Details for: DCPS

Gene ID: 28960

Symbol: DCPS

Ensembl ID: ENSG00000110063

Description: decapping enzyme, scavenger

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 103.9569
    Cell Significance Index: -16.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.9016
    Cell Significance Index: -14.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.4344
    Cell Significance Index: -19.0900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 37.6955
    Cell Significance Index: -19.3900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 28.6131
    Cell Significance Index: -19.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.8424
    Cell Significance Index: -18.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7795
    Cell Significance Index: -18.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.2369
    Cell Significance Index: -11.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.1804
    Cell Significance Index: -12.8400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.9654
    Cell Significance Index: -6.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1629
    Cell Significance Index: 29.5100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.7483
    Cell Significance Index: 29.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7476
    Cell Significance Index: 172.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3471
    Cell Significance Index: 156.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3471
    Cell Significance Index: 69.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2228
    Cell Significance Index: 73.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0409
    Cell Significance Index: 30.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8855
    Cell Significance Index: 144.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6246
    Cell Significance Index: 73.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6146
    Cell Significance Index: 42.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4628
    Cell Significance Index: 21.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4117
    Cell Significance Index: 74.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3854
    Cell Significance Index: 76.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3678
    Cell Significance Index: 73.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3078
    Cell Significance Index: 19.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2994
    Cell Significance Index: 36.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2547
    Cell Significance Index: 11.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2417
    Cell Significance Index: 33.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2359
    Cell Significance Index: 15.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2357
    Cell Significance Index: 10.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2138
    Cell Significance Index: 40.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1970
    Cell Significance Index: 87.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1880
    Cell Significance Index: 102.6800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1748
    Cell Significance Index: 2.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1658
    Cell Significance Index: 21.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1634
    Cell Significance Index: 3.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1601
    Cell Significance Index: 57.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1380
    Cell Significance Index: 9.7600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1232
    Cell Significance Index: 1.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1076
    Cell Significance Index: 74.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0947
    Cell Significance Index: 1.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0837
    Cell Significance Index: 0.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0795
    Cell Significance Index: 2.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0768
    Cell Significance Index: 9.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0732
    Cell Significance Index: 137.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0430
    Cell Significance Index: 1.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0425
    Cell Significance Index: 1.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0343
    Cell Significance Index: 5.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0334
    Cell Significance Index: 21.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0293
    Cell Significance Index: 2.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0188
    Cell Significance Index: 16.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0124
    Cell Significance Index: 9.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0076
    Cell Significance Index: 0.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0060
    Cell Significance Index: 0.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0060
    Cell Significance Index: 0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0040
    Cell Significance Index: -7.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0061
    Cell Significance Index: -0.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0062
    Cell Significance Index: -9.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0096
    Cell Significance Index: -13.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0164
    Cell Significance Index: -1.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0227
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0228
    Cell Significance Index: -16.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0275
    Cell Significance Index: -2.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0277
    Cell Significance Index: -12.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0297
    Cell Significance Index: -16.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0352
    Cell Significance Index: -21.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0386
    Cell Significance Index: -1.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0451
    Cell Significance Index: -0.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0454
    Cell Significance Index: -6.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0499
    Cell Significance Index: -14.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0624
    Cell Significance Index: -0.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0781
    Cell Significance Index: -4.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0788
    Cell Significance Index: -1.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0989
    Cell Significance Index: -2.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1047
    Cell Significance Index: -22.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1054
    Cell Significance Index: -12.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1284
    Cell Significance Index: -3.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1347
    Cell Significance Index: -4.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1435
    Cell Significance Index: -8.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1544
    Cell Significance Index: -10.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1590
    Cell Significance Index: -4.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1634
    Cell Significance Index: -12.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1682
    Cell Significance Index: -17.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1745
    Cell Significance Index: -9.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2072
    Cell Significance Index: -10.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2331
    Cell Significance Index: -10.3100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2645
    Cell Significance Index: -3.7100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2803
    Cell Significance Index: -3.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2960
    Cell Significance Index: -11.2100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2983
    Cell Significance Index: -4.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2988
    Cell Significance Index: -5.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3138
    Cell Significance Index: -19.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3145
    Cell Significance Index: -5.8100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3502
    Cell Significance Index: -8.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3882
    Cell Significance Index: -5.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4040
    Cell Significance Index: -11.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4089
    Cell Significance Index: -11.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4169
    Cell Significance Index: -14.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4340
    Cell Significance Index: -15.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic activity:** DCPS is a decapping enzyme that catalyzes the removal of the 5' cap from mRNA, a process essential for regulating gene expression. 2. **Expression pattern:** DCPS is widely expressed in various cell types, including extravillous trophoblast, mural cell, bladder urothelial cell, and blood cells. 3. **Subcellular localization:** DCPS is primarily localized to the cytosol and nucleus, where it regulates mRNA decapping and degradation. 4. **Protein-protein interactions:** DCPS interacts with various proteins, including the mRNA decapping complex, to facilitate mRNA decapping. **Pathways and Functions:** 1. **Deadenylation-dependent decapping of mRNA:** DCPS catalyzes the removal of the 5' cap from mRNA, a critical step in regulating gene expression. 2. **RNA degradation:** DCPS is involved in the degradation of deadenylated mRNA, a process that ensures the removal of aberrant or excess mRNAs. 3. **Metabolic regulation:** DCPS regulates metabolic processes by controlling the degradation of mRNAs involved in energy metabolism, growth, and differentiation. 4. **Cellular homeostasis:** DCPS maintains cellular homeostasis by regulating gene expression and ensuring the proper degradation of mRNAs. **Clinical Significance:** 1. **Disease association:** Alterations in DCPS expression have been linked to various diseases, including cancer, where DCPS dysregulation contributes to tumorigenesis and tumor progression. 2. **Therapeutic potential:** Targeting DCPS may provide a novel therapeutic approach for treating diseases associated with DCPS dysregulation. 3. **Cancer biomarker:** DCPS may serve as a potential biomarker for cancer diagnosis and prognosis, as its expression is often altered in cancer cells. 4. **Regulation of gene expression:** DCPS plays a critical role in regulating gene expression, and its dysregulation may contribute to various diseases. In conclusion, DCPS is a crucial enzyme involved in regulating mRNA decapping and degradation, and its dysregulation has been linked to various diseases. Further research is necessary to fully elucidate the role of DCPS in cellular homeostasis and to explore its therapeutic potential.

Genular Protein ID: 2624088522

Symbol: DCPS_HUMAN

Name: m7GpppX diphosphatase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12198172

Title: The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases.

PubMed ID: 12198172

DOI: 10.1093/emboj/cdf448

PubMed ID: 12871939

Title: Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1.

PubMed ID: 12871939

DOI: 10.1074/jbc.m306355200

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11747811

Title: Functional link between the mammalian exosome and mRNA decapping.

PubMed ID: 11747811

DOI: 10.1016/s0092-8674(01)00592-x

PubMed ID: 14523240

Title: DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway.

PubMed ID: 14523240

DOI: 10.1073/pnas.1635192100

PubMed ID: 15273322

Title: Functional analysis of mRNA scavenger decapping enzymes.

PubMed ID: 15273322

DOI: 10.1261/rna.7660804

PubMed ID: 15383679

Title: Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and characterization of C. elegans scavenger DcpS.

PubMed ID: 15383679

DOI: 10.1261/rna.7690504

PubMed ID: 16140270

Title: Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity.

PubMed ID: 16140270

DOI: 10.1016/j.bbrc.2005.08.129

PubMed ID: 18426921

Title: DcpS scavenger decapping enzyme can modulate pre-mRNA splicing.

PubMed ID: 18426921

DOI: 10.1261/rna.1008208

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 18725266

Title: Proteomic approach to the identification of novel delta-lactoferrin target genes: Characterization of DcpS, an mRNA scavenger decapping enzyme.

PubMed ID: 18725266

DOI: 10.1016/j.biochi.2008.07.009

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22985415

Title: 7-Methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (dcpS) enzymes and potently inhibits their activity.

PubMed ID: 22985415

DOI: 10.1021/bi300781g

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25712129

Title: Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defects.

PubMed ID: 25712129

DOI: 10.1093/hmg/ddv067

PubMed ID: 25701870

Title: Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment.

PubMed ID: 25701870

DOI: 10.1093/hmg/ddv069

PubMed ID: 15068804

Title: Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity.

PubMed ID: 15068804

DOI: 10.1016/s1097-2765(04)00180-7

PubMed ID: 15769464

Title: Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.

PubMed ID: 15769464

DOI: 10.1016/j.jmb.2005.01.062

PubMed ID: 18839960

Title: DcpS as a therapeutic target for spinal muscular atrophy.

PubMed ID: 18839960

DOI: 10.1021/cb800120t

Sequence Information:

  • Length: 337
  • Mass: 38609
  • Checksum: C9C5A33C212D7A52
  • Sequence:
  • MADAAPQLGK RKRELDVEEA HAASTEEKEA GVGNGTCAPV RLPFSGFRLQ KVLRESARDK 
    IIFLHGKVNE ASGDGDGEDA VVILEKTPFQ VEQVAQLLTG SPELQLQFSN DIYSTYHLFP 
    PRQLNDVKTT VVYPATEKHL QKYLRQDLRL IRETGDDYRN ITLPHLESQS LSIQWVYNIL 
    DKKAEADRIV FENPDPSDGF VLIPDLKWNQ QQLDDLYLIA ICHRRGIRSL RDLTPEHLPL 
    LRNILHQGQE AILQRYRMKG DHLRVYLHYL PSYYHLHVHF TALGFEAPGS GVERAHLLAE 
    VIENLECDPR HYQQRTLTFA LRADDPLLKL LQEAQQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.