Details for: INPP5J

Gene ID: 27124

Symbol: INPP5J

Ensembl ID: ENSG00000185133

Description: inositol polyphosphate-5-phosphatase J

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.4364
    Cell Significance Index: -7.7200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 10.7448
    Cell Significance Index: -7.2100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.4193
    Cell Significance Index: 36.3300
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 2.6143
    Cell Significance Index: 10.0100
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 2.1829
    Cell Significance Index: 12.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7040
    Cell Significance Index: 49.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6353
    Cell Significance Index: 161.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5448
    Cell Significance Index: 293.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8876
    Cell Significance Index: 19.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7100
    Cell Significance Index: 32.1800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.6337
    Cell Significance Index: 3.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5359
    Cell Significance Index: 58.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5325
    Cell Significance Index: 31.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4817
    Cell Significance Index: 78.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4758
    Cell Significance Index: 35.4600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3802
    Cell Significance Index: 5.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3386
    Cell Significance Index: 17.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2996
    Cell Significance Index: 6.3800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2665
    Cell Significance Index: 3.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2617
    Cell Significance Index: 18.1000
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.2461
    Cell Significance Index: 0.8500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2262
    Cell Significance Index: 3.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2166
    Cell Significance Index: 7.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2136
    Cell Significance Index: 4.4300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1816
    Cell Significance Index: 2.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1686
    Cell Significance Index: 11.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.1560
    Cell Significance Index: 3.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1444
    Cell Significance Index: 28.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1360
    Cell Significance Index: 7.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1186
    Cell Significance Index: 5.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1035
    Cell Significance Index: 7.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0939
    Cell Significance Index: 64.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0899
    Cell Significance Index: 32.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0768
    Cell Significance Index: 69.3200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0677
    Cell Significance Index: 1.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0584
    Cell Significance Index: 1.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0530
    Cell Significance Index: 9.5500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0528
    Cell Significance Index: 0.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0434
    Cell Significance Index: 1.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0382
    Cell Significance Index: 1.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0222
    Cell Significance Index: 0.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0176
    Cell Significance Index: 3.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0139
    Cell Significance Index: 2.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0113
    Cell Significance Index: 7.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0085
    Cell Significance Index: 0.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0068
    Cell Significance Index: 4.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0067
    Cell Significance Index: 1.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0048
    Cell Significance Index: 2.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0004
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0023
    Cell Significance Index: -3.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0025
    Cell Significance Index: -1.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0046
    Cell Significance Index: -6.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0072
    Cell Significance Index: -3.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0073
    Cell Significance Index: -5.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0101
    Cell Significance Index: -5.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0130
    Cell Significance Index: -8.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0161
    Cell Significance Index: -1.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0165
    Cell Significance Index: -0.5300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0178
    Cell Significance Index: -0.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0185
    Cell Significance Index: -2.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0190
    Cell Significance Index: -2.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0198
    Cell Significance Index: -5.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0242
    Cell Significance Index: -1.4900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0256
    Cell Significance Index: -0.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0312
    Cell Significance Index: -1.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0332
    Cell Significance Index: -3.3900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0347
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0354
    Cell Significance Index: -7.4600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0385
    Cell Significance Index: -0.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0390
    Cell Significance Index: -5.3500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0454
    Cell Significance Index: -0.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0462
    Cell Significance Index: -1.2900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0484
    Cell Significance Index: -1.0100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0527
    Cell Significance Index: -0.3500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0555
    Cell Significance Index: -0.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0568
    Cell Significance Index: -6.7000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0594
    Cell Significance Index: -0.4900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0603
    Cell Significance Index: -1.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0637
    Cell Significance Index: -1.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0667
    Cell Significance Index: -4.0900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0725
    Cell Significance Index: -1.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0744
    Cell Significance Index: -1.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0767
    Cell Significance Index: -7.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0776
    Cell Significance Index: -2.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0817
    Cell Significance Index: -6.4700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0856
    Cell Significance Index: -0.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0877
    Cell Significance Index: -5.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0884
    Cell Significance Index: -4.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0884
    Cell Significance Index: -3.9100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0896
    Cell Significance Index: -1.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0936
    Cell Significance Index: -1.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0991
    Cell Significance Index: -5.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1001
    Cell Significance Index: -3.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1011
    Cell Significance Index: -2.0000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1029
    Cell Significance Index: -1.1700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1061
    Cell Significance Index: -4.6100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1092
    Cell Significance Index: -1.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** INPP5J is a phosphatase enzyme that specifically hydrolyzes inositol polyphosphates, thereby regulating the levels of inositol-1,4,5-trisphosphate (IP3) and inositol-1,3,4,5-tetrakisphosphate (IP4) in the cytosol. 2. **Tissue-Specific Expression:** INPP5J is expressed in various tissues, including the kidney, brain, and intestinal epithelial cells, suggesting its role in maintaining cellular homeostasis in different organs. 3. **Cellular Localization:** INPP5J is primarily localized to the cytosol, with some expression at the plasma membrane, indicating its involvement in both intracellular and cell surface signaling pathways. 4. **Regulatory Interactions:** INPP5J interacts with various proteins, including PI5PA, a phosphatidylinositol 4,5-bisphosphate 5-phosphatase, and Sh3 domain-binding proteins, suggesting its involvement in complex signaling networks. **Pathways and Functions:** 1. **Inositol Phosphate Metabolism:** INPP5J plays a central role in regulating the levels of IP3 and IP4, which are crucial signaling molecules involved in various cellular processes, including neuronal development, apoptosis, and immune responses. 2. **Neuronal Development:** INPP5J negatively regulates neuron projection development, suggesting its involvement in the regulation of axon outgrowth and neuronal differentiation. 3. **Lipid Metabolism:** INPP5J is involved in the regulation of phospholipid metabolism, including the synthesis and degradation of phosphatidylinositol (PI) and its derivatives. 4. **Immune Responses:** INPP5J regulates immune responses by modulating the activity of dendritic cells and other immune cells, highlighting its potential role in immune system development and function. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in INPP5J expression or function have been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and Alzheimer's disease. 2. **Cancer:** INPP5J has been shown to be overexpressed in certain types of cancer, including breast and colon cancer, suggesting its potential role as a tumor suppressor. 3. **Immunological Disorders:** INPP5J regulates immune responses, and alterations in its expression or function may contribute to the development of immunological disorders, such as autoimmune diseases. 4. **Metabolic Disorders:** INPP5J is involved in lipid metabolism, and alterations in its expression or function may contribute to the development of metabolic disorders, including obesity and diabetes. In conclusion, INPP5J is a multifunctional gene that plays a critical role in regulating inositol phosphate metabolism, neuronal development, lipid metabolism, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying INPP5J's functions and its potential therapeutic applications.

Genular Protein ID: 1714227368

Symbol: PI5PA_HUMAN

Name: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 1006
  • Mass: 107197
  • Checksum: ADB6382AA33E15AC
  • Sequence:
  • MEGQSSRGSR RPGTRAGLGS LPMPQGVAQT GAPSKVDSSF QLPAKKNAAL GPSEPRLALA 
    PVGPRAAMSA SSEGPRLALA SPRPILAPLC TPEGQKTATA HRSSSLAPTS VGQLVMSASA 
    GPKPPPATTG SVLAPTSLGL VMPASAGPRS PPVTLGPNLA PTSRDQKQEP PASVGPKPTL 
    AASGLSLALA SEEQPPELPS TPSPVPSPVL SPTQEQALAP ASTASGAASV GQTSARKRDA 
    PAPRPLPASE GHLQPPAQTS GPTGSPPCIQ TSPDPRLSPS FRARPEALHS SPEDPVLPRP 
    PQTLPLDVGQ GPSEPGTHSP GLLSPTFRPG APSGQTVPPP LPKPPRSPSR SPSHSPNRSP 
    CVPPAPDMAL PRLGTQSTGP GRCLSPNLQA QEAPAPVTTS SSTSTLSSSP WSAQPTWKSD 
    PGFRITVVTW NVGTAMPPDD VTSLLHLGGG DDSDGADMIA IGLQEVNSML NKRLKDALFT 
    DQWSELFMDA LGPFNFVLVS SVRMQGVILL LFAKYYHLPF LRDVQTDCTR TGLGGYWGNK 
    GGVSVRLAAF GHMLCFLNCH LPAHMDKAEQ RKDNFQTILS LQQFQGPGAQ GILDHDLVFW 
    FGDLNFRIES YDLHFVKFAI DSDQLHQLWE KDQLNMAKNT WPILKGFQEG PLNFAPTFKF 
    DVGTNKYDTS AKKRKPAWTD RILWKVKAPG GGPSPSGRKS HRLQVTQHSY RSHMEYTVSD 
    HKPVAAQFLL QFAFRDDMPL VRLEVADEWV RPEQAVVRYR METVFARSSW DWIGLYRVGF 
    RHCKDYVAYV WAKHEDVDGN TYQVTFSEES LPKGHGDFIL GYYSHNHSIL IGITEPFQIS 
    LPSSELASSS TDSSGTSSEG EDDSTLELLA PKSRSPSPGK SKRHRSRSPG LARFPGLALR 
    PSSRERRGAS RSPSPQSRRL SRVAPDRSSN GSSRGSSEEG PSGLPGPWAF PPAVPRSLGL 
    LPALRLETVD PGGGGSWGPD REALAPNSLS PSPQGHRGLE EGGLGP

Genular Protein ID: 4098813849

Symbol: B4DF95_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 939
  • Mass: 100492
  • Checksum: FA6B1971217EC01F
  • Sequence:
  • MSASSEGPRL ALASPRPILA PLCTPEGQKT ATAHRSSSLA PTSVGQLVMS ASAGPKPPPA 
    TTGSVLAPTS LGLVMPASAG PRSPPVTLGP NLAPTSRDQK QEPPASVGPK PTLAASGLSL 
    ALASEEQPPE LPSTPSPVPS PVLSPTQEQA LAPASTASGA ASVGQTSARK RDAPAPRPLP 
    ASEGHLQPPA QTSGPTGSPP CIQTSPDPRL SPSFRARPEA LHSSPEDPVL PRPPQTLPLD 
    VGQGPSEPGT HSPGLLSPTF RPGAPSGQTV PPPLPKPPRS PSRSPSHSPN RSPCVPPAPD 
    MALPRLGTQS TGPGRCLSPN LQAQEAPAPV TTSSSTSTLS SSPWSAQPTW KSDPGFRITV 
    VTWNVGTAMP PDDVTSLLHL GGGDDSDGAD MIAIGLQEVN SMLNKRLKDA LFTDQWSELF 
    MDALGPFNFV LVSSVRMQGV ILLLFAKYYH LPFLRDVQTD CTRTGLGGYW GNKGGVSVRL 
    AAFGHMLCFL NCHLPAHMDK AEQRKDNFQT ILSLQQFQGP GAQGILDHDL VFWFGDLNFR 
    IESYDLHFVK FAIDSDQLHQ LWEKDQLNMA KNTWPILKGF QEGPLNFAPT FKFDVGTNKY 
    DTSAKKRKPA WTDRILWKVK APGGGPSPSG RKSHRLQVTQ HSYRSHMEYT VSDHKPVAAQ 
    FLLQFAFRDD MPLVRLEVAD EWVRPEQAVV RYRMETVFAR SSWDWIGLYR VGFRHCKDYV 
    AYVWAKHEDV DGNTYQVTFS EESLPKGHGD FILGYYSHNH SILIGITEPF QISLPSSELA 
    SSSTDSSGTS SEGEDDSTLE LLAPKSRSPS PGKSKRHRSR SPGLARFPGL ALRPSSRERR 
    GASRSPSPQS RRLSRVAPDR SSNGSSRGSS EEGPSGLPGP WAFPPAVPRS LGLLPALRLE 
    TVDPGGGGSW GPDREALAPN SLSPSPQGHR GLEEGGLGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.