Details for: SLC39A1

Gene ID: 27173

Symbol: SLC39A1

Ensembl ID: ENSG00000143570

Description: solute carrier family 39 member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 172.7472
    Cell Significance Index: -26.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.4740
    Cell Significance Index: -24.4700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 66.9017
    Cell Significance Index: -27.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 62.4235
    Cell Significance Index: -25.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.7469
    Cell Significance Index: -28.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.9005
    Cell Significance Index: -28.2400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 43.0090
    Cell Significance Index: -28.8600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.8973
    Cell Significance Index: -25.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.1030
    Cell Significance Index: -28.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.8620
    Cell Significance Index: -23.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.6946
    Cell Significance Index: -26.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2680
    Cell Significance Index: -28.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4915
    Cell Significance Index: -9.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9452
    Cell Significance Index: 316.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.8649
    Cell Significance Index: 97.1400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.8140
    Cell Significance Index: 32.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5545
    Cell Significance Index: 17.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5185
    Cell Significance Index: 113.1700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.4967
    Cell Significance Index: 11.9500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.4137
    Cell Significance Index: 8.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3707
    Cell Significance Index: 36.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3127
    Cell Significance Index: 180.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2824
    Cell Significance Index: 139.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2651
    Cell Significance Index: 36.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0966
    Cell Significance Index: 51.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0482
    Cell Significance Index: 36.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9580
    Cell Significance Index: 123.7700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.9174
    Cell Significance Index: 5.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9139
    Cell Significance Index: 117.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9074
    Cell Significance Index: 24.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8642
    Cell Significance Index: 18.0900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7736
    Cell Significance Index: 8.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7058
    Cell Significance Index: 385.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6734
    Cell Significance Index: 82.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6496
    Cell Significance Index: 117.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5703
    Cell Significance Index: 252.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4751
    Cell Significance Index: 4.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4740
    Cell Significance Index: 33.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4379
    Cell Significance Index: 86.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4049
    Cell Significance Index: 28.0000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4021
    Cell Significance Index: 5.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3855
    Cell Significance Index: 38.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2313
    Cell Significance Index: 14.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2181
    Cell Significance Index: 3.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1994
    Cell Significance Index: 37.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1770
    Cell Significance Index: 5.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1609
    Cell Significance Index: 18.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1325
    Cell Significance Index: 2.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1187
    Cell Significance Index: 3.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0750
    Cell Significance Index: 3.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0650
    Cell Significance Index: 49.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0447
    Cell Significance Index: 0.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0251
    Cell Significance Index: 0.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0072
    Cell Significance Index: 0.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0057
    Cell Significance Index: 4.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0042
    Cell Significance Index: -0.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0068
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0087
    Cell Significance Index: -5.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0143
    Cell Significance Index: -26.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0150
    Cell Significance Index: -2.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0189
    Cell Significance Index: -34.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0227
    Cell Significance Index: -34.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0238
    Cell Significance Index: -8.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0257
    Cell Significance Index: -34.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0266
    Cell Significance Index: -18.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0309
    Cell Significance Index: -17.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0314
    Cell Significance Index: -6.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0355
    Cell Significance Index: -7.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0380
    Cell Significance Index: -0.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0413
    Cell Significance Index: -2.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0421
    Cell Significance Index: -26.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0451
    Cell Significance Index: -1.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0467
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0638
    Cell Significance Index: -7.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0656
    Cell Significance Index: -29.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0782
    Cell Significance Index: -22.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0987
    Cell Significance Index: -11.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1400
    Cell Significance Index: -16.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1431
    Cell Significance Index: -6.6700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1635
    Cell Significance Index: -0.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1768
    Cell Significance Index: -4.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1950
    Cell Significance Index: -28.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2329
    Cell Significance Index: -6.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2445
    Cell Significance Index: -7.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2666
    Cell Significance Index: -6.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2696
    Cell Significance Index: -15.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2780
    Cell Significance Index: -28.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3076
    Cell Significance Index: -23.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3185
    Cell Significance Index: -25.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3268
    Cell Significance Index: -20.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3282
    Cell Significance Index: -17.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3438
    Cell Significance Index: -21.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3974
    Cell Significance Index: -7.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4366
    Cell Significance Index: -29.3600
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.4443
    Cell Significance Index: -2.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4468
    Cell Significance Index: -28.1600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4620
    Cell Significance Index: -3.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5561
    Cell Significance Index: -22.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5927
    Cell Significance Index: -29.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc transporter:** The SLC39A1 gene encodes a zinc transporter protein, ZIP1, which is responsible for transporting zinc ions into cells. 2. **Monoatomic cation transport:** ZIP1 is capable of transporting other monoatomic cations, such as manganese, magnesium, and cadmium, although its primary function is zinc transport. 3. **Membrane localization:** ZIP1 is localized to the plasma membrane, where it regulates zinc influx into cells. 4. **Regulation of gene expression:** ZIP1 has been shown to regulate the expression of genes involved in zinc homeostasis, cell growth, and differentiation. **Pathways and Functions:** 1. **Zinc homeostasis:** The SLC39A1 gene plays a critical role in maintaining zinc homeostasis within cells by regulating zinc influx and efflux. 2. **Cell growth and differentiation:** ZIP1 is involved in regulating cell growth and differentiation by influencing gene expression and signaling pathways. 3. **Reproductive development:** The SLC39A1 gene is significantly expressed in placental villous trophoblast, suggesting its role in reproductive development and zinc homeostasis during pregnancy. 4. **Immune response:** ZIP1 is expressed in myeloid leukocytes, indicating its involvement in the immune response and zinc homeostasis in immune cells. 5. **Cancer development:** Abnormal expression of ZIP1 has been linked to cancer development, suggesting its potential role as a tumor suppressor gene. **Clinical Significance:** 1. **Zinc deficiency:** Zinc deficiency has been linked to various diseases, including growth retardation, impaired immune function, and increased risk of infections. 2. **Neonatal zinc deficiency:** Neonatal zinc deficiency has been associated with impaired growth and development, highlighting the importance of zinc homeostasis during fetal development. 3. **Cancer therapy:** ZIP1 may serve as a target for cancer therapy, as its expression is altered in various types of cancer. 4. **Immunodeficiency disorders:** ZIP1 may play a role in regulating immune function, and its dysfunction may contribute to immunodeficiency disorders. In conclusion, the SLC39A1 gene plays a critical role in maintaining zinc homeostasis and regulating developmental and cellular processes. Its dysregulation has been linked to various diseases, including zinc deficiency, cancer, and immunodeficiency disorders. Further research is needed to fully understand the mechanisms by which ZIP1 regulates zinc homeostasis and its clinical significance.

Genular Protein ID: 3810454912

Symbol: S39A1_HUMAN

Name: Zinc transporter ZIP1

UniProtKB Accession Codes:

Q9NY26 B4DDY7 Q5T4K1 Q8N2H7 Q9BTV0 Q9UBI7 Q9Y2Z7 Q9Y380

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 18 Ensembl 6 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 Rhea 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10610721

Title: Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex.

PubMed ID: 10610721

DOI: 10.1006/geno.1999.5993

PubMed ID: 11696349

Title: Differential subcellular localization of hZip1 in adherent and non-adherent cells.

PubMed ID: 11696349

DOI: 10.1016/s0014-5793(01)02950-7

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11301334

Title: The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells.

PubMed ID: 11301334

DOI: 10.1074/jbc.m101772200

PubMed ID: 12888280

Title: Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.

PubMed ID: 12888280

DOI: 10.1016/s0162-0134(03)00249-6

PubMed ID: 16153295

Title: hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer.

PubMed ID: 16153295

DOI: 10.1186/1476-4598-4-32

PubMed ID: 16844077

Title: Histidine residues in the region between transmembrane domains III and IV of hZip1 are required for zinc transport across the plasma membrane in PC-3 cells.

PubMed ID: 16844077

DOI: 10.1016/j.bbamem.2006.06.005

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 324
  • Mass: 34250
  • Checksum: 884C168AA8E8C0DF
  • Sequence:
    • MGPWGEPELL VWRPEAVASE PPVPVGLEVK LGALVLLLVL TLLCSLVPIC VLRRPGANHE 
GSASRQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL AALHVTLQFP LQEFILAMGF 
FLVLVMEQIT LAYKEQSGPS PLEETRALLG TVNGGPQHWH DGPGVPQASG APATPSALRA 
CVLVFSLALH SVFEGLAVGL QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRAQVVA 
GCGILFSCMT PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELASSE 
QRILKVILLL AGFALLTGLL FIQI

Genular Protein ID: 3935688690

Symbol: A0A0A0MTL8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MTL8

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 2 Proteomes 2 RefSeq 1 SAM 2 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 116
  • Mass: 11771
  • Checksum: B26115703BF85131
  • Sequence:
    • MGPWGEPELL VWRPEAVASE PPVPVGLEVK LGALVLLLVL TLLCSLVPIC VLRRPGANHE 
GSAPVPTARV HPGHGLLPGP GDGADHTGLQ GAVRAVTSGG NKGSAGNSEW WAAALA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.