Details for: ZNF285

Gene ID: 26974

Symbol: ZNF285

Ensembl ID: ENSG00000267508

Description: zinc finger protein 285

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 37.0953
    Cell Significance Index: -5.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.5854
    Cell Significance Index: -5.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 12.3591
    Cell Significance Index: -5.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.6960
    Cell Significance Index: -5.7900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4551
    Cell Significance Index: 7.2200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.4354
    Cell Significance Index: 6.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3800
    Cell Significance Index: 37.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3023
    Cell Significance Index: 19.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2898
    Cell Significance Index: 17.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2856
    Cell Significance Index: 257.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2503
    Cell Significance Index: 27.2200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2502
    Cell Significance Index: 6.2400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2421
    Cell Significance Index: 3.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2005
    Cell Significance Index: 32.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1922
    Cell Significance Index: 38.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1450
    Cell Significance Index: 5.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1400
    Cell Significance Index: 40.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1198
    Cell Significance Index: 5.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1165
    Cell Significance Index: 7.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1164
    Cell Significance Index: 41.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1069
    Cell Significance Index: 7.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0950
    Cell Significance Index: 2.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0849
    Cell Significance Index: 6.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0754
    Cell Significance Index: 2.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0660
    Cell Significance Index: 12.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0626
    Cell Significance Index: 3.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0513
    Cell Significance Index: 2.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0490
    Cell Significance Index: 1.1800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0403
    Cell Significance Index: 0.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0402
    Cell Significance Index: 1.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0310
    Cell Significance Index: 3.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0286
    Cell Significance Index: 0.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0239
    Cell Significance Index: 4.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0160
    Cell Significance Index: 0.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0111
    Cell Significance Index: 0.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0097
    Cell Significance Index: 6.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0080
    Cell Significance Index: 4.3800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.0023
    Cell Significance Index: 0.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0013
    Cell Significance Index: 0.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0012
    Cell Significance Index: 0.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0031
    Cell Significance Index: -5.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0035
    Cell Significance Index: -6.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0042
    Cell Significance Index: -6.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0047
    Cell Significance Index: -0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0048
    Cell Significance Index: -6.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0056
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0083
    Cell Significance Index: -6.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0090
    Cell Significance Index: -5.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0134
    Cell Significance Index: -6.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0155
    Cell Significance Index: -0.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0176
    Cell Significance Index: -2.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0184
    Cell Significance Index: -2.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0187
    Cell Significance Index: -2.4000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0216
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0255
    Cell Significance Index: -4.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0259
    Cell Significance Index: -0.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0262
    Cell Significance Index: -1.3200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0267
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0284
    Cell Significance Index: -5.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0309
    Cell Significance Index: -3.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0397
    Cell Significance Index: -4.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0402
    Cell Significance Index: -5.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0441
    Cell Significance Index: -5.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0487
    Cell Significance Index: -1.0100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0504
    Cell Significance Index: -0.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0529
    Cell Significance Index: -3.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0569
    Cell Significance Index: -2.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0627
    Cell Significance Index: -4.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0654
    Cell Significance Index: -5.1800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0668
    Cell Significance Index: -2.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0669
    Cell Significance Index: -2.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0710
    Cell Significance Index: -2.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0727
    Cell Significance Index: -4.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0787
    Cell Significance Index: -2.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0841
    Cell Significance Index: -2.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0850
    Cell Significance Index: -4.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0875
    Cell Significance Index: -4.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0907
    Cell Significance Index: -1.0300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0911
    Cell Significance Index: -1.2300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0955
    Cell Significance Index: -1.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0987
    Cell Significance Index: -3.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1019
    Cell Significance Index: -3.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1027
    Cell Significance Index: -2.1500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1037
    Cell Significance Index: -1.4900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1044
    Cell Significance Index: -0.9900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1116
    Cell Significance Index: -2.2400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1173
    Cell Significance Index: -1.4600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1194
    Cell Significance Index: -1.8000
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.1196
    Cell Significance Index: -1.1400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1207
    Cell Significance Index: -3.0100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1217
    Cell Significance Index: -2.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1239
    Cell Significance Index: -3.6500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1253
    Cell Significance Index: -3.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1282
    Cell Significance Index: -3.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1297
    Cell Significance Index: -2.1700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1315
    Cell Significance Index: -2.6000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1388
    Cell Significance Index: -2.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1455
    Cell Significance Index: -5.3400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1459
    Cell Significance Index: -1.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ZNF285 protein contains a C2H2 zinc finger domain, which is a characteristic feature of zinc finger transcription factors. This domain allows the protein to bind to specific DNA sequences, thereby regulating gene expression. The protein's expression profile, which includes various epithelial and neural cell types, suggests that it may be involved in maintaining tissue-specific gene expression programs. Additionally, the protein's presence in stem cells, including intestinal crypt stem cells, implies a role in regulating the self-renewal and differentiation of these cells. **Pathways and Functions** ZNF285 has been implicated in several biological pathways, including: 1. **DNA-binding transcription factor activity**: ZNF285 can bind to specific DNA sequences, thereby regulating the expression of target genes. 2. **Gene expression (transcription)**: As a transcription factor, ZNF285 plays a crucial role in regulating the expression of genes involved in various cellular processes. 3. **Metal ion binding**: The zinc finger domain of ZNF285 allows it to bind to metal ions, which are essential for protein function and stability. 4. **Protein binding**: ZNF285 can interact with other proteins, including RNA polymerase II, to regulate gene expression. 5. **Regulation of DNA-templated transcription**: ZNF285 may play a role in regulating the transcription of genes involved in DNA replication and repair. **Clinical Significance** The clinical significance of ZNF285 is an emerging area of research. Given its expression in various tissues, including epithelial and neural cells, ZNF285 may play a role in maintaining tissue homeostasis and responding to environmental cues. Dysregulation of ZNF285 expression has been implicated in several diseases, including: 1. **Intestinal disorders**: Altered expression of ZNF285 in intestinal epithelial cells may contribute to the development of intestinal disorders, such as inflammatory bowel disease. 2. **Neurological disorders**: ZNF285 expression in cerebral cortex GABAergic interneurons may be involved in the pathogenesis of neurological disorders, such as epilepsy. 3. **Cancer**: ZNF285 may play a role in regulating the expression of genes involved in cancer development and progression. In conclusion, ZNF285 is a zinc finger transcription factor that plays a crucial role in regulating gene expression in various tissues, including the immune system and epithelial tissues. Its clinical significance is an emerging area of research, and further studies are needed to elucidate its role in human disease.

Genular Protein ID: 4164696096

Symbol: ZN285_HUMAN

Name: Zinc finger protein 285

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 590
  • Mass: 68135
  • Checksum: 2CF340F4DDCA4DD1
  • Sequence:
  • MIKFQERVTF KDVAVVFTKE ELALLDKAQI NLYQDVMLEN FRNLMLVRDG IKNNILNLQA 
    KGLSYLSQEV LHCWQIWKQR IRDLTVSQDY IVNLQEECSP HLEDVSLSEE WAGISLQISE 
    NENYVVNAII KNQDITAWQS LTQVLTPESW RKANIMTEPQ NSQGRYKGIY MEEKLYRRAQ 
    HDDSLSWTSC DHHESQECKG EDPGRHPSCG KNLGMKSTVE KRNAAHVLPQ PFPCNNCGVA 
    FADDTDPHVH HSTHLGEKSY KCDQYGKNFS QSQDLIVHCK THSGKTPYEF HEWPMGCKQS 
    SDLPRYQKVS SGDKPYKCKE CGKGFRRSSS LHNHHRVHTG EMPYKCDECG KGFGFRSLLC 
    IHQGVHTGKK PYKCEECGKG FDQSSNLLVH QRVHTGEKPY KCSECGKCFS SSSVLQVHWR 
    FHTGEKPYRC GECGKGFSQC THLHIHQRVH TGEKPYKCNV CGKDFAYSSV LHTHQRVHTG 
    EKPYKCEVCG KCFSYSSYFH LHQRDHIREK PYKCDECGKG FSRNSDLNVH LRVHTGERPY 
    KCKACGKGFS RNSYLLAHQR VHIDETQYTH CERGKDLLTH QRLHEQRETL

Genular Protein ID: 3064494026

Symbol: K7EIK6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 597
  • Mass: 68911
  • Checksum: 0F8F0221473DE4D3
  • Sequence:
  • MIKFQIQGIH VQERVTFKDV AVVFTKEELA LLDKAQINLY QDVMLENFRN LMLVRDGIKN 
    NILNLQAKGL SYLSQEVLHC WQIWKQRIRD LTVSQDYIVN LQEECSPHLE DVSLSEEWAG 
    ISLQISENEN YVVNAIIKNQ DITAWQSLTQ VLTPESWRKA NIMTEPQNSQ GRYKGIYMEE 
    KLYRRAQHDD SLSWTSCDHH ESQECKGEDP GRHPSCGKNL GMKSTVEKRN AAHVLPQPFP 
    CNNCGVAFAD DTDPHVHHST HLGEKSYKCD QYGKNFSQSQ DLIVHCKTHS GKTPYEFHEW 
    PMGCKQSSDL PRYQKVSSGD KPYKCKECGK GFRRSSSLHN HHRVHTGEMP YKCDECGKGF 
    GFRSLLCIHQ GVHTGKKPYK CEECGKGFDQ SSNLLVHQRV HTGEKPYKCS ECGKCFSSSS 
    VLQVHWRFHT GEKPYRCGEC GKGFSQCTHL HIHQRVHTGE KPYKCNVCGK DFAYSSVLHT 
    HQRVHTGEKP YKCEVCGKCF SYSSYFHLHQ RDHIREKPYK CDECGKGFSR NSDLNVHLRV 
    HTGERPYKCK ACGKGFSRNS YLLAHQRVHI DETQYTHCER GKDLLTHQRL HEQRETL

Genular Protein ID: 1673593989

Symbol: B7ZLR9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 614
  • Mass: 70805
  • Checksum: F19D804CE5C542E8
  • Sequence:
  • TLGSAFPESC PFQKEDGMIK FQIQGIHVQE RVTFKDVAVV FTKEELALLD KAQINLYQDV 
    MLENFRNLML VRDGIKNNIL NLQAKGLSYL SQEVLHCWQI WKQRIRDLTV SQDYIVNLQE 
    ECSPHLEDVS LSEEWAGISL QISENENYVV NAIIKNQDIT AWQSLTQVLT PESWRKANIM 
    TEPQNSQGRY KGIYMEEKLY RRAQHDDSLS WTSCDHHESQ ECKGEDPGRH PSCGKNLGMK 
    STVEKRNAAH VLPQPFPCNN CGVAFADDTD PHVHHSTHLG EKSYKCDQYG KNFSQSQDLI 
    VHCKTHSGKT PYEFHEWPMG CKQSSDLPRY QKVSSGDKPY KCKECGKGFR RSSSLHNHHR 
    VHTGEMPYKC DECGKGFGFR SLLCIHQGVH TGKKPYKCEE CGKGFDQSSN LLVHQRVHTG 
    EKPYKCSECG KCFSSSSVLQ VHWRFHTGEK PYRCGECGKG FSQCTHLHIH QRVHTGEKPY 
    KCNVCGKDFA YSSVLHTHQR VHTGEKPYKC EVCGKCFSYS SYFHLHQRDH IREKPYKCDE 
    CGKGFSRNSD LNVHLRVHTR ERPYKCKACG KGFSRNSYLL AHQRVHIDET QYTHCERGKD 
    LLTHQRLHEQ RETL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.