPTRLV AEFDFRTFDP EGILLFAGGH QDSTWIVLAL RAGRLELQLR 
YNGVGRVTSS GPVINHGMWQ TISVEELARN LVIKVNRDAV MKIAVAGDLF QPERGLYHLN 
LTVGGIPFHE KDLVQPINPR LDGCMRSWNW LNGEDTTIQE TVKVNTRMQC FSVTERGSFY 
PGSGFAFYSL DYMRTPLDVG TESTWEVEVV AHIRPAADTG VLFALWAPDL RAVPLSVALV 
DYHSTKKLKK QLVVLAVEHT ALALMEIKVC DGQEHVVTVS LRDGEATLEV DGTRGQSEVS 
AAQLQERLAV LERHLRSPVL TFAGGLPDVP VTSAPVTAFY RGCMTLEVNR RLLDLDEAAY 
KHSDITAHSC PPVEPAAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.