Details for: AFF4

Gene ID: 27125

Symbol: AFF4

Ensembl ID: ENSG00000072364

Description: ALF transcription elongation factor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 573.6595
    Cell Significance Index: -89.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 339.5712
    Cell Significance Index: -86.1300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 248.6845
    Cell Significance Index: -102.4500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 202.1509
    Cell Significance Index: -95.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 187.4183
    Cell Significance Index: -76.1400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 169.6977
    Cell Significance Index: -87.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 80.2206
    Cell Significance Index: -76.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 73.5144
    Cell Significance Index: -90.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 32.1144
    Cell Significance Index: -86.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.0821
    Cell Significance Index: -80.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.0991
    Cell Significance Index: -91.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.2349
    Cell Significance Index: -37.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4830
    Cell Significance Index: 498.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2624
    Cell Significance Index: 448.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.2493
    Cell Significance Index: 126.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.2072
    Cell Significance Index: 169.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1911
    Cell Significance Index: 99.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9468
    Cell Significance Index: 698.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.4617
    Cell Significance Index: 41.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3304
    Cell Significance Index: 163.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3161
    Cell Significance Index: 36.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2800
    Cell Significance Index: 66.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2712
    Cell Significance Index: 229.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2292
    Cell Significance Index: 35.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1631
    Cell Significance Index: 159.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1299
    Cell Significance Index: 122.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0857
    Cell Significance Index: 750.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0105
    Cell Significance Index: 551.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9733
    Cell Significance Index: 43.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9633
    Cell Significance Index: 18.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.9397
    Cell Significance Index: 1769.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8015
    Cell Significance Index: 30.3500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7768
    Cell Significance Index: 9.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7697
    Cell Significance Index: 340.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7681
    Cell Significance Index: 20.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7616
    Cell Significance Index: 46.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7586
    Cell Significance Index: 48.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7407
    Cell Significance Index: 20.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7128
    Cell Significance Index: 47.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6439
    Cell Significance Index: 16.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6089
    Cell Significance Index: 28.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5768
    Cell Significance Index: 366.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5417
    Cell Significance Index: 40.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5343
    Cell Significance Index: 68.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5104
    Cell Significance Index: 13.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4822
    Cell Significance Index: 742.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4325
    Cell Significance Index: 797.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3805
    Cell Significance Index: 10.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3802
    Cell Significance Index: 172.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3755
    Cell Significance Index: 13.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3705
    Cell Significance Index: 36.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3502
    Cell Significance Index: 16.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3321
    Cell Significance Index: 39.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2924
    Cell Significance Index: 55.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2725
    Cell Significance Index: 44.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2595
    Cell Significance Index: 33.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2438
    Cell Significance Index: 12.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2115
    Cell Significance Index: 287.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1495
    Cell Significance Index: 25.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0250
    Cell Significance Index: -1.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0292
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0433
    Cell Significance Index: -32.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0435
    Cell Significance Index: -31.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0440
    Cell Significance Index: -2.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0530
    Cell Significance Index: -3.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0607
    Cell Significance Index: -37.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0877
    Cell Significance Index: -66.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0921
    Cell Significance Index: -9.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1227
    Cell Significance Index: -69.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2104
    Cell Significance Index: -44.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2528
    Cell Significance Index: -36.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2733
    Cell Significance Index: -78.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2755
    Cell Significance Index: -28.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2935
    Cell Significance Index: -34.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3834
    Cell Significance Index: -9.2000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3902
    Cell Significance Index: -9.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4921
    Cell Significance Index: -56.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4949
    Cell Significance Index: -56.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5424
    Cell Significance Index: -7.4000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5758
    Cell Significance Index: -9.7000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6697
    Cell Significance Index: -14.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6721
    Cell Significance Index: -19.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7442
    Cell Significance Index: -12.4600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8555
    Cell Significance Index: -12.6300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.9554
    Cell Significance Index: -13.7200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9633
    Cell Significance Index: -5.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9639
    Cell Significance Index: -76.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9983
    Cell Significance Index: -21.2600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.0137
    Cell Significance Index: -14.5800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.0371
    Cell Significance Index: -9.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0501
    Cell Significance Index: -24.2600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.1134
    Cell Significance Index: -13.8100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.1521
    Cell Significance Index: -23.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.2530
    Cell Significance Index: -43.5400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.2981
    Cell Significance Index: -19.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3419
    Cell Significance Index: -82.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.4896
    Cell Significance Index: -22.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.4971
    Cell Significance Index: -47.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.5221
    Cell Significance Index: -32.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.5934
    Cell Significance Index: -29.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AFF4 is a member of the FMR2 family of proteins, which are involved in regulating transcription elongation and gene expression. The AFF4 protein is a transcription elongation factor that binds to the RNA polymerase II (Pol II) complex and facilitates the transcription of genes involved in various cellular processes. AFF4 has been shown to interact with other proteins, including the super elongation complex, which is involved in regulating the elongation of RNA Pol II. **Pathways and Functions:** AFF4 is involved in several cellular pathways, including: 1. **Transcription elongation**: AFF4 binds to the RNA Pol II complex and facilitates the transcription of genes involved in various cellular processes, including cell growth, differentiation, and survival. 2. **Gene expression regulation**: AFF4 regulates the expression of genes involved in various cellular processes, including cell growth, differentiation, and survival. 3. **Super elongation complex**: AFF4 interacts with the super elongation complex, which is involved in regulating the elongation of RNA Pol II. 4. **Euchromatin formation**: AFF4 is involved in the formation of euchromatin, a highly transcriptionally active state of chromatin. **Clinical Significance:** Dysregulation of AFF4 has been implicated in several diseases, including: 1. **Fragile X syndrome**: AFF4 is mutated in individuals with Fragile X syndrome, a neurodevelopmental disorder characterized by intellectual disability and behavioral problems. 2. **Cancer**: AFF4 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer. 3. **Neurodevelopmental disorders**: AFF4 has been implicated in several neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. Overall, AFF4 is a critical component of the transcriptional machinery, and its dysregulation can have significant consequences for cellular function and disease. Further research is needed to fully understand the role of AFF4 in regulating gene expression and its implications for human disease. In conclusion, AFF4 is a multifunctional protein that plays a critical role in regulating gene expression and transcription elongation. Its dysregulation has been implicated in several diseases, including neurodevelopmental disorders and cancer. Further research is needed to fully understand the role of AFF4 in regulating gene expression and its implications for human disease.

Genular Protein ID: 3932813001

Symbol: AFF4_HUMAN

Name: AF4/FMR2 family member 4

UniProtKB Accession Codes:

Q9UHB7 B2RP19 B7WPD2 Q498B2 Q59FB3 Q6P592 Q8TDR1 Q9P0E4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10588740

Title: AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23).

PubMed ID: 10588740

DOI: 10.1073/pnas.96.25.14535

PubMed ID: 12065898

Title: MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein.

PubMed ID: 12065898

DOI: 10.1007/bf02256070

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20471948

Title: HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.

PubMed ID: 20471948

DOI: 10.1016/j.molcel.2010.04.013

PubMed ID: 20159561

Title: AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.

PubMed ID: 20159561

DOI: 10.1016/j.molcel.2010.01.026

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22195968

Title: The little elongation complex regulates small nuclear RNA transcription.

PubMed ID: 22195968

DOI: 10.1016/j.molcel.2011.12.008

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22483617

Title: The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription.

PubMed ID: 22483617

DOI: 10.1016/j.molcel.2012.03.007

PubMed ID: 22895430

Title: The super elongation complex (SEC) family in transcriptional control.

PubMed ID: 22895430

DOI: 10.1038/nrm3417

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23251033

Title: HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold.

PubMed ID: 23251033

DOI: 10.1073/pnas.1216971110

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25730767

Title: Germline gain-of-function mutations in AFF4 cause a developmental syndrome functionally linking the super elongation complex and cohesin.

PubMed ID: 25730767

DOI: 10.1038/ng.3229

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30134174

Title: Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex.

PubMed ID: 30134174

DOI: 10.1016/j.celrep.2018.07.064

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 1163
  • Mass: 127459
  • Checksum: 474E1906B8832AC1
  • Sequence:
    • MNREDRNVLR MKERERRNQE IQQGEDAFPP SSPLFAEPYK VTSKEDKLSS RIQSMLGNYD 
EMKDFIGDRS IPKLVAIPKP TVPPSADEKS NPNFFEQRHG GSHQSSKWTP VGPAPSTSQS 
QKRSSGLQSG HSSQRTSAGS SSGTNSSGQR HDRESYNNSG SSSRKKGQHG SEHSKSRSSS 
PGKPQAVSSL NSSHSRSHGN DHHSKEHQRS KSPRDPDANW DSPSRVPFSS GQHSTQSFPP 
SLMSKSNSML QKPTAYVRPM DGQESMEPKL SSEHYSSQSH GNSMTELKPS SKAHLTKLKI 
PSQPLDASAS GDVSCVDEIL KEMTHSWPPP LTAIHTPCKT EPSKFPFPTK ESQQSNFGTG 
EQKRYNPSKT SNGHQSKSML KDDLKLSSSE DSDGEQDCDK TMPRSTPGSN SEPSHHNSEG 
ADNSRDDSSS HSGSESSSGS DSESESSSSD SEANEPSQSA SPEPEPPPTN KWQLDNWLNK 
VNPHKVSPAS SVDSNIPSSQ GYKKEGREQG TGNSYTDTSG PKETSSATPG RDSKTIQKGS 
ESGRGRQKSP AQSDSTTQRR TVGKKQPKKA EKAAAEEPRG GLKIESETPV DLASSMPSSR 
HKAATKGSRK PNIKKESKSS PRPTAEKKKY KSTSKSSQKS REIIETDTSS SDSDESESLP 
PSSQTPKYPE SNRTPVKPSS VEEEDSFFRQ RMFSPMEEKE LLSPLSEPDD RYPLIVKIDL 
NLLTRIPGKP YKETEPPKGE KKNVPEKHTR EAQKQASEKV SNKGKRKHKN EDDNRASESK 
KPKTEDKNSA GHKPSSNRES SKQSAAKEKD LLPSPAGPVP SKDPKTEHGS RKRTISQSSS 
LKSSSNSNKE TSGSSKNSSS TSKQKKTEGK TSSSSKEVKE KAPSSSSNCP PSAPTLDSSK 
PRRTKLVFDD RNYSADHYLQ EAKKLKHNAD ALSDRFEKAV YYLDAVVSFI ECGNALEKNA 
QESKSPFPMY SETVDLIKYT MKLKNYLAPD ATAADKRLTV LCLRCESLLY LRLFKLKKEN 
ALKYSKTLTE HLKNSYNNSQ APSPGLGSKA VGMPSPVSPK LSPGNSGNYS SGASSASASG 
SSVTIPQKIH QMAASYVQVT SNFLYATEIW DQAEQLSKEQ KEFFAELDKV MGPLIFNASI 
MTDLVRYTRQ GLHWLRQDAK LIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.