Details for: GMDS

Gene ID: 2762

Symbol: GMDS

Ensembl ID: ENSG00000112699

Description: GDP-mannose 4,6-dehydratase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 376.6107
    Cell Significance Index: -58.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 220.5459
    Cell Significance Index: -55.9400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 135.8182
    Cell Significance Index: -55.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 123.0009
    Cell Significance Index: -49.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 88.4621
    Cell Significance Index: -59.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.5482
    Cell Significance Index: -50.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.9498
    Cell Significance Index: -59.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.2288
    Cell Significance Index: -54.1900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.9483
    Cell Significance Index: -41.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.8478
    Cell Significance Index: -58.5900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 10.1802
    Cell Significance Index: 217.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.7771
    Cell Significance Index: 315.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 6.3318
    Cell Significance Index: 437.8800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 5.3770
    Cell Significance Index: 47.7300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 5.1818
    Cell Significance Index: 31.9700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 4.4737
    Cell Significance Index: 45.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.5159
    Cell Significance Index: 155.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 3.5108
    Cell Significance Index: 210.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.3321
    Cell Significance Index: 126.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.7277
    Cell Significance Index: 2462.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6094
    Cell Significance Index: 523.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.4491
    Cell Significance Index: 878.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2939
    Cell Significance Index: 455.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.1581
    Cell Significance Index: 1492.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.0653
    Cell Significance Index: 138.8700
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 2.0226
    Cell Significance Index: 20.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.9519
    Cell Significance Index: 55.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6177
    Cell Significance Index: 45.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3802
    Cell Significance Index: 162.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2194
    Cell Significance Index: 26.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1540
    Cell Significance Index: 33.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8411
    Cell Significance Index: 39.5300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8399
    Cell Significance Index: 12.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7820
    Cell Significance Index: 77.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7320
    Cell Significance Index: 44.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5864
    Cell Significance Index: 26.5800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.5389
    Cell Significance Index: 11.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4561
    Cell Significance Index: 289.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4340
    Cell Significance Index: 237.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4156
    Cell Significance Index: 23.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3989
    Cell Significance Index: 181.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3884
    Cell Significance Index: 171.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3641
    Cell Significance Index: 11.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3332
    Cell Significance Index: 40.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3210
    Cell Significance Index: 24.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3166
    Cell Significance Index: 57.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2646
    Cell Significance Index: 4.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2427
    Cell Significance Index: 5.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2184
    Cell Significance Index: 37.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1834
    Cell Significance Index: 34.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1509
    Cell Significance Index: 284.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1339
    Cell Significance Index: 9.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1004
    Cell Significance Index: 185.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0839
    Cell Significance Index: 10.8400
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.0647
    Cell Significance Index: 0.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0446
    Cell Significance Index: 68.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0213
    Cell Significance Index: -15.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0230
    Cell Significance Index: -31.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0491
    Cell Significance Index: -2.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0624
    Cell Significance Index: -46.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0636
    Cell Significance Index: -48.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1035
    Cell Significance Index: -58.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1071
    Cell Significance Index: -66.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1509
    Cell Significance Index: -2.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1566
    Cell Significance Index: -18.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1640
    Cell Significance Index: -23.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1780
    Cell Significance Index: -51.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1892
    Cell Significance Index: -19.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2179
    Cell Significance Index: -29.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2342
    Cell Significance Index: -30.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2426
    Cell Significance Index: -3.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2665
    Cell Significance Index: -27.2200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2909
    Cell Significance Index: -3.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3027
    Cell Significance Index: -63.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3798
    Cell Significance Index: -24.5100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3817
    Cell Significance Index: -6.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3865
    Cell Significance Index: -13.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3906
    Cell Significance Index: -29.1100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4351
    Cell Significance Index: -6.6200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4403
    Cell Significance Index: -4.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4506
    Cell Significance Index: -51.6300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4552
    Cell Significance Index: -6.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5750
    Cell Significance Index: -45.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6309
    Cell Significance Index: -32.8700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6673
    Cell Significance Index: -9.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6784
    Cell Significance Index: -22.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6936
    Cell Significance Index: -14.7200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6982
    Cell Significance Index: -8.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7027
    Cell Significance Index: -22.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7143
    Cell Significance Index: -18.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7668
    Cell Significance Index: -47.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8589
    Cell Significance Index: -12.3000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.8643
    Cell Significance Index: -5.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9009
    Cell Significance Index: -22.5200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9043
    Cell Significance Index: -17.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9618
    Cell Significance Index: -19.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0138
    Cell Significance Index: -63.9000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0142
    Cell Significance Index: -25.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0224
    Cell Significance Index: -53.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GMDS is a GDP-mannose 4,6-dehydratase enzyme that catalyzes the conversion of GDP-mannose to GDP-4,6-dehydratose, a key intermediate in the biosynthesis of GDP-l-fucose. This enzyme is a member of the 2,3-bisphosphoglycerate dehydrogenase family and exhibits a high degree of specificity towards GDP-mannose. The expression of GMDS is tightly regulated, with its levels varying across different cell types and tissues. The enzyme's activity is also influenced by various post-translational modifications, including phosphorylation and ubiquitination. **Pathways and Functions:** GMDS is involved in several critical pathways, including: 1. **GDP-l-fucose biosynthesis**: GMDS is a key enzyme in this pathway, which is essential for the production of N-glycans and O-glycans. 2. **Asparagine n-linked glycosylation**: GMDS is required for the formation of N-glycans, which are attached to asparagine residues on proteins. 3. **Biosynthesis of dolichol lipid-linked oligosaccharide (LLO)**: GMDS is involved in the formation of LLO, a precursor to N-glycans. 4. **Notch signaling pathway**: GMDS has been shown to interact with Notch receptors, influencing the signaling pathway's activity. 5. **Glycosylation of proteins**: GMDS is essential for the glycosylation of proteins, which is critical for their proper folding, stability, and function. **Clinical Significance:** Dysregulation of GMDS has been implicated in various diseases, including: 1. **Cancer**: Aberrant glycosylation patterns have been observed in cancer cells, and GMDS has been shown to be overexpressed in several types of cancer. 2. **Neurodegenerative diseases**: GMDS has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Immunological disorders**: GMDS has been shown to play a role in the regulation of immune responses, and its dysfunction has been linked to autoimmune diseases. In conclusion, GMDS is a critical enzyme involved in the biosynthesis of glycoproteins and glycolipids, and its dysregulation has been implicated in various diseases. Further research is needed to fully elucidate the role of GMDS in human health and disease.

Genular Protein ID: 2968091807

Symbol: GMDS_HUMAN

Name: GDP-D-mannose dehydratase

UniProtKB Accession Codes:

O60547 E9PI88 O75357 Q5T954 Q6FH09 Q9UGZ3 Q9UJK9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 13 Ensembl 2 EvolutionaryTrace 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9525924

Title: Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro.

PubMed ID: 9525924

DOI: 10.1074/jbc.273.14.8193

PubMed ID: 9603974

Title: Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells.

PubMed ID: 9603974

DOI: 10.1074/jbc.273.23.14582

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 372
  • Mass: 41950
  • Checksum: B1BAC441736D4C2B
  • Sequence:
    • MAHAPARCPS ARGSGDGEMG KPRNVALITG ITGQDGSYLA EFLLEKGYEV HGIVRRSSSF 
NTGRIEHLYK NPQAHIEGNM KLHYGDLTDS TCLVKIINEV KPTEIYNLGA QSHVKISFDL 
AEYTADVDGV GTLRLLDAVK TCGLINSVKF YQASTSELYG KVQEIPQKET TPFYPRSPYG 
AAKLYAYWIV VNFREAYNLF AVNGILFNHE SPRRGANFVT RKISRSVAKI YLGQLECFSL 
GNLDAKRDWG HAKDYVEAMW LMLQNDEPED FVIATGEVHS VREFVEKSFL HIGKTIVWEG 
KNENEVGRCK ETGKVHVTVD LKYYRPTEVD FLQGDCTKAK QKLNWKPRVA FDELVREMVH 
ADVELMRTNP NA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.