Details for: PELP1

Gene ID: 27043

Symbol: PELP1

Ensembl ID: ENSG00000141456

Description: proline, glutamate and leucine rich protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 135.2340
    Cell Significance Index: -21.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 80.1125
    Cell Significance Index: -20.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 49.8387
    Cell Significance Index: -23.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.0361
    Cell Significance Index: -19.5200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.5919
    Cell Significance Index: -19.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.5368
    Cell Significance Index: -22.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.8933
    Cell Significance Index: -21.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8920
    Cell Significance Index: -23.2500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.8279
    Cell Significance Index: -17.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.6028
    Cell Significance Index: -7.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6445
    Cell Significance Index: 162.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3695
    Cell Significance Index: 159.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2328
    Cell Significance Index: 16.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9964
    Cell Significance Index: 59.8200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.9953
    Cell Significance Index: 7.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9841
    Cell Significance Index: 107.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8632
    Cell Significance Index: 171.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7722
    Cell Significance Index: 125.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6126
    Cell Significance Index: 17.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5855
    Cell Significance Index: 117.4600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.5709
    Cell Significance Index: 9.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5610
    Cell Significance Index: 15.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4824
    Cell Significance Index: 25.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4653
    Cell Significance Index: 32.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4144
    Cell Significance Index: 11.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4136
    Cell Significance Index: 50.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4058
    Cell Significance Index: 221.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3576
    Cell Significance Index: 128.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3443
    Cell Significance Index: 62.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3164
    Cell Significance Index: 43.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2848
    Cell Significance Index: 17.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2552
    Cell Significance Index: 6.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2526
    Cell Significance Index: 111.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2213
    Cell Significance Index: 10.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2202
    Cell Significance Index: 15.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2100
    Cell Significance Index: 4.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1894
    Cell Significance Index: 22.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1844
    Cell Significance Index: 127.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1769
    Cell Significance Index: 11.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1701
    Cell Significance Index: 8.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1697
    Cell Significance Index: 32.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1533
    Cell Significance Index: 4.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1463
    Cell Significance Index: 18.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1365
    Cell Significance Index: 3.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1173
    Cell Significance Index: 5.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1090
    Cell Significance Index: 5.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0907
    Cell Significance Index: 6.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0728
    Cell Significance Index: 2.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0657
    Cell Significance Index: 1.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0594
    Cell Significance Index: 7.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0491
    Cell Significance Index: 3.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0324
    Cell Significance Index: 0.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0269
    Cell Significance Index: 1.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0230
    Cell Significance Index: 1.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0195
    Cell Significance Index: 36.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0177
    Cell Significance Index: 15.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0083
    Cell Significance Index: 0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0044
    Cell Significance Index: 8.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0037
    Cell Significance Index: 5.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0011
    Cell Significance Index: 0.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0012
    Cell Significance Index: -0.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0015
    Cell Significance Index: -2.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0069
    Cell Significance Index: -4.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0092
    Cell Significance Index: -1.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0127
    Cell Significance Index: -9.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0162
    Cell Significance Index: -12.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0164
    Cell Significance Index: -7.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0240
    Cell Significance Index: -3.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0247
    Cell Significance Index: -18.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0321
    Cell Significance Index: -18.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0413
    Cell Significance Index: -25.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0467
    Cell Significance Index: -4.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0616
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0621
    Cell Significance Index: -7.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0667
    Cell Significance Index: -19.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0742
    Cell Significance Index: -4.9900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0802
    Cell Significance Index: -0.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0916
    Cell Significance Index: -4.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1018
    Cell Significance Index: -2.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1205
    Cell Significance Index: -25.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1389
    Cell Significance Index: -2.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1427
    Cell Significance Index: -4.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1441
    Cell Significance Index: -5.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1458
    Cell Significance Index: -4.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1461
    Cell Significance Index: -3.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1964
    Cell Significance Index: -20.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2309
    Cell Significance Index: -2.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2471
    Cell Significance Index: -5.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2517
    Cell Significance Index: -19.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2697
    Cell Significance Index: -7.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2771
    Cell Significance Index: -16.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2951
    Cell Significance Index: -8.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3385
    Cell Significance Index: -9.9700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3760
    Cell Significance Index: -7.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3762
    Cell Significance Index: -9.6700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3805
    Cell Significance Index: -9.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4194
    Cell Significance Index: -6.3200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4299
    Cell Significance Index: -6.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4353
    Cell Significance Index: -2.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proline-rich protein**: PELP1 is characterized by its proline-rich motif, which is essential for its interactions with other proteins and DNA. 2. **Chromatin binding**: PELP1 has been shown to bind to chromatin, suggesting its role in regulating gene expression and chromatin remodeling. 3. **RNA processing**: PELP1 is involved in the regulation of RNA processing, including rRNA processing in the nucleolus and cytosol. 4. **Transcriptional regulation**: PELP1 has been implicated in the positive regulation of transcription by RNA polymerase II, highlighting its role in transcriptional control. 5. **Cellular localization**: PELP1 is localized to the nucleus, cytoplasm, and nucleolus, indicating its involvement in multiple cellular processes. **Pathways and Functions:** 1. **Cellular response to estrogen stimulus**: PELP1 has been implicated in the cellular response to estrogen, suggesting its potential role in estrogen-mediated gene regulation. 2. **Chromatin binding**: PELP1's chromatin-binding activity is essential for its role in regulating gene expression and chromatin remodeling. 3. **RNA processing**: PELP1's involvement in rRNA processing highlights its role in regulating ribosome biogenesis and function. 4. **Transcriptional regulation**: PELP1's positive regulation of transcription by RNA polymerase II underscores its role in transcriptional control and gene expression. 5. **Signaling by non-receptor tyrosine kinases**: PELP1's involvement in signaling pathways suggests its potential role in cellular responses to external stimuli. **Clinical Significance:** 1. **Cancer**: PELP1's involvement in chromatin binding and transcriptional regulation suggests its potential role in cancer development and progression. 2. **Neurological disorders**: PELP1's expression in GABAergic interneurons and its involvement in RNA processing and transcriptional regulation highlight its potential role in neurological disorders, such as epilepsy and schizophrenia. 3. **Reproductive disorders**: PELP1's expression in oogonial cells and primordial germ cells suggests its potential role in reproductive disorders, such as infertility and germ cell tumors. 4. **Neurodevelopmental disorders**: PELP1's expression in forebrain radial glial cells and its involvement in RNA processing and transcriptional regulation highlight its potential role in neurodevelopmental disorders, such as autism spectrum disorder. In conclusion, PELP1 is a multifaceted protein with widespread implications in cellular processes, including chromatin binding, RNA processing, and transcriptional regulation. Its broad expression profile and involvement in multiple cellular pathways underscore its potential significance in various physiological and pathological processes. Further studies are necessary to elucidate the precise mechanisms by which PELP1 regulates cellular processes and to explore its potential therapeutic applications.

Genular Protein ID: 2979623186

Symbol: PELP1_HUMAN

Name: Proline-, glutamic acid- and leucine-rich protein 1

UniProtKB Accession Codes:

Q8IZL8 O15450 Q5EGN3 Q6NTE6 Q96FT1 Q9BU60

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 EMDB 3 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11481323

Title: Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha.

PubMed ID: 11481323

DOI: 10.1074/jbc.m103783200

PubMed ID: 12415108

Title: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.

PubMed ID: 12415108

DOI: 10.1073/pnas.192569699

PubMed ID: 19666546

Title:

PubMed ID: 19666546

DOI: 10.1073/pnas.0908685106

PubMed ID: 12682072

Title: Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein.

PubMed ID: 12682072

DOI: 10.1074/jbc.m212822200

PubMed ID: 14963108

Title: Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc.

PubMed ID: 14963108

DOI: 10.1210/me.2003-0335

PubMed ID: 15374949

Title: Potential role of a novel transcriptional coactivator PELP1 in histone H1 displacement in cancer cells.

PubMed ID: 15374949

DOI: 10.1158/0008-5472.can-04-1786

PubMed ID: 15456770

Title: The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains.

PubMed ID: 15456770

DOI: 10.1074/jbc.m406831200

PubMed ID: 15579769

Title: Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors.

PubMed ID: 15579769

DOI: 10.1210/jc.2004-0909

PubMed ID: 16140940

Title: Functional implications of altered subcellular localization of PELP1 in breast cancer cells.

PubMed ID: 16140940

DOI: 10.1158/0008-5472.can-05-0614

PubMed ID: 15994929

Title: Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation.

PubMed ID: 15994929

DOI: 10.1158/0008-5472.can-04-4664

PubMed ID: 15960975

Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

PubMed ID: 15960975

DOI: 10.1016/j.cell.2005.04.031

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16574651

Title: 9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway.

PubMed ID: 16574651

DOI: 10.1074/jbc.m601593200

PubMed ID: 16352611

Title: Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) interacts with PELP1 and activates MAPK.

PubMed ID: 16352611

DOI: 10.1074/jbc.m510368200

PubMed ID: 16567619

Title: NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression.

PubMed ID: 16567619

DOI: 10.1073/pnas.0601066103

PubMed ID: 17505058

Title: Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1).

PubMed ID: 17505058

DOI: 10.1210/me.2006-0514

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21326211

Title: The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex.

PubMed ID: 21326211

DOI: 10.1038/emboj.2011.33

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22872859

Title: Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.

PubMed ID: 22872859

DOI: 10.1074/mcp.m112.017194

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27814492

Title: The AAA ATPase MDN1 acts as a SUMO-targeted regulator in mammalian pre-ribosome remodeling.

PubMed ID: 27814492

DOI: 10.1016/j.molcel.2016.09.039

Sequence Information:

  • Length: 1130
  • Mass: 119700
  • Checksum: 7B0DEE7A198DA9A6
  • Sequence:
    • MAAAVLSGPS AGSAAGVPGG TGGLSAVSSG PRLRLLLLES VSGLLQPRTG SAVAPVHPPN 
RSAPHLPGLM CLLRLHGSVG GAQNLSALGA LVSLSNARLS SIKTRFEGLC LLSLLVGESP 
TELFQQHCVS WLRSIQQVLQ TQDPPATMEL AVAVLRDLLR YAAQLPALFR DISMNHLPGL 
LTSLLGLRPE CEQSALEGMK ACMTYFPRAC GSLKGKLASF FLSRVDALSP QLQQLACECY 
SRLPSLGAGF SQGLKHTESW EQELHSLLAS LHTLLGALYE GAETAPVQNE GPGVEMLLSS 
EDGDAHVLLQ LRQRFSGLAR CLGLMLSSEF GAPVSVPVQE ILDFICRTLS VSSKNISLHG 
DGPLRLLLLP SIHLEALDLL SALILACGSR LLRFGILIGR LLPQVLNSWS IGRDSLSPGQ 
ERPYSTVRTK VYAILELWVQ VCGASAGMLQ GGASGEALLT HLLSDISPPA DALKLRSPRG 
SPDGSLQTGK PSAPKKLKLD VGEAMAPPSH RKGDSNANSD VCAAALRGLS RTILMCGPLI 
KEETHRRLHD LVLPLVMGVQ QGEVLGSSPY TSSRCRRELY CLLLALLLAP SPRCPPPLAC 
ALQAFSLGQR EDSLEVSSFC SEALVTCAAL THPRVPPLQP MGPTCPTPAP VPPPEAPSPF 
RAPPFHPPGP MPSVGSMPSA GPMPSAGPMP SAGPVPSARP GPPTTANHLG LSVPGLVSVP 
PRLLPGPENH RAGSNEDPIL APSGTPPPTI PPDETFGGRV PRPAFVHYDK EEASDVEISL 
ESDSDDSVVI VPEGLPPLPP PPPSGATPPP IAPTGPPTAS PPVPAKEEPE ELPAAPGPLP 
PPPPPPPPVP GPVTLPPPQL VPEGTPGGGG PPALEEDLTV ININSSDEEE EEEEEEEEEE 
EEEEEEEEDF EEEEEDEEEY FEEEEEEEEE FEEEFEEEEG ELEEEEEEED EEEEEELEEV 
EDLEFGTAGG EVEEGAPPPP TLPPALPPPE SPPKVQPEPE PEPGLLLEVE EPGTEEERGA 
DTAPTLAPEA LPSQGEVERE GESPAAGPPP QELVEEEPSA PPTLLEEETE DGSDKVQPPP 
ETPAEEEMET ETEAEALQEK EQDDTAAMLA DFIDCPPDDE KPPPPTEPDS

Genular Protein ID: 4293778686

Symbol: B4DEX7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DEX7

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 4 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 906
  • Mass: 96891
  • Checksum: ECD1B0C7533E584C
  • Sequence:
    • MELAVAVLRD LLRYAAQLPA LFRDISMNHL PGLLTSLLGL RPECEQSALE GMKACMTYFP 
RACGSLKGKL ASFFLSRVDA LSPQLQQLAC ECYSRLPSLG AGFSQGLKHT ESWEQELHSL 
LASLHTLLGA LYEGAETAPV QNEGPGVEML LSSEDGDAHV LLQLRQRFSG LARCLGLMLS 
SEFGAPVSVP VQEILDFICR TLSVSSKNIS LHGDGPLRLL LLPSIHLEAL DLLSALILAC 
GSRLLRFGIL IGRLLPQVLN SWSIGRDSLS PGQERPYSTV RTKVYAILEL WVQVCGASAG 
MLQGGASGEA LLTHLLSDIS PPADALKPRS PRGSPDGSLQ TGKPSAPKKL KLDVGEAMAP 
PSHRKGDSNA NSDVCAAALR GLSRTILMCG PLIKEETHRR LHDLVLPLVM GVQQGEVLGS 
SPYTSSRCRR ELYCLLLALL LAPSPRCPPP LACALQAFSL GQREDSLEVS SFCSEALVTC 
AALTHPRVPP LQPMGPTCPT PAPVPPPEAP SPFRAPPFHP PGPMPSVGSM PSAGPMPSAG 
PMPSAGPVPS ARPGPPTTAN HLGLSVPGLV SVPPRLLPGP ENHRAGSNED PILAPSGTPP 
PTIPPDETFG GRVPRPAFVH YDKEEASDVE ISLESDSDDS VVIVPEGLPP LPPPPPSGAT 
PPPIAPTGPP TASPPVPAKE EPEELPAAPG PLPPPPPPPP PVPGPVTLPP PQLVPEGTPG 
GGGPPALEED LTVININSSD EEEEEEEEEE EEEEEEEEEE EDFEEEEEDE EEYFEEEEEE 
EEEFEEEFEE EEGELEEEEE EEDEEEEEEL EEVEREGESP AAGPPPQELV EEEPSAPPTL 
LEEETEDGSD KVQPPPETPA EEEMETETEA EALQEKEQDD TAAMLADFID CPPDDEKPPP 
PTEPDS

Genular Protein ID: 3122937243

Symbol: E7EV54_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EV54

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 906
  • Mass: 96907
  • Checksum: 393DB76833B1B72C
  • Sequence:
    • MELAVAVLRD LLRYAAQLPA LFRDISMNHL PGLLTSLLGL RPECEQSALE GMKACMTYFP 
RACGSLKGKL ASFFLSRVDA LSPQLQQLAC ECYSRLPSLG AGFSQGLKHT ESWEQELHSL 
LASLHTLLGA LYEGAETAPV QNEGPGVEML LSSEDGDAHV LLQLRQRFSG LARCLGLMLS 
SEFGAPVSVP VQEILDFICR TLSVSSKNIS LHGDGPLRLL LLPSIHLEAL DLLSALILAC 
GSRLLRFGIL IGRLLPQVLN SWSIGRDSLS PGQERPYSTV RTKVYAILEL WVQVCGASAG 
MLQGGASGEA LLTHLLSDIS PPADALKLRS PRGSPDGSLQ TGKPSAPKKL KLDVGEAMAP 
PSHRKGDSNA NSDVCAAALR GLSRTILMCG PLIKEETHRR LHDLVLPLVM GVQQGEVLGS 
SPYTSSRCRR ELYCLLLALL LAPSPRCPPP LACALQAFSL GQREDSLEVS SFCSEALVTC 
AALTHPRVPP LQPMGPTCPT PAPVPPPEAP SPFRAPPFHP PGPMPSVGSM PSAGPMPSAG 
PMPSAGPVPS ARPGPPTTAN HLGLSVPGLV SVPPRLLPGP ENHRAGSNED PILAPSGTPP 
PTIPPDETFG GRVPRPAFVH YDKEEASDVE ISLESDSDDS VVIVPEGLPP LPPPPPSGAT 
PPPIAPTGPP TASPPVPAKE EPEELPAAPG PLPPPPPPPP PVPGPVTLPP PQLVPEGTPG 
GGGPPALEED LTVININSSD EEEEEEEEEE EEEEEEEEEE EDFEEEEEDE EEYFEEEEEE 
EEEFEEEFEE EEGELEEEEE EEDEEEEEEL EEVEREGESP AAGPPPQELV EEEPSAPPTL 
LEEETEDGSD KVQPPPETPA EEEMETETEA EALQEKEQDD TAAMLADFID CPPDDEKPPP 
PTEPDS

Genular Protein ID: 133425572

Symbol: C9JFV4_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JFV4 I3L3A8

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 4 KEGG 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1180
  • Mass: 124944
  • Checksum: C55902905D406629
  • Sequence:
    • MLLPSLSPRV QPAFTQCARP QPPPHAPSPV GGRRGVFASS RHATTGTRGK MAAAVLSGPS 
AGSAAGVPGG TGGLSAVSSG PRLRLLLLES VSGLLQPRTG SAVAPVHPPN RSAPHLPGLM 
CLLRLHGSVG GAQNLSALGA LVSLSNARLS SIKTRFEGLC LLSLLVGESP TELFQQHCVS 
WLRSIQQVLQ TQDPPATMEL AVAVLRDLLR YAAQLPALFR DISMNHLPGL LTSLLGLRPE 
CEQSALEGMK ACMTYFPRAC GSLKGKLASF FLSRVDALSP QLQQLACECY SRLPSLGAGF 
SQGLKHTESW EQELHSLLAS LHTLLGALYE GAETAPVQNE GPGVEMLLSS EDGDAHVLLQ 
LRQRFSGLAR CLGLMLSSEF GAPVSVPVQE ILDFICRTLS VSSKNISLHG DGPLRLLLLP 
SIHLEALDLL SALILACGSR LLRFGILIGR LLPQVLNSWS IGRDSLSPGQ ERPYSTVRTK 
VYAILELWVQ VCGASAGMLQ GGASGEALLT HLLSDISPPA DALKLRSPRG SPDGSLQTGK 
PSAPKKLKLD VGEAMAPPSH RKGDSNANSD VCAAALRGLS RTILMCGPLI KEETHRRLHD 
LVLPLVMGVQ QGEVLGSSPY TSSRCRRELY CLLLALLLAP SPRCPPPLAC ALQAFSLGQR 
EDSLEVSSFC SEALVTCAAL THPRVPPLQP MGPTCPTPAP VPPPEAPSPF RAPPFHPPGP 
MPSVGSMPSA GPMPSAGPMP SAGPVPSARP GPPTTANHLG LSVPGLVSVP PRLLPGPENH 
RAGSNEDPIL APSGTPPPTI PPDETFGGRV PRPAFVHYDK EEASDVEISL ESDSDDSVVI 
VPEGLPPLPP PPPSGATPPP IAPTGPPTAS PPVPAKEEPE ELPAAPGPLP PPPPPPPPVP 
GPVTLPPPQL VPEGTPGGGG PPALEEDLTV ININSSDEEE EEEEEEEEEE EEEEEEEEDF 
EEEEEDEEEY FEEEEEEEEE FEEEFEEEEG ELEEEEEEED EEEEEELEEV EDLEFGTAGG 
EVEEGAPPPP TLPPALPPPE SPPKVQPEPE PEPGLLLEVE EPGTEEERGA DTAPTLAPEA 
LPSQGEVERE GESPAAGPPP QELVEEEPSA PPTLLEEETE DGSDKVQPPP ETPAEEEMET 
ETEAEALQEK EQDDTAAMLA DFIDCPPDDE KPPPPTEPDS

Genular Protein ID: 3197061199

Symbol: B4DR36_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DR36

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 4 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 1180
  • Mass: 124868
  • Checksum: 275132B4F5547311
  • Sequence:
    • MLLPSLSPRV QPAFTQCARP QPPPHAPSPV GGRRGVSASS RHATTGTRGK MAAAVLSGPS 
AGSAAGVPGG TGGLSAVSSG PRLRLLLLES VSGLLQPRTG SAVAPVHPPN RSAPHLPGLM 
CLLRLHGSVG GAQNLSALGA LVSLSNARLS SIKTRFEGLC LLSLLVGESP TELFQQHCVS 
WLRSIQQVLQ TQDPPATMEL AVAVLRDLLR YAAQLPALFR DISMNHLPGL LTSLLGLRPE 
CEQSALEGMK ACMTYFPRAC GSLKGKLASF FLSRVDALSP QLQQLACECY SRLPSLGAGF 
SQGLKHTESW EQELHSLLAS LHTLLGALYE GAETAPVQNE GPGVEMLLSS EDGDAHVLLQ 
LRQRFSGLAR CLGLMLSSEF GAPVSVPVQE ILDFICRTLS VSSKNISLHG DGPLRLLLLP 
SIHLEALDLP SALILACGSR LLRFGILIGR LLPQVLNSWS IGRDSLSPGQ ERPYSTVRTK 
VYAILELWVQ VCGASAGMLQ GGASGEALLT HLLSDISPPA DALKLRSPRG SPDGSLQTGK 
PSAPKKLKLD VGEAMAPPSH RKGDSNANSD VCAAALRGLS RTILMCGPLI KEETHRRLHD 
LVLPLVMGVQ QGEVLGSSPY TSSRCRRELY CLLLALLLAP SPRCPPPLAC ALQAFSLGQR 
EDSLEVSSFC SEALVTCAAL THPRVPPLQP MGPTCPTPAP VPPPEAPSPF RAPPFHPPGP 
MPSVGSMPSA GPMPSAGPMP SAGPVPSARP GPPTTANHLG LSVPGLVSVP PRLLPGPENH 
RAGSNEDPIL APSGTPPPTI PPDETFGGRV PRPAFVHYDK EEASDVEISL ESDSDDSVVI 
VPEGLPPLPP PPPSGATPPP IAPTGPPTAS PPVPAKEEPE ELPAAPGPLP PPPPPPPPVP 
GPVTLPPPQL VPEGTPGGGG PPALEEDLTV ININSSDEEE EEEEEEEEEE EEEEEEEEDF 
EEEEEDEEEY FEEEEEEEEE FEEEFEEEEG ELEEEEEEED EEEEEELEEV EDLEFGTAGG 
EVEEGAPPPP TLPPALPPPE SPPKVQPEPE PEPGLLLEVE EPGTEEERGA DTAPTLAPEA 
LPSQGEVERE GESPAAGPPP QELVEEEPSA PPTLLEEETE DGSDKVQPPP ETPAEEEMET 
ETEAEALQEK EQDDTAAMLA DFIDCPPDDE KPPPPTEPDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.