Details for: GPX7

Gene ID: 2882

Symbol: GPX7

Ensembl ID: ENSG00000116157

Description: glutathione peroxidase 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 98.5565
    Cell Significance Index: -15.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.0743
    Cell Significance Index: -9.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.7624
    Cell Significance Index: -15.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.4416
    Cell Significance Index: -15.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.9988
    Cell Significance Index: -16.0700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.1916
    Cell Significance Index: 53.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9533
    Cell Significance Index: -15.6000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.6877
    Cell Significance Index: 22.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.9133
    Cell Significance Index: 60.9800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.4854
    Cell Significance Index: 27.0200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.1906
    Cell Significance Index: 17.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2181
    Cell Significance Index: 42.3300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.1611
    Cell Significance Index: 6.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0732
    Cell Significance Index: 69.2400
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.9438
    Cell Significance Index: 5.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7425
    Cell Significance Index: 19.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7318
    Cell Significance Index: 15.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6312
    Cell Significance Index: 62.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5560
    Cell Significance Index: 16.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4754
    Cell Significance Index: 28.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4418
    Cell Significance Index: 398.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4242
    Cell Significance Index: 58.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4005
    Cell Significance Index: 43.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3900
    Cell Significance Index: 50.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3495
    Cell Significance Index: 9.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3405
    Cell Significance Index: 40.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3283
    Cell Significance Index: 53.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2864
    Cell Significance Index: 56.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2695
    Cell Significance Index: 4.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2454
    Cell Significance Index: 13.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2061
    Cell Significance Index: 5.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1836
    Cell Significance Index: 12.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1617
    Cell Significance Index: 20.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1306
    Cell Significance Index: 71.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1218
    Cell Significance Index: 53.8300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1198
    Cell Significance Index: 1.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1011
    Cell Significance Index: 17.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1001
    Cell Significance Index: 62.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0923
    Cell Significance Index: 6.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0541
    Cell Significance Index: 1.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0519
    Cell Significance Index: 9.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0499
    Cell Significance Index: 10.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0436
    Cell Significance Index: 15.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0352
    Cell Significance Index: 0.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0344
    Cell Significance Index: 0.9900
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.0305
    Cell Significance Index: 0.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0217
    Cell Significance Index: 2.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0183
    Cell Significance Index: 12.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0178
    Cell Significance Index: 2.0700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0124
    Cell Significance Index: 1.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0059
    Cell Significance Index: -11.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0067
    Cell Significance Index: -0.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0090
    Cell Significance Index: -6.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0097
    Cell Significance Index: -5.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0112
    Cell Significance Index: -20.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0115
    Cell Significance Index: -8.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0128
    Cell Significance Index: -19.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0157
    Cell Significance Index: -21.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0185
    Cell Significance Index: -11.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0199
    Cell Significance Index: -1.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0214
    Cell Significance Index: -3.8500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0224
    Cell Significance Index: -0.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0232
    Cell Significance Index: -0.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0287
    Cell Significance Index: -3.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0295
    Cell Significance Index: -0.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0309
    Cell Significance Index: -3.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0328
    Cell Significance Index: -14.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0331
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0355
    Cell Significance Index: -7.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0381
    Cell Significance Index: -10.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0525
    Cell Significance Index: -7.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0687
    Cell Significance Index: -3.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0887
    Cell Significance Index: -2.4800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1112
    Cell Significance Index: -0.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1170
    Cell Significance Index: -3.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1289
    Cell Significance Index: -6.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1311
    Cell Significance Index: -8.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1358
    Cell Significance Index: -10.4200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1492
    Cell Significance Index: -0.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1503
    Cell Significance Index: -15.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1507
    Cell Significance Index: -11.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1622
    Cell Significance Index: -5.2000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1735
    Cell Significance Index: -0.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1739
    Cell Significance Index: -10.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1837
    Cell Significance Index: -14.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1850
    Cell Significance Index: -4.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2055
    Cell Significance Index: -13.8200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2073
    Cell Significance Index: -2.9500
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.2099
    Cell Significance Index: -1.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2200
    Cell Significance Index: -6.4800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2269
    Cell Significance Index: -1.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2509
    Cell Significance Index: -6.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2550
    Cell Significance Index: -13.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2663
    Cell Significance Index: -10.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2733
    Cell Significance Index: -12.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2736
    Cell Significance Index: -13.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2774
    Cell Significance Index: -12.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2795
    Cell Significance Index: -6.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2830
    Cell Significance Index: -1.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPX7 belongs to the glutathione peroxidase family, which consists of enzymes that catalyze the reduction of hydrogen peroxide and other ROS using glutathione as a cofactor. GPX7 exhibits catalase activity, which is essential for maintaining cellular redox balance. The enzyme is also involved in cellular responses to stimuli, stress, and chemical stress, highlighting its role in regulating cellular homeostasis. GPX7 is widely expressed in various tissues, including enterocytes, interstitial cells of the ovary, and epithelial cells of the nephron, suggesting its involvement in maintaining tissue homeostasis. **Pathways and Functions:** GPX7 is involved in several key pathways, including: 1. **Catalase activity:** GPX7 catalyzes the reduction of hydrogen peroxide and other ROS, thereby protecting cells from oxidative damage. 2. **Cellular oxidant detoxification:** GPX7 plays a crucial role in detoxifying ROS, which are reactive molecules that can cause cellular damage. 3. **Cellular responses to stimuli:** GPX7 is involved in regulating cellular responses to stress, including heat shock, oxidative stress, and chemical stress. 4. **Cellular response to chemical stress:** GPX7 helps to protect cells from chemical stress, such as exposure to toxic substances. 5. **Cellular response to oxidative stress:** GPX7 is essential for maintaining cellular homeostasis in the face of oxidative stress, which can cause cellular damage and death. **Clinical Significance:** GPX7 has been implicated in several diseases and disorders, including: 1. **Oxidative stress-related disorders:** GPX7 has been shown to play a role in the pathogenesis of oxidative stress-related disorders, such as atherosclerosis, cancer, and neurodegenerative diseases. 2. **Inflammatory disorders:** GPX7 has been implicated in inflammatory disorders, such as arthritis and asthma, where oxidative stress plays a key role. 3. **Cancer:** GPX7 has been shown to have anti-cancer properties, and its expression is often downregulated in cancer tissues. 4. **Neurodegenerative diseases:** GPX7 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where oxidative stress plays a key role. In conclusion, GPX7 is an essential enzyme that plays a crucial role in maintaining cellular homeostasis by regulating cellular responses to stress, detoxification, and catalase activity. Its clinical significance is evident in its involvement in various diseases and disorders, including oxidative stress-related disorders, inflammatory disorders, cancer, and neurodegenerative diseases. Further research is needed to fully elucidate the role of GPX7 in human health and disease.

Genular Protein ID: 3708635036

Symbol: GPX7_HUMAN

Name: Glutathione peroxidase 7

UniProtKB Accession Codes:

Q96SL4 O95337 Q5T501

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22157330

Title: Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells.

PubMed ID: 22157330

DOI: 10.1136/gutjnl-2011-301078

Sequence Information:

  • Length: 187
  • Mass: 20996
  • Checksum: 0ACB80AC2522EFCD
  • Sequence:
    • MVAATVAAAW LLLWAAACAQ QEQDFYDFKA VNIRGKLVSL EKYRGSVSLV VNVASECGFT 
DQHYRALQQL QRDLGPHHFN VLAFPCNQFG QQEPDSNKEI ESFARRTYSV SFPMFSKIAV 
TGTGAHPAFK YLAQTSGKEP TWNFWKYLVA PDGKVVGAWD PTVSVEEVRP QITALVRKLI 
LLKREDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.