Details for: TRBJ1 2

Gene ID: 28634

Symbol: TRBJ1 2

Ensembl ID: ENSG00000282420

Description: T cell receptor beta joining 1-2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.18
    Marker Score: 1,210
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 201
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.47
    Marker Score: 250
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.42
    Marker Score: 243
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.34
    Marker Score: 227
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.16
    Marker Score: 137
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.09
    Marker Score: 76
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.06
    Marker Score: 115
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.05
    Marker Score: 87
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.05
    Marker Score: 74
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.04
    Marker Score: 2,221
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.04
    Marker Score: 130
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.04
    Marker Score: 43
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 30
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.02
    Marker Score: 38
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 36
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.02
    Marker Score: 55
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.02
    Marker Score: 109
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 25
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 11

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBJ1-2 is a gene that belongs to the TCR beta (TRB) locus, which is responsible for encoding the beta chains of the TCR complex. The beta chain is a critical component of the TCR, as it recognizes and binds to MHC molecules, triggering a signaling cascade that leads to T cell activation and proliferation. TRBJ1-2 is a joining gene that combines with the TRB gene to form a functional TCR. This gene is highly conserved across species, suggesting its essential role in the adaptive immune response. **Pathways and Functions:** The TRBJ1-2 gene is involved in the adaptive immune response, specifically in the recognition and response to antigens presented by MHC molecules. The TCR complex, which includes the TRBJ1-2 gene, recognizes and binds to MHC-peptide complexes on antigen-presenting cells. This binding event triggers a signaling cascade that leads to T cell activation, proliferation, and differentiation into effector cells. The TRBJ1-2 gene is also involved in the development and maturation of T cells in the thymus, where T cells undergo negative selection and positive selection to become functional T cells. **Clinical Significance:** Dysregulation or dysfunction of the TRBJ1-2 gene can lead to impaired immune function and increased susceptibility to infections. For example, certain T cell receptor mutations or polymorphisms have been associated with autoimmune diseases, such as rheumatoid arthritis and lupus. Additionally, TRBJ1-2 has been implicated in cancer, as altered TCR signaling can contribute to tumor immune evasion. Furthermore, TRBJ1-2 has been used as a marker for T cell subsets, such as alpha-beta cytotoxic T cells, which are critical for controlling viral infections and tumor immunity. In conclusion, the TRBJ1-2 gene plays a vital role in the adaptive immune response, and its dysregulation can have significant clinical implications. Further research is needed to fully understand the mechanisms of TRBJ1-2 and its role in immune function, with potential applications in the development of novel immunotherapies for autoimmune and cancer diseases. **Key Takeaways:** * TRBJ1-2 is a joining gene that combines with the TRB gene to form a functional TCR complex. * The TRBJ1-2 gene is significantly expressed in various hematopoietic cells, including T cells, mast cells, and erythrocytes. * The TRBJ1-2 gene is involved in the adaptive immune response, specifically in the recognition and response to antigens presented by MHC molecules. * Dysregulation or dysfunction of the TRBJ1-2 gene can lead to impaired immune function and increased susceptibility to infections. * TRBJ1-2 has been implicated in autoimmune diseases, cancer, and T cell subset specification.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.