Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 503.0048
Cell Significance Index: -78.2400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 300.5401
Cell Significance Index: -76.2300 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 180.7754
Cell Significance Index: -74.4700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 168.3417
Cell Significance Index: -68.3900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 148.0797
Cell Significance Index: -76.1700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 72.2812
Cell Significance Index: -69.0100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 63.9277
Cell Significance Index: -78.8200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 28.7025
Cell Significance Index: -76.8900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 22.8621
Cell Significance Index: -70.2200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 20.0378
Cell Significance Index: -79.0700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 18.9666
Cell Significance Index: -41.5100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 3.1834
Cell Significance Index: 1141.8400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.0705
Cell Significance Index: 615.9300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.6094
Cell Significance Index: 175.4600 - Cell Name: preadipocyte (CL0002334)
Fold Change: 2.3031
Cell Significance Index: 44.9500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.2829
Cell Significance Index: 100.9800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.2430
Cell Significance Index: 84.9400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 2.2397
Cell Significance Index: 64.5300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 2.2385
Cell Significance Index: 63.8800 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.9648
Cell Significance Index: 24.3700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.6878
Cell Significance Index: 1167.3400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2358
Cell Significance Index: 245.2500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.1966
Cell Significance Index: 91.8300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.0833
Cell Significance Index: 69.8900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0781
Cell Significance Index: 175.3500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0587
Cell Significance Index: 190.8500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.0262
Cell Significance Index: 63.0800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.0123
Cell Significance Index: 45.8900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.9485
Cell Significance Index: 27.1900 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.9420
Cell Significance Index: 20.1400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.9061
Cell Significance Index: 19.6300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.8115
Cell Significance Index: 42.2700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.8096
Cell Significance Index: 99.5500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7962
Cell Significance Index: 718.8900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.7923
Cell Significance Index: 10.8100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.7217
Cell Significance Index: 40.5000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.6926
Cell Significance Index: 439.8800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6417
Cell Significance Index: 44.3800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.5971
Cell Significance Index: 811.9000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5596
Cell Significance Index: 55.3600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5048
Cell Significance Index: 275.6600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.4984
Cell Significance Index: 938.3500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.4931
Cell Significance Index: 223.7900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4926
Cell Significance Index: 23.1500 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.4887
Cell Significance Index: 11.7200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3748
Cell Significance Index: 51.4700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.3180
Cell Significance Index: 5.4500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2924
Cell Significance Index: 10.2800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2828
Cell Significance Index: 435.3800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2740
Cell Significance Index: 121.1400 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.2427
Cell Significance Index: 3.4900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2020
Cell Significance Index: 12.7300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1832
Cell Significance Index: 21.6100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1709
Cell Significance Index: 315.1300 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.1420
Cell Significance Index: 2.1600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0986
Cell Significance Index: 16.8300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0648
Cell Significance Index: 7.0500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0444
Cell Significance Index: 8.4500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0125
Cell Significance Index: 0.3400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0286
Cell Significance Index: -17.8400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0313
Cell Significance Index: -23.1700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0412
Cell Significance Index: -30.2200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0421
Cell Significance Index: -31.8800 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0558
Cell Significance Index: -7.1500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0849
Cell Significance Index: -4.4100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1016
Cell Significance Index: -57.2700 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1374
Cell Significance Index: -0.8300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1623
Cell Significance Index: -18.5300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1922
Cell Significance Index: -19.6300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2058
Cell Significance Index: -43.3500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2332
Cell Significance Index: -33.9000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2445
Cell Significance Index: -70.3600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2517
Cell Significance Index: -6.7400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2614
Cell Significance Index: -27.2200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.3172
Cell Significance Index: -40.9800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3269
Cell Significance Index: -16.5200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3381
Cell Significance Index: -38.7300 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.4533
Cell Significance Index: -6.5100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4869
Cell Significance Index: -56.7400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.5063
Cell Significance Index: -14.1500 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.5352
Cell Significance Index: -5.5400 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.5982
Cell Significance Index: -7.4600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.6547
Cell Significance Index: -46.3000 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.7440
Cell Significance Index: -16.2900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.7445
Cell Significance Index: -55.4900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7715
Cell Significance Index: -61.1000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.8072
Cell Significance Index: -42.3800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.8694
Cell Significance Index: -40.5400 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.8890
Cell Significance Index: -11.2200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.9460
Cell Significance Index: -30.3000 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -1.1124
Cell Significance Index: -15.8400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.1979
Cell Significance Index: -73.4400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.2707
Cell Significance Index: -18.7600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -1.2801
Cell Significance Index: -34.1800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.2971
Cell Significance Index: -27.6300 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -1.3149
Cell Significance Index: -17.5400 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.3493
Cell Significance Index: -16.0900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.3928
Cell Significance Index: -45.6000 - Cell Name: granulosa cell (CL0000501)
Fold Change: -1.4287
Cell Significance Index: -37.5700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -1.4321
Cell Significance Index: -42.0600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1499868910
Symbol: GLSK_HUMAN
Name: Glutaminase kidney isoform, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11015561
Title: Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing.
PubMed ID: 11015561
PubMed ID: 10048485
Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10048485
PubMed ID: 10719215
Title: Isolation, characterization and expression of a human brain mitochondrial glutaminase cDNA.
PubMed ID: 10719215
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14759258
PubMed ID: 16899818
Title: Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels.
PubMed ID: 16899818
DOI: 10.1242/jcs.03061
PubMed ID: 17940881
Title: Relative expression of mRNAs coding for glutaminase isoforms in CNS tissues and CNS tumors.
PubMed ID: 17940881
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22228304
Title: Mitochondrial localization and structure-based phosphate activation mechanism of glutaminase C with implications for cancer metabolism.
PubMed ID: 22228304
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30575854
Title: Identification of a loss-of-function mutation in the context of glutaminase deficiency and neonatal epileptic encephalopathy.
PubMed ID: 30575854
PubMed ID: 30239721
Title: GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay.
PubMed ID: 30239721
DOI: 10.1093/hmg/ddy330
PubMed ID: 30970188
Title: Glutaminase deficiency caused by short tandem repeat expansion in GLS.
PubMed ID: 30970188
PubMed ID: 22049910
Title: Full-length human glutaminase in complex with an allosteric inhibitor.
PubMed ID: 22049910
DOI: 10.1021/bi201613d
PubMed ID: 22538822
Title: Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.
PubMed ID: 22538822
PubMed ID: 24451979
Title: Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA).
PubMed ID: 24451979
DOI: 10.1038/srep03827
PubMed ID: 26988803
Title: Design and evaluation of novel glutaminase inhibitors.
PubMed ID: 26988803
PubMed ID: 28526749
Title: The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats.
PubMed ID: 28526749
PubMed ID: 29317493
Title: Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism.
PubMed ID: 29317493
Sequence Information:
- Length: 669
- Mass: 73461
- Checksum: 4E5E63505E84E0B7
- Sequence:
MMRLRGSGML RDLLLRSPAG VSATLRRAQP LVTLCRRPRG GGRPAAGPAA AARLHPWWGG GGWPAEPLAR GLSSSPSEIL QELGKGSTHP QPGVSPPAAP AAPGPKDGPG ETDAFGNSEG KELVASGENK IKQGLLPSLE DLLFYTIAEG QEKIPVHKFI TALKSTGLRT SDPRLKECMD MLRLTLQTTS DGVMLDKDLF KKCVQSNIVL LTQAFRRKFV IPDFMSFTSH IDELYESAKK QSGGKVADYI PQLAKFSPDL WGVSVCTVDG QRHSTGDTKV PFCLQSCVKP LKYAIAVNDL GTEYVHRYVG KEPSGLRFNK LFLNEDDKPH NPMVNAGAIV VTSLIKQGVN NAEKFDYVMQ FLNKMAGNEY VGFSNATFQS ERESGDRNFA IGYYLKEKKC FPEGTDMVGI LDFYFQLCSI EVTCESASVM AATLANGGFC PITGERVLSP EAVRNTLSLM HSCGMYDFSG QFAFHVGLPA KSGVAGGILL VVPNVMGMMC WSPPLDKMGN SVKGIHFCHD LVSLCNFHNY DNLRHFAKKL DPRREGGDQR VKSVINLLFA AYTGDVSALR RFALSAMDME QRDYDSRTAL HVAAAEGHVE VVKFLLEACK VNPFPKDRWN NTPMDEALHF GHHDVFKILQ EYQVQYTPQG DSDNGKENQT VHKNLDGLL
Genular Protein ID: 2588343333
Symbol: H7C201_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 661
- Mass: 72433
- Checksum: F17A321771F8F1DA
- Sequence:
MMRLRGSGML RDLLLRSPAG VSATLRRAQP LVTLCRRPRG GGRPAAGPAA AARLHPWWGG GGWPAEPLAR GLSSSPSEIL QELGKGSTHP QPGVSPPAAP AAPGPKDGPG ETDAFGNSEG KELVASGENK IKQGLLPSLE DLLFYTIAEG QEKIPVHKFI TALKSTGLRT SDPRLKECMD MLRLTLQTTS DGVMLDKDLF KKCVQSNIVL LTQAFRRKFV IPDFMSFTSH IDELYESAKK QSGGKVADYI PQLAKFSPDL WGVSVCTVDG QRHSTGDTKV PFCLQSCVKP LKYAIAVNDL GTEYVHRYVG KEPSGLRFNK LFLNEDDKPH NPMVNAGAIV VTSLIKQGVN NAEKFDYVMQ FLNKMAGNEY VGFSNATFQS ERESGDRNFA IGYYLKEKKC FPEGTDMVGI LDFYFQLCSI EVTCESASVM AATLANGGFC PITGERVLSP EAVRNTLSLM HSCGMYDFSG QFAFHVGLPA KSGVAGGILL VVPNVMGMMC WSPPLDKMGN SVKGIHFCHD LVSLCNFHNY DNLRHFAKKL DPRREGGDQR VKSVINLLFA AYTGDVSALR RFALSAMDME QRDYDSRTAL HVAAAEGGIT LPWMKHCTLD TMMYLKFSKN TKSSTHLKEI LTTGRKIKPS IRILMDCCNG LKSQDLNHLP I
Genular Protein ID: 3809364093
Symbol: Q68D38_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 252
- Mass: 28039
- Checksum: 7530656E426AA49F
- Sequence:
QGVNNAEKFD YVMQFLNKMA GNEYVGFSNA TFQSERESGD RNFAIGYYLK EKKCFPEGTD MVGILDFYFQ LCSIEVTCES ASVMAATLAN GGFCPITGER VLSPEAVRNT LSLMHSCGMY DFSGQFAFHV GLPAKSGVAG GILLVVPNVM GMMCWSPPLD KMGNSVKGIH FCHDLVSLCN FHNYDNLRHF AKKLDPRREG GDQRHSFGPL DYESLQQELA LKETVWKKVS PESNEDISTT VVYRMESLGE KS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.