Details for: TRBJ1 1

Gene ID: 28635

Symbol: TRBJ1 1

Ensembl ID: ENSG00000282320

Description: T cell receptor beta joining 1-1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,806
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,571
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,653
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,720
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,342
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 739
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.27
    Marker Score: 441
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.22
    Marker Score: 387
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.22
    Marker Score: 188
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.17
    Marker Score: 342
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.15
    Marker Score: 193
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.1
    Marker Score: 310
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.09
    Marker Score: 205
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.08
    Marker Score: 64
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.08
    Marker Score: 140
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.08
    Marker Score: 4,295
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.08
    Marker Score: 67
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.04
    Marker Score: 74
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.03
    Marker Score: 77
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.02
    Marker Score: 72
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 18
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 14
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 50

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** The TRBJ1 gene is located on chromosome 11q22.3 and consists of a single exon that encodes a protein with a molecular weight of approximately 20 kDa. 2. **Expression Patterns:** The TRBJ1 gene is expressed in various cell types, including goblet cells, neoplastic cells, and intestinal epithelial cells, suggesting its involvement in immune responses and tissue homeostasis. 3. **Cell Type-Specific Expression:** The TRBJ1 gene is specifically expressed in alpha-beta T cells, which are a subset of T cells responsible for cell-mediated immunity. 4. **Evolutionary Conservation:** The TRBJ1 gene is conserved across species, suggesting its essential role in maintaining immune homeostasis. **Pathways and Functions:** 1. **Adaptive Immune Response:** The TRBJ1 gene plays a critical role in the adaptive immune response by contributing to the development and functioning of alpha-beta T cells. 2. **T Cell Receptor Complex:** The TRBJ1 gene is part of the TCR complex, which assembles on the surface of T cells to recognize and bind to antigens. 3. **MHC Restriction:** The TRBJ1 gene is restricted to interact with major histocompatibility complex (MHC) class I molecules, which are essential for antigen presentation and T cell activation. 4. **Gene Regulation:** The TRBJ1 gene is regulated by various transcription factors, including TCF1 and NFAT, which control its expression in T cells and other cell types. **Clinical Significance:** 1. **Autoimmune Diseases:** Alterations in the TRBJ1 gene have been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes, highlighting its potential role in disease pathogenesis. 2. **Cancer:** The TRBJ1 gene is overexpressed in certain types of cancer, including colorectal cancer, suggesting its involvement in tumorigenesis and tumor progression. 3. **Infectious Diseases:** The TRBJ1 gene may play a role in the immune response to infectious diseases, such as HIV and tuberculosis, although its exact mechanisms of action remain unclear. 4. **Immunotherapy:** The TRBJ1 gene has been identified as a potential target for immunotherapy, particularly in the context of cancer treatment, where it may be used to enhance T cell activation and anti-tumor responses. In conclusion, the TRBJ1 gene is a critical component of the adaptive immune system, and its dysregulation has been implicated in various diseases. Further research is needed to elucidate the mechanisms of action of the TRBJ1 gene and its clinical significance, ultimately leading to the development of novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.