Details for: GPX3

Gene ID: 2878

Symbol: GPX3

Ensembl ID: ENSG00000211445

Description: glutathione peroxidase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 242.1804
    Cell Significance Index: -37.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 148.9887
    Cell Significance Index: -37.7900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 89.5988
    Cell Significance Index: -36.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 74.2392
    Cell Significance Index: -35.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.5526
    Cell Significance Index: -37.6700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 29.2546
    Cell Significance Index: 198.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.4500
    Cell Significance Index: -37.2900
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 5.5997
    Cell Significance Index: 20.8700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.5139
    Cell Significance Index: 62.1000
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 2.6636
    Cell Significance Index: 26.8800
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.3404
    Cell Significance Index: 19.7300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.1371
    Cell Significance Index: 18.9700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.9344
    Cell Significance Index: 15.4500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.7945
    Cell Significance Index: 11.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.7689
    Cell Significance Index: 1123.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2142
    Cell Significance Index: 32.4200
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.2014
    Cell Significance Index: 4.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1909
    Cell Significance Index: 236.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1070
    Cell Significance Index: 141.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.0104
    Cell Significance Index: 80.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9149
    Cell Significance Index: 106.6200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8639
    Cell Significance Index: 16.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8260
    Cell Significance Index: 43.3700
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.7833
    Cell Significance Index: 3.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7499
    Cell Significance Index: 74.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7436
    Cell Significance Index: 20.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7029
    Cell Significance Index: 20.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6966
    Cell Significance Index: 629.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.6678
    Cell Significance Index: 7.9600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4580
    Cell Significance Index: 7.7100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.4268
    Cell Significance Index: 3.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3624
    Cell Significance Index: 49.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3415
    Cell Significance Index: 55.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3324
    Cell Significance Index: 625.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3122
    Cell Significance Index: 59.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3034
    Cell Significance Index: 165.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1397
    Cell Significance Index: 15.2000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1083
    Cell Significance Index: 0.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0417
    Cell Significance Index: 28.8600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0364
    Cell Significance Index: 0.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0344
    Cell Significance Index: 25.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0233
    Cell Significance Index: 2.3800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.0189
    Cell Significance Index: 0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0135
    Cell Significance Index: 24.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0112
    Cell Significance Index: -17.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0157
    Cell Significance Index: -7.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0280
    Cell Significance Index: -21.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0293
    Cell Significance Index: -39.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0298
    Cell Significance Index: -5.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0312
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0318
    Cell Significance Index: -23.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0447
    Cell Significance Index: -1.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0492
    Cell Significance Index: -6.0600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0510
    Cell Significance Index: -0.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0537
    Cell Significance Index: -23.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0551
    Cell Significance Index: -31.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0599
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0607
    Cell Significance Index: -37.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0609
    Cell Significance Index: -2.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0783
    Cell Significance Index: -15.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0817
    Cell Significance Index: -23.5100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0872
    Cell Significance Index: -0.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0937
    Cell Significance Index: -13.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0949
    Cell Significance Index: -1.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0985
    Cell Significance Index: -35.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1100
    Cell Significance Index: -6.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1209
    Cell Significance Index: -9.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1274
    Cell Significance Index: -5.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1445
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1497
    Cell Significance Index: -25.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1673
    Cell Significance Index: -35.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1694
    Cell Significance Index: -21.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2318
    Cell Significance Index: -5.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2795
    Cell Significance Index: -16.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3035
    Cell Significance Index: -35.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3201
    Cell Significance Index: -36.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3205
    Cell Significance Index: -33.3700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.3314
    Cell Significance Index: -2.3800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3369
    Cell Significance Index: -14.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3426
    Cell Significance Index: -25.5300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.3907
    Cell Significance Index: -5.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4227
    Cell Significance Index: -25.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4269
    Cell Significance Index: -11.9300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.4564
    Cell Significance Index: -4.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5240
    Cell Significance Index: -8.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5360
    Cell Significance Index: -36.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5461
    Cell Significance Index: -35.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5819
    Cell Significance Index: -18.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5919
    Cell Significance Index: -20.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6010
    Cell Significance Index: -36.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6018
    Cell Significance Index: -16.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6218
    Cell Significance Index: -32.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6515
    Cell Significance Index: -36.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7059
    Cell Significance Index: -36.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7216
    Cell Significance Index: -33.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7256
    Cell Significance Index: -19.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7351
    Cell Significance Index: -32.5200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.7501
    Cell Significance Index: -11.9000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.7544
    Cell Significance Index: -9.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7553
    Cell Significance Index: -16.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Substrate specificity:** GPX3 exhibits a high affinity for hydrogen peroxide (H2O2) and lipid hydroperoxides, making it an essential enzyme for detoxifying these reactive species. 2. **Selenium-dependent:** GPX3 is a selenoprotein, meaning it requires selenium as a cofactor for its catalytic activity. 3. **Extracellular localization:** GPX3 is primarily found in the extracellular space, where it can interact with other cellular components and influence cellular signaling pathways. 4. **Tissue specificity:** GPX3 is highly expressed in tissues that are susceptible to oxidative stress, such as the thyroid, skeletal muscle, and lung. **Pathways and Functions:** 1. **Cellular oxidant detoxification:** GPX3 plays a critical role in the detoxification of ROS, which are generated as byproducts of cellular metabolism and can cause oxidative damage. 2. **Hydrogen peroxide catabolic process:** GPX3 catalyzes the reduction of H2O2 to water, thereby preventing oxidative damage to cellular components. 3. **Lipid hydroperoxide reduction:** GPX3 also reduces lipid hydroperoxides, which can damage cell membranes and contribute to oxidative stress. 4. **Cellular response to stimuli:** GPX3 is involved in the cellular response to oxidative stress, inflammation, and other stimuli that can lead to ROS production. 5. **Detoxification of reactive oxygen species:** GPX3 is a key enzyme in the detoxification of ROS, which are generated during various cellular processes, including metabolism, respiration, and immune responses. **Clinical Significance:** 1. **Thyroid disease:** GPX3 has been implicated in thyroid disease, including hypothyroidism and hyperthyroidism, where oxidative stress plays a significant role in disease pathogenesis. 2. **Skeletal muscle disease:** GPX3 has been associated with skeletal muscle disease, including muscular dystrophy and myopathy, where oxidative stress can contribute to muscle damage and dysfunction. 3. **Pulmonary disease:** GPX3 has been shown to be involved in pulmonary disease, including chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis, where oxidative stress can contribute to disease progression. 4. **Cancer:** GPX3 has been implicated in cancer, where oxidative stress can contribute to tumor growth and progression. 5. **Neurodegenerative disease:** GPX3 has been associated with neurodegenerative disease, including Alzheimer's disease and Parkinson's disease, where oxidative stress can contribute to disease pathology. In conclusion, GPX3 is a critical enzyme involved in the cellular detoxification of ROS and plays a vital role in maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, including thyroid disease, skeletal muscle disease, pulmonary disease, cancer, and neurodegenerative disease. Further research is needed to fully understand the role of GPX3 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 4204234968

Symbol: GPX3_HUMAN

Name: Extracellular glutathione peroxidase

UniProtKB Accession Codes:

P22352 O43787 Q86W78 Q9NZ74 Q9UEL1

Database IDs:

AGR 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 11 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2229017

Title: Primary structure of human plasma glutathione peroxidase deduced from cDNA sequences.

PubMed ID: 2229017

DOI: 10.1093/oxfordjournals.jbchem.a123172

PubMed ID: 1339300

Title: Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents.

PubMed ID: 1339300

PubMed ID: 8056346

Title: The human plasma glutathione peroxidase-encoding gene: organization, sequence and localization to chromosome 5q32.

PubMed ID: 8056346

DOI: 10.1016/0378-1119(94)90023-x

PubMed ID: 10970826

Title: Differential induction of extracellular glutathione peroxidase and nitric oxide synthase 2 in airways of healthy individuals exposed to 100% O(2) or cigarette smoke.

PubMed ID: 10970826

DOI: 10.1165/ajrcmb.23.3.4076

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1897960

Title: Characterization and partial amino acid sequence of human plasma glutathione peroxidase.

PubMed ID: 1897960

DOI: 10.1016/0003-9861(91)90048-n

Sequence Information:

  • Length: 226
  • Mass: 25552
  • Checksum: A839E87A5CDB51A9
  • Sequence:
    • MARLLQASCL LSLLLAGFVS QSRGQEKSKM DCHGGISGTI YEYGALTIDG EEYIPFKQYA 
GKYVLFVNVA SYUGLTGQYI ELNALQEELA PFGLVILGFP CNQFGKQEPG ENSEILPTLK 
YVRPGGGFVP NFQLFEKGDV NGEKEQKFYT FLKNSCPPTS ELLGTSDRLF WEPMKVHDIR 
WNFEKFLVGP DGIPIMRWHH RTTVSNVKMD ILSYMRRQAA LGVKRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.