Details for: ITGB1BP2

Gene ID: 26548

Symbol: ITGB1BP2

Ensembl ID: ENSG00000147166

Description: integrin subunit beta 1 binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 12.5365
    Cell Significance Index: -1.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 7.6485
    Cell Significance Index: -1.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 4.3845
    Cell Significance Index: -2.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 1.8853
    Cell Significance Index: -1.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.6302
    Cell Significance Index: -2.0100
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.4177
    Cell Significance Index: 6.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2751
    Cell Significance Index: 40.8400
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.9247
    Cell Significance Index: 2.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.8382
    Cell Significance Index: 51.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2908
    Cell Significance Index: 55.3400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2865
    Cell Significance Index: 4.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2796
    Cell Significance Index: 5.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2704
    Cell Significance Index: 26.7500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.2166
    Cell Significance Index: 1.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1501
    Cell Significance Index: 135.5300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1476
    Cell Significance Index: 0.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1386
    Cell Significance Index: 15.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1349
    Cell Significance Index: 10.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1344
    Cell Significance Index: 21.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1270
    Cell Significance Index: 7.6300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.1250
    Cell Significance Index: 1.4200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1233
    Cell Significance Index: 1.7900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1090
    Cell Significance Index: 1.5300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0655
    Cell Significance Index: 0.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0578
    Cell Significance Index: 4.0000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0425
    Cell Significance Index: 0.7000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0258
    Cell Significance Index: 0.6300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0253
    Cell Significance Index: 0.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0195
    Cell Significance Index: 13.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0172
    Cell Significance Index: 0.4800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0167
    Cell Significance Index: 0.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0147
    Cell Significance Index: 0.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0130
    Cell Significance Index: 1.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0118
    Cell Significance Index: 0.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0066
    Cell Significance Index: 3.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0065
    Cell Significance Index: 0.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0055
    Cell Significance Index: 3.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0034
    Cell Significance Index: 0.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0029
    Cell Significance Index: 1.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0009
    Cell Significance Index: 0.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0007
    Cell Significance Index: 0.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0003
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0009
    Cell Significance Index: -1.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0020
    Cell Significance Index: -1.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0024
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -1.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0028
    Cell Significance Index: -2.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0035
    Cell Significance Index: -1.9900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0046
    Cell Significance Index: -0.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0053
    Cell Significance Index: -0.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0057
    Cell Significance Index: -0.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0060
    Cell Significance Index: -0.1300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0062
    Cell Significance Index: -0.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0065
    Cell Significance Index: -0.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0066
    Cell Significance Index: -0.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0075
    Cell Significance Index: -0.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0087
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0103
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0104
    Cell Significance Index: -2.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0105
    Cell Significance Index: -0.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0105
    Cell Significance Index: -1.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0117
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0141
    Cell Significance Index: -1.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0145
    Cell Significance Index: -0.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0146
    Cell Significance Index: -1.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0146
    Cell Significance Index: -0.9200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0147
    Cell Significance Index: -0.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0152
    Cell Significance Index: -1.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0169
    Cell Significance Index: -0.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0171
    Cell Significance Index: -1.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0179
    Cell Significance Index: -0.4600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0200
    Cell Significance Index: -0.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0205
    Cell Significance Index: -1.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0209
    Cell Significance Index: -0.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0222
    Cell Significance Index: -1.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0240
    Cell Significance Index: -1.2600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0242
    Cell Significance Index: -0.3100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0268
    Cell Significance Index: -0.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0281
    Cell Significance Index: -1.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0284
    Cell Significance Index: -1.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0284
    Cell Significance Index: -2.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0289
    Cell Significance Index: -1.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0291
    Cell Significance Index: -0.7800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0326
    Cell Significance Index: -0.4400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0326
    Cell Significance Index: -1.4200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0340
    Cell Significance Index: -0.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0382
    Cell Significance Index: -0.6400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0397
    Cell Significance Index: -0.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0400
    Cell Significance Index: -1.0700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0417
    Cell Significance Index: -0.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0440
    Cell Significance Index: -0.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0454
    Cell Significance Index: -1.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0457
    Cell Significance Index: -2.0200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0461
    Cell Significance Index: -0.6800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0486
    Cell Significance Index: -0.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** ITGB1BP2 is expressed in various cell types, including goblet cells, mural cells, intestinal crypt stem cells, enterocytes, and GABAergic interneurons in the brain. 2. **Protein binding:** ITGB1BP2 interacts with integrin beta 1, a key component of the integrin family, and other proteins, such as Sh3 domain-containing proteins, to regulate cell adhesion and signaling. 3. **Calcium and zinc binding:** ITGB1BP2 binds to calcium and zinc ions, which are essential for maintaining cellular homeostasis and regulating protein function. 4. **Muscle organ development:** ITGB1BP2 is involved in the development of muscle organs, such as the Z disc, which is a critical structure in muscle cells. **Pathways and Functions:** 1. **Integrin signaling:** ITGB1BP2 regulates integrin signaling by interacting with integrin beta 1 and other proteins, thereby modulating cell adhesion, migration, and proliferation. 2. **Cell migration:** ITGB1BP2 is involved in cell migration, which is essential for tissue development, wound healing, and immune responses. 3. **Zinc ion homeostasis:** ITGB1BP2 regulates zinc ion homeostasis by binding to zinc ions, which is critical for maintaining cellular function and preventing zinc toxicity. 4. **Calcium ion homeostasis:** ITGB1BP2 regulates calcium ion homeostasis by interacting with calcium ions, which is essential for maintaining cellular function and signaling. **Clinical Significance:** 1. **Cancer progression:** Alterations in ITGB1BP2 expression have been linked to cancer progression, including metastasis and tumor growth. 2. **Immune responses:** ITGB1BP2 plays a critical role in regulating immune responses, including T cell activation and cytokine production. 3. **Neurological disorders:** ITGB1BP2 is involved in the regulation of neuronal function and behavior, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Muscle disorders:** ITGB1BP2 is involved in the regulation of muscle function and development, making it a potential target for the treatment of muscle disorders, such as muscular dystrophy. In conclusion, ITGB1BP2 is a multifunctional protein that plays a critical role in various cellular processes, including cell adhesion, migration, and signaling. Its unique characteristics and clinical significance make it an attractive target for further investigation, particularly in the context of immune responses, tissue homeostasis, and neurological disorders.

Genular Protein ID: 2798317470

Symbol: ITBP2_HUMAN

Name: Integrin beta-1-binding protein 2

UniProtKB Accession Codes:

Q9UKP3 Q32N04 Q549J7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 16 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10506186

Title: Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain.

PubMed ID: 10506186

DOI: 10.1074/jbc.274.41.29282

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 347
  • Mass: 38382
  • Checksum: 1D0A94931821E74D
  • Sequence:
    • MSLLCRNKGC GQHFDPNTNL PDSCCHHPGV PIFHDALKGW SCCRKRTVDF SEFLNIKGCT 
MGPHCAEKLP EAPQPEGPAT SSSLQEQKPL NVIPKSAETL RRERPKSELP LKLLPLNISQ 
ALEMALEQKE LDQEPGAGLD SLIRTGSSCQ NPGCDAVYQG PESDATPCTY HPGAPRFHEG 
MKSWSCCGIQ TLDFGAFLAQ PGCRVGRHDW GKQLPASCRH DWHQTDSLVV VTVYGQIPLP 
AFNWVKASQT ELHVHIVFDG NRVFQAQMKL WGVINVEQSS VFLMPSRVEI SLVKADPGSW 
AQLEHPDALA KKARAGVVLE MDEEESDDSD DDLSWTEEEE EEEAMGE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.