Details for: GPX7

Gene ID: 2882

Symbol: GPX7

Ensembl ID: ENSG00000116157

Description: glutathione peroxidase 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.24
    Marker Score: 3452.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2
    Marker Score: 13000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.83
    Marker Score: 24146
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.8
    Marker Score: 511
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.54
    Marker Score: 2695
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.46
    Marker Score: 3049
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.42
    Marker Score: 15969
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.29
    Marker Score: 3047
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.27
    Marker Score: 1267
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.23
    Marker Score: 1239
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.22
    Marker Score: 813
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.2
    Marker Score: 581
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.18
    Marker Score: 2014
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.16
    Marker Score: 1094
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.16
    Marker Score: 271
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.15
    Marker Score: 11684
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4750.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.12
    Marker Score: 1957
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.11
    Marker Score: 4775.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.09
    Marker Score: 1162
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.07
    Marker Score: 2914.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.07
    Marker Score: 1469
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.07
    Marker Score: 4359
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.06
    Marker Score: 521
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.06
    Marker Score: 996
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.04
    Marker Score: 10507
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.04
    Marker Score: 573
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.03
    Marker Score: 356
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.02
    Marker Score: 1082
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71757
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47981
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.98
    Marker Score: 1303
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.98
    Marker Score: 1506
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.96
    Marker Score: 610
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.96
    Marker Score: 600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.96
    Marker Score: 1153
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.91
    Marker Score: 1312
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.91
    Marker Score: 220
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2711
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.9
    Marker Score: 688
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 355
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.88
    Marker Score: 309
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5250
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.87
    Marker Score: 359
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.86
    Marker Score: 930
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4857
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.84
    Marker Score: 2278.5
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.83
    Marker Score: 339
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.82
    Marker Score: 980.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.81
    Marker Score: 308
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.79
    Marker Score: 5024
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.78
    Marker Score: 257
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.77
    Marker Score: 248
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 578
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.75
    Marker Score: 472.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.75
    Marker Score: 624
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 681
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.74
    Marker Score: 250
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.74
    Marker Score: 1913
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.72
    Marker Score: 342
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.71
    Marker Score: 875
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.7
    Marker Score: 163
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.7
    Marker Score: 224
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.7
    Marker Score: 505
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.67
    Marker Score: 345
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.66
    Marker Score: 453
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.66
    Marker Score: 933
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.66
    Marker Score: 168
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.66
    Marker Score: 479
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.65
    Marker Score: 2573
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.64
    Marker Score: 160
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.63
    Marker Score: 462
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.63
    Marker Score: 1857
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.62
    Marker Score: 143
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.62
    Marker Score: 656
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.62
    Marker Score: 305
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.61
    Marker Score: 9602.5
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.6
    Marker Score: 358
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.6
    Marker Score: 3539
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.59
    Marker Score: 313
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.58
    Marker Score: 654
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.58
    Marker Score: 414
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.58
    Marker Score: 1102
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.58
    Marker Score: 2132
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.57
    Marker Score: 325
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.57
    Marker Score: 171
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.56
    Marker Score: 303
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.56
    Marker Score: 317
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.56
    Marker Score: 134
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.56
    Marker Score: 1465
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.56
    Marker Score: 294
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.55
    Marker Score: 276

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Other Information

**Key characteristics:** - GPX7 is a member of the glutathione peroxidase family of enzymes. - It is a highly conserved protein with a conserved catalytic domain. - It is expressed in high levels in the colon, suggesting a role in protecting the gut from oxidative damage. **Pathways and functions:** - GPX7 is involved in multiple cellular pathways, including: - Catalase activity: It catalyzes the reduction of hydrogen peroxide to water, protecting cells from oxidative damage. - Cellular oxidant detoxification: It helps remove harmful reactive oxygen species (ROS) produced by other antioxidant defenses. - Cellular responses to stimuli: It is involved in the regulation of inflammation and immune responses. - Cellular response to stress: It helps protect cells from damage caused by stress factors. - Cellular response to chemical stress: It detoxifies harmful chemicals, such as hydrogen peroxide and ammonia. - Detoxification of reactive oxygen species: It plays a crucial role in protecting cells from oxidative damage caused by ROS generated during cellular metabolism. **Clinical significance:** - Mutations in the GPX7 gene have been linked to an increased risk of certain diseases, including colorectal cancer, liver disease, and neurodegenerative disorders. - GPX7 inhibitors are being investigated as potential cancer drugs. - Studies on animal models have shown that GPX7 deficiency enhances cancer cell survival and metastasis. **Additional notes:** - GPX7 is a relatively new protein, with most of the sequence identified in the last decade. - It is a highly regulated protein, with its expression being controlled by various factors, including the redox environment, cellular stress, and inflammation.

Genular Protein ID: 3708635036

Symbol: GPX7_HUMAN

Name: Glutathione peroxidase 7

UniProtKB Accession Codes:

Q96SL4 O95337 Q5T501

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22157330

Title: Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells.

PubMed ID: 22157330

DOI: 10.1136/gutjnl-2011-301078

Sequence Information:

  • Length: 187
  • Mass: 20996
  • Checksum: 0ACB80AC2522EFCD
  • Sequence:
    • MVAATVAAAW LLLWAAACAQ QEQDFYDFKA VNIRGKLVSL EKYRGSVSLV VNVASECGFT 
DQHYRALQQL QRDLGPHHFN VLAFPCNQFG QQEPDSNKEI ESFARRTYSV SFPMFSKIAV 
TGTGAHPAFK YLAQTSGKEP TWNFWKYLVA PDGKVVGAWD PTVSVEEVRP QITALVRKLI 
LLKREDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.