Details for: GPS1

Gene ID: 2873

Symbol: GPS1

Ensembl ID: ENSG00000169727

Description: G protein pathway suppressor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 165.6753
    Cell Significance Index: -25.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 105.6207
    Cell Significance Index: -26.7900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 68.3557
    Cell Significance Index: -27.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 60.8299
    Cell Significance Index: -31.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.3168
    Cell Significance Index: -27.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.5508
    Cell Significance Index: -30.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.5074
    Cell Significance Index: -22.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0067
    Cell Significance Index: -31.6000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.2441
    Cell Significance Index: -22.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6011
    Cell Significance Index: -10.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.0516
    Cell Significance Index: 141.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6206
    Cell Significance Index: 188.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2856
    Cell Significance Index: 17.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1354
    Cell Significance Index: 184.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0799
    Cell Significance Index: 11.7400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.0089
    Cell Significance Index: 8.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.9557
    Cell Significance Index: 24.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8991
    Cell Significance Index: 18.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7822
    Cell Significance Index: 36.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7159
    Cell Significance Index: 37.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6850
    Cell Significance Index: 14.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6844
    Cell Significance Index: 44.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6801
    Cell Significance Index: 67.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5612
    Cell Significance Index: 77.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5540
    Cell Significance Index: 19.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5263
    Cell Significance Index: 62.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5170
    Cell Significance Index: 13.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5017
    Cell Significance Index: 14.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4792
    Cell Significance Index: 21.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4765
    Cell Significance Index: 25.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4739
    Cell Significance Index: 258.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4614
    Cell Significance Index: 91.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4290
    Cell Significance Index: 12.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4261
    Cell Significance Index: 76.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3699
    Cell Significance Index: 19.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3608
    Cell Significance Index: 44.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3174
    Cell Significance Index: 63.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3065
    Cell Significance Index: 58.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3048
    Cell Significance Index: 134.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2842
    Cell Significance Index: 3.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2803
    Cell Significance Index: 35.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2684
    Cell Significance Index: 20.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2036
    Cell Significance Index: 12.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1871
    Cell Significance Index: 24.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1697
    Cell Significance Index: 60.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1398
    Cell Significance Index: 96.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1261
    Cell Significance Index: 113.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1175
    Cell Significance Index: 8.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0845
    Cell Significance Index: 1.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0836
    Cell Significance Index: 3.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0730
    Cell Significance Index: 2.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0512
    Cell Significance Index: 1.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0161
    Cell Significance Index: 0.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0090
    Cell Significance Index: 0.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0060
    Cell Significance Index: 1.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0021
    Cell Significance Index: 3.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0011
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0016
    Cell Significance Index: -1.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0034
    Cell Significance Index: -0.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0119
    Cell Significance Index: -8.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0165
    Cell Significance Index: -30.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0177
    Cell Significance Index: -1.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0207
    Cell Significance Index: -31.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0248
    Cell Significance Index: -15.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0257
    Cell Significance Index: -34.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0373
    Cell Significance Index: -27.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0528
    Cell Significance Index: -29.8000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0538
    Cell Significance Index: -0.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0562
    Cell Significance Index: -25.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0589
    Cell Significance Index: -36.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0948
    Cell Significance Index: -27.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0958
    Cell Significance Index: -1.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1464
    Cell Significance Index: -21.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1630
    Cell Significance Index: -5.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1767
    Cell Significance Index: -37.2200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1811
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1860
    Cell Significance Index: -21.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2411
    Cell Significance Index: -16.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2863
    Cell Significance Index: -21.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2916
    Cell Significance Index: -5.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2942
    Cell Significance Index: -30.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2955
    Cell Significance Index: -18.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3064
    Cell Significance Index: -24.2700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3557
    Cell Significance Index: -10.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4013
    Cell Significance Index: -11.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4127
    Cell Significance Index: -23.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4234
    Cell Significance Index: -11.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4270
    Cell Significance Index: -5.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4385
    Cell Significance Index: -10.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4605
    Cell Significance Index: -28.2300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4762
    Cell Significance Index: -4.0000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.4801
    Cell Significance Index: -3.6300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4927
    Cell Significance Index: -5.1000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5589
    Cell Significance Index: -7.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6035
    Cell Significance Index: -26.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6454
    Cell Significance Index: -18.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6724
    Cell Significance Index: -17.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7061
    Cell Significance Index: -15.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7153
    Cell Significance Index: -27.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7159
    Cell Significance Index: -26.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GPS1 is a member of the GPS family of proteins, which are known to regulate protein neddylation, a post-translational modification process that plays a critical role in protein stability and function. GPS1 is characterized by its ability to inhibit the activity of Rho GTPases, which are key regulators of actin cytoskeleton dynamics and cell migration. Additionally, GPS1 interacts with the COP9 signalosome, a complex involved in the regulation of protein neddylation and the ubiquitin-proteasome pathway. These interactions suggest that GPS1 plays a crucial role in regulating protein modification and signaling pathways. **Pathways and Functions** GPS1 is involved in various signaling pathways, including: 1. **Clathrin-mediated endocytosis**: GPS1 regulates the formation of clathrin-coated vesicles, which are involved in the uptake of nutrients and signaling molecules. 2. **COP9 signalosome**: GPS1 interacts with the COP9 signalosome, which regulates protein neddylation and the ubiquitin-proteasome pathway. 3. **JNK cascade**: GPS1 inhibits the activity of JNK kinases, which are involved in stress response and cell survival. 4. **Rho GTPase cycle**: GPS1 regulates the activity of Rho GTPases, which are involved in cell migration and cytoskeleton dynamics. 5. **DNA repair**: GPS1 is involved in the regulation of DNA repair pathways, including the global genome nucleotide excision repair (GG-NER) pathway. **Clinical Significance** GPS1 has been implicated in various diseases, including: 1. **Cancer**: GPS1 is overexpressed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential role as a tumor suppressor. 2. **Neurological disorders**: GPS1 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, suggesting its potential role in regulating neuronal function and survival. 3. **Immune-related disorders**: GPS1 has been implicated in immune-related disorders, including rheumatoid arthritis and lupus, suggesting its potential role in regulating immune cell function and inflammation. In conclusion, GPS1 is a multifunctional protein that regulates various cellular processes, including signal transduction, protein modification, and DNA repair. Its clinical significance is evident in its role in various diseases, including cancer, neurological disorders, and immune-related disorders. Further research is needed to fully understand the mechanisms of GPS1 and its potential therapeutic applications.

Genular Protein ID: 2178375362

Symbol: CSN1_HUMAN

Name: COP9 signalosome complex subunit 1

UniProtKB Accession Codes:

Q13098 Q8NA10 Q9BWL1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 14 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 5 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8943324

Title: Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells.

PubMed ID: 8943324

DOI: 10.1128/mcb.16.12.6698

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9535219

Title: A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.

PubMed ID: 9535219

DOI: 10.1096/fasebj.12.6.469

PubMed ID: 11285227

Title: COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.

PubMed ID: 11285227

DOI: 10.1093/emboj/20.7.1630

PubMed ID: 11114242

Title: The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain.

PubMed ID: 11114242

DOI: 10.1006/jmbi.2000.4288

PubMed ID: 11337588

Title: Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.

PubMed ID: 11337588

DOI: 10.1126/science.1059780

PubMed ID: 12324474

Title: Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1.

PubMed ID: 12324474

DOI: 10.1074/jbc.m208709200

PubMed ID: 12732143

Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

PubMed ID: 12732143

DOI: 10.1016/s0092-8674(03)00316-7

PubMed ID: 12628923

Title: Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.

PubMed ID: 12628923

DOI: 10.1093/emboj/cdg127

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18850735

Title: Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.

PubMed ID: 18850735

DOI: 10.1021/pr800574c

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26456823

Title: CSNAP is a stoichiometric subunit of the COP9 signalosome.

PubMed ID: 26456823

DOI: 10.1016/j.celrep.2015.09.021

PubMed ID: 35913642

Title: USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection.

PubMed ID: 35913642

DOI: 10.1007/s00018-022-04489-7

Sequence Information:

  • Length: 491
  • Mass: 55537
  • Checksum: BF925164ED985638
  • Sequence:
    • MPLPVQVFNL QGAVEPMQID VDPQEDPQNA PDVNYVVENP SLDLEQYAAS YSGLMRIERL 
QFIADHCPTL RVEALKMALS FVQRTFNVDM YEEIHRKLSE ATRSSLRELQ NAPDAIPESG 
VEPPALDTAW VEATRKKALL KLEKLDTDLK NYKGNSIKES IRRGHDDLGD HYLDCGDLSN 
ALKCYSRARD YCTSAKHVIN MCLNVIKVSV YLQNWSHVLS YVSKAESTPE IAEQRGERDS 
QTQAILTKLK CAAGLAELAA RKYKQAAKCL LLASFDHCDF PELLSPSNVA IYGGLCALAT 
FDRQELQRNV ISSSSFKLFL ELEPQVRDII FKFYESKYAS CLKMLDEMKD NLLLDMYLAP 
HVRTLYTQIR NRALIQYFSP YVSADMHRMA AAFNTTVAAL EDELTQLILE GLISARVDSH 
SKILYARDVD QRSTTFEKSL LMGKEFQRRA KAMMLRAAVL RNQIHVKSPP REGSQGELTP 
ANSQSRMSTN M

Genular Protein ID: 1336598411

Symbol: C9JFE4_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JFE4

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 5 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 471
  • Mass: 53372
  • Checksum: 99B0B3DE9737C93D
  • Sequence:
    • MQIDVDPQED PQNAPDVNYV VENPSLDLEQ YAASYSGLMR IERLQFIADH CPTLRVEALK 
MALSFVQRTF NVDMYEEIHR KLSEATRELQ NAPDAIPESG VEPPALDTAW VEATRKKALL 
KLEKLDTDLK NYKGNSIKES IRRGHDDLGD HYLDCGDLSN ALKCYSRARD YCTSAKHVIN 
MCLNVIKVSV YLQNWSHVLS YVSKAESTPE IAEQRGERDS QTQAILTKLK CAAGLAELAA 
RKYKQAAKCL LLASFDHCDF PELLSPSNVA IYGGLCALAT FDRQELQRNV ISSSSFKLFL 
ELEPQVRDII FKFYESKYAS CLKMLDEMKD NLLLDMYLAP HVRTLYTQIR NRALIQYFSP 
YVSADMHRMA AAFNTTVAAL EDELTQLILE GLISARVDSH SKILYARDVD QRSTTFEKSL 
LMGKEFQRRA KAMMLRAAVL RNQIHVKSPP REGSQGELTP ANSQSRMSTN M

Genular Protein ID: 2052292936

Symbol: A0A096LP07_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A096LP07

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 486
  • Mass: 54965
  • Checksum: 04D4D1A21556ADCF
  • Sequence:
    • MPLPVQVFNL QGAVEPMQID VDPQEDPQNA PDVNYVVENP SLDLEQYAAS YSGLMRIERL 
QFIADHCPTL RVEALKMALS FVQRTFNVDM YEEIHRKLSE ATRELQNAPD AIPESGVEPP 
ALDTAWVEAT RKKALLKLEK LDTDLKNYKG NSIKESIRRG HDDLGDHYLD CGDLSNALKC 
YSRARDYCTS AKHVINMCLN VIKVSVYLQN WSHVLSYVSK AESTPEIAER GERDSQTQAI 
LTKLKCAAGL AELAARKYKQ AAKCLLLASF DHCDFPELLS PSNVAIYGGL CALATFDRQE 
LQRNVISSSS FKLFLELEPQ VRDIIFKFYE SKYASCLKML DEMKDNLLLD MYLAPHVRTL 
YTQIRNRALI QYFSPYVSAD MHRMAAAFNT TVAALEDELT QLILEGLISA RVDSHSKILY 
ARDVDQRSTT FEKSLLMGKE FQRRAKAMML RAAVLRNQIH VKSPPREGSQ GELTPANSQS 
RMSTNM

Genular Protein ID: 3229010062

Symbol: A0A9L9PXT0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A9L9PXT0

Database IDs:

ARBA 3 CTD 1 EMBL 1 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 559
  • Mass: 62363
  • Checksum: 8FD79D0D85733B5A
  • Sequence:
    • MPLPVQVFNL QQPASSVSGS GGAESQDRMR DSSAPSSASS SVTDLYCTPH SSRSDLVLPG 
TAGDFSLSAS LSACTLLYEG AVEPMQIDVD PQEDPQNAPD VNYVVENPSL DLEQYAASYS 
GLMRIERLQF IADHCPTLRV EALKMALSFV QRTFNVDMYE EIHRKLSEAT RSSLRELQNA 
PDAIPESGVE PPALDTAWVE ATRKKALLKL EKLDTDLKNY KGNSIKESIR RGHDDLGDHY 
LDCGDLSNAL KCYSRARDYC TSAKHVINMC LNVIKVSVYL QNWSHVLSYV SKAESTPEIA 
EQRGERDSQT QAILTKLKCA AGLAELAARK YKQAAKCLLL ASFDHCDFPE LLSPSNVAIY 
GGLCALATFD RQELQRNVIS SSSFKLFLEL EPQVRDIIFK FYESKYASCL KMLDEMKDNL 
LLDMYLAPHV RTLYTQIRNR ALIQYFSPYV SADMHRMAAA FNTTVAALED ELTQLILEGL 
ISARVDSHSK ILYARDVDQR STTFEKSLLM GKEFQRRAKA MMLRAAVLRN QIHVKSPPRE 
GSQGELTPAN SQSRMSTNM

Genular Protein ID: 2626922673

Symbol: A0A096LPJ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A096LPJ3

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 490
  • Mass: 55408
  • Checksum: 96EAE9C1CA6330EA
  • Sequence:
    • MPLPVQVFNL QGAVEPMQID VDPQEDPQNA PDVNYVVENP SLDLEQYAAS YSGLMRIERL 
QFIADHCPTL RVEALKMALS FVQRTFNVDM YEEIHRKLSE ATRSSLRELQ NAPDAIPESG 
VEPPALDTAW VEATRKKALL KLEKLDTDLK NYKGNSIKES IRRGHDDLGD HYLDCGDLSN 
ALKCYSRARD YCTSAKHVIN MCLNVIKVSV YLQNWSHVLS YVSKAESTPE IAERGERDSQ 
TQAILTKLKC AAGLAELAAR KYKQAAKCLL LASFDHCDFP ELLSPSNVAI YGGLCALATF 
DRQELQRNVI SSSSFKLFLE LEPQVRDIIF KFYESKYASC LKMLDEMKDN LLLDMYLAPH 
VRTLYTQIRN RALIQYFSPY VSADMHRMAA AFNTTVAALE DELTQLILEG LISARVDSHS 
KILYARDVDQ RSTTFEKSLL MGKEFQRRAK AMMLRAAVLR NQIHVKSPPR EGSQGELTPA 
NSQSRMSTNM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.