Details for: GBP3

Gene ID: 2635

Symbol: GBP3

Ensembl ID: ENSG00000117226

Description: guanylate binding protein 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.64
    Marker Score: 7871
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.51
    Marker Score: 13271
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.31
    Marker Score: 4518
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.23
    Marker Score: 1810
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.22
    Marker Score: 10596
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.14
    Marker Score: 761
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.03
    Marker Score: 3224.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.01
    Marker Score: 1917
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71749
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47974
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1
    Marker Score: 491
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.99
    Marker Score: 1518
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.96
    Marker Score: 6140
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.95
    Marker Score: 649
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.93
    Marker Score: 1651
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.93
    Marker Score: 1340
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2711
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.89
    Marker Score: 935
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5250
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4891
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.84
    Marker Score: 242
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.83
    Marker Score: 2031
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.81
    Marker Score: 772
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.79
    Marker Score: 1091
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 580.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.76
    Marker Score: 1916
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.74
    Marker Score: 183
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.72
    Marker Score: 338
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.71
    Marker Score: 741
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.69
    Marker Score: 17717
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.69
    Marker Score: 260
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.69
    Marker Score: 832
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2857.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 616
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.64
    Marker Score: 1170
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.64
    Marker Score: 302
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.63
    Marker Score: 1601
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.62
    Marker Score: 608
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.62
    Marker Score: 158
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.61
    Marker Score: 356
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.61
    Marker Score: 615
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.6
    Marker Score: 5944
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.6
    Marker Score: 1195.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.57
    Marker Score: 1285
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.56
    Marker Score: 325
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.56
    Marker Score: 127
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.55
    Marker Score: 252
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.55
    Marker Score: 1956
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.54
    Marker Score: 130
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.54
    Marker Score: 763
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.53
    Marker Score: 589
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 336
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.52
    Marker Score: 464
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.52
    Marker Score: 407
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.51
    Marker Score: 340
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.51
    Marker Score: 1221
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5
    Marker Score: 16981.5
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.49
    Marker Score: 143
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.49
    Marker Score: 420.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 292
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.48
    Marker Score: 95
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.48
    Marker Score: 16754
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.48
    Marker Score: 792
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.48
    Marker Score: 117
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.48
    Marker Score: 594
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.47
    Marker Score: 123
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.47
    Marker Score: 403
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.47
    Marker Score: 293
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.47
    Marker Score: 127
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.46
    Marker Score: 675
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.46
    Marker Score: 396
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.46
    Marker Score: 1201
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.46
    Marker Score: 5171
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.46
    Marker Score: 145
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.46
    Marker Score: 441
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.45
    Marker Score: 495.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.45
    Marker Score: 1657
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.44
    Marker Score: 3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.44
    Marker Score: 438
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.44
    Marker Score: 1225.5
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.44
    Marker Score: 438
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.44
    Marker Score: 260
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 189
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.43
    Marker Score: 115
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.43
    Marker Score: 1347
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.42
    Marker Score: 294
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.42
    Marker Score: 355
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.42
    Marker Score: 97
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.41
    Marker Score: 1080

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Other Information

**Key characteristics:** * GBP3 is a protein of the immunoglobulin superfamily. * It is expressed in high levels in mucosal tissues, such as the gut, lungs, and bladder. * GBP3 is a key regulator of the inflammatory response to a variety of pathogens. * It is involved in the regulation of the immune response to bacterial and viral infections. * GBP3 is also involved in the regulation of cell death. **Pathways and functions:** * GBP3 is involved in the regulation of the inflammatory response to a variety of pathogens. * It is a key regulator of the innate immune response. * GBP3 is involved in the regulation of the adaptive immune response. * GBP3 is also involved in the regulation of cell death. **Clinical significance:** * GBP3 is a potential therapeutic target for a variety of diseases, including inflammatory bowel disease, asthma, and cancer. * GBP3 inhibitors are being investigated as a treatment for these diseases. * GBP3 is a promising target for the development of new therapies for cancer.

Genular Protein ID: 2726241150

Symbol: GBP3_HUMAN

Name: Guanylate-binding protein 3

UniProtKB Accession Codes:

Q9H0R5 A2A317 A6NF86 B2RTW0 F8UW81 Q05D54 Q5T8L8 Q5T8L9 Q6P3V3 Q9NV33

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 22106366

Title: A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replication.

PubMed ID: 22106366

DOI: 10.1096/fj.11-189886

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17266443

Title: Unique features of different members of the human guanylate-binding protein family.

PubMed ID: 17266443

DOI: 10.1089/jir.2007.0086

PubMed ID: 21151871

Title: Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.

PubMed ID: 21151871

DOI: 10.1371/journal.pone.0014246

PubMed ID: 31216343

Title: Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8.

PubMed ID: 31216343

DOI: 10.1371/journal.ppat.1007876

Sequence Information:

  • Length: 595
  • Mass: 68114
  • Checksum: 410A9BED9ABD2DDF
  • Sequence:
    • MAPEIHMTGP MCLIENTNGE LVANPEALKI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG 
KNKGFSLGST VKSHTKGIWM WCVPHPKKPE HTLVLLDTEG LGDVKKGDNQ NDSWIFTLAV 
LLSSTLVYNS MGTINQQAMD QLYYVTELTH RIRSKSSPDE NENEDSADFV SFFPDFVWTL 
RDFSLDLEAD GQPLTPDEYL EYSLKLTQGT SQKDKNFNLP RLCIRKFFPK KKCFVFDLPI 
HRRKLAQLEK LQDEELDPEF VQQVADFCSY IFSNSKTKTL SGGIKVNGPR LESLVLTYIN 
AISRGDLPCM ENAVLALAQI ENSAAVQKAI AHYDQQMGQK VQLPAETLQE LLDLHRVSER 
EATEVYMKNS FKDVDHLFQK KLAAQLDKKR DDFCKQNQEA SSDRCSALLQ VIFSPLEEEV 
KAGIYSKPGG YCLFIQKLQD LEKKYYEEPR KGIQAEEILQ TYLKSKESVT DAILQTDQIL 
TEKEKEIEVE CVKAESAQAS AKMVEEMQIK YQQMMEEKEK SYQEHVKQLT EKMERERAQL 
LEEQEKTLTS KLQEQARVLK ERCQGESTQL QNEIQKLQKT LKKKTKRYMS HKLKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.