Details for: CCDC22

Gene ID: 28952

Symbol: CCDC22

Ensembl ID: ENSG00000101997

Description: coiled-coil domain containing 22

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 73.6763
    Cell Significance Index: -11.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.8377
    Cell Significance Index: -9.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 28.4248
    Cell Significance Index: -13.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.1841
    Cell Significance Index: -11.4500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 20.0739
    Cell Significance Index: -13.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.1289
    Cell Significance Index: -11.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.6922
    Cell Significance Index: -11.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5836
    Cell Significance Index: -9.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1170
    Cell Significance Index: -12.3000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.0572
    Cell Significance Index: -9.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.7911
    Cell Significance Index: -3.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0422
    Cell Significance Index: 941.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9681
    Cell Significance Index: 58.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6373
    Cell Significance Index: 103.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6221
    Cell Significance Index: 40.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4706
    Cell Significance Index: 32.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4443
    Cell Significance Index: 23.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3320
    Cell Significance Index: 4.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3078
    Cell Significance Index: 9.0400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2345
    Cell Significance Index: 3.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2208
    Cell Significance Index: 6.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2156
    Cell Significance Index: 10.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2110
    Cell Significance Index: 13.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1842
    Cell Significance Index: 8.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1817
    Cell Significance Index: 4.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1805
    Cell Significance Index: 98.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1686
    Cell Significance Index: 19.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1673
    Cell Significance Index: 4.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1540
    Cell Significance Index: 18.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1516
    Cell Significance Index: 30.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1352
    Cell Significance Index: 24.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1271
    Cell Significance Index: 16.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1183
    Cell Significance Index: 8.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1157
    Cell Significance Index: 15.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1052
    Cell Significance Index: 46.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0982
    Cell Significance Index: 5.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0962
    Cell Significance Index: 19.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0747
    Cell Significance Index: 5.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0702
    Cell Significance Index: 3.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0549
    Cell Significance Index: 7.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0540
    Cell Significance Index: 19.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0424
    Cell Significance Index: 29.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0415
    Cell Significance Index: 4.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0399
    Cell Significance Index: 7.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0259
    Cell Significance Index: 0.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0233
    Cell Significance Index: 0.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0129
    Cell Significance Index: 0.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0006
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0058
    Cell Significance Index: -10.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0063
    Cell Significance Index: -9.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0067
    Cell Significance Index: -4.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0071
    Cell Significance Index: -1.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0074
    Cell Significance Index: -5.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0095
    Cell Significance Index: -0.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0099
    Cell Significance Index: -13.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0108
    Cell Significance Index: -0.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0121
    Cell Significance Index: -7.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0148
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0160
    Cell Significance Index: -11.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0186
    Cell Significance Index: -8.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0196
    Cell Significance Index: -11.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0233
    Cell Significance Index: -14.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0240
    Cell Significance Index: -0.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0268
    Cell Significance Index: -0.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0313
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0343
    Cell Significance Index: -3.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0376
    Cell Significance Index: -0.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0393
    Cell Significance Index: -1.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0443
    Cell Significance Index: -12.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0492
    Cell Significance Index: -0.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0510
    Cell Significance Index: -7.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0517
    Cell Significance Index: -1.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0535
    Cell Significance Index: -2.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0622
    Cell Significance Index: -7.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0694
    Cell Significance Index: -14.6200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0927
    Cell Significance Index: -0.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1003
    Cell Significance Index: -1.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1053
    Cell Significance Index: -7.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1151
    Cell Significance Index: -11.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1236
    Cell Significance Index: -7.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1290
    Cell Significance Index: -10.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1292
    Cell Significance Index: -2.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1339
    Cell Significance Index: -8.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1370
    Cell Significance Index: -7.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1389
    Cell Significance Index: -3.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1562
    Cell Significance Index: -2.3400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1610
    Cell Significance Index: -1.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1613
    Cell Significance Index: -2.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1732
    Cell Significance Index: -7.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2051
    Cell Significance Index: -7.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2200
    Cell Significance Index: -6.4800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2239
    Cell Significance Index: -3.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2328
    Cell Significance Index: -3.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2698
    Cell Significance Index: -9.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2711
    Cell Significance Index: -7.7700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2726
    Cell Significance Index: -3.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2736
    Cell Significance Index: -9.6200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2888
    Cell Significance Index: -2.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2917
    Cell Significance Index: -9.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CCDC22 is a coiled-coil domain-containing protein, which suggests its involvement in protein-protein interactions and structural integrity. Its significant expression in various cell types indicates a broad range of cellular functions. Notably, CCDC22 is involved in the regulation of NF-κB signaling pathways, which is crucial for immune responses and inflammation. Additionally, its role in protein binding, transport, and modification suggests its involvement in various cellular processes, including endocytic recycling and protein homeostasis. **Pathways and Functions:** CCDC22 is involved in several cellular pathways, including: 1. **NF-κB signaling:** CCDC22 acts as a positive regulator of canonical NF-κB signaling, which is essential for immune responses and inflammation. 2. **Protein binding and transport:** CCDC22 interacts with various proteins, including Cullin family proteins, and regulates their transport and modification. 3. **Endocytic recycling:** CCDC22 is involved in the regulation of endocytic recycling, which is crucial for maintaining cellular homeostasis and immune function. 4. **Intracellular copper ion homeostasis:** CCDC22 plays a role in regulating intracellular copper ion homeostasis, which is essential for maintaining cellular function and immune responses. **Clinical Significance:** The clinical significance of CCDC22 lies in its involvement in various immune-related disorders, including: 1. **Autoimmune diseases:** CCDC22's role in regulating NF-κB signaling pathways suggests its involvement in autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** CCDC22's involvement in protein binding and transport suggests its potential role in cancer development and progression. 3. **Neurological disorders:** CCDC22's expression in GABAergic interneurons and its role in regulating NF-κB signaling pathways suggest its potential involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CCDC22 is a complex protein involved in various cellular processes, including protein binding, transport, and modification, as well as regulation of NF-κB signaling pathways. Its clinical significance lies in its potential involvement in immune-related disorders, including autoimmune diseases, cancer, and neurological disorders. Further research is necessary to fully elucidate the role of CCDC22 in human health and disease.

Genular Protein ID: 1743701678

Symbol: CCD22_HUMAN

Name: Coiled-coil domain-containing protein 22

UniProtKB Accession Codes:

O60826 A8K7G1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 5 Ensembl 1 ExpressionAtlas 1 GO 13 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24916641

Title: Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome.

PubMed ID: 24916641

DOI: 10.1038/ejhg.2014.109

PubMed ID: 21826058

Title: CCDC22: a novel candidate gene for syndromic X-linked intellectual disability.

PubMed ID: 21826058

DOI: 10.1038/mp.2011.95

PubMed ID: 23563313

Title: CCDC22 deficiency in humans blunts activation of proinflammatory NF-kappaB signaling.

PubMed ID: 23563313

DOI: 10.1172/jci66466

PubMed ID: 26638075

Title: A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.

PubMed ID: 26638075

DOI: 10.1016/j.cell.2015.10.065

PubMed ID: 25355947

Title: COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.

PubMed ID: 25355947

DOI: 10.1091/mbc.e14-06-1073

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28892079

Title: Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

PubMed ID: 28892079

DOI: 10.1038/ncb3610

PubMed ID: 23092983

Title: Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE.

PubMed ID: 23092983

DOI: 10.1038/tp.2012.102

Sequence Information:

  • Length: 627
  • Mass: 70756
  • Checksum: C3704BBCD9EA0386
  • Sequence:
    • MEEADRILIH SLRQAGTAVP PDVQTLRAFT TELVVEAVVR CLRVINPAVG SGLSPLLPLA 
MSARFRLAMS LAQACMDLGY PLELGYQNFL YPSEPDLRDL LLFLAERLPT DASEDADQPA 
GDSAILLRAI GSQIRDQLAL PWVPPHLRTP KLQHLQGSAL QKPFHASRLV VPELSSRGEP 
REFQASPLLL PVPTQVPQPV GRVASLLEHH ALQLCQQTGR DRPGDEDWVH RTSRLPPQED 
TRAQRQRLQK QLTEHLRQSW GLLGAPIQAR DLGELLQAWG AGAKTGAPKG SRFTHSEKFT 
FHLEPQAQAT QVSDVPATSR RPEQVTWAAQ EQELESLREQ LEGVNRSIEE VEADMKTLGV 
SFVQAESECR HSKLSTAERE QALRLKSRAV ELLPDGTANL AKLQLVVENS AQRVIHLAGQ 
WEKHRVPLLA EYRHLRKLQD CRELESSRRL AEIQELHQSV RAAAEEARRK EEVYKQLMSE 
LETLPRDVSR LAYTQRILEI VGNIRKQKEE ITKILSDTKE LQKEINSLSG KLDRTFAVTD 
ELVFKDAKKD DAVRKAYKYL AALHENCSQL IQTIEDTGTI MREVRDLEEQ IETELGKKTL 
SNLEKIREDY RALRQENAGL LGRVREA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.