Details for: SULT1B1

Gene ID: 27284

Symbol: SULT1B1

Ensembl ID: ENSG00000173597

Description: sulfotransferase family 1B member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 19.4799
    Cell Significance Index: -3.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 11.7882
    Cell Significance Index: -2.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 8.8361
    Cell Significance Index: -3.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.0072
    Cell Significance Index: 297.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.7805
    Cell Significance Index: 126.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.4413
    Cell Significance Index: -3.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.2499
    Cell Significance Index: 244.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.1623
    Cell Significance Index: 32.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.0315
    Cell Significance Index: 1834.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5657
    Cell Significance Index: 33.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2908
    Cell Significance Index: 89.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2104
    Cell Significance Index: 34.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2039
    Cell Significance Index: 195.8000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.9628
    Cell Significance Index: 5.2500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4690
    Cell Significance Index: 7.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2392
    Cell Significance Index: 5.9800
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.2312
    Cell Significance Index: 0.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2214
    Cell Significance Index: 7.0900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2124
    Cell Significance Index: 3.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2038
    Cell Significance Index: 4.3400
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.1969
    Cell Significance Index: 1.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1882
    Cell Significance Index: 35.8200
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.1715
    Cell Significance Index: 1.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1666
    Cell Significance Index: 3.4600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1647
    Cell Significance Index: 1.7100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1476
    Cell Significance Index: 0.9800
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.1352
    Cell Significance Index: 1.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0935
    Cell Significance Index: 1.3800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0918
    Cell Significance Index: 0.9200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0793
    Cell Significance Index: 0.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0672
    Cell Significance Index: 1.8000
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0664
    Cell Significance Index: 0.7200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.0376
    Cell Significance Index: 0.4000
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.0298
    Cell Significance Index: 0.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0219
    Cell Significance Index: 0.7700
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0206
    Cell Significance Index: 0.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0099
    Cell Significance Index: 1.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0027
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0022
    Cell Significance Index: -3.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0038
    Cell Significance Index: -2.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0040
    Cell Significance Index: -1.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0047
    Cell Significance Index: -3.5000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0048
    Cell Significance Index: -0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0054
    Cell Significance Index: -3.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0057
    Cell Significance Index: -3.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0058
    Cell Significance Index: -3.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0058
    Cell Significance Index: -3.1500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0061
    Cell Significance Index: -0.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0062
    Cell Significance Index: -3.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0066
    Cell Significance Index: -1.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0074
    Cell Significance Index: -3.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0077
    Cell Significance Index: -1.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0096
    Cell Significance Index: -2.7600
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0126
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0168
    Cell Significance Index: -3.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0169
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0169
    Cell Significance Index: -2.8800
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.0170
    Cell Significance Index: -0.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0189
    Cell Significance Index: -2.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0219
    Cell Significance Index: -3.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0220
    Cell Significance Index: -1.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0221
    Cell Significance Index: -3.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0224
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0286
    Cell Significance Index: -3.2800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0287
    Cell Significance Index: -1.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0287
    Cell Significance Index: -2.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0313
    Cell Significance Index: -3.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0326
    Cell Significance Index: -3.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0334
    Cell Significance Index: -4.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0342
    Cell Significance Index: -0.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0384
    Cell Significance Index: -2.9500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0422
    Cell Significance Index: -2.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0444
    Cell Significance Index: -2.8000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0448
    Cell Significance Index: -0.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0453
    Cell Significance Index: -1.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0473
    Cell Significance Index: -2.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0474
    Cell Significance Index: -2.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0477
    Cell Significance Index: -3.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0506
    Cell Significance Index: -3.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0522
    Cell Significance Index: -2.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0537
    Cell Significance Index: -1.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0578
    Cell Significance Index: -4.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0591
    Cell Significance Index: -1.5800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0611
    Cell Significance Index: -0.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0626
    Cell Significance Index: -4.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0633
    Cell Significance Index: -3.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0638
    Cell Significance Index: -2.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0640
    Cell Significance Index: -1.3400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0698
    Cell Significance Index: -1.7400
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0741
    Cell Significance Index: -0.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0742
    Cell Significance Index: -2.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0768
    Cell Significance Index: -2.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0801
    Cell Significance Index: -3.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0817
    Cell Significance Index: -2.1000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0839
    Cell Significance Index: -1.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0842
    Cell Significance Index: -3.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0873
    Cell Significance Index: -2.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SULT1B1 exhibits high specificity and activity towards various substrates, including 17α-hydroxyprogesterone, 3β-hydroxy-5α-pregnane-20α-carboxylic acid, and estradiol-17β-sulfate. Its expression is widespread in various tissues, including the enterocyte, colon epithelial cell, kidney proximal convoluted tubule epithelial cell, and cerebral cortex GABAergic interneuron. SULT1B1 is a cytosolic enzyme, primarily found in the cytosol of cells, where it plays a crucial role in sulfonation reactions. **Pathways and Functions:** SULT1B1 is involved in various metabolic pathways, including: 1. **Sulfonation of steroids**: SULT1B1 is responsible for the sulfonation of steroid hormones, such as 17α-hydroxyprogesterone and estradiol-17β-sulfate, which regulates their activity and disposition. 2. **Flavonoid metabolism**: SULT1B1 catalyzes the sulfonation of flavonoids, which affects their antioxidant and anti-inflammatory properties. 3. **Xenobiotic metabolism**: SULT1B1 is involved in the sulfonation of xenobiotics, including drugs and environmental toxins, which enhances their excretion and reduces their toxicity. 4. **Biogenic amine metabolism**: SULT1B1 is also involved in the sulfonation of biogenic amines, such as serotonin and dopamine, which regulates their neurotransmitter activity. **Clinical Significance:** Dysregulation of SULT1B1 activity has been implicated in various diseases, including: 1. **Cancer**: SULT1B1 overexpression has been observed in various types of cancer, including breast, prostate, and colon cancer, where it may contribute to tumor growth and progression. 2. **Neurological disorders**: SULT1B1 has been linked to neurological disorders, such as Parkinson's disease and Alzheimer's disease, where it may play a role in the regulation of neurotransmitter activity. 3. **Metabolic disorders**: SULT1B1 activity has been implicated in metabolic disorders, such as obesity and diabetes, where it may contribute to insulin resistance and glucose metabolism. In conclusion, SULT1B1 is a critical enzyme in sulfonation metabolism, playing a pivotal role in regulating the activity and disposition of various endogenous and exogenous compounds. Its dysregulation has been implicated in various diseases, highlighting the importance of SULT1B1 in human health and disease. Further research is necessary to fully elucidate the functions and clinical significance of SULT1B1.

Genular Protein ID: 2881302856

Symbol: ST1B1_HUMAN

Name: Sulfotransferase family cytosolic 1B member 1

UniProtKB Accession Codes:

O43704 O15497 Q96FI1 Q9UK34

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 41 ChEMBL 1 DNASU 1 DisGeNET 1 DrugBank 10 EC 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 14 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9443824

Title: Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases.

PubMed ID: 9443824

DOI: 10.1093/oxfordjournals.jbchem.a021846

PubMed ID: 9463486

Title: Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver.

PubMed ID: 9463486

DOI: 10.1124/mol.53.2.274

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 35165440

Title: A gut-derived metabolite alters brain activity and anxiety behaviour in mice.

PubMed ID: 35165440

DOI: 10.1038/s41586-022-04396-8

PubMed ID: 28084139

Title: A high frequency missense SULT1B1 allelic variant (L145V) selectively expressed in African descendants exhibits altered kinetic properties.

PubMed ID: 28084139

DOI: 10.1080/00498254.2017.1282646

PubMed ID: 16804942

Title: Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP).

PubMed ID: 16804942

DOI: 10.1002/prot.21048

Sequence Information:

  • Length: 296
  • Mass: 34899
  • Checksum: AFEB61B21DBD782C
  • Sequence:
    • MLSPKDILRK DLKLVHGYPM TCAFASNWEK IEQFHSRPDD IVIATYPKSG TTWVSEIIDM 
ILNDGDIEKC KRGFITEKVP MLEMTLPGLR TSGIEQLEKN PSPRIVKTHL PTDLLPKSFW 
ENNCKMIYLA RNAKDVSVSY YHFDLMNNLQ PFPGTWEEYL EKFLTGKVAY GSWFTHVKNW 
WKKKEEHPIL FLYYEDMKEN PKEEIKKIIR FLEKNLNDEI LDRIIHHTSF EVMKDNPLVN 
YTHLPTTVMD HSKSPFMRKG TAGDWKNYFT VAQNEKFDAI YETEMSKTAL QFRTEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.