Details for: AAMDC

Gene ID: 28971

Symbol: AAMDC

Ensembl ID: ENSG00000087884

Description: adipogenesis associated Mth938 domain containing

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 274.5182
    Cell Significance Index: -42.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 158.4902
    Cell Significance Index: -40.2000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 109.0551
    Cell Significance Index: -44.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.3476
    Cell Significance Index: -45.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 89.2046
    Cell Significance Index: -36.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.1359
    Cell Significance Index: -36.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.4142
    Cell Significance Index: -46.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.2742
    Cell Significance Index: -40.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.9487
    Cell Significance Index: -47.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.1716
    Cell Significance Index: -24.4500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.6860
    Cell Significance Index: -29.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.1125
    Cell Significance Index: 110.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2275
    Cell Significance Index: 60.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9252
    Cell Significance Index: 209.4000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.6730
    Cell Significance Index: 17.7800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.5443
    Cell Significance Index: 23.1400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.5394
    Cell Significance Index: 35.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5133
    Cell Significance Index: 78.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4556
    Cell Significance Index: 19.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1055
    Cell Significance Index: 23.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1007
    Cell Significance Index: 23.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9598
    Cell Significance Index: 866.6000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8931
    Cell Significance Index: 17.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8747
    Cell Significance Index: 173.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7902
    Cell Significance Index: 36.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7749
    Cell Significance Index: 59.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7348
    Cell Significance Index: 19.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7148
    Cell Significance Index: 91.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7099
    Cell Significance Index: 20.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6230
    Cell Significance Index: 85.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6182
    Cell Significance Index: 34.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6110
    Cell Significance Index: 75.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5979
    Cell Significance Index: 44.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5529
    Cell Significance Index: 28.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5265
    Cell Significance Index: 287.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4941
    Cell Significance Index: 48.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4694
    Cell Significance Index: 207.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4567
    Cell Significance Index: 82.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4315
    Cell Significance Index: 19.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4066
    Cell Significance Index: 81.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3414
    Cell Significance Index: 44.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3135
    Cell Significance Index: 22.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2785
    Cell Significance Index: 99.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2596
    Cell Significance Index: 179.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2486
    Cell Significance Index: 3.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1917
    Cell Significance Index: 295.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1371
    Cell Significance Index: 22.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1281
    Cell Significance Index: 236.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1141
    Cell Significance Index: 155.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0978
    Cell Significance Index: 184.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0753
    Cell Significance Index: 2.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0748
    Cell Significance Index: 14.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0732
    Cell Significance Index: 3.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0301
    Cell Significance Index: 22.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0192
    Cell Significance Index: 12.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0040
    Cell Significance Index: 1.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0050
    Cell Significance Index: -0.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0125
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0180
    Cell Significance Index: -3.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0264
    Cell Significance Index: -19.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0550
    Cell Significance Index: -5.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0588
    Cell Significance Index: -43.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0718
    Cell Significance Index: -1.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0776
    Cell Significance Index: -43.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0829
    Cell Significance Index: -51.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0957
    Cell Significance Index: -6.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0965
    Cell Significance Index: -4.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1169
    Cell Significance Index: -33.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1346
    Cell Significance Index: -15.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1353
    Cell Significance Index: -5.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1521
    Cell Significance Index: -22.1200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1953
    Cell Significance Index: -4.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2054
    Cell Significance Index: -5.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2348
    Cell Significance Index: -27.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2465
    Cell Significance Index: -28.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2488
    Cell Significance Index: -52.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2626
    Cell Significance Index: -8.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2762
    Cell Significance Index: -7.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2948
    Cell Significance Index: -7.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3289
    Cell Significance Index: -11.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3341
    Cell Significance Index: -26.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3502
    Cell Significance Index: -3.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3802
    Cell Significance Index: -9.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3846
    Cell Significance Index: -40.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3952
    Cell Significance Index: -19.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4462
    Cell Significance Index: -28.1200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4593
    Cell Significance Index: -6.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4610
    Cell Significance Index: -31.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4830
    Cell Significance Index: -25.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5726
    Cell Significance Index: -15.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5743
    Cell Significance Index: -12.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6147
    Cell Significance Index: -17.6200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6202
    Cell Significance Index: -10.9600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.7172
    Cell Significance Index: -8.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7347
    Cell Significance Index: -21.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7369
    Cell Significance Index: -45.1800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7868
    Cell Significance Index: -8.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.8067
    Cell Significance Index: -8.7700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.8413
    Cell Significance Index: -6.8600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.9500
    Cell Significance Index: -7.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AAMDC is a protein-coding gene, with a single coding sequence that spans approximately 1,000 base pairs. The gene is expressed in multiple cell types, including cortical cells of the adrenal gland, lens epithelial cells, and Leydig cells. Notably, AAMDC is also found in cells of the lens, where it may play a role in maintaining lens homeostasis. The protein's Mth938 domain, which is conserved across species, is a key structural motif that may contribute to its functional properties. **Pathways and Functions:** AAMDC is involved in various cellular processes, including positive regulation of fat cell differentiation (positive regulation of adipogenesis). The protein's role in adipogenesis is thought to be mediated through its interaction with other proteins, such as those involved in the Wnt/β-catenin signaling pathway. Additionally, AAMDC may play a role in maintaining cellular homeostasis, as it is expressed in cells of the lens and adrenal gland, where it may contribute to the regulation of cell growth and differentiation. Furthermore, AAMDC has been implicated in the regulation of protein binding, suggesting that it may act as a scaffold or adapter protein, facilitating interactions between other proteins and modulating cellular signaling pathways. **Clinical Significance:** The clinical significance of AAMDC is an area of ongoing research. Studies have implicated AAMDC in various diseases, including obesity, diabetes, and certain types of cancer. For example, alterations in AAMDC expression have been observed in human adipose tissue, suggesting that the protein may play a role in adipogenesis and metabolic regulation. Additionally, AAMDC has been identified as a potential biomarker for certain types of cancer, including breast and ovarian cancer. Furthermore, AAMDC's role in lens development and maintenance has been proposed, with implications for the treatment of cataracts and other lens-related disorders. Further research is needed to fully elucidate the clinical significance of AAMDC, but its potential as a therapeutic target or biomarker is an area of active investigation. In conclusion, AAMDC is a multifunctional protein with a wide range of cellular expressions and potential roles in adipogenesis, cellular differentiation, and other biological processes. Further research is needed to fully elucidate its functions and clinical significance, but its potential as a therapeutic target or biomarker is an area of active investigation.

Genular Protein ID: 641870701

Symbol: AAMDC_HUMAN

Name: Mth938 domain-containing protein

UniProtKB Accession Codes:

Q9H7C9 Q96AQ4 Q9Y6B1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 6 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 17850744

Title: Ensemble refinement of protein crystal structures: validation and application.

PubMed ID: 17850744

DOI: 10.1016/j.str.2007.06.019

Sequence Information:

  • Length: 122
  • Mass: 13332
  • Checksum: A0C88AD311E62C78
  • Sequence:
    • MTSPEIASLS WGQMKVKGSN TTYKDCKVWP GGSRTWDWRE TGTEHSPGVQ PADVKEVVEK 
GVQTLVIGRG MSEALKVPSS TVEYLKKHGI DVRVLQTEQA VKEYNALVAQ GVRVGGVFHS 
TC

Genular Protein ID: 1458740256

Symbol: E9PLK9_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PLK9

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 137
  • Mass: 15190
  • Checksum: E17D608EF89B6DC2
  • Sequence:
    • MTSPEIASLS WGQMKVKGSN TTYKDCKVWP GGSRTWDWRE TGTEHSPGVQ PADVKEVVEK 
GVQTLVIGRG MSEALKAPTQ QLPSGVHVRA VVQFHLATAS WHILERCKTD QELEQLGVFS 
TLLWTGEGSW TEHQTCL

Genular Protein ID: 3536523980

Symbol: K4DI89_HUMAN

Name: N/A

UniProtKB Accession Codes:

K4DI89

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 147
  • Mass: 16369
  • Checksum: 7CBEAE4100FB9545
  • Sequence:
    • MTSPEIASLS WGQMKVKGSN TTYKDCKVWP GGSRTWDWRE TGTEHSPGVQ PADVKEVVEK 
GVQTLVIGRG MSEALKAPTQ QLPSGVHVRA VVQFHLATAS WHILERCKTG AGLSIKHVCE 
LAMSHLSTFL YQIYDAIILK MHLYFMK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.