Details for: GMDS

Gene ID: 2762

Symbol: GMDS

Ensembl ID: ENSG00000112699

Description: GDP-mannose 4,6-dehydratase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.26
    Marker Score: 2,265
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.25
    Marker Score: 2,882
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 3.1
    Marker Score: 893
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.81
    Marker Score: 1,637
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.8
    Marker Score: 1,384
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.79
    Marker Score: 15,010
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.76
    Marker Score: 93,174
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.62
    Marker Score: 5,970
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.52
    Marker Score: 5,533
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.49
    Marker Score: 2,387
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.3
    Marker Score: 34,433
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.28
    Marker Score: 2,619
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.26
    Marker Score: 17,325
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.22
    Marker Score: 1,708
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.21
    Marker Score: 1,320
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.21
    Marker Score: 2,438
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.18
    Marker Score: 3,814
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.16
    Marker Score: 3,633
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.16
    Marker Score: 13,798
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.13
    Marker Score: 80,751
  • Cell Name: interneuron (CL0000099)
    Fold Change: 2.12
    Marker Score: 969
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.11
    Marker Score: 4,793
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.1
    Marker Score: 8,701
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.1
    Marker Score: 10,065
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.08
    Marker Score: 5,925
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.08
    Marker Score: 8,025
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.05
    Marker Score: 40,686
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.04
    Marker Score: 1,154
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.03
    Marker Score: 592
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.02
    Marker Score: 74,417
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2
    Marker Score: 18,826
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.99
    Marker Score: 8,088
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.97
    Marker Score: 2,865
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.97
    Marker Score: 121,034
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.96
    Marker Score: 2,110
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.94
    Marker Score: 607
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.94
    Marker Score: 8,955
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.93
    Marker Score: 612
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.9
    Marker Score: 703
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.87
    Marker Score: 19,340
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.87
    Marker Score: 17,764
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.85
    Marker Score: 671
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.84
    Marker Score: 6,808
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.83
    Marker Score: 1,855
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.83
    Marker Score: 15,683
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.81
    Marker Score: 1,568
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.8
    Marker Score: 843
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.8
    Marker Score: 2,956
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.79
    Marker Score: 4,253
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.76
    Marker Score: 5,537
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.76
    Marker Score: 1,993
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.71
    Marker Score: 407
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.7
    Marker Score: 538
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.7
    Marker Score: 3,582
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.68
    Marker Score: 885
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.66
    Marker Score: 3,198
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.63
    Marker Score: 1,302
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.63
    Marker Score: 414
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.6
    Marker Score: 3,762
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6
    Marker Score: 4,737
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.57
    Marker Score: 2,429
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.57
    Marker Score: 1,650
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.52
    Marker Score: 1,059
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.49
    Marker Score: 360
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.48
    Marker Score: 732
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.47
    Marker Score: 538
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,122
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.44
    Marker Score: 30,702
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.44
    Marker Score: 373
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.44
    Marker Score: 778
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.44
    Marker Score: 601
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.42
    Marker Score: 567
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.42
    Marker Score: 595
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.41
    Marker Score: 1,649
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.39
    Marker Score: 503
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.37
    Marker Score: 1,945
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.34
    Marker Score: 506
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.34
    Marker Score: 3,582
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.31
    Marker Score: 492
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.29
    Marker Score: 1,987
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.29
    Marker Score: 773
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.28
    Marker Score: 903
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.28
    Marker Score: 1,048
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.26
    Marker Score: 1,348
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.25
    Marker Score: 252
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.24
    Marker Score: 465
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.24
    Marker Score: 617
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.24
    Marker Score: 1,669
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.23
    Marker Score: 1,168
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.22
    Marker Score: 9,235
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.22
    Marker Score: 2,234
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.22
    Marker Score: 346
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.22
    Marker Score: 2,480
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.21
    Marker Score: 465
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18,854
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.2
    Marker Score: 7,700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.19
    Marker Score: 5,137
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.19
    Marker Score: 2,106
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.18
    Marker Score: 375
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.17
    Marker Score: 4,917

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GMDS is a GDP-mannose 4,6-dehydratase enzyme that catalyzes the conversion of GDP-mannose to GDP-4,6-dehydratose, a key intermediate in the biosynthesis of GDP-l-fucose. This enzyme is a member of the 2,3-bisphosphoglycerate dehydrogenase family and exhibits a high degree of specificity towards GDP-mannose. The expression of GMDS is tightly regulated, with its levels varying across different cell types and tissues. The enzyme's activity is also influenced by various post-translational modifications, including phosphorylation and ubiquitination. **Pathways and Functions:** GMDS is involved in several critical pathways, including: 1. **GDP-l-fucose biosynthesis**: GMDS is a key enzyme in this pathway, which is essential for the production of N-glycans and O-glycans. 2. **Asparagine n-linked glycosylation**: GMDS is required for the formation of N-glycans, which are attached to asparagine residues on proteins. 3. **Biosynthesis of dolichol lipid-linked oligosaccharide (LLO)**: GMDS is involved in the formation of LLO, a precursor to N-glycans. 4. **Notch signaling pathway**: GMDS has been shown to interact with Notch receptors, influencing the signaling pathway's activity. 5. **Glycosylation of proteins**: GMDS is essential for the glycosylation of proteins, which is critical for their proper folding, stability, and function. **Clinical Significance:** Dysregulation of GMDS has been implicated in various diseases, including: 1. **Cancer**: Aberrant glycosylation patterns have been observed in cancer cells, and GMDS has been shown to be overexpressed in several types of cancer. 2. **Neurodegenerative diseases**: GMDS has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Immunological disorders**: GMDS has been shown to play a role in the regulation of immune responses, and its dysfunction has been linked to autoimmune diseases. In conclusion, GMDS is a critical enzyme involved in the biosynthesis of glycoproteins and glycolipids, and its dysregulation has been implicated in various diseases. Further research is needed to fully elucidate the role of GMDS in human health and disease.

Genular Protein ID: 2968091807

Symbol: GMDS_HUMAN

Name: GDP-D-mannose dehydratase

UniProtKB Accession Codes:

O60547 E9PI88 O75357 Q5T954 Q6FH09 Q9UGZ3 Q9UJK9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 13 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 7 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 2 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9525924

Title: Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro.

PubMed ID: 9525924

DOI: 10.1074/jbc.273.14.8193

PubMed ID: 9603974

Title: Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells.

PubMed ID: 9603974

DOI: 10.1074/jbc.273.23.14582

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 372
  • Mass: 41950
  • Checksum: B1BAC441736D4C2B
  • Sequence:
    • MAHAPARCPS ARGSGDGEMG KPRNVALITG ITGQDGSYLA EFLLEKGYEV HGIVRRSSSF 
NTGRIEHLYK NPQAHIEGNM KLHYGDLTDS TCLVKIINEV KPTEIYNLGA QSHVKISFDL 
AEYTADVDGV GTLRLLDAVK TCGLINSVKF YQASTSELYG KVQEIPQKET TPFYPRSPYG 
AAKLYAYWIV VNFREAYNLF AVNGILFNHE SPRRGANFVT RKISRSVAKI YLGQLECFSL 
GNLDAKRDWG HAKDYVEAMW LMLQNDEPED FVIATGEVHS VREFVEKSFL HIGKTIVWEG 
KNENEVGRCK ETGKVHVTVD LKYYRPTEVD FLQGDCTKAK QKLNWKPRVA FDELVREMVH 
ADVELMRTNP NA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.