Gene GNB2 - ENSG00000172354 | NCBI Gene ID: 2783

Details for: GNB2

Gene ID: 2783

Symbol: GNB2

Ensembl ID: ENSG00000172354

Description: G protein subunit beta 2

Associated with

Activation of gabab receptors
(R-HSA-991365)
Activation of g protein gated potassium channels
(R-HSA-1296041)
Activation of kainate receptors upon glutamate binding
(R-HSA-451326)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Adp signalling through p2y purinoceptor 1
(R-HSA-418592)
Adp signalling through p2y purinoceptor 12
(R-HSA-392170)
Adrenaline,noradrenaline inhibits insulin secretion
(R-HSA-400042)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Chaperonin-mediated protein folding
(R-HSA-390466)
Class b/2 (secretin family receptors)
(R-HSA-373080)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-HSA-6814122)
Disease
(R-HSA-1643685)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
G-protein activation
(R-HSA-202040)
G-protein beta:gamma signalling
(R-HSA-397795)
Gaba b receptor activation
(R-HSA-977444)
Gaba receptor activation
(R-HSA-977443)
G alpha (12/13) signalling events
(R-HSA-416482)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
G alpha (s) signalling events
(R-HSA-418555)
G alpha (z) signalling events
(R-HSA-418597)
G beta:gamma signalling through btk
(R-HSA-8964315)
G beta:gamma signalling through cdc42
(R-HSA-8964616)
G beta:gamma signalling through pi3kgamma
(R-HSA-392451)
G beta:gamma signalling through plc beta
(R-HSA-418217)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon-type ligand receptors
(R-HSA-420092)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Gper1 signaling
(R-HSA-9634597)
G protein gated potassium channels
(R-HSA-1296059)
Hemostasis
(R-HSA-109582)
Infectious disease
(R-HSA-5663205)
Inhibition of voltage gated ca2+ channels via gbeta/gamma subunits
(R-HSA-997272)
Integration of energy metabolism
(R-HSA-163685)
Inwardly rectifying k+ channels
(R-HSA-1296065)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet homeostasis
(R-HSA-418346)
Potassium channels
(R-HSA-1296071)
Presynaptic function of kainate receptors
(R-HSA-500657)
Prostacyclin signalling through prostacyclin receptor
(R-HSA-392851)
Protein folding
(R-HSA-391251)
Regulation of insulin secretion
(R-HSA-422356)
Signal amplification
(R-HSA-392518)
Signaling by gpcr
(R-HSA-372790)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Thrombin signalling through proteinase activated receptors (pars)
(R-HSA-456926)
Thromboxane signalling through tp receptor
(R-HSA-428930)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Focal adhesion
(GO:0005925)
G protein-coupled receptor signaling pathway
(GO:0007186)
Gtpase activity
(GO:0003924)
Gtpase binding
(GO:0051020)
Heterotrimeric g-protein complex
(GO:0005834)
Lysosomal membrane
(GO:0005765)
Membrane
(GO:0016020)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Regulation of potassium ion transmembrane transport
(GO:1901379)
Signaling receptor complex adaptor activity
(GO:0030159)
Vesicle
(GO:0031982)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 3.5
Marker Score: 7377.5
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.22
Marker Score: 180343
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.73
Marker Score: 3299
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.55
Marker Score: 19910
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.49
Marker Score: 21479.5
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.48
Marker Score: 2782
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.46
Marker Score: 18293
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.44
Marker Score: 7666
Cell Name: decidual cell (CL2000002)
Fold Change: 2.38
Marker Score: 10257.5
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.37
Marker Score: 15402
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.29
Marker Score: 2008
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.28
Marker Score: 58374
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.28
Marker Score: 30062.5
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.27
Marker Score: 78578
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.27
Marker Score: 4418
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.26
Marker Score: 2581
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.23
Marker Score: 1754
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.19
Marker Score: 1277
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.19
Marker Score: 8436.5
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.18
Marker Score: 5936
Cell Name: motor neuron (CL0000100)
Fold Change: 2.17
Marker Score: 1287
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 2.14
Marker Score: 18626
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.14
Marker Score: 5329.5
Cell Name: mature T cell (CL0002419)
Fold Change: 2.14
Marker Score: 21177
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.13
Marker Score: 3080
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.13
Marker Score: 2003
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.09
Marker Score: 21023
Cell Name: myelocyte (CL0002193)
Fold Change: 2.09
Marker Score: 901.5
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.06
Marker Score: 3282
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.06
Marker Score: 5238
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.06
Marker Score: 3028
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.05
Marker Score: 2055
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 2.05
Marker Score: 970
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.03
Marker Score: 12979
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 2.02
Marker Score: 842
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 2.01
Marker Score: 1339
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 2.01
Marker Score: 676
Cell Name: Unknown (CL0000548)
Fold Change: 2.01
Marker Score: 1463
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2
Marker Score: 22529
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2
Marker Score: 2941
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.99
Marker Score: 4534
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.99
Marker Score: 2140
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.98
Marker Score: 1859
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.96
Marker Score: 8392
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.96
Marker Score: 729
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.96
Marker Score: 11600
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.95
Marker Score: 1224
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.92
Marker Score: 19506
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.92
Marker Score: 4645
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.92
Marker Score: 1950
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.9
Marker Score: 4482
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.9
Marker Score: 6004
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.9
Marker Score: 3055
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.9
Marker Score: 1044
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.9
Marker Score: 7448
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.89
Marker Score: 16631.5
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.89
Marker Score: 1042.5
Cell Name: endocrine cell (CL0000163)
Fold Change: 1.88
Marker Score: 971
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.88
Marker Score: 1765
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.88
Marker Score: 3075
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.87
Marker Score: 4579.5
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.87
Marker Score: 11387
Cell Name: supporting cell (CL0000630)
Fold Change: 1.87
Marker Score: 3516
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.86
Marker Score: 3716
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 1.86
Marker Score: 4532
Cell Name: Unknown (CL0002371)
Fold Change: 1.85
Marker Score: 1968
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.85
Marker Score: 1259
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.85
Marker Score: 441
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.83
Marker Score: 944
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.83
Marker Score: 3246
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.83
Marker Score: 5422.5
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.83
Marker Score: 1968
Cell Name: enterocyte (CL0000584)
Fold Change: 1.82
Marker Score: 8735
Cell Name: PP cell (CL0000696)
Fold Change: 1.82
Marker Score: 409
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.81
Marker Score: 1739
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.8
Marker Score: 4830.5
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.79
Marker Score: 1918
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.78
Marker Score: 1598
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.77
Marker Score: 4581
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.76
Marker Score: 609
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.75
Marker Score: 2906
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 1.75
Marker Score: 907
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.74
Marker Score: 1456
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.74
Marker Score: 503
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.74
Marker Score: 1479
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.74
Marker Score: 2940
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.73
Marker Score: 1176
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.73
Marker Score: 4857
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.73
Marker Score: 3282
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.73
Marker Score: 11037
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.72
Marker Score: 1866.5
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.72
Marker Score: 2118
Cell Name: enteric neuron (CL0007011)
Fold Change: 1.72
Marker Score: 913
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 1.72
Marker Score: 5007
Cell Name: stem cell (CL0000034)
Fold Change: 1.71
Marker Score: 4072
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.7
Marker Score: 421
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.7
Marker Score: 1736
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 1.7
Marker Score: 1045
Cell Name: muscle cell (CL0000187)
Fold Change: 1.7
Marker Score: 482
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.7
Marker Score: 1766

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**Key characteristics:** - GNB2 is a type of G protein that is involved in a variety of cellular processes, including water transport, cell signaling, and blood clotting. - It is a transmembrane protein that is composed of two subunits, a G protein-coupled receptor (GPRC) and a guanine nucleotide-binding protein (GNB). - The GNB2 subunit is responsible for the second binding event of the G protein, which is required for the activation of the GPRC. - GNB2 is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. **Pathways and functions:** - GNB2 is involved in the regulation of water transport in cells. - It is expressed in the plasma membrane of blood vessels, where it is responsible for regulating water flow into and out of cells. - GNB2 is also involved in the regulation of cell signaling. It is a key regulator of the MAPK signaling pathway, which is involved in cell growth, differentiation, and apoptosis. - GNB2 is also involved in the regulation of blood clotting. It is a key regulator of the coagulation cascade, which is responsible for the conversion of fibrinogen into fibrin, which is a protein that is responsible for blood clotting. **Clinical significance:** GNB2 mutations can lead to a variety of diseases, including hemophilia A, which is caused by a deficiency of GNB2. Hemophilia A is a genetic disorder that is caused by a mutation in the GNB2 gene. People with hemophilia A have a severe decrease in their ability to produce GNB2 protein, which leads to a decrease in the amount of GNB2 in the blood. This results in a decrease in water transport and cell signaling, which can lead to a variety of symptoms, including bleeding disorders, joint pain, and muscle weakness.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Genular Protein ID: 3988152366

Symbol: GBB2_HUMAN

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

UniProtKB Accession Codes:

P62879 B3KPU1 P11016 P54312

Database IDs:

Citations:

PubMed ID: 3108879

Title: Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning.

PubMed ID: 3108879

DOI: 10.1073/pnas.84.11.3792

PubMed ID: 3114742

Title: A second form of the beta subunit of signal-transducing G proteins.

PubMed ID: 3114742

DOI: 10.1073/pnas.84.17.6122

PubMed ID: 9799793

Title: Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.

PubMed ID: 9799793

DOI: 10.1101/gr.8.10.1060

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14512443

Title: G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.

PubMed ID: 14512443

DOI: 10.1161/01.res.0000097607.14733.0c

PubMed ID: 16498633

Title: Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit.

PubMed ID: 16498633

DOI: 10.1002/jnr.20807

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19255495

Title: The cationic region of Rhes mediates its interactions with specific Gbeta subunits.

PubMed ID: 19255495

DOI: 10.1159/000204075

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26900580

Title: Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy.

PubMed ID: 26900580

DOI: 10.1002/acn3.276

PubMed ID: 28219978

Title: A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction.

PubMed ID: 28219978

DOI: 10.1161/circresaha.116.310112

PubMed ID: 31698099

Title: Exome reports A de novo GNB2 variant associated with global developmental delay, intellectual disability, and dysmorphic features.

PubMed ID: 31698099

DOI: 10.1016/j.ejmg.2019.103804

PubMed ID: 34183358

Title: Recurrent de novo missense variants in GNB2 can cause syndromic intellectual disability.

PubMed ID: 34183358

DOI: 10.1136/jmedgenet-2020-107462

PubMed ID: 33971351

Title: Second patient with GNB2-related neurodevelopmental disease: Further evidence for a gene-disease association.

PubMed ID: 33971351

DOI: 10.1016/j.ejmg.2021.104243

Sequence Information:

Length: 340
Mass: 37331
Checksum: 5D08FFA240ADEEE6
Sequence:

MSELEQLRQE AEQLRNQIRD ARKACGDSTL TQITAGLDPV GRIQMRTRRT LRGHLAKIYA 
MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN FVACGGLDNI 
CSIYSLKTRE GNVRVSRELP GHTGYLSCCR FLDDNQIITS SGDTTCALWD IETGQQTVGF 
AGHSGDVMSL SLAPDGRTFV SGACDASIKL WDVRDSMCRQ TFIGHESDIN AVAFFPNGYA 
FTTGSDDATC RLFDLRADQE LLMYSHDNII CGITSVAFSR SGRLLLAGYD DFNCNIWDAM 
KGDRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GNB2

Associated with

Cells (max top 100)

Other Information

Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning. PubMed ID: 3108879

A second form of the beta subunit of signal-transducing G proteins. PubMed ID: 3114742

Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. PubMed ID: 9799793

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production. PubMed ID: 14512443

Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit. PubMed ID: 16498633

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

The cationic region of Rhes mediates its interactions with specific Gbeta subunits. PubMed ID: 19255495

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy. PubMed ID: 26900580

A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction. PubMed ID: 28219978

Exome reports A de novo GNB2 variant associated with global developmental delay, intellectual disability, and dysmorphic features. PubMed ID: 31698099

Recurrent de novo missense variants in GNB2 can cause syndromic intellectual disability. PubMed ID: 34183358

Second patient with GNB2-related neurodevelopmental disease: Further evidence for a gene-disease association. PubMed ID: 33971351