Details for: TMEM14A

Gene ID: 28978

Symbol: TMEM14A

Ensembl ID: ENSG00000096092

Description: transmembrane protein 14A

Associated with

  • Apoptotic process
    (GO:0006915)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Mitochondrial membrane
    (GO:0031966)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
    (GO:1901029)
  • Protein binding
    (GO:0005515)
  • Regulation of heme biosynthetic process
    (GO:0070453)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 210.1640
    Cell Significance Index: -32.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 127.0287
    Cell Significance Index: -32.2200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 91.7957
    Cell Significance Index: -37.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 78.3271
    Cell Significance Index: -36.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 55.2441
    Cell Significance Index: -37.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.6604
    Cell Significance Index: -36.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9669
    Cell Significance Index: -26.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.5374
    Cell Significance Index: -37.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.3581
    Cell Significance Index: -22.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.6744
    Cell Significance Index: 311.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.1586
    Cell Significance Index: 56.7600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.7930
    Cell Significance Index: 19.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4813
    Cell Significance Index: 88.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2487
    Cell Significance Index: 1127.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1872
    Cell Significance Index: 61.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0016
    Cell Significance Index: 52.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9967
    Cell Significance Index: 199.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9660
    Cell Significance Index: 123.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7362
    Cell Significance Index: 101.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7338
    Cell Significance Index: 15.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7016
    Cell Significance Index: 24.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6754
    Cell Significance Index: 50.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6666
    Cell Significance Index: 18.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6628
    Cell Significance Index: 40.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6613
    Cell Significance Index: 81.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6273
    Cell Significance Index: 13.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6251
    Cell Significance Index: 73.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5966
    Cell Significance Index: 8.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5662
    Cell Significance Index: 39.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5296
    Cell Significance Index: 95.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4912
    Cell Significance Index: 176.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4364
    Cell Significance Index: 238.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4008
    Cell Significance Index: 177.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3911
    Cell Significance Index: 270.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3878
    Cell Significance Index: 11.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3705
    Cell Significance Index: 36.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3308
    Cell Significance Index: 62.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2915
    Cell Significance Index: 57.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2882
    Cell Significance Index: 49.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2816
    Cell Significance Index: 17.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2527
    Cell Significance Index: 11.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2118
    Cell Significance Index: 5.4100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1966
    Cell Significance Index: 1.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1793
    Cell Significance Index: 23.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1525
    Cell Significance Index: 4.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1368
    Cell Significance Index: 6.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1332
    Cell Significance Index: 9.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1231
    Cell Significance Index: 3.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0631
    Cell Significance Index: 2.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0571
    Cell Significance Index: 1.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0384
    Cell Significance Index: 1.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0146
    Cell Significance Index: 0.2500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0139
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0131
    Cell Significance Index: 24.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0014
    Cell Significance Index: 1.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0024
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0058
    Cell Significance Index: -3.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0058
    Cell Significance Index: -8.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0059
    Cell Significance Index: -4.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0072
    Cell Significance Index: -13.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0097
    Cell Significance Index: -7.3300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0164
    Cell Significance Index: -0.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0237
    Cell Significance Index: -32.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0258
    Cell Significance Index: -14.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0323
    Cell Significance Index: -20.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0556
    Cell Significance Index: -2.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0610
    Cell Significance Index: -2.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0669
    Cell Significance Index: -30.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0709
    Cell Significance Index: -7.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0745
    Cell Significance Index: -15.7000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0804
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0848
    Cell Significance Index: -9.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0944
    Cell Significance Index: -27.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1611
    Cell Significance Index: -1.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1662
    Cell Significance Index: -5.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1851
    Cell Significance Index: -26.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1934
    Cell Significance Index: -22.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2410
    Cell Significance Index: -16.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2428
    Cell Significance Index: -5.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2594
    Cell Significance Index: -5.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2618
    Cell Significance Index: -16.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3487
    Cell Significance Index: -36.3100
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.3643
    Cell Significance Index: -2.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3790
    Cell Significance Index: -30.0200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3819
    Cell Significance Index: -5.8000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3985
    Cell Significance Index: -3.6700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4272
    Cell Significance Index: -7.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4438
    Cell Significance Index: -34.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4510
    Cell Significance Index: -25.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4812
    Cell Significance Index: -12.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5203
    Cell Significance Index: -12.0200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5282
    Cell Significance Index: -11.2100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5436
    Cell Significance Index: -7.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5733
    Cell Significance Index: -18.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5742
    Cell Significance Index: -18.8000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5766
    Cell Significance Index: -7.1900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5807
    Cell Significance Index: -16.5700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.5898
    Cell Significance Index: -3.8500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5954
    Cell Significance Index: -7.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5975
    Cell Significance Index: -36.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TMEM14A is a transmembrane protein with 14 transmembrane domains, which suggests its involvement in cell-cell interactions and signaling pathways. The protein's structure and localization suggest that it may play a role in regulating the permeability of the endoplasmic reticulum and mitochondrial membranes, as well as the regulation of apoptotic processes. TMEM14A has been shown to interact with other proteins, including those involved in heme biosynthesis, further supporting its role in cellular homeostasis. **Pathways and Functions** TMEM14A is involved in several key cellular pathways, including: 1. **Apoptotic process**: TMEM14A has been shown to regulate the negative regulation of apoptotic processes, suggesting its role in preventing excessive cell death. 2. **Endoplasmic reticulum membrane**: TMEM14A is localized to the endoplasmic reticulum membrane, where it may regulate the permeability of this organelle. 3. **Mitochondrial membrane**: TMEM14A has been implicated in the regulation of mitochondrial outer membrane permeabilization, a key event in apoptotic signaling pathways. 4. **Protein binding**: TMEM14A interacts with other proteins, including those involved in heme biosynthesis, suggesting its role in regulating protein-protein interactions. 5. **Regulation of heme biosynthetic process**: TMEM14A has been shown to regulate the biosynthesis of heme, a critical molecule involved in various cellular processes. **Clinical Significance** TMEM14A has been implicated in several diseases and disorders, including: 1. **Neurological disorders**: TMEM14A has been linked to neurological disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 2. **Cancer**: TMEM14A has been implicated in the development and progression of various cancers, including colorectal and breast cancer. 3. **Cardiovascular disease**: TMEM14A has been linked to cardiovascular disease, including atherosclerosis and cardiac arrhythmias. 4. **Neurodegenerative disorders**: TMEM14A has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TMEM14A is a critical protein involved in regulating various cellular processes, including apoptosis, heme biosynthesis, and protein binding. Its dysregulation has been implicated in several diseases and disorders, highlighting the importance of further research into the function and clinical significance of this protein.

Genular Protein ID: 3605603732

Symbol: TM14A_HUMAN

Name: Transmembrane protein 14A

UniProtKB Accession Codes:

Q9Y6G1 B2R552

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21723035

Title: TMEM14A inhibits N-(4-hydroxyphenyl)retinamide-induced apoptosis through the stabilization of mitochondrial membrane potential.

PubMed ID: 21723035

DOI: 10.1016/j.canlet.2011.05.031

PubMed ID: 26896463

Title: Knockdown of TMEM14A expression by RNAi inhibits the proliferation and invasion of human ovarian cancer cells.

PubMed ID: 26896463

DOI: 10.1042/bsr20150258

PubMed ID: 22609626

Title: Facile backbone structure determination of human membrane proteins by NMR spectroscopy.

PubMed ID: 22609626

DOI: 10.1038/nmeth.2033

Sequence Information:

  • Length: 99
  • Mass: 10712
  • Checksum: D41CBB95241969B3
  • Sequence:
    • MDLIGFGYAA LVTFGSIFGY KRRGGVPSLI AGLFVGCLAG YGAYRVSNDK RDVKVSLFTA 
FFLATIMGVR FKRSKKIMPA GLVAGLSLMM ILRLVLLLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.