Details for: ZNF330

Gene ID: 27309

Symbol: ZNF330

Ensembl ID: ENSG00000109445

Description: zinc finger protein 330

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 198.0774
    Cell Significance Index: -30.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 103.0975
    Cell Significance Index: -26.1500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 81.5152
    Cell Significance Index: -33.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 69.7806
    Cell Significance Index: -32.9500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.7436
    Cell Significance Index: -31.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.9701
    Cell Significance Index: -32.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1536
    Cell Significance Index: -27.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2703
    Cell Significance Index: -32.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1945
    Cell Significance Index: -9.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.3653
    Cell Significance Index: 275.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3455
    Cell Significance Index: 103.2500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.0068
    Cell Significance Index: 7.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8821
    Cell Significance Index: 24.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8312
    Cell Significance Index: 11.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6769
    Cell Significance Index: 31.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6237
    Cell Significance Index: 85.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6086
    Cell Significance Index: 332.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6080
    Cell Significance Index: 42.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5608
    Cell Significance Index: 68.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5226
    Cell Significance Index: 14.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4360
    Cell Significance Index: 27.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4319
    Cell Significance Index: 42.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4184
    Cell Significance Index: 184.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4070
    Cell Significance Index: 73.3700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3861
    Cell Significance Index: 5.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3842
    Cell Significance Index: 11.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3659
    Cell Significance Index: 17.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3658
    Cell Significance Index: 73.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3610
    Cell Significance Index: 46.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3302
    Cell Significance Index: 38.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3206
    Cell Significance Index: 8.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3077
    Cell Significance Index: 21.7600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.3068
    Cell Significance Index: 4.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3024
    Cell Significance Index: 60.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2958
    Cell Significance Index: 56.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2899
    Cell Significance Index: 13.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2769
    Cell Significance Index: 6.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2258
    Cell Significance Index: 11.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2092
    Cell Significance Index: 5.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2091
    Cell Significance Index: 75.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2045
    Cell Significance Index: 26.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1645
    Cell Significance Index: 113.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1402
    Cell Significance Index: 22.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1390
    Cell Significance Index: 125.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0869
    Cell Significance Index: 1.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0853
    Cell Significance Index: 6.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0663
    Cell Significance Index: 4.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0656
    Cell Significance Index: 123.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0376
    Cell Significance Index: 23.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0152
    Cell Significance Index: 2.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0092
    Cell Significance Index: 0.1700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0074
    Cell Significance Index: 0.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0027
    Cell Significance Index: -0.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0037
    Cell Significance Index: -0.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0067
    Cell Significance Index: -12.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0119
    Cell Significance Index: -18.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0128
    Cell Significance Index: -9.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0131
    Cell Significance Index: -0.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0162
    Cell Significance Index: -7.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0235
    Cell Significance Index: -31.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0250
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0294
    Cell Significance Index: -21.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0341
    Cell Significance Index: -3.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0476
    Cell Significance Index: -26.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0616
    Cell Significance Index: -38.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0802
    Cell Significance Index: -23.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0818
    Cell Significance Index: -5.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0825
    Cell Significance Index: -1.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0883
    Cell Significance Index: -12.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0930
    Cell Significance Index: -3.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1040
    Cell Significance Index: -1.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1287
    Cell Significance Index: -7.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1334
    Cell Significance Index: -3.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1380
    Cell Significance Index: -2.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1639
    Cell Significance Index: -34.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1666
    Cell Significance Index: -4.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1788
    Cell Significance Index: -20.4900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1929
    Cell Significance Index: -1.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2236
    Cell Significance Index: -7.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2529
    Cell Significance Index: -6.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2617
    Cell Significance Index: -27.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2675
    Cell Significance Index: -7.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2753
    Cell Significance Index: -13.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2991
    Cell Significance Index: -23.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3353
    Cell Significance Index: -8.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3490
    Cell Significance Index: -23.4700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3674
    Cell Significance Index: -5.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3978
    Cell Significance Index: -9.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3984
    Cell Significance Index: -17.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4136
    Cell Significance Index: -25.3600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4216
    Cell Significance Index: -7.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4516
    Cell Significance Index: -4.9100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.4552
    Cell Significance Index: -4.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4701
    Cell Significance Index: -17.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5037
    Cell Significance Index: -9.8300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5399
    Cell Significance Index: -9.1000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6037
    Cell Significance Index: -14.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6127
    Cell Significance Index: -10.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6440
    Cell Significance Index: -5.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** ZNF330 possesses a zinc finger domain, a structural motif that allows for the binding of zinc ions, which is essential for its function. 2. **Cellular Expression:** ZNF330 is expressed in a diverse range of cell types, indicating its potential role in various cellular processes. 3. **Metal Ion Binding:** ZNF330's ability to bind metal ions, particularly zinc, suggests its involvement in redox reactions and cellular signaling pathways. 4. **Protein Binding:** ZNF330's capacity to bind proteins highlights its potential role in protein-protein interactions and regulation of cellular processes. **Pathways and Functions:** 1. **Metal Ion Binding Pathway:** ZNF330's metal ion binding activity is crucial for its function, as it regulates redox reactions and cellular signaling pathways. 2. **Zinc Ion Binding Pathway:** ZNF330's ability to bind zinc ions is essential for its function, as it modulates protein-protein interactions and cellular processes. 3. **Protein Binding Pathway:** ZNF330's protein binding activity is vital for its function, as it regulates protein-protein interactions and cellular processes. 4. **Cellular Homeostasis:** ZNF330's involvement in maintaining cellular homeostasis is crucial for its function, as it regulates various cellular processes, including redox reactions and protein-protein interactions. **Clinical Significance:** 1. **Immunological Disorders:** ZNF330's involvement in regulating cellular processes makes it a potential target for the treatment of immunological disorders, such as autoimmune diseases and immunodeficiency disorders. 2. **Cancer:** ZNF330's expression in various cancer cell types suggests its potential role in cancer development and progression. 3. **Neurological Disorders:** ZNF330's involvement in metal ion binding and protein binding pathways makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Regulatory T Cells:** ZNF330's expression in regulatory T cells suggests its potential role in maintaining immune tolerance and preventing autoimmune diseases. In conclusion, ZNF330 is a crucial component of the human immune system, playing a pivotal role in regulating various cellular processes. Its involvement in metal ion binding, protein binding, and zinc ion binding pathways underscores its importance in maintaining cellular homeostasis. Further research is necessary to elucidate the clinical significance of ZNF330 and its potential role in various diseases.

Genular Protein ID: 980681630

Symbol: ZN330_HUMAN

Name: Zinc finger protein 330

UniProtKB Accession Codes:

Q9Y3S2 B2RDA3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 12 Ensembl 1 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10593942

Title: Molecular cloning of a zinc finger autoantigen transiently associated with interphase nucleolus and mitotic centromeres and midbodies. Orthologous proteins with nine CXXC motifs highly conserved from nematodes to humans.

PubMed ID: 10593942

DOI: 10.1074/jbc.274.51.36456

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 320
  • Mass: 36201
  • Checksum: CC7F03EE70BF8FD1
  • Sequence:
    • MPKKKTGARK KAENRREREK QLRASRSTID LAKHPCNASM ECDKCQRRQK NRAFCYFCNS 
VQKLPICAQC GKTKCMMKSS DCVIKHAGVY STGLAMVGAI CDFCEAWVCH GRKCLSTHAC 
ACPLTDAECV ECERGVWDHG GRIFSCSFCH NFLCEDDQFE HQASCQVLEA ETFKCVSCNR 
LGQHSCLRCK ACFCDDHTRS KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG 
GEEGDGASGY DAYWKNLSSD KYGDTSYHDE EEDEYEAEDD EEEEDEGRKD SDTESSDLFT 
NLNLGRTYAS GYAHYEEQEN

Genular Protein ID: 1390245880

Symbol: B4DFG9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DFG9

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 260
  • Mass: 29157
  • Checksum: BDA15CA29E32E883
  • Sequence:
    • MPQWNVTSVR GKTKCMMKSS DCVIKHAGVY STGLAMVGAI CDFCEAWVCH GRKCLSTHAC 
ACPLTDAECV ECERGVWDHG GRIFSCSFCH NFLCEDDQFE HQASCQVLEA GTFKCVSCNR 
LGQHSCLRCK ACFCDDHTRS KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG 
GEEGDGASGY DAYWKNLSSD KYGDTSYHDE EEDEYEAEDD EEEEDEGRKD SDTESSDLFT 
NLNLGRTYAS GYAHYEEQEN

Genular Protein ID: 1606376349

Symbol: Q53EN0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53EN0

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 2 SAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 320
  • Mass: 36227
  • Checksum: C50666FB70BF9AC4
  • Sequence:
    • MPKKKTGARK KAENRREREK QLRASRSTID LAKHPCNASM ECDKCQRRQK NRAFCYFCNS 
VQKLPICAQC GKTKCMMKSS DCVIKHAGVY STGLAMVGAI CDFCEAWVCH GRKCLSTHAC 
ACPLTDAECV ECERGVWDHG GRIFSCSFCH NFLCEDDQFE HQASCQVLEA ETFKCVSCNR 
LGQYSCLRCK ACFCDDHTRS KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG 
GEEGDGASGY DAYWKNLSSD KYGDTSYHDE EEDEYEAEDD EEEEDEGRKD SDTESSDLFT 
NLNLGRTYAS GYAHYEEQEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.