Details for: TRBJ1 1

Gene ID: 28635

Symbol: TRBJ1 1

Ensembl ID: ENSG00000282320

Description: T cell receptor beta joining 1-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5647
    Cell Significance Index: 37.9000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5475
    Cell Significance Index: 7.9800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3654
    Cell Significance Index: 4.8000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1944
    Cell Significance Index: 1.0600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0812
    Cell Significance Index: 1.0300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0138
    Cell Significance Index: 0.1500
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0013
    Cell Significance Index: -0.0100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0136
    Cell Significance Index: -0.2300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0141
    Cell Significance Index: -0.2800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0177
    Cell Significance Index: -0.2400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0209
    Cell Significance Index: -0.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0235
    Cell Significance Index: -0.6000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0248
    Cell Significance Index: -0.2800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0259
    Cell Significance Index: -0.2400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0288
    Cell Significance Index: -0.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0319
    Cell Significance Index: -0.5900
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0405
    Cell Significance Index: -0.4200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0427
    Cell Significance Index: -0.3600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0438
    Cell Significance Index: -0.7100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0452
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0465
    Cell Significance Index: -0.4700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0465
    Cell Significance Index: -0.5500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0467
    Cell Significance Index: -0.6200
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0500
    Cell Significance Index: -0.4100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0501
    Cell Significance Index: -0.6600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0504
    Cell Significance Index: -0.5800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0504
    Cell Significance Index: -0.6200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0506
    Cell Significance Index: -0.5600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0509
    Cell Significance Index: -0.6000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0526
    Cell Significance Index: -0.5300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0526
    Cell Significance Index: -0.6100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0530
    Cell Significance Index: -0.6100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0532
    Cell Significance Index: -0.5400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0537
    Cell Significance Index: -0.4700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0544
    Cell Significance Index: -0.7100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0547
    Cell Significance Index: -0.5800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0556
    Cell Significance Index: -0.4700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0560
    Cell Significance Index: -0.5900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0560
    Cell Significance Index: -0.6200
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0572
    Cell Significance Index: -0.5800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0580
    Cell Significance Index: -0.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0583
    Cell Significance Index: -0.5600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0595
    Cell Significance Index: -0.5500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0620
    Cell Significance Index: -0.5800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0621
    Cell Significance Index: -0.6200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0626
    Cell Significance Index: -0.7400
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.0640
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0645
    Cell Significance Index: -0.6800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0650
    Cell Significance Index: -0.6100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0652
    Cell Significance Index: -0.7100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0656
    Cell Significance Index: -0.5100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0666
    Cell Significance Index: -0.6200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0667
    Cell Significance Index: -0.5400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0667
    Cell Significance Index: -0.7500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0672
    Cell Significance Index: -0.5700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0685
    Cell Significance Index: -0.6100
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0685
    Cell Significance Index: -0.7100
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0704
    Cell Significance Index: -0.6500
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0718
    Cell Significance Index: -0.6000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0718
    Cell Significance Index: -0.7000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0726
    Cell Significance Index: -0.6200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0744
    Cell Significance Index: -0.7600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0751
    Cell Significance Index: -0.6000
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.0757
    Cell Significance Index: -0.6200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0763
    Cell Significance Index: -0.7900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0781
    Cell Significance Index: -0.5400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0847
    Cell Significance Index: -0.6300
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0858
    Cell Significance Index: -0.5900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0860
    Cell Significance Index: -0.7900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0897
    Cell Significance Index: -0.7900
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0908
    Cell Significance Index: -0.7400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1001
    Cell Significance Index: -0.7700
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1345
    Cell Significance Index: -0.7200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1772
    Cell Significance Index: -0.5400
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.2895
    Cell Significance Index: -0.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** The TRBJ1 gene is located on chromosome 11q22.3 and consists of a single exon that encodes a protein with a molecular weight of approximately 20 kDa. 2. **Expression Patterns:** The TRBJ1 gene is expressed in various cell types, including goblet cells, neoplastic cells, and intestinal epithelial cells, suggesting its involvement in immune responses and tissue homeostasis. 3. **Cell Type-Specific Expression:** The TRBJ1 gene is specifically expressed in alpha-beta T cells, which are a subset of T cells responsible for cell-mediated immunity. 4. **Evolutionary Conservation:** The TRBJ1 gene is conserved across species, suggesting its essential role in maintaining immune homeostasis. **Pathways and Functions:** 1. **Adaptive Immune Response:** The TRBJ1 gene plays a critical role in the adaptive immune response by contributing to the development and functioning of alpha-beta T cells. 2. **T Cell Receptor Complex:** The TRBJ1 gene is part of the TCR complex, which assembles on the surface of T cells to recognize and bind to antigens. 3. **MHC Restriction:** The TRBJ1 gene is restricted to interact with major histocompatibility complex (MHC) class I molecules, which are essential for antigen presentation and T cell activation. 4. **Gene Regulation:** The TRBJ1 gene is regulated by various transcription factors, including TCF1 and NFAT, which control its expression in T cells and other cell types. **Clinical Significance:** 1. **Autoimmune Diseases:** Alterations in the TRBJ1 gene have been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes, highlighting its potential role in disease pathogenesis. 2. **Cancer:** The TRBJ1 gene is overexpressed in certain types of cancer, including colorectal cancer, suggesting its involvement in tumorigenesis and tumor progression. 3. **Infectious Diseases:** The TRBJ1 gene may play a role in the immune response to infectious diseases, such as HIV and tuberculosis, although its exact mechanisms of action remain unclear. 4. **Immunotherapy:** The TRBJ1 gene has been identified as a potential target for immunotherapy, particularly in the context of cancer treatment, where it may be used to enhance T cell activation and anti-tumor responses. In conclusion, the TRBJ1 gene is a critical component of the adaptive immune system, and its dysregulation has been implicated in various diseases. Further research is needed to elucidate the mechanisms of action of the TRBJ1 gene and its clinical significance, ultimately leading to the development of novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.