Details for: SERP1

Gene ID: 27230

Symbol: SERP1

Ensembl ID: ENSG00000120742

Description: stress associated endoplasmic reticulum protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 652.8648
    Cell Significance Index: -101.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 345.2879
    Cell Significance Index: -87.5800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 281.4678
    Cell Significance Index: -115.9500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 255.2832
    Cell Significance Index: -120.5300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 236.2043
    Cell Significance Index: -121.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 179.8376
    Cell Significance Index: -120.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 91.5280
    Cell Significance Index: -112.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.0178
    Cell Significance Index: -88.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 30.0022
    Cell Significance Index: -118.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 27.0002
    Cell Significance Index: -82.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.1043
    Cell Significance Index: -44.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.6105
    Cell Significance Index: 122.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.4765
    Cell Significance Index: 255.3400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.4352
    Cell Significance Index: 27.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.2237
    Cell Significance Index: 314.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.2067
    Cell Significance Index: 197.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.0710
    Cell Significance Index: 110.8100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.3331
    Cell Significance Index: 77.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.0765
    Cell Significance Index: 362.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.8082
    Cell Significance Index: 385.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.7728
    Cell Significance Index: 358.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.6550
    Cell Significance Index: 171.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.5013
    Cell Significance Index: 1366.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1876
    Cell Significance Index: 394.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1440
    Cell Significance Index: 263.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.1149
    Cell Significance Index: 361.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.0157
    Cell Significance Index: 57.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8663
    Cell Significance Index: 96.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8078
    Cell Significance Index: 48.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.7462
    Cell Significance Index: 36.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.6180
    Cell Significance Index: 47.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.6032
    Cell Significance Index: 205.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5800
    Cell Significance Index: 316.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4910
    Cell Significance Index: 147.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3673
    Cell Significance Index: 604.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3621
    Cell Significance Index: 270.3200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.1536
    Cell Significance Index: 24.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0377
    Cell Significance Index: 27.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9024
    Cell Significance Index: 63.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7840
    Cell Significance Index: 7.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6601
    Cell Significance Index: 236.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5053
    Cell Significance Index: 5.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4469
    Cell Significance Index: 338.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3274
    Cell Significance Index: 62.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1550
    Cell Significance Index: 291.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1326
    Cell Significance Index: 84.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0896
    Cell Significance Index: 9.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0420
    Cell Significance Index: 77.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0404
    Cell Significance Index: 62.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0096
    Cell Significance Index: 7.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0076
    Cell Significance Index: -0.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0081
    Cell Significance Index: -7.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0147
    Cell Significance Index: -0.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0262
    Cell Significance Index: -35.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0316
    Cell Significance Index: -3.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0535
    Cell Significance Index: -39.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0661
    Cell Significance Index: -41.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0735
    Cell Significance Index: -1.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0955
    Cell Significance Index: -3.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1135
    Cell Significance Index: -6.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1291
    Cell Significance Index: -72.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1476
    Cell Significance Index: -42.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1480
    Cell Significance Index: -67.1900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1919
    Cell Significance Index: -21.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2427
    Cell Significance Index: -51.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4025
    Cell Significance Index: -46.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4629
    Cell Significance Index: -20.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4798
    Cell Significance Index: -69.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5081
    Cell Significance Index: -14.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6459
    Cell Significance Index: -16.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6818
    Cell Significance Index: -79.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8032
    Cell Significance Index: -12.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8071
    Cell Significance Index: -45.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8572
    Cell Significance Index: -57.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8935
    Cell Significance Index: -12.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.9421
    Cell Significance Index: -27.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0181
    Cell Significance Index: -80.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0615
    Cell Significance Index: -110.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.1553
    Cell Significance Index: -12.5600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.1957
    Cell Significance Index: -21.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2839
    Cell Significance Index: -41.1200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.3562
    Cell Significance Index: -23.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3581
    Cell Significance Index: -33.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.3894
    Cell Significance Index: -23.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3946
    Cell Significance Index: -87.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5701
    Cell Significance Index: -96.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.5805
    Cell Significance Index: -79.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.5986
    Cell Significance Index: -70.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.7522
    Cell Significance Index: -37.9600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.8372
    Cell Significance Index: -11.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.8956
    Cell Significance Index: -40.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.9304
    Cell Significance Index: -51.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.0088
    Cell Significance Index: -76.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.1023
    Cell Significance Index: -56.2400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -2.1582
    Cell Significance Index: -13.4100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -2.2316
    Cell Significance Index: -28.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.2475
    Cell Significance Index: -57.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.4692
    Cell Significance Index: -72.7300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -2.5155
    Cell Significance Index: -26.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.6083
    Cell Significance Index: -95.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SERP1 is a protein-coding gene that is significantly expressed in various cell types, including immune cells, epithelial cells, and cells of the prostate and salivary glands. The gene is involved in multiple cellular processes, including glucose metabolism, insulin secretion, and growth hormone regulation. SERP1 is also implicated in the regulation of protein glycosylation, localization, and modification, highlighting its critical role in maintaining cellular homeostasis. **Pathways and Functions:** SERP1 is integrated into various signaling pathways that respond to cellular stress, including the UPR, cellular responses to stimuli, and cellular responses to stress. The UPR is a conserved mechanism that responds to ER stress by activating chaperones, which help to restore ER homeostasis. SERP1 is involved in this pathway through its interaction with Ire1α and Xbp1, two key regulators of the UPR. Additionally, SERP1 is involved in the regulation of protein binding, glycosylation, localization, and modification, highlighting its importance in maintaining protein homeostasis. **Functions:** SERP1 plays a multifaceted role in cellular processes, including: 1. **Cellular stress response**: SERP1 is involved in the regulation of the UPR, which is a critical mechanism for responding to ER stress. 2. **Protein homeostasis**: SERP1 regulates protein glycosylation, localization, and modification, ensuring the proper functioning of proteins within the cell. 3. **Metabolic regulation**: SERP1 is involved in glucose metabolism and insulin secretion, highlighting its importance in maintaining cellular energy homeostasis. 4. **Growth regulation**: SERP1 regulates growth hormone secretion, organ growth, and post-embryonic development, underscoring its role in cellular growth and differentiation. **Clinical Significance:** SERP1 has significant implications for various diseases, including: 1. **Diabetes**: SERP1 is involved in glucose metabolism and insulin secretion, making it a potential target for the development of novel therapeutic strategies for diabetes. 2. **Cancer**: SERP1 is overexpressed in various types of cancer, including prostate and salivary gland cancer, highlighting its potential role in cancer development and progression. 3. **Neurological disorders**: SERP1 is involved in the regulation of protein homeostasis, which is critical for maintaining neuronal function and integrity, making it a potential target for the treatment of neurological disorders such as Alzheimer's disease. In conclusion, SERP1 is a critical gene that plays a multifaceted role in cellular processes, including cellular stress response, protein homeostasis, metabolic regulation, and growth regulation. Its clinical significance is underscored by its involvement in various diseases, including diabetes, cancer, and neurological disorders. Further research is necessary to fully elucidate the mechanisms by which SERP1 regulates cellular processes and to explore its potential applications in disease diagnosis and treatment.

Genular Protein ID: 3712191637

Symbol: SERP1_HUMAN

Name: Stress-associated endoplasmic reticulum protein 1

UniProtKB Accession Codes:

Q9Y6X1 D3DNI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 18 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 66
  • Mass: 7374
  • Checksum: DC15C0143AAE0D91
  • Sequence:
    • MVAKQRIRMA NEKHSKNITQ RGNVAKTSRN APEEKASVGP WLLALFIFVV CGSAIFQIIQ 
SIRMGM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.