Details for: GLS

Gene ID: 2744

Symbol: GLS

Ensembl ID: ENSG00000115419

Description: glutaminase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 503.0048
    Cell Significance Index: -78.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 300.5401
    Cell Significance Index: -76.2300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 180.7754
    Cell Significance Index: -74.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 168.3417
    Cell Significance Index: -68.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 148.0797
    Cell Significance Index: -76.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 72.2812
    Cell Significance Index: -69.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 63.9277
    Cell Significance Index: -78.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.7025
    Cell Significance Index: -76.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.8621
    Cell Significance Index: -70.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.0378
    Cell Significance Index: -79.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.9666
    Cell Significance Index: -41.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.1834
    Cell Significance Index: 1141.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0705
    Cell Significance Index: 615.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.6094
    Cell Significance Index: 175.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.3031
    Cell Significance Index: 44.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.2829
    Cell Significance Index: 100.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.2430
    Cell Significance Index: 84.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.2397
    Cell Significance Index: 64.5300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.2385
    Cell Significance Index: 63.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.9648
    Cell Significance Index: 24.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.6878
    Cell Significance Index: 1167.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2358
    Cell Significance Index: 245.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1966
    Cell Significance Index: 91.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0833
    Cell Significance Index: 69.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0781
    Cell Significance Index: 175.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0587
    Cell Significance Index: 190.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0262
    Cell Significance Index: 63.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0123
    Cell Significance Index: 45.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9485
    Cell Significance Index: 27.1900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9420
    Cell Significance Index: 20.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9061
    Cell Significance Index: 19.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8115
    Cell Significance Index: 42.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8096
    Cell Significance Index: 99.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7962
    Cell Significance Index: 718.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7923
    Cell Significance Index: 10.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7217
    Cell Significance Index: 40.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6926
    Cell Significance Index: 439.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6417
    Cell Significance Index: 44.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.5971
    Cell Significance Index: 811.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5596
    Cell Significance Index: 55.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5048
    Cell Significance Index: 275.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4984
    Cell Significance Index: 938.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4931
    Cell Significance Index: 223.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4926
    Cell Significance Index: 23.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4887
    Cell Significance Index: 11.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3748
    Cell Significance Index: 51.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3180
    Cell Significance Index: 5.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2924
    Cell Significance Index: 10.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2828
    Cell Significance Index: 435.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2740
    Cell Significance Index: 121.1400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2427
    Cell Significance Index: 3.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2020
    Cell Significance Index: 12.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1832
    Cell Significance Index: 21.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1709
    Cell Significance Index: 315.1300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.1420
    Cell Significance Index: 2.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0986
    Cell Significance Index: 16.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0648
    Cell Significance Index: 7.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0444
    Cell Significance Index: 8.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0125
    Cell Significance Index: 0.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0286
    Cell Significance Index: -17.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0313
    Cell Significance Index: -23.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0412
    Cell Significance Index: -30.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0421
    Cell Significance Index: -31.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0558
    Cell Significance Index: -7.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0849
    Cell Significance Index: -4.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1016
    Cell Significance Index: -57.2700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1374
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1623
    Cell Significance Index: -18.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1922
    Cell Significance Index: -19.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2058
    Cell Significance Index: -43.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2332
    Cell Significance Index: -33.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2445
    Cell Significance Index: -70.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2517
    Cell Significance Index: -6.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2614
    Cell Significance Index: -27.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3172
    Cell Significance Index: -40.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3269
    Cell Significance Index: -16.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3381
    Cell Significance Index: -38.7300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4533
    Cell Significance Index: -6.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4869
    Cell Significance Index: -56.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5063
    Cell Significance Index: -14.1500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5352
    Cell Significance Index: -5.5400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5982
    Cell Significance Index: -7.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6547
    Cell Significance Index: -46.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7440
    Cell Significance Index: -16.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7445
    Cell Significance Index: -55.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7715
    Cell Significance Index: -61.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8072
    Cell Significance Index: -42.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8694
    Cell Significance Index: -40.5400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.8890
    Cell Significance Index: -11.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9460
    Cell Significance Index: -30.3000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.1124
    Cell Significance Index: -15.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1979
    Cell Significance Index: -73.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.2707
    Cell Significance Index: -18.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.2801
    Cell Significance Index: -34.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2971
    Cell Significance Index: -27.6300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.3149
    Cell Significance Index: -17.5400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.3493
    Cell Significance Index: -16.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3928
    Cell Significance Index: -45.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.4287
    Cell Significance Index: -37.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.4321
    Cell Significance Index: -42.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Isoforms:** GLS exists in two main isoforms: cytosolic and mitochondrial. The cytosolic isoform (GLS1) is primarily expressed in the brain, while the mitochondrial isoform (GLSK) is predominantly found in the kidney. 2. **Tissue distribution:** GLS is widely expressed in various tissues, including the brain, kidney, and retina. 3. **Regulation:** GLS activity is tightly regulated by post-translational modifications, including phosphorylation and ubiquitination, as well as transcriptional control by factors like TP53. 4. **Substrate specificity:** GLS has a high affinity for glutamine, with a Km value of approximately 0.5 mM. **Pathways and Functions:** 1. **Glutamate biosynthesis:** GLS plays a critical role in the production of glutamate from glutamine, which is then utilized for various cellular processes. 2. **Neurotransmitter release cycle:** GLS regulates glutamate levels during the release cycle, influencing neurotransmitter release and synaptic plasticity. 3. **Intracellular glutamate homeostasis:** GLS helps maintain glutamate homeostasis by regulating its levels in the cytosol and mitochondria. 4. **Metabolic regulation:** GLS is involved in the regulation of energy metabolism, particularly in the context of oxidative stress and mitochondrial function. **Clinical Significance:** 1. **Neurological disorders:** Dysregulation of GLS has been implicated in various neurological disorders, including epilepsy, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cognitive impairments:** Alterations in GLS activity have been linked to cognitive impairments, including attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). 3. **Cancer:** GLS has been implicated in cancer progression, particularly in the context of TP53-mediated regulation. 4. **Therapeutic potential:** Targeting GLS activity has been explored as a potential therapeutic strategy for the treatment of neurological disorders and cancer. In conclusion, GLS plays a critical role in maintaining glutamate homeostasis and regulating various cellular processes, including neurotransmitter release and energy metabolism. The dysregulation of GLS has been implicated in several neurological disorders and cancer, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms underlying GLS function and its role in human disease.

Genular Protein ID: 1499868910

Symbol: GLSK_HUMAN

Name: Glutaminase kidney isoform, mitochondrial

UniProtKB Accession Codes:

O94925 Q9UL05 Q9UL06 Q9UL07 Q9UN40

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 9 EMDB 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 49 PDBsum 49 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 1 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11015561

Title: Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing.

PubMed ID: 11015561

DOI: 10.1152/physiolgenomics.1999.1.2.51

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 10719215

Title: Isolation, characterization and expression of a human brain mitochondrial glutaminase cDNA.

PubMed ID: 10719215

DOI: 10.1016/s0169-328x(99)00331-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 16899818

Title: Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels.

PubMed ID: 16899818

DOI: 10.1242/jcs.03061

PubMed ID: 17940881

Title: Relative expression of mRNAs coding for glutaminase isoforms in CNS tissues and CNS tumors.

PubMed ID: 17940881

DOI: 10.1007/s11064-007-9507-6

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22228304

Title: Mitochondrial localization and structure-based phosphate activation mechanism of glutaminase C with implications for cancer metabolism.

PubMed ID: 22228304

DOI: 10.1073/pnas.1112495109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30575854

Title: Identification of a loss-of-function mutation in the context of glutaminase deficiency and neonatal epileptic encephalopathy.

PubMed ID: 30575854

DOI: 10.1001/jamaneurol.2018.2941

PubMed ID: 30239721

Title: GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay.

PubMed ID: 30239721

DOI: 10.1093/hmg/ddy330

PubMed ID: 30970188

Title: Glutaminase deficiency caused by short tandem repeat expansion in GLS.

PubMed ID: 30970188

DOI: 10.1056/nejmoa1806627

PubMed ID: 22049910

Title: Full-length human glutaminase in complex with an allosteric inhibitor.

PubMed ID: 22049910

DOI: 10.1021/bi201613d

PubMed ID: 22538822

Title: Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.

PubMed ID: 22538822

DOI: 10.1073/pnas.1116573109

PubMed ID: 24451979

Title: Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA).

PubMed ID: 24451979

DOI: 10.1038/srep03827

PubMed ID: 26988803

Title: Design and evaluation of novel glutaminase inhibitors.

PubMed ID: 26988803

DOI: 10.1016/j.bmc.2016.03.009

PubMed ID: 28526749

Title: The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats.

PubMed ID: 28526749

DOI: 10.1074/jbc.m117.787291

PubMed ID: 29317493

Title: Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism.

PubMed ID: 29317493

DOI: 10.1074/jbc.m117.810101

Sequence Information:

  • Length: 669
  • Mass: 73461
  • Checksum: 4E5E63505E84E0B7
  • Sequence:
    • MMRLRGSGML RDLLLRSPAG VSATLRRAQP LVTLCRRPRG GGRPAAGPAA AARLHPWWGG 
GGWPAEPLAR GLSSSPSEIL QELGKGSTHP QPGVSPPAAP AAPGPKDGPG ETDAFGNSEG 
KELVASGENK IKQGLLPSLE DLLFYTIAEG QEKIPVHKFI TALKSTGLRT SDPRLKECMD 
MLRLTLQTTS DGVMLDKDLF KKCVQSNIVL LTQAFRRKFV IPDFMSFTSH IDELYESAKK 
QSGGKVADYI PQLAKFSPDL WGVSVCTVDG QRHSTGDTKV PFCLQSCVKP LKYAIAVNDL 
GTEYVHRYVG KEPSGLRFNK LFLNEDDKPH NPMVNAGAIV VTSLIKQGVN NAEKFDYVMQ 
FLNKMAGNEY VGFSNATFQS ERESGDRNFA IGYYLKEKKC FPEGTDMVGI LDFYFQLCSI 
EVTCESASVM AATLANGGFC PITGERVLSP EAVRNTLSLM HSCGMYDFSG QFAFHVGLPA 
KSGVAGGILL VVPNVMGMMC WSPPLDKMGN SVKGIHFCHD LVSLCNFHNY DNLRHFAKKL 
DPRREGGDQR VKSVINLLFA AYTGDVSALR RFALSAMDME QRDYDSRTAL HVAAAEGHVE 
VVKFLLEACK VNPFPKDRWN NTPMDEALHF GHHDVFKILQ EYQVQYTPQG DSDNGKENQT 
VHKNLDGLL

Genular Protein ID: 2588343333

Symbol: H7C201_HUMAN

Name: N/A

UniProtKB Accession Codes:

H7C201

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChEBI 4 ChiTaRS 1 EC 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 3 GeneTree 1 HAMAP 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 661
  • Mass: 72433
  • Checksum: F17A321771F8F1DA
  • Sequence:
    • MMRLRGSGML RDLLLRSPAG VSATLRRAQP LVTLCRRPRG GGRPAAGPAA AARLHPWWGG 
GGWPAEPLAR GLSSSPSEIL QELGKGSTHP QPGVSPPAAP AAPGPKDGPG ETDAFGNSEG 
KELVASGENK IKQGLLPSLE DLLFYTIAEG QEKIPVHKFI TALKSTGLRT SDPRLKECMD 
MLRLTLQTTS DGVMLDKDLF KKCVQSNIVL LTQAFRRKFV IPDFMSFTSH IDELYESAKK 
QSGGKVADYI PQLAKFSPDL WGVSVCTVDG QRHSTGDTKV PFCLQSCVKP LKYAIAVNDL 
GTEYVHRYVG KEPSGLRFNK LFLNEDDKPH NPMVNAGAIV VTSLIKQGVN NAEKFDYVMQ 
FLNKMAGNEY VGFSNATFQS ERESGDRNFA IGYYLKEKKC FPEGTDMVGI LDFYFQLCSI 
EVTCESASVM AATLANGGFC PITGERVLSP EAVRNTLSLM HSCGMYDFSG QFAFHVGLPA 
KSGVAGGILL VVPNVMGMMC WSPPLDKMGN SVKGIHFCHD LVSLCNFHNY DNLRHFAKKL 
DPRREGGDQR VKSVINLLFA AYTGDVSALR RFALSAMDME QRDYDSRTAL HVAAAEGGIT 
LPWMKHCTLD TMMYLKFSKN TKSSTHLKEI LTTGRKIKPS IRILMDCCNG LKSQDLNHLP 
I

Genular Protein ID: 3809364093

Symbol: Q68D38_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q68D38

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 2 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 252
  • Mass: 28039
  • Checksum: 7530656E426AA49F
  • Sequence:
    • QGVNNAEKFD YVMQFLNKMA GNEYVGFSNA TFQSERESGD RNFAIGYYLK EKKCFPEGTD 
MVGILDFYFQ LCSIEVTCES ASVMAATLAN GGFCPITGER VLSPEAVRNT LSLMHSCGMY 
DFSGQFAFHV GLPAKSGVAG GILLVVPNVM GMMCWSPPLD KMGNSVKGIH FCHDLVSLCN 
FHNYDNLRHF AKKLDPRREG GDQRHSFGPL DYESLQQELA LKETVWKKVS PESNEDISTT 
VVYRMESLGE KS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.