Details for: LSM1

Gene ID: 27257

Symbol: LSM1

Ensembl ID: ENSG00000175324

Description: LSM1 homolog, mRNA degradation associated

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 191.0698
    Cell Significance Index: -29.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 119.1437
    Cell Significance Index: -30.2200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 88.3850
    Cell Significance Index: -36.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 82.9657
    Cell Significance Index: -39.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.2039
    Cell Significance Index: -37.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.9386
    Cell Significance Index: -35.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.7097
    Cell Significance Index: -38.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.5451
    Cell Significance Index: -25.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.4785
    Cell Significance Index: -22.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.8257
    Cell Significance Index: -12.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.3478
    Cell Significance Index: 231.5200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.1179
    Cell Significance Index: 17.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0076
    Cell Significance Index: 46.9800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8584
    Cell Significance Index: 7.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8570
    Cell Significance Index: 44.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8389
    Cell Significance Index: 17.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8080
    Cell Significance Index: 441.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8058
    Cell Significance Index: 28.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7914
    Cell Significance Index: 58.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7593
    Cell Significance Index: 104.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7579
    Cell Significance Index: 20.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7462
    Cell Significance Index: 35.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7456
    Cell Significance Index: 91.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6835
    Cell Significance Index: 123.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6295
    Cell Significance Index: 18.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6243
    Cell Significance Index: 44.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6171
    Cell Significance Index: 8.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6117
    Cell Significance Index: 270.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6099
    Cell Significance Index: 60.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4997
    Cell Significance Index: 13.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4840
    Cell Significance Index: 139.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4378
    Cell Significance Index: 395.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4356
    Cell Significance Index: 56.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4118
    Cell Significance Index: 26.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3937
    Cell Significance Index: 46.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3819
    Cell Significance Index: 20.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3525
    Cell Significance Index: 22.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3378
    Cell Significance Index: 43.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3093
    Cell Significance Index: 8.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3080
    Cell Significance Index: 61.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2957
    Cell Significance Index: 59.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2715
    Cell Significance Index: 51.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2394
    Cell Significance Index: 2.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2276
    Cell Significance Index: 4.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2111
    Cell Significance Index: 36.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1817
    Cell Significance Index: 113.4700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1444
    Cell Significance Index: 1.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1333
    Cell Significance Index: 6.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0789
    Cell Significance Index: 28.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0407
    Cell Significance Index: 30.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0265
    Cell Significance Index: 18.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0075
    Cell Significance Index: 5.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0074
    Cell Significance Index: 1.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0030
    Cell Significance Index: 0.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0013
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0038
    Cell Significance Index: -2.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0125
    Cell Significance Index: -23.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0236
    Cell Significance Index: -43.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0279
    Cell Significance Index: -42.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0299
    Cell Significance Index: -40.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0335
    Cell Significance Index: -18.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0379
    Cell Significance Index: -3.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0437
    Cell Significance Index: -27.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0620
    Cell Significance Index: -28.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0718
    Cell Significance Index: -8.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0730
    Cell Significance Index: -15.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0982
    Cell Significance Index: -11.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1564
    Cell Significance Index: -3.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1597
    Cell Significance Index: -4.0800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1628
    Cell Significance Index: -1.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1769
    Cell Significance Index: -25.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1825
    Cell Significance Index: -5.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1935
    Cell Significance Index: -4.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2010
    Cell Significance Index: -22.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2148
    Cell Significance Index: -6.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2149
    Cell Significance Index: -6.1600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2185
    Cell Significance Index: -1.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2284
    Cell Significance Index: -6.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2521
    Cell Significance Index: -19.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3028
    Cell Significance Index: -23.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3641
    Cell Significance Index: -37.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3727
    Cell Significance Index: -22.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4247
    Cell Significance Index: -12.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4345
    Cell Significance Index: -24.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4410
    Cell Significance Index: -29.6500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4480
    Cell Significance Index: -5.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5598
    Cell Significance Index: -34.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6520
    Cell Significance Index: -16.7600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6701
    Cell Significance Index: -7.1200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7088
    Cell Significance Index: -12.5300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7243
    Cell Significance Index: -29.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7353
    Cell Significance Index: -13.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7402
    Cell Significance Index: -32.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8371
    Cell Significance Index: -30.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8674
    Cell Significance Index: -32.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8729
    Cell Significance Index: -30.5800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.8979
    Cell Significance Index: -6.7800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8986
    Cell Significance Index: -15.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9045
    Cell Significance Index: -15.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9116
    Cell Significance Index: -13.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LSM1 is a member of the Sm-like protein family and is characterized by its ability to associate with U6 small nuclear RNA (snRNA). This interaction enables LSM1 to regulate mRNA decay and processing, particularly in the context of deadenylation-dependent decapping. LSM1's role in mRNA degradation is further underscored by its involvement in the Lsm1-7-Pat1 complex, which is a key regulator of mRNA decay. **Pathways and Functions:** LSM1 is involved in several key pathways and processes, including: 1. **Deadenylation-dependent decapping of nuclear-transcribed mRNA**: LSM1 plays a crucial role in the deadenylation-dependent decapping of mRNA, a process that regulates mRNA stability and translation. 2. **mRNA decay by 5' to 3' exoribonuclease**: LSM1 is involved in the decay of mRNA by 5' to 3' exoribonuclease, a process that regulates mRNA degradation. 3. **Negative regulation of neuron differentiation**: LSM1 has been shown to play a role in the negative regulation of neuron differentiation, highlighting its importance in neural development and function. 4. **Stem cell population maintenance**: LSM1 is involved in the maintenance of stem cell populations, particularly in the context of oogonial cells and erythroid progenitor cells. **Clinical Significance:** LSM1 dysregulation has been implicated in various diseases, including: 1. **Cancer**: LSM1's role in mRNA decay and processing makes it a potential target for cancer therapy. 2. **Neurological disorders**: LSM1's involvement in neuron differentiation and maintenance makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Reproductive disorders**: LSM1's role in oogonial cell maintenance makes it a potential target for the treatment of reproductive disorders, such as infertility. In conclusion, LSM1 is a critical gene involved in the regulation of mRNA decay and processing. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of LSM1 function and its potential as a therapeutic target.

Genular Protein ID: 1258726279

Symbol: LSM1_HUMAN

Name: U6 snRNA-associated Sm-like protein LSm1

UniProtKB Accession Codes:

O15116 B2R5E6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9230209

Title: CaSm: an Sm-like protein that contributes to the transformed state in cancer cells.

PubMed ID: 9230209

PubMed ID: 10369684

Title: Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin.

PubMed ID: 10369684

DOI: 10.1093/emboj/18.12.3451

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18172165

Title: Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.

PubMed ID: 18172165

DOI: 10.1101/gad.1622708

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 133
  • Mass: 15179
  • Checksum: FF798CDA9447037A
  • Sequence:
    • MNYMPGTASL IEDIDKKHLV LLRDGRTLIG FLRSIDQFAN LVLHQTVERI HVGKKYGDIP 
RGIFVVRGEN VVLLGEIDLE KESDTPLQQV SIEEILEEQR VEQQTKLEAE KLKVQALKDR 
GLSIPRADTL DEY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.