Details for: GATA2

Gene ID: 2624

Symbol: GATA2

Ensembl ID: ENSG00000179348

Description: GATA binding protein 2

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Factors involved in megakaryocyte development and platelet production
    (R-HSA-983231)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Hemostasis
    (R-HSA-109582)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Runx1 regulates transcription of genes involved in differentiation of hscs
    (R-HSA-8939236)
  • Transcriptional regulation by runx1
    (R-HSA-8878171)
  • Transcriptional regulation of granulopoiesis
    (R-HSA-9616222)
  • Brown fat cell differentiation
    (GO:0050873)
  • C2h2 zinc finger domain binding
    (GO:0070742)
  • Cell differentiation in hindbrain
    (GO:0021533)
  • Cell fate commitment
    (GO:0045165)
  • Cell fate determination
    (GO:0001709)
  • Central nervous system neuron development
    (GO:0021954)
  • Chromatin binding
    (GO:0003682)
  • Cochlea development
    (GO:0090102)
  • Commitment of neuronal cell to specific neuron type in forebrain
    (GO:0021902)
  • Cytoplasm
    (GO:0005737)
  • Definitive hemopoiesis
    (GO:0060216)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Embryonic placenta development
    (GO:0001892)
  • Eosinophil fate commitment
    (GO:0035854)
  • Fat cell differentiation
    (GO:0045444)
  • Gabaergic neuron differentiation
    (GO:0097154)
  • Glandular epithelial cell maturation
    (GO:0002071)
  • Hematopoietic progenitor cell differentiation
    (GO:0002244)
  • Hematopoietic stem cell homeostasis
    (GO:0061484)
  • Homeostasis of number of cells within a tissue
    (GO:0048873)
  • Inner ear morphogenesis
    (GO:0042472)
  • Negative regulation of brown fat cell differentiation
    (GO:1903444)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of hematopoietic progenitor cell differentiation
    (GO:1901533)
  • Negative regulation of macrophage differentiation
    (GO:0045650)
  • Negative regulation of neural precursor cell proliferation
    (GO:2000178)
  • Negative regulation of neuroblast proliferation
    (GO:0007406)
  • Negative regulation of notch signaling pathway
    (GO:0045746)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuroblast proliferation
    (GO:0007405)
  • Neuron maturation
    (GO:0042551)
  • Neuron migration
    (GO:0001764)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Phagocytosis
    (GO:0006909)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
    (GO:1903589)
  • Positive regulation of cell migration involved in sprouting angiogenesis
    (GO:0090050)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of erythrocyte differentiation
    (GO:0045648)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of mast cell degranulation
    (GO:0043306)
  • Positive regulation of megakaryocyte differentiation
    (GO:0045654)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of phagocytosis, engulfment
    (GO:0060100)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of forebrain neuron differentiation
    (GO:2000977)
  • Regulation of primitive erythrocyte differentiation
    (GO:0010725)
  • Response to lipid
    (GO:0033993)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Semicircular canal development
    (GO:0060872)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Thyroid-stimulating hormone-secreting cell differentiation
    (GO:0060129)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription coactivator binding
    (GO:0001223)
  • Transcription coregulator binding
    (GO:0001221)
  • Transcription regulator complex
    (GO:0005667)
  • Urogenital system development
    (GO:0001655)
  • Vascular wound healing
    (GO:0061042)
  • Ventral spinal cord interneuron differentiation
    (GO:0021514)
  • Zinc ion binding
    (GO:0008270)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.11
    Marker Score: 4382
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.07
    Marker Score: 1460
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.33
    Marker Score: 5934
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.85
    Marker Score: 594
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.73
    Marker Score: 4262
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.71
    Marker Score: 2469
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.58
    Marker Score: 13837
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.57
    Marker Score: 3963
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169158
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.46
    Marker Score: 2919
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.36
    Marker Score: 987
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.3
    Marker Score: 1117
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.25
    Marker Score: 393
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.25
    Marker Score: 1083
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.21
    Marker Score: 4767
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.21
    Marker Score: 422
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.17
    Marker Score: 1723
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.16
    Marker Score: 895
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.12
    Marker Score: 12585
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.08
    Marker Score: 645
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.08
    Marker Score: 628
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.04
    Marker Score: 1719
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71812
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48037
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.98
    Marker Score: 192
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.98
    Marker Score: 1422
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.97
    Marker Score: 909
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5340
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.93
    Marker Score: 419
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.89
    Marker Score: 555
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.85
    Marker Score: 1209
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 489
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 619.5
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.79
    Marker Score: 189
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.77
    Marker Score: 406
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.76
    Marker Score: 251
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.74
    Marker Score: 965
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.73
    Marker Score: 415
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.72
    Marker Score: 726
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.72
    Marker Score: 771
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.71
    Marker Score: 368
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.71
    Marker Score: 642
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.7
    Marker Score: 598
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.69
    Marker Score: 1168
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.67
    Marker Score: 926
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.67
    Marker Score: 424
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.66
    Marker Score: 461
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.65
    Marker Score: 138
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.64
    Marker Score: 9970
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.63
    Marker Score: 152
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.61
    Marker Score: 546
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.61
    Marker Score: 2623
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.6
    Marker Score: 404
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.58
    Marker Score: 135
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.55
    Marker Score: 1061
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.53
    Marker Score: 1009
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.53
    Marker Score: 351
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.53
    Marker Score: 997
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.52
    Marker Score: 217
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.47
    Marker Score: 1002
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.46
    Marker Score: 129
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.46
    Marker Score: 488
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.46
    Marker Score: 1119
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.46
    Marker Score: 106
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.45
    Marker Score: 185
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.43
    Marker Score: 877
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.43
    Marker Score: 131
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.42
    Marker Score: 374
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.42
    Marker Score: 206
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 196
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.41
    Marker Score: 93
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.4
    Marker Score: 115
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.4
    Marker Score: 129
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.39
    Marker Score: 297
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.38
    Marker Score: 77
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.38
    Marker Score: 123
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.37
    Marker Score: 85
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.37
    Marker Score: 230
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.37
    Marker Score: 91
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.37
    Marker Score: 300
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.36
    Marker Score: 91
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.36
    Marker Score: 626
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.36
    Marker Score: 188
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.36
    Marker Score: 155
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.35
    Marker Score: 186
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.35
    Marker Score: 76
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.34
    Marker Score: 89
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.32
    Marker Score: 386
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.32
    Marker Score: 2113

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * GATA2 is a highly conserved protein that is found in mammals, birds, and fish. * It is a member of the GATA family of transcription factors. * GATA2 is a nuclear protein that is located in the nucleus of cells. * It is a DNA-binding transcription factor that is responsible for regulating the expression of a variety of genes. **Pathways and functions:** * GATA2 is a key regulator of hematopoiesis. * It is essential for the development and maintenance of the hematopoietic system. * It is involved in the regulation of the development of megakaryocytes, which are blood cells that are responsible for the production of red blood cells. * It is also involved in the regulation of platelet production. * GATA2 is a key regulator of the immune system. * It is expressed in a variety of immune cells, including endothelial cells, macrophages, and dendritic cells. * It is involved in the regulation of inflammation and immunity. **Clinical significance:** GATA2 is a promising target for the treatment of a variety of diseases, including cancer and autoimmune disorders. * In cancer, GATA2 is expressed in tumors and is involved in the growth and metastasis of tumors. * In autoimmune disorders, GATA2 is expressed in immune cells and is involved in the regulation of inflammation and immune responses. * Targeting GATA2 has been shown to be effective in inhibiting cancer growth and inflammation.

Genular Protein ID: 4041311595

Symbol: GATA2_HUMAN

Name: Endothelial transcription factor GATA-2

UniProtKB Accession Codes:

P23769 D3DNB3 Q53YE0 Q96BH0 Q96BH8 Q9BUJ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 70 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 7 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1714909

Title: Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells.

PubMed ID: 1714909

DOI: 10.1016/s0021-9258(18)98533-9

PubMed ID: 1370462

Title: Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells.

PubMed ID: 1370462

DOI: 10.1016/s0021-9258(18)48426-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23887938

Title: CCAR1 promotes chromatin loading of androgen receptor (AR) transcription complex by stabilizing the association between AR and GATA2.

PubMed ID: 23887938

DOI: 10.1093/nar/gkt644

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 21670465

Title: Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome.

PubMed ID: 21670465

DOI: 10.1182/blood-2011-05-356352

PubMed ID: 21892158

Title: Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome).

PubMed ID: 21892158

DOI: 10.1038/ng.923

PubMed ID: 21892162

Title: Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia.

PubMed ID: 21892162

DOI: 10.1038/ng.913

Sequence Information:

  • Length: 480
  • Mass: 50500
  • Checksum: C879CC932C355E6A
  • Sequence:
    • MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY 
ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHNPWTVSP 
FSKTPLHPSA AGGPGGPLSV YPGAGGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE 
VSPDPSTTGA ASPASSSAGG SAARGEDKDG VKYQVSLTES MKMESGSPLR PGLATMGTQP 
ATHHPIPTYP SYVPAAAHDY SSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA 
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW 
RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SNKSKKSKKG AECFEELSKC 
MQEKSSPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.