Details for: GPD2

Gene ID: 2820

Symbol: GPD2

Ensembl ID: ENSG00000115159

Description: glycerol-3-phosphate dehydrogenase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.42
    Marker Score: 51695
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.03
    Marker Score: 2300.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.94
    Marker Score: 4268.5
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.72
    Marker Score: 495.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.68
    Marker Score: 6843
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.66
    Marker Score: 14251
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.63
    Marker Score: 1802
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.63
    Marker Score: 1071.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.63
    Marker Score: 61756
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.56
    Marker Score: 1085
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.55
    Marker Score: 11855
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.54
    Marker Score: 3136
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168043
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.46
    Marker Score: 15050
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.36
    Marker Score: 719
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.3
    Marker Score: 25779
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.29
    Marker Score: 1120
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.28
    Marker Score: 4930
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.27
    Marker Score: 12106
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.27
    Marker Score: 1129
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.27
    Marker Score: 739
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.25
    Marker Score: 76711
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.23
    Marker Score: 1414
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.23
    Marker Score: 18338
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.21
    Marker Score: 5066
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.21
    Marker Score: 40850
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.21
    Marker Score: 1491
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.19
    Marker Score: 1254
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18590
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.18
    Marker Score: 375
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.16
    Marker Score: 42755.5
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.13
    Marker Score: 414
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.13
    Marker Score: 978
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.13
    Marker Score: 676
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.1
    Marker Score: 864
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.09
    Marker Score: 540
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.07
    Marker Score: 1151
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.06
    Marker Score: 1322
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.05
    Marker Score: 518
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.05
    Marker Score: 211
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.04
    Marker Score: 9827
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.03
    Marker Score: 4773
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.02
    Marker Score: 369
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.01
    Marker Score: 2870
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71742
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47967
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.98
    Marker Score: 755
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.97
    Marker Score: 579
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.96
    Marker Score: 1850
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.95
    Marker Score: 3920
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.94
    Marker Score: 1391
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.93
    Marker Score: 14974
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.93
    Marker Score: 450
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.92
    Marker Score: 514
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.92
    Marker Score: 5531
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.92
    Marker Score: 514
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1486
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.91
    Marker Score: 294
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2718
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.9
    Marker Score: 1166
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9
    Marker Score: 2053
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.89
    Marker Score: 2229
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.89
    Marker Score: 1494
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.87
    Marker Score: 1590
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4950
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.86
    Marker Score: 270
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.85
    Marker Score: 567
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.85
    Marker Score: 3535
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.84
    Marker Score: 490
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.83
    Marker Score: 21308
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.81
    Marker Score: 944
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.8
    Marker Score: 1889
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 610
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.78
    Marker Score: 1200
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.77
    Marker Score: 288.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.77
    Marker Score: 6644
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.77
    Marker Score: 222
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.77
    Marker Score: 1914
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.76
    Marker Score: 223
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.76
    Marker Score: 1342.5
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.75
    Marker Score: 280
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.75
    Marker Score: 1787
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.74
    Marker Score: 2334.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.74
    Marker Score: 1047
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.74
    Marker Score: 351.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380.5
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.73
    Marker Score: 281
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.73
    Marker Score: 265
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3061
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.72
    Marker Score: 691
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.71
    Marker Score: 3406
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.7
    Marker Score: 362
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.7
    Marker Score: 1712

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Other Information

**Key characteristics:** - GPD2 is a glycoprotein with a molecular weight of approximately 120 kDa. - It is found in the mitochondria of cells. - It is a key enzyme in the citric acid cycle, which is responsible for the production of energy in cells. **Pathways and functions:** - GPD2 is involved in the regulation of calcium ion concentrations in the brain. - It is a key enzyme in the citric acid cycle, which is responsible for the production of energy in cells. - It is also involved in the regulation of apoptosis, cell growth, and differentiation. **Clinical significance:** - Mutations in GPD2 have been linked to several neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke. - These disorders are characterized by changes in calcium ion concentrations, which can be caused by mutations in genes that regulate GPD2. - Targeting GPD2 has been investigated as a potential treatment for these disorders.

Genular Protein ID: 3626871269

Symbol: GPDM_HUMAN

Name: mtGPD

UniProtKB Accession Codes:

P43304 A8K4V0 B3KSA9 Q59FR1 Q9HAP9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 24 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 8 Gene3D 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 2 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7821823

Title: The sequence of a human mitochondrial glycerol-3-phosphate dehydrogenase-encoding cDNA.

PubMed ID: 7821823

DOI: 10.1016/0378-1119(94)90469-3

PubMed ID: 8549872

Title: Mitochondrial glycerol-3-phosphate dehydrogenase. Cloning of an alternatively spliced human islet-cell cDNA, tissue distribution, physical mapping, and identification of a polymorphic genetic marker.

PubMed ID: 8549872

DOI: 10.2337/diab.45.2.262

PubMed ID: 8682323

Title: Structural organization and mapping of the human mitochondrial glycerol phosphate dehydrogenase-encoding gene and pseudogene.

PubMed ID: 8682323

DOI: 10.1016/0378-1119(96)00019-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9070847

Title: Mutation in the calcium-binding domain of the mitochondrial glycerophosphate dehydrogenase gene in a family of diabetic subjects.

PubMed ID: 9070847

DOI: 10.1006/bbrc.1997.6147

Sequence Information:

  • Length: 727
  • Mass: 80853
  • Checksum: 70D8B4E5CB4F2EFD
  • Sequence:
    • MAFQKAVKGT ILVGGGALAT VLGLSQFAHY RRKQMNLAYV KAADCISEPV NREPPSREAQ 
LLTLQNTSEF DILVIGGGAT GSGCALDAVT RGLKTALVER DDFSSGTSSR STKLIHGGVR 
YLQKAIMKLD IEQYRMVKEA LHERANLLEI APHLSAPLPI MLPVYKWWQL PYYWVGIKLY 
DLVAGSNCLK SSYVLSKSRA LEHFPMLQKD KLVGAIVYYD GQHNDARMNL AIALTAARYG 
AATANYMEVV SLLKKTDPQT GKVRVSGARC KDVLTGQEFD VRAKCVINAT GPFTDSVRKM 
DDKDAAAICQ PSAGVHIVMP GYYSPESMGL LDPATSDGRV IFFLPWQKMT IAGTTDTPTD 
VTHHPIPSEE DINFILNEVR NYLSCDVEVR RGDVLAAWSG IRPLVTDPKS ADTQSISRNH 
VVDISESGLI TIAGGKWTTY RSMAEDTINA AVKTHNLKAG PSRTVGLFLQ GGKDWSPTLY 
IRLVQDYGLE SEVAQHLAAT YGDKAFEVAK MASVTGKRWP IVGVRLVSEF PYIEAEVKYG 
IKEYACTAVD MISRRTRLAF LNVQAAEEAL PRIVELMGRE LNWDDYKKQE QLETARKFLY 
YEMGYKSRSE QLTDRSEISL LPSDIDRYKK RFHKFDADQK GFITIVDVQR VLESINVQMD 
ENTLHEILNE VDLNKNGQVE LNEFLQLMSA IQKGRVSGSR LAILMKTAEE NLDRRVPIPV 
DRSCGGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.