Details for: GBP3

Gene ID: 2635

Symbol: GBP3

Ensembl ID: ENSG00000117226

Description: guanylate binding protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 88.0773
    Cell Significance Index: -13.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.5865
    Cell Significance Index: -12.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.3779
    Cell Significance Index: -11.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.1873
    Cell Significance Index: -13.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.6657
    Cell Significance Index: -12.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.2088
    Cell Significance Index: -13.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.1251
    Cell Significance Index: -12.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.7217
    Cell Significance Index: -9.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5124
    Cell Significance Index: -13.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.7949
    Cell Significance Index: 145.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.3476
    Cell Significance Index: 121.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7268
    Cell Significance Index: 23.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3660
    Cell Significance Index: 29.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9453
    Cell Significance Index: 8.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7947
    Cell Significance Index: 86.4400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.7690
    Cell Significance Index: 10.6700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7211
    Cell Significance Index: 16.6600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.5953
    Cell Significance Index: 9.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5910
    Cell Significance Index: 106.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5634
    Cell Significance Index: 69.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5269
    Cell Significance Index: 52.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4824
    Cell Significance Index: 33.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4202
    Cell Significance Index: 11.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4008
    Cell Significance Index: 10.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3708
    Cell Significance Index: 70.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3319
    Cell Significance Index: 53.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3204
    Cell Significance Index: 9.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2839
    Cell Significance Index: 38.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2787
    Cell Significance Index: 13.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2618
    Cell Significance Index: 142.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2511
    Cell Significance Index: 226.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2157
    Cell Significance Index: 2.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1912
    Cell Significance Index: 5.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1495
    Cell Significance Index: 7.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1149
    Cell Significance Index: 14.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1128
    Cell Significance Index: 14.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1084
    Cell Significance Index: 8.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0889
    Cell Significance Index: 55.5000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0828
    Cell Significance Index: 1.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0784
    Cell Significance Index: 34.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0715
    Cell Significance Index: 2.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0694
    Cell Significance Index: 2.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0621
    Cell Significance Index: 4.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0543
    Cell Significance Index: 2.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0539
    Cell Significance Index: 6.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0476
    Cell Significance Index: 1.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0133
    Cell Significance Index: 2.2700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0078
    Cell Significance Index: 0.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0013
    Cell Significance Index: -0.0200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0043
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0049
    Cell Significance Index: -9.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0066
    Cell Significance Index: -5.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0072
    Cell Significance Index: -5.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0077
    Cell Significance Index: -5.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0078
    Cell Significance Index: -14.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0085
    Cell Significance Index: -5.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0102
    Cell Significance Index: -15.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0115
    Cell Significance Index: -6.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0121
    Cell Significance Index: -16.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0173
    Cell Significance Index: -1.2200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0213
    Cell Significance Index: -0.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0213
    Cell Significance Index: -2.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0231
    Cell Significance Index: -0.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0286
    Cell Significance Index: -12.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0296
    Cell Significance Index: -5.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0353
    Cell Significance Index: -12.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0373
    Cell Significance Index: -7.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0402
    Cell Significance Index: -4.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0431
    Cell Significance Index: -12.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0455
    Cell Significance Index: -9.1300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0482
    Cell Significance Index: -0.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0482
    Cell Significance Index: -0.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0500
    Cell Significance Index: -7.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0572
    Cell Significance Index: -1.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0697
    Cell Significance Index: -1.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0705
    Cell Significance Index: -8.3100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0909
    Cell Significance Index: -10.3800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1097
    Cell Significance Index: -1.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1184
    Cell Significance Index: -5.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1190
    Cell Significance Index: -3.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1303
    Cell Significance Index: -13.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1456
    Cell Significance Index: -11.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1861
    Cell Significance Index: -14.2800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1974
    Cell Significance Index: -2.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2067
    Cell Significance Index: -13.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2130
    Cell Significance Index: -13.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2147
    Cell Significance Index: -13.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2248
    Cell Significance Index: -14.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2268
    Cell Significance Index: -9.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2566
    Cell Significance Index: -4.3000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2767
    Cell Significance Index: -4.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2794
    Cell Significance Index: -15.6800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2802
    Cell Significance Index: -4.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2998
    Cell Significance Index: -8.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3095
    Cell Significance Index: -16.2500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3104
    Cell Significance Index: -5.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3152
    Cell Significance Index: -11.5700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3225
    Cell Significance Index: -1.9900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3378
    Cell Significance Index: -4.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GBP3 is a cytosolic protein that possesses GTPase activity, enabling it to regulate the activation and inactivation of G-proteins. This function is critical in modulating downstream signaling pathways involved in immune response. GBP3 is characterized by its ability to bind guanylate nucleotides, which is essential for its GTPase activity. Additionally, GBP3 exhibits homodimerization activity, suggesting its potential role in forming protein complexes that regulate immune signaling. **Pathways and Functions:** GBP3 is involved in several key signaling pathways that regulate immune responses: 1. **Cytokine Signaling:** GBP3 interacts with G-proteins to modulate cytokine signaling, including IL-1β, TNF, and IFN-γ. This interaction is crucial for the regulation of immune responses, including inflammation and cell survival. 2. **Pyroptosis:** GBP3 has been shown to positively regulate pyroptosis, a form of programmed cell death that is essential for eliminating infected cells. This function is mediated through its interaction with the inflammasome complex. 3. **Interferon Signaling:** GBP3 plays a role in regulating interferon signaling, which is critical for the defense against viral infections. 4. **Cellular Response to Pathogens:** GBP3 is involved in the cellular response to LPS, a key component of bacterial cell walls. Its expression is upregulated in response to LPS, highlighting its role in mediating immune responses to bacterial infections. **Clinical Significance:** GBP3 has been implicated in various diseases, including: 1. **Inflammatory Disorders:** GBP3 has been shown to contribute to the pathogenesis of inflammatory disorders, such as atherosclerosis and rheumatoid arthritis. 2. **Viral Infections:** GBP3 plays a role in regulating viral infections, including HIV and influenza. 3. **Cancer:** GBP3 has been implicated in cancer progression, particularly in the context of immune evasion. In conclusion, GBP3 is a critical protein that regulates immune responses and cellular defense. Its involvement in various signaling pathways highlights its potential as a therapeutic target for the treatment of inflammatory and infectious diseases. Further research is necessary to fully elucidate the mechanisms of GBP3 and its role in human disease.

Genular Protein ID: 2726241150

Symbol: GBP3_HUMAN

Name: Guanylate-binding protein 3

UniProtKB Accession Codes:

Q9H0R5 A2A317 A6NF86 B2RTW0 F8UW81 Q05D54 Q5T8L8 Q5T8L9 Q6P3V3 Q9NV33

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 22106366

Title: A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replication.

PubMed ID: 22106366

DOI: 10.1096/fj.11-189886

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17266443

Title: Unique features of different members of the human guanylate-binding protein family.

PubMed ID: 17266443

DOI: 10.1089/jir.2007.0086

PubMed ID: 21151871

Title: Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.

PubMed ID: 21151871

DOI: 10.1371/journal.pone.0014246

PubMed ID: 31216343

Title: Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8.

PubMed ID: 31216343

DOI: 10.1371/journal.ppat.1007876

Sequence Information:

  • Length: 595
  • Mass: 68114
  • Checksum: 410A9BED9ABD2DDF
  • Sequence:
    • MAPEIHMTGP MCLIENTNGE LVANPEALKI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG 
KNKGFSLGST VKSHTKGIWM WCVPHPKKPE HTLVLLDTEG LGDVKKGDNQ NDSWIFTLAV 
LLSSTLVYNS MGTINQQAMD QLYYVTELTH RIRSKSSPDE NENEDSADFV SFFPDFVWTL 
RDFSLDLEAD GQPLTPDEYL EYSLKLTQGT SQKDKNFNLP RLCIRKFFPK KKCFVFDLPI 
HRRKLAQLEK LQDEELDPEF VQQVADFCSY IFSNSKTKTL SGGIKVNGPR LESLVLTYIN 
AISRGDLPCM ENAVLALAQI ENSAAVQKAI AHYDQQMGQK VQLPAETLQE LLDLHRVSER 
EATEVYMKNS FKDVDHLFQK KLAAQLDKKR DDFCKQNQEA SSDRCSALLQ VIFSPLEEEV 
KAGIYSKPGG YCLFIQKLQD LEKKYYEEPR KGIQAEEILQ TYLKSKESVT DAILQTDQIL 
TEKEKEIEVE CVKAESAQAS AKMVEEMQIK YQQMMEEKEK SYQEHVKQLT EKMERERAQL 
LEEQEKTLTS KLQEQARVLK ERCQGESTQL QNEIQKLQKT LKKKTKRYMS HKLKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.