Details for: GPX3

Gene ID: 2878

Symbol: GPX3

Ensembl ID: ENSG00000211445

Description: glutathione peroxidase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 6.8
    Marker Score: 5321
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 6.72
    Marker Score: 4424
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.21
    Marker Score: 10704
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.03
    Marker Score: 5832
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.77
    Marker Score: 13385
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.74
    Marker Score: 3218
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.52
    Marker Score: 3763
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 3.14
    Marker Score: 918
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.12
    Marker Score: 8173
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.99
    Marker Score: 696
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.8
    Marker Score: 1599
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.64
    Marker Score: 3664
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.62
    Marker Score: 2496
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.61
    Marker Score: 3146
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.41
    Marker Score: 625
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.38
    Marker Score: 1986.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.35
    Marker Score: 2212.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.27
    Marker Score: 8929
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.17
    Marker Score: 615
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 2.14
    Marker Score: 862
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.11
    Marker Score: 1024.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.09
    Marker Score: 481
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.07
    Marker Score: 4208
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.02
    Marker Score: 592
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2
    Marker Score: 747
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.99
    Marker Score: 5320
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.94
    Marker Score: 3740
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.9
    Marker Score: 1013
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.88
    Marker Score: 3531
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.88
    Marker Score: 1599
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.86
    Marker Score: 7766
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.83
    Marker Score: 4501
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.83
    Marker Score: 794
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.82
    Marker Score: 626
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.76
    Marker Score: 385
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.74
    Marker Score: 636
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.74
    Marker Score: 1540
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.73
    Marker Score: 428
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.69
    Marker Score: 2451
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.68
    Marker Score: 979
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.67
    Marker Score: 14378
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.66
    Marker Score: 1606
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.65
    Marker Score: 421
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.63
    Marker Score: 12724
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.62
    Marker Score: 1582.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.59
    Marker Score: 2642
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.58
    Marker Score: 1127
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.55
    Marker Score: 976
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.53
    Marker Score: 2598
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.53
    Marker Score: 39198
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.52
    Marker Score: 1754
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.49
    Marker Score: 370
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.49
    Marker Score: 602
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.48
    Marker Score: 1487
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.47
    Marker Score: 370
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167533
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.46
    Marker Score: 567
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.46
    Marker Score: 383
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.43
    Marker Score: 1318
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.42
    Marker Score: 741
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.38
    Marker Score: 311
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.38
    Marker Score: 5331
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.35
    Marker Score: 750
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.33
    Marker Score: 13708
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.32
    Marker Score: 729.5
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.31
    Marker Score: 1404.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.26
    Marker Score: 841
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.26
    Marker Score: 320
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.25
    Marker Score: 646
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.21
    Marker Score: 2854
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.2
    Marker Score: 437
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.19
    Marker Score: 496
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.17
    Marker Score: 963
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.15
    Marker Score: 1163
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.14
    Marker Score: 396
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.13
    Marker Score: 2302
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.13
    Marker Score: 657
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.13
    Marker Score: 629
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.13
    Marker Score: 17606
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.12
    Marker Score: 2815
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.11
    Marker Score: 2704.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.1
    Marker Score: 2328
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.1
    Marker Score: 291
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1
    Marker Score: 17628
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.1
    Marker Score: 722
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.1
    Marker Score: 373
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.09
    Marker Score: 567
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.08
    Marker Score: 323
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.08
    Marker Score: 36879
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.07
    Marker Score: 960
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.06
    Marker Score: 6438
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.05
    Marker Score: 1129
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.04
    Marker Score: 263
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.03
    Marker Score: 3386
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 1.02
    Marker Score: 288
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1
    Marker Score: 1009
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1
    Marker Score: 1996
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71736
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47961.5
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.99
    Marker Score: 397

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Other Information

**Key characteristics:** * GPX3 is a large protein with a molecular weight of approximately 130 kDa. * It is a transmembrane protein that is found in the endoplasmic reticulum (ER). * GPX3 has a unique structure that allows it to form a heterodimeric complex with another protein called GPX4. * GPX3 is a highly conserved protein that is found in organisms from yeast to humans. **Pathways and functions:** * GPX3 is involved in a variety of cellular pathways, including cellular oxidant detoxification, cellular responses to stimuli, cellular responses to stress, and cellular response to chemical stress. * It helps to protect cells from damage caused by ROS generated during oxidative stress. * It also plays a role in the regulation of inflammation and cell survival. * Studies have shown that GPX3 deficiency leads to increased oxidative stress and cell death. **Clinical significance:** * Mutations in the GPX3 gene have been linked to several human diseases, including cancer and neurodegenerative disorders. * GPX3 inhibitors are being investigated as potential treatments for these diseases. * Understanding the role of GPX3 in cellular defense could lead to the development of new strategies for cancer treatment and other diseases that are characterized by oxidative stress.

Genular Protein ID: 4204234968

Symbol: GPX3_HUMAN

Name: Extracellular glutathione peroxidase

UniProtKB Accession Codes:

P22352 O43787 Q86W78 Q9NZ74 Q9UEL1

Database IDs:

AGR 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 11 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2229017

Title: Primary structure of human plasma glutathione peroxidase deduced from cDNA sequences.

PubMed ID: 2229017

DOI: 10.1093/oxfordjournals.jbchem.a123172

PubMed ID: 1339300

Title: Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents.

PubMed ID: 1339300

PubMed ID: 8056346

Title: The human plasma glutathione peroxidase-encoding gene: organization, sequence and localization to chromosome 5q32.

PubMed ID: 8056346

DOI: 10.1016/0378-1119(94)90023-x

PubMed ID: 10970826

Title: Differential induction of extracellular glutathione peroxidase and nitric oxide synthase 2 in airways of healthy individuals exposed to 100% O(2) or cigarette smoke.

PubMed ID: 10970826

DOI: 10.1165/ajrcmb.23.3.4076

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1897960

Title: Characterization and partial amino acid sequence of human plasma glutathione peroxidase.

PubMed ID: 1897960

DOI: 10.1016/0003-9861(91)90048-n

Sequence Information:

  • Length: 226
  • Mass: 25552
  • Checksum: A839E87A5CDB51A9
  • Sequence:
    • MARLLQASCL LSLLLAGFVS QSRGQEKSKM DCHGGISGTI YEYGALTIDG EEYIPFKQYA 
GKYVLFVNVA SYUGLTGQYI ELNALQEELA PFGLVILGFP CNQFGKQEPG ENSEILPTLK 
YVRPGGGFVP NFQLFEKGDV NGEKEQKFYT FLKNSCPPTS ELLGTSDRLF WEPMKVHDIR 
WNFEKFLVGP DGIPIMRWHH RTTVSNVKMD ILSYMRRQAA LGVKRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.