Details for: FAM162A

Gene ID: 26355

Symbol: FAM162A

Ensembl ID: ENSG00000114023

Description: family with sequence similarity 162 member A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 315.7281
    Cell Significance Index: -49.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 167.1244
    Cell Significance Index: -42.3900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 130.8055
    Cell Significance Index: -53.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 121.0810
    Cell Significance Index: -49.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 119.2910
    Cell Significance Index: -56.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 107.1765
    Cell Significance Index: -55.1300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 83.8907
    Cell Significance Index: -56.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.8988
    Cell Significance Index: -49.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.7695
    Cell Significance Index: -51.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.6518
    Cell Significance Index: -39.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.3551
    Cell Significance Index: -52.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.5543
    Cell Significance Index: -38.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.7317
    Cell Significance Index: -19.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.4984
    Cell Significance Index: 233.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 4.1965
    Cell Significance Index: 190.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.4084
    Cell Significance Index: 28.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.3842
    Cell Significance Index: 21.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1905
    Cell Significance Index: 394.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0726
    Cell Significance Index: 124.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0475
    Cell Significance Index: 55.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8941
    Cell Significance Index: 1034.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7683
    Cell Significance Index: 217.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6386
    Cell Significance Index: 115.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6377
    Cell Significance Index: 1478.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6219
    Cell Significance Index: 717.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4949
    Cell Significance Index: 22.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4744
    Cell Significance Index: 43.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.1798
    Cell Significance Index: 201.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1539
    Cell Significance Index: 231.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1530
    Cell Significance Index: 53.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0761
    Cell Significance Index: 24.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9897
    Cell Significance Index: 51.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9580
    Cell Significance Index: 25.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7679
    Cell Significance Index: 75.9600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.7260
    Cell Significance Index: 12.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7046
    Cell Significance Index: 52.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7027
    Cell Significance Index: 33.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6947
    Cell Significance Index: 95.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6280
    Cell Significance Index: 102.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5799
    Cell Significance Index: 115.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5548
    Cell Significance Index: 12.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.5431
    Cell Significance Index: 836.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4497
    Cell Significance Index: 611.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4343
    Cell Significance Index: 9.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4257
    Cell Significance Index: 11.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4148
    Cell Significance Index: 53.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4037
    Cell Significance Index: 51.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3874
    Cell Significance Index: 138.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3297
    Cell Significance Index: 10.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3256
    Cell Significance Index: 9.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3208
    Cell Significance Index: 61.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2764
    Cell Significance Index: 520.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2342
    Cell Significance Index: 10.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1685
    Cell Significance Index: 116.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1567
    Cell Significance Index: 288.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1509
    Cell Significance Index: 17.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1390
    Cell Significance Index: 101.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1353
    Cell Significance Index: 61.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1209
    Cell Significance Index: 4.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0507
    Cell Significance Index: 3.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0312
    Cell Significance Index: 23.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0284
    Cell Significance Index: 18.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0283
    Cell Significance Index: 0.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0045
    Cell Significance Index: 0.1200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0045
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0088
    Cell Significance Index: -6.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0123
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0124
    Cell Significance Index: -7.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0313
    Cell Significance Index: -3.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0475
    Cell Significance Index: -0.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0601
    Cell Significance Index: -33.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1010
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1119
    Cell Significance Index: -23.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1543
    Cell Significance Index: -44.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1760
    Cell Significance Index: -13.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1958
    Cell Significance Index: -28.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2187
    Cell Significance Index: -25.0500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.2188
    Cell Significance Index: -1.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2337
    Cell Significance Index: -6.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2608
    Cell Significance Index: -30.3900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2624
    Cell Significance Index: -2.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2707
    Cell Significance Index: -17.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2757
    Cell Significance Index: -31.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2774
    Cell Significance Index: -18.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2993
    Cell Significance Index: -10.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3189
    Cell Significance Index: -33.2100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3394
    Cell Significance Index: -2.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3546
    Cell Significance Index: -19.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3885
    Cell Significance Index: -5.3000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3926
    Cell Significance Index: -4.6800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4268
    Cell Significance Index: -4.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4366
    Cell Significance Index: -22.7400
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.4494
    Cell Significance Index: -2.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4508
    Cell Significance Index: -11.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4650
    Cell Significance Index: -11.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5371
    Cell Significance Index: -7.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5395
    Cell Significance Index: -33.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6248
    Cell Significance Index: -31.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6513
    Cell Significance Index: -39.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7187
    Cell Significance Index: -19.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** FAM162A is widely expressed in stratified epithelial cells, colon epithelial cells, lens epithelial cells, and neurons, highlighting its broad tissue-specific roles. 2. **Apoptosis Regulation:** FAM162A is involved in the activation of cysteine-type endopeptidase activity, a key step in the apoptotic process, suggesting its role in regulating programmed cell death. 3. **Hypoxia Response:** FAM162A is also implicated in the cellular response to hypoxia, a condition characterized by inadequate oxygen supply, underscoring its importance in maintaining cellular homeostasis under stress conditions. 4. **Protein Binding:** FAM162A interacts with various proteins, including cytochrome c, to regulate its release from mitochondria, a critical step in the apoptotic process. **Pathways and Functions:** 1. **Activation of Cysteine-Type Endopeptidase Activity:** FAM162A is involved in the activation of cysteine-type endopeptidase activity, a crucial step in the apoptotic process, which involves the cleavage of specific cellular proteins. 2. **Positive Regulation of Apoptotic Process:** FAM162A promotes the apoptotic process by regulating the expression of pro-apoptotic genes and inhibiting the expression of anti-apoptotic genes. 3. **Release of Cytochrome c from Mitochondria:** FAM162A is involved in the regulation of cytochrome c release from mitochondria, a critical step in the apoptotic process, which triggers the activation of caspases and ultimately leads to cell death. 4. **Cellular Response to Hypoxia:** FAM162A is implicated in the cellular response to hypoxia, which involves the regulation of genes involved in energy metabolism, angiogenesis, and apoptosis. **Clinical Significance:** 1. **Cancer:** Dysregulation of FAM162A has been implicated in various cancers, including colon, breast, and lung cancer, suggesting its potential as a therapeutic target. 2. **Neurodegenerative Disorders:** FAM162A's involvement in the regulation of apoptosis and cellular response to hypoxia makes it a potential candidate for the treatment of neurodegenerative disorders, such as Alzheimer's and Parkinson's disease. 3. **Cardiovascular Disease:** FAM162A's role in regulating apoptosis and cellular response to hypoxia may also contribute to the development of cardiovascular disease, highlighting the need for further research in this area. 4. **Personalized Medicine:** The potential therapeutic applications of FAM162A underscore the importance of personalized medicine approaches, which involve tailoring treatment strategies to an individual's unique genetic profile. In conclusion, FAM162A is a complex gene involved in regulating apoptosis and cellular response to hypoxia. Its dysregulation has significant implications for various diseases, including cancer, neurodegenerative disorders, and cardiovascular disease. Further research is necessary to fully elucidate the mechanisms underlying FAM162A's functions and to explore its potential as a therapeutic target.

Genular Protein ID: 1966799657

Symbol: F162A_HUMAN

Name: Protein FAM162A

UniProtKB Accession Codes:

Q96A26 Q9NRN6 Q9UJX8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11085516

Title: Effects of estrogen on global gene expression: identification of novel targets of estrogen action.

PubMed ID: 11085516

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15082785

Title: Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway.

PubMed ID: 15082785

DOI: 10.1128/mcb.24.9.3918-3927.2004

PubMed ID: 16698020

Title: Interaction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascades.

PubMed ID: 16698020

DOI: 10.1016/j.febslet.2006.05.001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 154
  • Mass: 17342
  • Checksum: 3C4457C83044ADD8
  • Sequence:
    • MGSLSGLRLA AGSCFRLCER DVSSSLRLTR SSDLKRINGF CTKPQESPGA PSRTYNRVPL 
HKPTDWQKKI LIWSGRFKKE DEIPETVSLE MLDAAKNKMR VKISYLMIAL TVVGCIFMVI 
EGKKAAQRHE TLTSLNLEKK ARLKEEAAMK AKTE

Genular Protein ID: 3682562164

Symbol: Q9H2P1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9H2P1

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 190
  • Mass: 21551
  • Checksum: EE75DC0BAFA0CD4F
  • Sequence:
    • MGSLSGLRLA AGSCFRLCER DVSSSLRLTR SSDLKRINGF CTKPQESPGA PFPHLQQSAF 
TQTYGLAEKD PHMVRSLQKE DEIPETVSLE MLDAAKNKMR VKISYLMIAL TVVGCIFHWL 
LRARSLPKDR DFNQLGPLEK KARLKEGSSY EGQNRLPKVS VLVGILKIQE LCFNVPVLKR 
MWYEDPFHKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.