Details for: PRPF19

Gene ID: 27339

Symbol: PRPF19

Ensembl ID: ENSG00000110107

Description: pre-mRNA processing factor 19

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 134.3018
    Cell Significance Index: -20.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 78.1609
    Cell Significance Index: -19.8300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 72.5942
    Cell Significance Index: -29.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 60.6512
    Cell Significance Index: -24.6400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.6478
    Cell Significance Index: -28.1100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 42.1894
    Cell Significance Index: -28.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.9756
    Cell Significance Index: -24.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.6877
    Cell Significance Index: -26.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.7089
    Cell Significance Index: -23.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1058
    Cell Significance Index: -28.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.2860
    Cell Significance Index: 371.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.0061
    Cell Significance Index: 27.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6105
    Cell Significance Index: 187.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4895
    Cell Significance Index: 89.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3640
    Cell Significance Index: 1231.5800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9807
    Cell Significance Index: 7.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9449
    Cell Significance Index: 189.5400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8702
    Cell Significance Index: 9.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7376
    Cell Significance Index: 25.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7205
    Cell Significance Index: 37.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7197
    Cell Significance Index: 19.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6895
    Cell Significance Index: 68.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6740
    Cell Significance Index: 79.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5533
    Cell Significance Index: 71.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5509
    Cell Significance Index: 197.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5415
    Cell Significance Index: 40.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4896
    Cell Significance Index: 30.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4683
    Cell Significance Index: 207.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4584
    Cell Significance Index: 62.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4510
    Cell Significance Index: 9.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4450
    Cell Significance Index: 31.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4378
    Cell Significance Index: 28.2500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.4303
    Cell Significance Index: 0.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3697
    Cell Significance Index: 8.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3681
    Cell Significance Index: 9.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3621
    Cell Significance Index: 44.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3448
    Cell Significance Index: 9.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3360
    Cell Significance Index: 17.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3282
    Cell Significance Index: 59.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3257
    Cell Significance Index: 41.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3216
    Cell Significance Index: 63.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3176
    Cell Significance Index: 173.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2681
    Cell Significance Index: 12.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2589
    Cell Significance Index: 13.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2519
    Cell Significance Index: 43.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2444
    Cell Significance Index: 11.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2428
    Cell Significance Index: 11.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2159
    Cell Significance Index: 6.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1608
    Cell Significance Index: 5.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1539
    Cell Significance Index: 29.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1295
    Cell Significance Index: 3.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0955
    Cell Significance Index: 66.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0422
    Cell Significance Index: 2.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0154
    Cell Significance Index: 0.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0088
    Cell Significance Index: 0.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0085
    Cell Significance Index: -0.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0158
    Cell Significance Index: -8.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0160
    Cell Significance Index: -29.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0189
    Cell Significance Index: -29.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0194
    Cell Significance Index: -12.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0199
    Cell Significance Index: -14.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0206
    Cell Significance Index: -13.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0209
    Cell Significance Index: -0.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0226
    Cell Significance Index: -30.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0281
    Cell Significance Index: -2.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0387
    Cell Significance Index: -17.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0394
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0686
    Cell Significance Index: -14.4400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0695
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0717
    Cell Significance Index: -8.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0823
    Cell Significance Index: -23.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1210
    Cell Significance Index: -3.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1230
    Cell Significance Index: -3.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1352
    Cell Significance Index: -19.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1385
    Cell Significance Index: -3.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1611
    Cell Significance Index: -1.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1829
    Cell Significance Index: -8.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1877
    Cell Significance Index: -21.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2141
    Cell Significance Index: -12.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2250
    Cell Significance Index: -13.8300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2288
    Cell Significance Index: -2.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2483
    Cell Significance Index: -19.0600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2595
    Cell Significance Index: -3.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2613
    Cell Significance Index: -27.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2725
    Cell Significance Index: -10.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3082
    Cell Significance Index: -24.4100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3318
    Cell Significance Index: -3.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3544
    Cell Significance Index: -21.7300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3658
    Cell Significance Index: -2.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4239
    Cell Significance Index: -12.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4639
    Cell Significance Index: -7.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4709
    Cell Significance Index: -10.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4759
    Cell Significance Index: -10.1000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4824
    Cell Significance Index: -8.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5069
    Cell Significance Index: -12.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5636
    Cell Significance Index: -17.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5666
    Cell Significance Index: -16.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRPF19 is a 55-kDa protein that belongs to the pre-mRNA processing factor family. It is characterized by its ability to interact with various proteins, including other components of the spliceosome, and its capacity to regulate pre-mRNA splicing. PRPF19 is also known to be involved in the repair of DNA double-strand breaks and the regulation of gene expression through the modulation of alternative splicing. **Pathways and Functions:** PRPF19 is involved in several key pathways, including: 1. **Pre-mRNA Splicing:** PRPF19 plays a crucial role in the precise processing of pre-mRNA, ensuring the accurate incorporation of exons and the exclusion of introns. It interacts with other components of the spliceosome, including U2 and U5 snRNPs, to facilitate the recognition and excision of introns. 2. **DNA Damage Response:** PRPF19 has been implicated in the repair of DNA double-strand breaks through non-homologous end joining (NHEJ). It interacts with proteins involved in the NHEJ pathway, including Ku70 and Ku80, to facilitate the repair of DNA damage. 3. **Lipid Metabolism:** PRPF19 has been shown to be involved in the regulation of lipid metabolism, specifically in the synthesis and ligation of lipid droplets. 4. **Gene Expression Regulation:** PRPF19 modulates gene expression through the regulation of alternative splicing, ensuring the accurate expression of genes involved in various cellular processes. **Clinical Significance:** PRPF19 has been implicated in various diseases, including: 1. **Spastic Paraplegia:** Mutations in the PRPF19 gene have been associated with spastic paraplegia, a neurodegenerative disorder characterized by progressive spasticity and weakness of the lower limbs. 2. **Cancer:** PRPF19 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer. Its overexpression has been associated with poor prognosis and reduced survival rates. 3. **Neurological Disorders:** PRPF19 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Its dysregulation has been associated with the development of these disorders. In conclusion, PRPF19 is a multifunctional protein that plays a critical role in various cellular processes, including pre-mRNA processing, DNA repair, and lipid metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying PRPF19 function and its role in human disease.

Genular Protein ID: 3046770802

Symbol: PRP19_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UMS4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 EMBL 4 EMDB 14 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11082287

Title: hNMP 200: a novel human common nuclear matrix protein combining structural and regulatory functions.

PubMed ID: 11082287

DOI: 10.1006/excr.2000.5025

PubMed ID: 12960389

Title: Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase.

PubMed ID: 12960389

DOI: 10.1073/pnas.1631060100

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10404385

Title: Reassembling proteins and chaperones in human nuclear matrix protein fractions.

PubMed ID: 10404385

DOI: 10.1002/(sici)1097-4644(19990801)74:2<145::aid-jcb1>3.3.co;2-r

PubMed ID: 11435423

Title: U box proteins as a new family of ubiquitin-protein ligases.

PubMed ID: 11435423

DOI: 10.1074/jbc.m102755200

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 16332694

Title: SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly.

PubMed ID: 16332694

DOI: 10.1093/nar/gki986

PubMed ID: 15660529

Title: Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome.

PubMed ID: 15660529

DOI: 10.1042/bj20041517

PubMed ID: 16223718

Title: The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links.

PubMed ID: 16223718

DOI: 10.1074/jbc.m508453200

PubMed ID: 16388800

Title: SNEV overexpression extends the life span of human endothelial cells.

PubMed ID: 16388800

DOI: 10.1016/j.yexcr.2005.11.025

PubMed ID: 17349974

Title: Mouse homologue of yeast Prp19 interacts with mouse SUG1, the regulatory subunit of 26S proteasome.

PubMed ID: 17349974

DOI: 10.1016/j.bbrc.2007.02.134

PubMed ID: 17981804

Title: Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair.

PubMed ID: 17981804

DOI: 10.1074/jbc.m706647200

PubMed ID: 18263876

Title: Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair.

PubMed ID: 18263876

DOI: 10.1074/jbc.m800150200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19641227

Title: Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4.

PubMed ID: 19641227

DOI: 10.1074/jbc.m109.036632

PubMed ID: 19188445

Title: APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

PubMed ID: 19188445

DOI: 10.1128/mcb.01337-08

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20595234

Title: The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.

PubMed ID: 20595234

DOI: 10.1101/gad.1925010

PubMed ID: 20176811

Title: Molecular architecture of the human Prp19/CDC5L complex.

PubMed ID: 20176811

DOI: 10.1128/mcb.01505-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21536736

Title: The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex.

PubMed ID: 21536736

DOI: 10.1101/gad.2038011

PubMed ID: 23022480

Title: Mpn1, mutated in poikiloderma with neutropenia protein 1, is a conserved 3'-to-5' RNA exonuclease processing U6 small nuclear RNA.

PubMed ID: 23022480

DOI: 10.1016/j.celrep.2012.08.031

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22961380

Title: Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly.

PubMed ID: 22961380

DOI: 10.1038/nsmb.2380

PubMed ID: 24332808

Title: PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

PubMed ID: 24332808

DOI: 10.1016/j.molcel.2013.11.002

PubMed ID: 24718257

Title: Small kinetochore associated protein (SKAP) promotes UV-induced cell apoptosis through negatively regulating pre-mRNA processing factor 19 (Prp19).

PubMed ID: 24718257

DOI: 10.1371/journal.pone.0092712

PubMed ID: 28962858

Title: Crystal structure of the WD40 domain of human PRPF19.

PubMed ID: 28962858

DOI: 10.1016/j.bbrc.2017.09.145

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 29360106

Title: Structure of the human activated spliceosome in three conformational states.

PubMed ID: 29360106

DOI: 10.1038/cr.2018.14

PubMed ID: 29301961

Title: Structure of a human catalytic step I spliceosome.

PubMed ID: 29301961

DOI: 10.1126/science.aar6401

PubMed ID: 30705154

Title: A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.

PubMed ID: 30705154

DOI: 10.1126/science.aaw5569

Sequence Information:

  • Length: 504
  • Mass: 55181
  • Checksum: B34C37496E8AA032
  • Sequence:
    • MSLICSISNE VPEHPCVSPV SNHVYERRLI EKYIAENGTD PINNQPLSEE QLIDIKVAHP 
IRPKPPSATS IPAILKALQD EWDAVMLHSF TLRQQLQTTR QELSHALYQH DAACRVIARL 
TKEVTAAREA LATLKPQAGL IVPQAVPSSQ PSVVGAGEPM DLGELVGMTP EIIQKLQDKA 
TVLTTERKKR GKTVPEELVK PEELSKYRQV ASHVGLHSAS IPGILALDLC PSDTNKILTG 
GADKNVVVFD KSSEQILATL KGHTKKVTSV VFHPSQDLVF SASPDATIRI WSVPNASCVQ 
VVRAHESAVT GLSLHATGDY LLSSSDDQYW AFSDIQTGRV LTKVTDETSG CSLTCAQFHP 
DGLIFGTGTM DSQIKIWDLK ERTNVANFPG HSGPITSIAF SENGYYLATA ADDSSVKLWD 
LRKLKNFKTL QLDNNFEVKS LIFDQSGTYL ALGGTDVQIY ICKQWTEILH FTEHSGLTTG 
VAFGHHAKFI ASTGMDRSLK FYSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.