Details for: MOCS3

Gene ID: 27304

Symbol: MOCS3

Ensembl ID: ENSG00000124217

Description: molybdenum cofactor synthesis 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.6243
    Cell Significance Index: -6.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 25.3506
    Cell Significance Index: -6.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 14.8267
    Cell Significance Index: -7.0000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.3751
    Cell Significance Index: -5.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.7180
    Cell Significance Index: -7.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.2323
    Cell Significance Index: -5.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8195
    Cell Significance Index: -7.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5336
    Cell Significance Index: 151.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4345
    Cell Significance Index: 272.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.2665
    Cell Significance Index: -3.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2648
    Cell Significance Index: 87.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8297
    Cell Significance Index: 49.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6562
    Cell Significance Index: 71.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6296
    Cell Significance Index: 568.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4626
    Cell Significance Index: 75.2300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4242
    Cell Significance Index: 6.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3216
    Cell Significance Index: 20.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3150
    Cell Significance Index: 16.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2778
    Cell Significance Index: 32.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2221
    Cell Significance Index: 3.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2017
    Cell Significance Index: 5.8100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1660
    Cell Significance Index: 2.3300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1636
    Cell Significance Index: 2.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1620
    Cell Significance Index: 4.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1431
    Cell Significance Index: 3.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1382
    Cell Significance Index: 75.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0987
    Cell Significance Index: 13.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0937
    Cell Significance Index: 2.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0884
    Cell Significance Index: 10.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0876
    Cell Significance Index: 3.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0791
    Cell Significance Index: 34.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0783
    Cell Significance Index: 5.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0712
    Cell Significance Index: 2.2800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0669
    Cell Significance Index: 1.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0605
    Cell Significance Index: 12.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0605
    Cell Significance Index: 12.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0568
    Cell Significance Index: 2.6500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0514
    Cell Significance Index: 0.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0505
    Cell Significance Index: 9.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0469
    Cell Significance Index: 1.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0352
    Cell Significance Index: 4.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0315
    Cell Significance Index: 0.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0296
    Cell Significance Index: 0.5000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0272
    Cell Significance Index: 0.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0217
    Cell Significance Index: 7.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0201
    Cell Significance Index: 0.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0180
    Cell Significance Index: 2.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0178
    Cell Significance Index: 1.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0137
    Cell Significance Index: 0.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0070
    Cell Significance Index: 0.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0059
    Cell Significance Index: 4.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0055
    Cell Significance Index: 0.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0019
    Cell Significance Index: 0.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0025
    Cell Significance Index: -0.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0032
    Cell Significance Index: -0.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0049
    Cell Significance Index: -3.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0049
    Cell Significance Index: -9.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0059
    Cell Significance Index: -8.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0060
    Cell Significance Index: -4.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0077
    Cell Significance Index: -5.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0078
    Cell Significance Index: -4.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0088
    Cell Significance Index: -0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0091
    Cell Significance Index: -5.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0110
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0129
    Cell Significance Index: -8.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0145
    Cell Significance Index: -6.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0175
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0244
    Cell Significance Index: -4.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0251
    Cell Significance Index: -0.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0299
    Cell Significance Index: -0.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0300
    Cell Significance Index: -1.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0336
    Cell Significance Index: -4.8900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0369
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0380
    Cell Significance Index: -8.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0396
    Cell Significance Index: -1.8600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0497
    Cell Significance Index: -0.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0568
    Cell Significance Index: -1.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0677
    Cell Significance Index: -3.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0683
    Cell Significance Index: -7.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0699
    Cell Significance Index: -5.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0757
    Cell Significance Index: -5.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0791
    Cell Significance Index: -5.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0812
    Cell Significance Index: -4.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0898
    Cell Significance Index: -5.5200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0942
    Cell Significance Index: -1.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0947
    Cell Significance Index: -2.7800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1035
    Cell Significance Index: -1.5600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1163
    Cell Significance Index: -1.4900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1208
    Cell Significance Index: -1.4400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1230
    Cell Significance Index: -0.7300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1241
    Cell Significance Index: -0.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1242
    Cell Significance Index: -2.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1361
    Cell Significance Index: -6.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1385
    Cell Significance Index: -3.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1411
    Cell Significance Index: -3.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1426
    Cell Significance Index: -4.2000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1547
    Cell Significance Index: -5.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Molybdenum cofactor biosynthesis**: MOCS3 is involved in the biosynthesis of molybdenum cofactors, which are essential for various enzymatic reactions, including those involved in metabolism, neurotransmission, and DNA repair. 2. **Cofactor biosynthesis pathway**: MOCS3 is part of the molybdenum cofactor biosynthesis pathway, which involves the conversion of molybdenum into its active form, molybdopterin. 3. **Expression in various cell types**: MOCS3 is expressed in multiple cell types, including cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, and intestinal epithelial cells. **Pathways and Functions:** MOCS3 is involved in various cellular processes, including: 1. **Metabolism of vitamins and cofactors**: MOCS3 is essential for the synthesis of molybdopterin, which is necessary for the metabolism of various vitamins and cofactors, including thiamine, riboflavin, and pantothenic acid. 2. **Metal ion binding**: MOCS3 is involved in the binding of metal ions, including molybdenum, which is essential for enzymatic reactions. 3. **Protein modification**: MOCS3 is involved in the modification of proteins, including the addition of sulfur groups to cysteine residues, which is essential for protein function. 4. **DNA repair**: MOCS3 is involved in the repair of DNA damage, including the repair of thymine and uracil residues. **Clinical Significance:** Dysregulation of MOCS3 has been implicated in various diseases, including: 1. **Molybdenum cofactor deficiency**: A rare genetic disorder characterized by impaired molybdenum cofactor biosynthesis, leading to impaired enzymatic reactions and various clinical symptoms. 2. **Neurological disorders**: MOCS3 has been implicated in the pathogenesis of neurological disorders, including epilepsy and schizophrenia, due to its role in neurotransmission and DNA repair. 3. **Cancer**: MOCS3 has been implicated in the development and progression of various cancers, including colorectal and breast cancer, due to its role in DNA repair and metabolism. In conclusion, MOCS3 is a crucial gene involved in the biosynthesis of molybdenum cofactors, essential for various enzymatic reactions and cellular processes. Dysregulation of MOCS3 has been implicated in various diseases, highlighting the importance of this gene in human health. Further research is necessary to fully understand the role of MOCS3 in disease and to develop therapeutic strategies for the treatment of MOCS3-related disorders.

Genular Protein ID: 300220686

Symbol: MOCS3_HUMAN

Name: Molybdopterin synthase sulfurylase

UniProtKB Accession Codes:

O95396

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 23 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EC 2 EMBL 3 Ensembl 1 EvolutionaryTrace 1 GO 16 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 8 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15073332

Title: Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans.

PubMed ID: 15073332

DOI: 10.1073/pnas.0308191101

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15910006

Title: Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry.

PubMed ID: 15910006

DOI: 10.1021/bi0503448

PubMed ID: 17459099

Title: Site-directed mutagenesis of the active site loop of the rhodanese-like domain of the human molybdopterin synthase sulfurase MOCS3. Major differences in substrate specificity between eukaryotic and bacterial homologs.

PubMed ID: 17459099

DOI: 10.1111/j.1742-4658.2007.05811.x

PubMed ID: 18650437

Title: A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis.

PubMed ID: 18650437

DOI: 10.1074/jbc.m804064200

PubMed ID: 19017811

Title: A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.

PubMed ID: 19017811

DOI: 10.1073/pnas.0808756105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23593335

Title: The L-cysteine desulfurase NFS1 is localized in the cytosol where it provides the sulfur for molybdenum cofactor biosynthesis in humans.

PubMed ID: 23593335

DOI: 10.1371/journal.pone.0060869

PubMed ID: 30817134

Title: Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome.

PubMed ID: 30817134

DOI: 10.1021/acs.biochem.8b01160

Sequence Information:

  • Length: 460
  • Mass: 49669
  • Checksum: 299A4E755173E324
  • Sequence:
    • MASREEVLAL QAEVAQREEE LNSLKQKLAS ALLAEQEPQP ERLVPVSPLP PKAALSRDEI 
LRYSRQLVLP ELGVHGQLRL GTACVLIVGC GGLGCPLAQY LAAAGVGRLG LVDYDVVEMS 
NLARQVLHGE ALAGQAKAFS AAASLRRLNS AVECVPYTQA LTPATALDLV RRYDVVADCS 
DNVPTRYLVN DACVLAGRPL VSASALRFEG QITVYHYDGG PCYRCIFPQP PPAETVTNCA 
DGGVLGVVTG VLGCLQALEV LKIAAGLGPS YSGSLLLFDA LRGHFRSIRL RSRRLDCAAC 
GERPTVTDLL DYEAFCGSSA TDKCRSLQLL SPEERVSVTD YKRLLDSGAF HLLLDVRPQV 
EVDICRLPHA LHIPLKHLER RDAESLKLLK EAIWEEKQGT QEGAAVPIYV ICKLGNDSQK 
AVKILQSLSA AQELDPLTVR DVVGGLMAWA AKIDGTFPQY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.