Details for: DCPS
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 103.9569
Cell Significance Index: -16.1700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 58.9016
Cell Significance Index: -14.9400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 40.4344
Cell Significance Index: -19.0900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 37.6955
Cell Significance Index: -19.3900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 28.6131
Cell Significance Index: -19.2000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 14.8424
Cell Significance Index: -18.3000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.7795
Cell Significance Index: -18.8600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.2369
Cell Significance Index: -11.3500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.1804
Cell Significance Index: -12.8400 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.9654
Cell Significance Index: -6.4900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.1629
Cell Significance Index: 29.5100 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.7483
Cell Significance Index: 29.4500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.7476
Cell Significance Index: 172.8800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.3471
Cell Significance Index: 156.9900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.3471
Cell Significance Index: 69.9800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.2228
Cell Significance Index: 73.4100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.0409
Cell Significance Index: 30.5700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8855
Cell Significance Index: 144.0200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.6246
Cell Significance Index: 73.6600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6146
Cell Significance Index: 42.5100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4628
Cell Significance Index: 21.5800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4117
Cell Significance Index: 74.2200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3854
Cell Significance Index: 76.4900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3678
Cell Significance Index: 73.7900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3078
Cell Significance Index: 19.4000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2994
Cell Significance Index: 36.8200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2547
Cell Significance Index: 11.9700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2417
Cell Significance Index: 33.1900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2359
Cell Significance Index: 15.2200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2357
Cell Significance Index: 10.6900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2138
Cell Significance Index: 40.6900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1970
Cell Significance Index: 87.0900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1880
Cell Significance Index: 102.6800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.1748
Cell Significance Index: 2.5800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1658
Cell Significance Index: 21.2600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1634
Cell Significance Index: 3.5400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1601
Cell Significance Index: 57.4200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1380
Cell Significance Index: 9.7600 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.1232
Cell Significance Index: 1.0400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1076
Cell Significance Index: 74.4300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0947
Cell Significance Index: 1.5900 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.0837
Cell Significance Index: 0.9100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0795
Cell Significance Index: 2.1300 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0768
Cell Significance Index: 9.9300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0732
Cell Significance Index: 137.8300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0430
Cell Significance Index: 1.1700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0425
Cell Significance Index: 1.3600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0343
Cell Significance Index: 5.8600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0334
Cell Significance Index: 21.2100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0293
Cell Significance Index: 2.2500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0188
Cell Significance Index: 16.9900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0124
Cell Significance Index: 9.0900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0076
Cell Significance Index: 0.1600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0060
Cell Significance Index: 0.2100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0060
Cell Significance Index: 0.1600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0040
Cell Significance Index: -7.3400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0061
Cell Significance Index: -0.1800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0062
Cell Significance Index: -9.5000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0075
Cell Significance Index: -5.6600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0096
Cell Significance Index: -13.0000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0164
Cell Significance Index: -1.6800 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0227
Cell Significance Index: -0.5800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0228
Cell Significance Index: -16.9200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0275
Cell Significance Index: -2.0500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0277
Cell Significance Index: -12.5500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0297
Cell Significance Index: -16.7500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0352
Cell Significance Index: -21.9800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0386
Cell Significance Index: -1.0800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0451
Cell Significance Index: -0.9600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0454
Cell Significance Index: -6.6000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0499
Cell Significance Index: -14.3700 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0624
Cell Significance Index: -0.5800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0781
Cell Significance Index: -4.3800 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0788
Cell Significance Index: -1.1800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0989
Cell Significance Index: -2.6500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1047
Cell Significance Index: -22.0500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1054
Cell Significance Index: -12.0800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1284
Cell Significance Index: -3.3000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1347
Cell Significance Index: -4.6800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1435
Cell Significance Index: -8.8200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1544
Cell Significance Index: -10.3900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1590
Cell Significance Index: -4.1800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1634
Cell Significance Index: -12.9500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1682
Cell Significance Index: -17.5200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1745
Cell Significance Index: -9.1600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2072
Cell Significance Index: -10.4700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2331
Cell Significance Index: -10.3100 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.2645
Cell Significance Index: -3.7100 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.2803
Cell Significance Index: -3.9900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2960
Cell Significance Index: -11.2100 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.2983
Cell Significance Index: -4.5300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2988
Cell Significance Index: -5.1200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3138
Cell Significance Index: -19.2400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3145
Cell Significance Index: -5.8100 - Cell Name: peg cell (CL4033014)
Fold Change: -0.3502
Cell Significance Index: -8.0900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3882
Cell Significance Index: -5.5600 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4040
Cell Significance Index: -11.9000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4089
Cell Significance Index: -11.7200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4169
Cell Significance Index: -14.6100 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4340
Cell Significance Index: -15.9300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2624088522
Symbol: DCPS_HUMAN
Name: m7GpppX diphosphatase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12198172
Title: The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases.
PubMed ID: 12198172
DOI: 10.1093/emboj/cdf448
PubMed ID: 12871939
Title: Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1.
PubMed ID: 12871939
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11747811
Title: Functional link between the mammalian exosome and mRNA decapping.
PubMed ID: 11747811
PubMed ID: 14523240
Title: DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway.
PubMed ID: 14523240
PubMed ID: 15273322
Title: Functional analysis of mRNA scavenger decapping enzymes.
PubMed ID: 15273322
DOI: 10.1261/rna.7660804
PubMed ID: 15383679
Title: Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and characterization of C. elegans scavenger DcpS.
PubMed ID: 15383679
DOI: 10.1261/rna.7690504
PubMed ID: 16140270
Title: Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity.
PubMed ID: 16140270
PubMed ID: 18426921
Title: DcpS scavenger decapping enzyme can modulate pre-mRNA splicing.
PubMed ID: 18426921
DOI: 10.1261/rna.1008208
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 18725266
Title: Proteomic approach to the identification of novel delta-lactoferrin target genes: Characterization of DcpS, an mRNA scavenger decapping enzyme.
PubMed ID: 18725266
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22985415
Title: 7-Methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (dcpS) enzymes and potently inhibits their activity.
PubMed ID: 22985415
DOI: 10.1021/bi300781g
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25712129
Title: Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defects.
PubMed ID: 25712129
DOI: 10.1093/hmg/ddv067
PubMed ID: 25701870
Title: Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment.
PubMed ID: 25701870
DOI: 10.1093/hmg/ddv069
PubMed ID: 15068804
Title: Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity.
PubMed ID: 15068804
PubMed ID: 15769464
Title: Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.
PubMed ID: 15769464
PubMed ID: 18839960
Title: DcpS as a therapeutic target for spinal muscular atrophy.
PubMed ID: 18839960
DOI: 10.1021/cb800120t
Sequence Information:
- Length: 337
- Mass: 38609
- Checksum: C9C5A33C212D7A52
- Sequence:
MADAAPQLGK RKRELDVEEA HAASTEEKEA GVGNGTCAPV RLPFSGFRLQ KVLRESARDK IIFLHGKVNE ASGDGDGEDA VVILEKTPFQ VEQVAQLLTG SPELQLQFSN DIYSTYHLFP PRQLNDVKTT VVYPATEKHL QKYLRQDLRL IRETGDDYRN ITLPHLESQS LSIQWVYNIL DKKAEADRIV FENPDPSDGF VLIPDLKWNQ QQLDDLYLIA ICHRRGIRSL RDLTPEHLPL LRNILHQGQE AILQRYRMKG DHLRVYLHYL PSYYHLHVHF TALGFEAPGS GVERAHLLAE VIENLECDPR HYQQRTLTFA LRADDPLLKL LQEAQQS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.