Details for: TRBJ1 2

Gene ID: 28634

Symbol: TRBJ1 2

Ensembl ID: ENSG00000282420

Description: T cell receptor beta joining 1-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.3251
    Cell Significance Index: 59.2400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2942
    Cell Significance Index: 31.3500
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.8355
    Cell Significance Index: 10.9900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.8211
    Cell Significance Index: 10.6200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.6657
    Cell Significance Index: 9.1300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.6024
    Cell Significance Index: 10.3000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.4591
    Cell Significance Index: 4.8800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3461
    Cell Significance Index: 5.0500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0590
    Cell Significance Index: 0.9600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0106
    Cell Significance Index: 0.1100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0022
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0022
    Cell Significance Index: -0.4500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0053
    Cell Significance Index: -0.0700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0061
    Cell Significance Index: -0.0800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0175
    Cell Significance Index: -0.2500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0271
    Cell Significance Index: -0.5300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0332
    Cell Significance Index: -0.3100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0370
    Cell Significance Index: -0.4700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0375
    Cell Significance Index: -0.4600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0419
    Cell Significance Index: -0.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0476
    Cell Significance Index: -0.8800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0539
    Cell Significance Index: -0.5900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0576
    Cell Significance Index: -0.7400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0587
    Cell Significance Index: -0.7800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0590
    Cell Significance Index: -0.7000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0613
    Cell Significance Index: -0.8000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0639
    Cell Significance Index: -0.6600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0657
    Cell Significance Index: -0.7400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0685
    Cell Significance Index: -0.8100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0724
    Cell Significance Index: -0.8400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0740
    Cell Significance Index: -0.8200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0747
    Cell Significance Index: -0.6500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0756
    Cell Significance Index: -0.8700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0766
    Cell Significance Index: -0.8700
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.0774
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0779
    Cell Significance Index: -0.7900
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0779
    Cell Significance Index: -0.6700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0783
    Cell Significance Index: -0.8800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0784
    Cell Significance Index: -0.7900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0805
    Cell Significance Index: -0.7500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0809
    Cell Significance Index: -0.8200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0810
    Cell Significance Index: -0.7900
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.0812
    Cell Significance Index: -0.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0822
    Cell Significance Index: -0.7900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0830
    Cell Significance Index: -0.8800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0831
    Cell Significance Index: -0.8400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0840
    Cell Significance Index: -0.7800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0844
    Cell Significance Index: -0.8000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0865
    Cell Significance Index: -0.7400
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0877
    Cell Significance Index: -0.8100
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0890
    Cell Significance Index: -0.7300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0898
    Cell Significance Index: -0.8400
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0933
    Cell Significance Index: -0.7800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0949
    Cell Significance Index: -0.8300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1013
    Cell Significance Index: -0.8200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1024
    Cell Significance Index: -1.0800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1026
    Cell Significance Index: -0.8200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1041
    Cell Significance Index: -0.8100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1117
    Cell Significance Index: -1.1400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1131
    Cell Significance Index: -0.8700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1137
    Cell Significance Index: -1.1400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1138
    Cell Significance Index: -0.9600
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1178
    Cell Significance Index: -0.8100
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1331
    Cell Significance Index: -0.9900
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1528
    Cell Significance Index: -1.3600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1653
    Cell Significance Index: -1.7400
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1951
    Cell Significance Index: -1.7400
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.2613
    Cell Significance Index: -2.1300
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2871
    Cell Significance Index: -0.8800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.3575
    Cell Significance Index: -1.9100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3583
    Cell Significance Index: -4.3600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4616
    Cell Significance Index: -5.4500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.7922
    Cell Significance Index: -4.3200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.8495
    Cell Significance Index: -14.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBJ1-2 is a gene that belongs to the TCR beta (TRB) locus, which is responsible for encoding the beta chains of the TCR complex. The beta chain is a critical component of the TCR, as it recognizes and binds to MHC molecules, triggering a signaling cascade that leads to T cell activation and proliferation. TRBJ1-2 is a joining gene that combines with the TRB gene to form a functional TCR. This gene is highly conserved across species, suggesting its essential role in the adaptive immune response. **Pathways and Functions:** The TRBJ1-2 gene is involved in the adaptive immune response, specifically in the recognition and response to antigens presented by MHC molecules. The TCR complex, which includes the TRBJ1-2 gene, recognizes and binds to MHC-peptide complexes on antigen-presenting cells. This binding event triggers a signaling cascade that leads to T cell activation, proliferation, and differentiation into effector cells. The TRBJ1-2 gene is also involved in the development and maturation of T cells in the thymus, where T cells undergo negative selection and positive selection to become functional T cells. **Clinical Significance:** Dysregulation or dysfunction of the TRBJ1-2 gene can lead to impaired immune function and increased susceptibility to infections. For example, certain T cell receptor mutations or polymorphisms have been associated with autoimmune diseases, such as rheumatoid arthritis and lupus. Additionally, TRBJ1-2 has been implicated in cancer, as altered TCR signaling can contribute to tumor immune evasion. Furthermore, TRBJ1-2 has been used as a marker for T cell subsets, such as alpha-beta cytotoxic T cells, which are critical for controlling viral infections and tumor immunity. In conclusion, the TRBJ1-2 gene plays a vital role in the adaptive immune response, and its dysregulation can have significant clinical implications. Further research is needed to fully understand the mechanisms of TRBJ1-2 and its role in immune function, with potential applications in the development of novel immunotherapies for autoimmune and cancer diseases. **Key Takeaways:** * TRBJ1-2 is a joining gene that combines with the TRB gene to form a functional TCR complex. * The TRBJ1-2 gene is significantly expressed in various hematopoietic cells, including T cells, mast cells, and erythrocytes. * The TRBJ1-2 gene is involved in the adaptive immune response, specifically in the recognition and response to antigens presented by MHC molecules. * Dysregulation or dysfunction of the TRBJ1-2 gene can lead to impaired immune function and increased susceptibility to infections. * TRBJ1-2 has been implicated in autoimmune diseases, cancer, and T cell subset specification.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.