Details for: PRELID1

Gene ID: 27166

Symbol: PRELID1

Ensembl ID: ENSG00000169230

Description: PRELI domain containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 396.0906
    Cell Significance Index: -61.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 259.2616
    Cell Significance Index: -65.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 178.3353
    Cell Significance Index: -72.4500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 166.0374
    Cell Significance Index: -78.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 154.6020
    Cell Significance Index: -79.5300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 117.4626
    Cell Significance Index: -78.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 59.9535
    Cell Significance Index: -73.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.9313
    Cell Significance Index: -78.6500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.5384
    Cell Significance Index: -56.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.3682
    Cell Significance Index: -27.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.2623
    Cell Significance Index: -22.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 9.5258
    Cell Significance Index: 1110.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.6165
    Cell Significance Index: 216.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.5805
    Cell Significance Index: 84.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.4860
    Cell Significance Index: 209.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.1663
    Cell Significance Index: 122.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.5859
    Cell Significance Index: 463.2800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.4432
    Cell Significance Index: 21.1900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.2035
    Cell Significance Index: 29.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.9311
    Cell Significance Index: 43.9200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.6846
    Cell Significance Index: 22.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.5872
    Cell Significance Index: 192.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.4321
    Cell Significance Index: 26.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.2907
    Cell Significance Index: 270.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.2899
    Cell Significance Index: 372.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.2109
    Cell Significance Index: 1207.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1448
    Cell Significance Index: 386.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1361
    Cell Significance Index: 262.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.9960
    Cell Significance Index: 274.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.8325
    Cell Significance Index: 129.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8259
    Cell Significance Index: 82.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.8126
    Cell Significance Index: 37.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7800
    Cell Significance Index: 114.8400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.6716
    Cell Significance Index: 18.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6697
    Cell Significance Index: 738.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6228
    Cell Significance Index: 46.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5975
    Cell Significance Index: 42.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3687
    Cell Significance Index: 71.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2043
    Cell Significance Index: 32.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2026
    Cell Significance Index: 41.7900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.1533
    Cell Significance Index: 9.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1026
    Cell Significance Index: 29.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9255
    Cell Significance Index: 118.6500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8419
    Cell Significance Index: 19.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5870
    Cell Significance Index: 30.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5287
    Cell Significance Index: 104.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4366
    Cell Significance Index: 43.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3107
    Cell Significance Index: 59.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1421
    Cell Significance Index: 128.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1385
    Cell Significance Index: 104.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1216
    Cell Significance Index: 3.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1150
    Cell Significance Index: 23.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0885
    Cell Significance Index: 15.1200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0427
    Cell Significance Index: 0.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0341
    Cell Significance Index: 25.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0194
    Cell Significance Index: 0.3300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0099
    Cell Significance Index: 0.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0026
    Cell Significance Index: -0.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0257
    Cell Significance Index: -9.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0318
    Cell Significance Index: -59.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0521
    Cell Significance Index: -96.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0621
    Cell Significance Index: -95.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0719
    Cell Significance Index: -97.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0764
    Cell Significance Index: -56.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1050
    Cell Significance Index: -66.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1273
    Cell Significance Index: -71.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1622
    Cell Significance Index: -101.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1668
    Cell Significance Index: -75.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2082
    Cell Significance Index: -59.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2323
    Cell Significance Index: -14.6400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2601
    Cell Significance Index: -3.9500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2662
    Cell Significance Index: -6.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3234
    Cell Significance Index: -11.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3696
    Cell Significance Index: -10.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4078
    Cell Significance Index: -85.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4553
    Cell Significance Index: -52.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4975
    Cell Significance Index: -72.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5525
    Cell Significance Index: -43.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5651
    Cell Significance Index: -15.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6730
    Cell Significance Index: -14.5800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.6851
    Cell Significance Index: -5.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6873
    Cell Significance Index: -7.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7547
    Cell Significance Index: -78.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8392
    Cell Significance Index: -51.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9667
    Cell Significance Index: -13.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0283
    Cell Significance Index: -78.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0343
    Cell Significance Index: -69.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0629
    Cell Significance Index: -28.4800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1191
    Cell Significance Index: -13.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1545
    Cell Significance Index: -70.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.1983
    Cell Significance Index: -67.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2006
    Cell Significance Index: -25.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.2434
    Cell Significance Index: -64.7700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.3618
    Cell Significance Index: -17.4400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.4485
    Cell Significance Index: -9.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4786
    Cell Significance Index: -43.5500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -1.5027
    Cell Significance Index: -9.3000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.5894
    Cell Significance Index: -27.4000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.6267
    Cell Significance Index: -22.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.6906
    Cell Significance Index: -48.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRELID1 is a mitochondrial protein that contains a PRELI domain, a conserved motif involved in protein-protein interactions. Its expression is widespread across different cell types, suggesting its essential role in maintaining cellular functions. PRELID1 is also involved in negative regulation of apoptotic processes, mitochondrial membrane potential, and release of cytochrome c from mitochondria, indicating its role in maintaining cellular integrity. **Pathways and Functions:** PRELID1 is implicated in several cellular pathways, including: 1. **Apoptotic Process:** PRELID1 regulates the negative apoptotic process by inhibiting the release of cytochrome c from mitochondria, thereby preventing cell death. 2. **Gene Expression (Transcription):** PRELID1 interacts with RNA polymerase II to regulate transcriptional activity, particularly in response to TP53. 3. **Metabolism of Proteins:** PRELID1 is involved in protein degradation and phospholipid transport, highlighting its role in maintaining cellular homeostasis. 4. **Mitochondrial Intermembrane Space:** PRELID1 regulates mitochondrial intermembrane space, which is crucial for maintaining mitochondrial function and cellular energy metabolism. **Clinical Significance:** The dysregulation of PRELID1 has been implicated in various diseases, including: 1. **Cancer:** Alterations in PRELID1 expression have been observed in various cancers, including pancreatic cancer, suggesting its role in tumorigenesis. 2. **Autoimmune Diseases:** PRELID1 is involved in the regulation of T cell differentiation and apoptosis, which may contribute to autoimmune diseases such as rheumatoid arthritis. 3. **Neurological Disorders:** Dysregulation of PRELID1 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, PRELID1 is a critical regulator of mitochondrial function and apoptosis, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which PRELID1 regulates cellular processes and to explore its potential therapeutic applications. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms by which PRELID1 regulates cellular processes. 2. The role of PRELID1 in various diseases, including cancer, autoimmune diseases, and neurological disorders, should be further investigated. 3. PRELID1 may be a potential therapeutic target for the treatment of diseases characterized by mitochondrial dysfunction and apoptosis. **Limitations:** The current understanding of PRELID1 is based on its expression patterns and functional studies. Further research is needed to fully understand the mechanisms by which PRELID1 regulates cellular processes and to explore its potential therapeutic applications.

Genular Protein ID: 2269958207

Symbol: PRLD1_HUMAN

Name: PRELI domain-containing protein 1, mitochondrial

UniProtKB Accession Codes:

Q9Y255 B2R5F7 D6RD25 Q549N2 Q9UI13 Q9UJS9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 2 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10784606

Title: PRELI, the human homologue of the avian px19, is expressed by germinal center B lymphocytes.

PubMed ID: 10784606

DOI: 10.1093/intimm/12.5.607

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14640972

Title: PRELI (protein of relevant evolutionary and lymphoid interest) is located within an evolutionarily conserved gene cluster on chromosome 5q34-q35 and encodes a novel mitochondrial protein.

PubMed ID: 14640972

DOI: 10.1042/bj20031504

PubMed ID: 18945965

Title: PRELI is a mitochondrial regulator of human primary T-helper cell apoptosis, STAT6, and Th2-cell differentiation.

PubMed ID: 18945965

DOI: 10.1182/blood-2008-07-166553

PubMed ID: 21364629

Title: Vital function of PRELI and essential requirement of its LEA motif.

PubMed ID: 21364629

DOI: 10.1038/cddis.2009.19

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23931759

Title: TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid.

PubMed ID: 23931759

DOI: 10.1016/j.cmet.2013.07.008

Sequence Information:

  • Length: 219
  • Mass: 25181
  • Checksum: CCDBF54FA573509F
  • Sequence:
    • MVKYFLGQSV LRSSWDQVFA AFWQRYPNPY SKHVLTEDIV HREVTPDQKL LSRRLLTKTN 
RMPRWAERLF PANVAHSVYV LEDSIVDPQN QTMTTFTWNI NHARLMVVEE RCVYCVNSDN 
SGWTEIRREA WVSSSLFGVS RAVQEFGLAR FKSNVTKTMK GFEYILAKLQ GEAPSKTLVE 
TAKEAKEKAK ETALAATEKA KDLASKAATK KQQQQQQFV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.