Details for: SNORD36C

Gene ID: 26813

Symbol: SNORD36C

Ensembl ID: ENSG00000252542

Description: small nucleolar RNA, C/D box 36C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.4154
    Cell Significance Index: 4.3000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.2027
    Cell Significance Index: 1.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0991
    Cell Significance Index: 1.3500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0584
    Cell Significance Index: 0.6500
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.0409
    Cell Significance Index: 0.4800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.0078
    Cell Significance Index: 0.0700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.0059
    Cell Significance Index: 0.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0014
    Cell Significance Index: 0.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0027
    Cell Significance Index: -0.7800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0061
    Cell Significance Index: -0.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0097
    Cell Significance Index: -0.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0118
    Cell Significance Index: -0.1400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0163
    Cell Significance Index: -0.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0187
    Cell Significance Index: -0.4100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0196
    Cell Significance Index: -0.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0203
    Cell Significance Index: -1.0600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0284
    Cell Significance Index: -0.2900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0302
    Cell Significance Index: -0.3200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0319
    Cell Significance Index: -0.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0376
    Cell Significance Index: -0.4100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0468
    Cell Significance Index: -0.5900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0470
    Cell Significance Index: -0.5600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0496
    Cell Significance Index: -0.6600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0504
    Cell Significance Index: -0.5700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0546
    Cell Significance Index: -0.7500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0547
    Cell Significance Index: -0.9200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0556
    Cell Significance Index: -0.7500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0599
    Cell Significance Index: -0.5500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0696
    Cell Significance Index: -0.6600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0697
    Cell Significance Index: -0.9100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0704
    Cell Significance Index: -0.8300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0719
    Cell Significance Index: -0.8600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0735
    Cell Significance Index: -0.8400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0751
    Cell Significance Index: -0.8600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0765
    Cell Significance Index: -0.9000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0774
    Cell Significance Index: -0.8300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0787
    Cell Significance Index: -0.9800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0788
    Cell Significance Index: -0.9900
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0821
    Cell Significance Index: -0.8100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0829
    Cell Significance Index: -0.8500
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0851
    Cell Significance Index: -0.5900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0886
    Cell Significance Index: -0.9700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0889
    Cell Significance Index: -1.0100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0966
    Cell Significance Index: -1.0600
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0973
    Cell Significance Index: -1.0300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0996
    Cell Significance Index: -1.2100
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1053
    Cell Significance Index: -1.0300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1097
    Cell Significance Index: -1.0300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1107
    Cell Significance Index: -1.3200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1112
    Cell Significance Index: -1.4000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.1115
    Cell Significance Index: -0.9800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1118
    Cell Significance Index: -1.0600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1296
    Cell Significance Index: -1.0500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1333
    Cell Significance Index: -1.4600
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1365
    Cell Significance Index: -1.4700
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.1473
    Cell Significance Index: -1.3800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1652
    Cell Significance Index: -1.2700
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: -0.1668
    Cell Significance Index: -1.2800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1740
    Cell Significance Index: -1.8200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1760
    Cell Significance Index: -1.4500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1793
    Cell Significance Index: -1.7300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1796
    Cell Significance Index: -2.1200
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.1804
    Cell Significance Index: -0.8700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1838
    Cell Significance Index: -1.9000
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1937
    Cell Significance Index: -2.0600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1946
    Cell Significance Index: -1.8200
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.3848
    Cell Significance Index: -0.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **C/D box snoRNA**: SNORD36C belongs to the C/D box family of snoRNAs, which are characterized by the presence of a C/D box motif (C=CGU or D=CGA) in their primary structure. 2. **Small nucleolar RNA**: SNORD36C is a small RNA molecule, typically ranging from 30 to 100 nucleotides in length. 3. **Significant expression in diverse cell types**: SNORD36C has been found to be expressed in various cell types, including type A enteroendocrine cells, retinal rod cells, macrophages, and pancreatic ductal cells. 4. **Involvement in RNA processing**: SNORD36C is likely involved in RNA processing pathways, including 2'-O-methylation and pseudouridylation of rRNA and other RNAs. **Pathways and Functions:** 1. **Ribosome biogenesis**: SNORD36C is involved in the biogenesis of ribosomes, which are essential for protein synthesis. The 2'-O-methylation and pseudouridylation of rRNA by snoRNAs like SNORD36C help to regulate ribosome function and maturation. 2. **RNA processing**: SNORD36C plays a role in the processing of various RNAs, including rRNA, transfer RNA (tRNA), and small nuclear RNAs (snRNAs). These processes are essential for regulating gene expression and maintaining cellular homeostasis. 3. **Cellular homeostasis**: SNORD36C may contribute to maintaining cellular homeostasis by regulating RNA processing pathways and ensuring proper ribosome biogenesis and function. **Clinical Significance:** 1. **Disease association**: SNORD36C has been associated with certain diseases, including cancer and neurological disorders. Further studies are needed to understand the role of SNORD36C in these diseases and to explore potential therapeutic strategies. 2. **Ribosome-related disorders**: SNORD36C may be involved in ribosome-related disorders, such as ribosomopathies, which are characterized by defects in ribosome biogenesis and function. Understanding the role of SNORD36C in these disorders may lead to the development of novel therapeutic strategies. 3. **Cancer research**: SNORD36C has been found to be overexpressed in certain types of cancer, suggesting a potential role in tumorigenesis. Further studies are needed to understand the mechanisms by which SNORD36C contributes to cancer development and to explore potential therapeutic strategies. In conclusion, SNORD36C is a small nucleolar RNA that plays a crucial role in RNA processing and cellular homeostasis. Its significant expression in various cell types and involvement in ribosome biogenesis and RNA processing pathways suggest a potential role in maintaining cellular homeostasis and regulating RNA processing pathways. Further studies are needed to fully understand the function of SNORD36C and its implications for human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.