Details for: LAT

Gene ID: 27040

Symbol: LAT

Ensembl ID: ENSG00000213658

Description: linker for activation of T cells

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 64.3543
    Cell Significance Index: -10.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.5598
    Cell Significance Index: -10.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.1993
    Cell Significance Index: -15.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 33.8462
    Cell Significance Index: -17.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.4717
    Cell Significance Index: -12.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.0944
    Cell Significance Index: -9.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 6.8603
    Cell Significance Index: 201.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.7035
    Cell Significance Index: -12.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.5000
    Cell Significance Index: -7.6600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.3074
    Cell Significance Index: 10.0800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 3.2290
    Cell Significance Index: 8.6500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.0352
    Cell Significance Index: 46.9600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.8260
    Cell Significance Index: -8.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7215
    Cell Significance Index: 137.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5111
    Cell Significance Index: 50.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3807
    Cell Significance Index: 343.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3327
    Cell Significance Index: 7.0900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.3178
    Cell Significance Index: 2.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2747
    Cell Significance Index: 44.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1525
    Cell Significance Index: 30.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1111
    Cell Significance Index: 6.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0984
    Cell Significance Index: 61.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0830
    Cell Significance Index: 5.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0784
    Cell Significance Index: 28.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0715
    Cell Significance Index: 49.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0602
    Cell Significance Index: 3.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0577
    Cell Significance Index: 11.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0303
    Cell Significance Index: 3.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0248
    Cell Significance Index: 0.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0053
    Cell Significance Index: 2.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0036
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0049
    Cell Significance Index: -3.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0075
    Cell Significance Index: -4.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0107
    Cell Significance Index: -8.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0114
    Cell Significance Index: -1.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0139
    Cell Significance Index: -0.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0214
    Cell Significance Index: -15.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0230
    Cell Significance Index: -3.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0282
    Cell Significance Index: -5.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0283
    Cell Significance Index: -12.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0315
    Cell Significance Index: -5.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0344
    Cell Significance Index: -5.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0346
    Cell Significance Index: -0.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0394
    Cell Significance Index: -11.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0420
    Cell Significance Index: -5.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0454
    Cell Significance Index: -2.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0581
    Cell Significance Index: -3.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0615
    Cell Significance Index: -1.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0715
    Cell Significance Index: -7.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0801
    Cell Significance Index: -9.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0806
    Cell Significance Index: -9.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0847
    Cell Significance Index: -3.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0851
    Cell Significance Index: -9.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0884
    Cell Significance Index: -2.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0980
    Cell Significance Index: -7.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1009
    Cell Significance Index: -5.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1064
    Cell Significance Index: -13.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1075
    Cell Significance Index: -7.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1088
    Cell Significance Index: -2.7200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1181
    Cell Significance Index: -1.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1229
    Cell Significance Index: -8.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1320
    Cell Significance Index: -5.8400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1384
    Cell Significance Index: -1.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1417
    Cell Significance Index: -2.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1471
    Cell Significance Index: -9.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1534
    Cell Significance Index: -9.4300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1625
    Cell Significance Index: -6.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1677
    Cell Significance Index: -6.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1680
    Cell Significance Index: -4.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1688
    Cell Significance Index: -9.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1704
    Cell Significance Index: -11.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1721
    Cell Significance Index: -7.4900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1735
    Cell Significance Index: -1.3500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1769
    Cell Significance Index: -3.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1813
    Cell Significance Index: -13.5100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1816
    Cell Significance Index: -0.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1995
    Cell Significance Index: -9.3000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2075
    Cell Significance Index: -3.4200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2107
    Cell Significance Index: -2.7600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2181
    Cell Significance Index: -2.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2225
    Cell Significance Index: -17.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2387
    Cell Significance Index: -6.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2490
    Cell Significance Index: -6.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2603
    Cell Significance Index: -13.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2629
    Cell Significance Index: -9.2100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2725
    Cell Significance Index: -2.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2877
    Cell Significance Index: -8.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3079
    Cell Significance Index: -16.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3121
    Cell Significance Index: -9.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3187
    Cell Significance Index: -8.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3189
    Cell Significance Index: -10.4400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3196
    Cell Significance Index: -3.0300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3330
    Cell Significance Index: -4.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3345
    Cell Significance Index: -12.2800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3404
    Cell Significance Index: -8.7000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3533
    Cell Significance Index: -6.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3560
    Cell Significance Index: -9.3600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3719
    Cell Significance Index: -5.3300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3867
    Cell Significance Index: -8.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3949
    Cell Significance Index: -10.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LAT is a non-receptor tyrosine kinase that is specifically expressed in T cells. It is a member of the LCK family of kinases, which are known for their ability to phosphorylate and activate downstream signaling molecules. LAT is characterized by its unique structure, which consists of three immunoreceptor tyrosine-based activation motifs (ITAMs) that are phosphorylated upon TCR engagement. These ITAMs serve as binding sites for downstream signaling molecules, including phospholipase Cγ2 (PLCγ2) and ZAP-70. **Pathways and Functions:** LAT plays a critical role in the TCR signaling pathway, which is essential for T cell activation, proliferation, and differentiation. The LAT protein is involved in the following signaling pathways: 1. **Calcium-mediated signaling:** LAT is phosphorylated upon TCR engagement, leading to the activation of PLCγ2 and the subsequent release of calcium ions from the endoplasmic reticulum. 2. **MAPK activation:** LAT phosphorylates and activates MAPK kinases, such as MAPK1 and MAPK3, which lead to the activation of downstream transcription factors. 3. **Protein kinase binding:** LAT binds to and activates various protein kinases, including ZAP-70, which phosphorylates and activates downstream signaling molecules. 4. **Regulation of T cell activation:** LAT is involved in the regulation of T cell activation, proliferation, and differentiation. It is also involved in the regulation of T cell homeostasis and the generation of memory T cells. **Clinical Significance:** LAT is an important gene in the context of T cell-related diseases, including: 1. **Immunodeficiency disorders:** LAT mutations or deletions have been associated with X-linked severe combined immunodeficiency (X-SCID) and other immunodeficiency disorders. 2. **Autoimmune diseases:** LAT is involved in the regulation of T cell activation and proliferation, which can contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer:** LAT is overexpressed in certain types of cancer, including T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoma. 4. **Vaccine development:** LAT is an important target for vaccine development, as it is involved in the regulation of T cell activation and proliferation in response to antigen presentation. In summary, LAT is a critical regulator of T cell receptor signaling, and its dysregulation can contribute to various diseases, including immunodeficiency disorders, autoimmune diseases, and cancer. Understanding the mechanisms of LAT signaling is essential for the development of novel therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 1465653977

Symbol: LAT_HUMAN

Name: Linker for activation of T-cells family member 1

UniProtKB Accession Codes:

O43561 B7WPI0 C7C5T6 G5E9K3 O43919

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CORUM 1 CPTAC 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 6 ExpressionAtlas 1 GO 26 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 7 RefSeq 4 SIGNOR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9489702

Title: LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.

PubMed ID: 9489702

DOI: 10.1016/s0092-8674(00)80901-0

PubMed ID: 9529333

Title: Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells.

PubMed ID: 9529333

DOI: 10.1084/jem.187.7.1157

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9729044

Title: LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.

PubMed ID: 9729044

DOI: 10.1016/s1074-7613(00)80606-8

PubMed ID: 10488157

Title: Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells.

PubMed ID: 10488157

DOI: 10.1074/jbc.274.39.28050

PubMed ID: 10072481

Title: A role for the adaptor protein LAT in human NK cell-mediated cytotoxicity.

PubMed ID: 10072481

PubMed ID: 10811803

Title: Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling.

PubMed ID: 10811803

DOI: 10.1074/jbc.m000404200

PubMed ID: 10781611

Title: The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells.

PubMed ID: 10781611

DOI: 10.1074/jbc.m909462199

PubMed ID: 10942756

Title: Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.

PubMed ID: 10942756

DOI: 10.1074/jbc.m001439200

PubMed ID: 11368773

Title: Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells.

PubMed ID: 11368773

DOI: 10.1042/0264-6021:3560461

PubMed ID: 11259588

Title: Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation.

PubMed ID: 11259588

DOI: 10.1128/mcb.21.7.2393-2403.2001

PubMed ID: 12186560

Title: Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.

PubMed ID: 12186560

DOI: 10.1021/bi025554o

PubMed ID: 12913111

Title: The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling.

PubMed ID: 12913111

DOI: 10.1083/jcb.200303040

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 14696041

Title: LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways.

PubMed ID: 14696041

DOI: 10.1002/bies.10384

PubMed ID: 16160011

Title: Transmembrane adaptor molecules: a new category of lymphoid-cell markers.

PubMed ID: 16160011

DOI: 10.1182/blood-2005-06-2273

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23514740

Title: TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter.

PubMed ID: 23514740

DOI: 10.4049/jimmunol.1202742

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25907557

Title: The Us3 Protein of Herpes Simplex Virus 1 Inhibits T Cell Signaling by Confining Linker for Activation of T Cells (LAT) Activation via TRAF6 Protein.

PubMed ID: 25907557

DOI: 10.1074/jbc.m115.646422

PubMed ID: 27242165

Title: Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.

PubMed ID: 27242165

DOI: 10.1084/jem.20151110

PubMed ID: 27522155

Title: Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency.

PubMed ID: 27522155

DOI: 10.1016/j.jaci.2016.05.036

Sequence Information:

  • Length: 262
  • Mass: 27930
  • Checksum: BCD80AE7DCA64153
  • Sequence:
    • MEEAILVPCV LGLLLLPILA MLMALCVHCH RLPGSYDSTS SDSLYPRGIQ FKRPHTVAPW 
PPAYPPVTSY PPLSQPDLLP IPRSPQPLGG SHRTPSSRRD SDGANSVASY ENEGASGIRG 
AQAGWGVWGP SWTRLTPVSL PPEPACEDAD EDEDDYHNPG YLVVLPDSTP ATSTAAPSAP 
ALSTPGIRDS AFSMESIDDY VNVPESGESA EASLDGSREY VNVSQELHPG AAKTEPAALS 
SQEAEEVEEE GAPDYENLQE LN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.