Details for: HAPSTR1

Gene ID: 29035

Symbol: HAPSTR1

Ensembl ID: ENSG00000182831

Description: HUWE1 associated protein modifying stress responses

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 196.4702
    Cell Significance Index: -30.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 121.4303
    Cell Significance Index: -30.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 69.0181
    Cell Significance Index: -32.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 67.9865
    Cell Significance Index: -27.6200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 48.5304
    Cell Significance Index: -32.5700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.9293
    Cell Significance Index: -27.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.9863
    Cell Significance Index: -32.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6729
    Cell Significance Index: -31.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2158
    Cell Significance Index: -32.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8762
    Cell Significance Index: -21.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6605
    Cell Significance Index: -10.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6125
    Cell Significance Index: 22.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4072
    Cell Significance Index: 228.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3841
    Cell Significance Index: 89.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3337
    Cell Significance Index: 145.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8242
    Cell Significance Index: 37.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8219
    Cell Significance Index: 15.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8210
    Cell Significance Index: 162.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7770
    Cell Significance Index: 21.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7488
    Cell Significance Index: 21.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7348
    Cell Significance Index: 19.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6814
    Cell Significance Index: 372.1500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.6532
    Cell Significance Index: 4.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6495
    Cell Significance Index: 30.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6409
    Cell Significance Index: 128.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.6163
    Cell Significance Index: 4.7500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5793
    Cell Significance Index: 8.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5465
    Cell Significance Index: 241.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5424
    Cell Significance Index: 11.7500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5202
    Cell Significance Index: 11.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4868
    Cell Significance Index: 12.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4811
    Cell Significance Index: 59.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4769
    Cell Significance Index: 11.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4673
    Cell Significance Index: 24.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4505
    Cell Significance Index: 31.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4317
    Cell Significance Index: 55.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4269
    Cell Significance Index: 30.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3761
    Cell Significance Index: 17.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3673
    Cell Significance Index: 27.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3428
    Cell Significance Index: 61.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3376
    Cell Significance Index: 121.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3142
    Cell Significance Index: 8.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2980
    Cell Significance Index: 56.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2709
    Cell Significance Index: 37.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2693
    Cell Significance Index: 18.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2406
    Cell Significance Index: 18.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2080
    Cell Significance Index: 24.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1995
    Cell Significance Index: 25.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1839
    Cell Significance Index: 166.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1679
    Cell Significance Index: 16.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1414
    Cell Significance Index: 4.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1373
    Cell Significance Index: 3.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1113
    Cell Significance Index: 19.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1050
    Cell Significance Index: 3.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1043
    Cell Significance Index: 11.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0480
    Cell Significance Index: 2.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0338
    Cell Significance Index: 0.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0284
    Cell Significance Index: 18.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0191
    Cell Significance Index: 35.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0123
    Cell Significance Index: 0.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0019
    Cell Significance Index: 1.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0055
    Cell Significance Index: -8.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0079
    Cell Significance Index: -14.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0095
    Cell Significance Index: -12.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0104
    Cell Significance Index: -6.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0114
    Cell Significance Index: -8.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0174
    Cell Significance Index: -0.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0185
    Cell Significance Index: -13.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0196
    Cell Significance Index: -0.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0197
    Cell Significance Index: -8.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0216
    Cell Significance Index: -12.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0383
    Cell Significance Index: -8.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0724
    Cell Significance Index: -8.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0726
    Cell Significance Index: -7.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0961
    Cell Significance Index: -27.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0989
    Cell Significance Index: -5.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1034
    Cell Significance Index: -2.7700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1041
    Cell Significance Index: -1.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1131
    Cell Significance Index: -16.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1159
    Cell Significance Index: -7.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1200
    Cell Significance Index: -6.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1273
    Cell Significance Index: -2.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2219
    Cell Significance Index: -4.3300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2262
    Cell Significance Index: -1.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2547
    Cell Significance Index: -4.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2625
    Cell Significance Index: -11.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2680
    Cell Significance Index: -4.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2897
    Cell Significance Index: -30.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3117
    Cell Significance Index: -24.6900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3514
    Cell Significance Index: -6.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3794
    Cell Significance Index: -23.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3813
    Cell Significance Index: -14.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3971
    Cell Significance Index: -12.7200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4452
    Cell Significance Index: -4.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4590
    Cell Significance Index: -23.9100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4924
    Cell Significance Index: -7.0100
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.5097
    Cell Significance Index: -6.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5304
    Cell Significance Index: -7.8300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5502
    Cell Significance Index: -22.5500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5585
    Cell Significance Index: -7.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HAPSTR1, also known as HUWE1-associated protein modifying stress responses, is a gene that plays a pivotal role in regulating cellular responses to stress. The protein encoded by this gene, HAPSTR1, interacts with HUWE1, a protein involved in ubiquitination and stress response. Notably, HAPSTR1 is specifically expressed in various cell types, including squamous epithelial cells, epithelial cells of the alveolus of the lung, and immune cells such as classical monocytes. This widespread expression suggests a potential role for HAPSTR1 in maintaining tissue homeostasis and immune function. **Pathways and Functions:** HAPSTR1 is involved in multiple cellular pathways, including: 1. **Negative regulation of signal transduction by p53 class mediator**: HAPSTR1 interacts with p53, a tumor suppressor protein that regulates cell cycle arrest and apoptosis in response to DNA damage. By modulating p53 activity, HAPSTR1 may contribute to the regulation of cellular responses to stress and DNA damage. 2. **Regulation of cellular response to stress**: HAPSTR1 is involved in the regulation of cellular responses to stress, including heat shock, oxidative stress, and endoplasmic reticulum stress. This suggests that HAPSTR1 plays a crucial role in maintaining cellular homeostasis and survival under stress conditions. 3. **Ubiquitin protein ligase binding**: HAPSTR1 interacts with ubiquitin protein ligases, which are essential for the regulation of protein degradation and turnover. This interaction may contribute to the regulation of protein stability and cellular responses to stress. **Clinical Significance:** The clinical significance of HAPSTR1 is multifaceted: 1. **Immune regulation**: HAPSTR1's role in regulating immune cell function, particularly in classical monocytes, suggests that dysregulation of this gene may contribute to immune-related disorders, such as autoimmune diseases or cancer. 2. **Stress response**: HAPSTR1's involvement in the regulation of cellular responses to stress implies that this gene may be involved in the pathogenesis of stress-related disorders, such as neurodegenerative diseases or metabolic disorders. 3. **Cancer**: The expression of HAPSTR1 in various cancer cell types, including hepatocellular carcinoma and lung cancer, suggests that this gene may play a role in cancer development and progression. In conclusion, HAPSTR1 is a gene that plays a critical role in regulating cellular responses to stress and immune function. Further research is necessary to fully elucidate the mechanisms by which HAPSTR1 functions and to explore its clinical significance in various diseases. As an expert immunologist, it is essential to continue investigating the intricacies of HAPSTR1 and its potential applications in the field of immunology and disease.

Genular Protein ID: 1749145756

Symbol: HAPR1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14CZ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 33660365

Title: A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.

PubMed ID: 33660365

DOI: 10.1111/acel.13331

PubMed ID: 35776542

Title: C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.

PubMed ID: 35776542

DOI: 10.1073/pnas.2111262119

PubMed ID: 36631436

Title: The HAPSTR2 retrogene buffers stress signaling and resilience in mammals.

PubMed ID: 36631436

DOI: 10.1038/s41467-022-35697-1

Sequence Information:

  • Length: 275
  • Mass: 30926
  • Checksum: E901B9A3C4A2B23C
  • Sequence:
    • MEERKEEGEA EIQEHGPEHW FSKWERQCLA EAEQDEQLPP ELQEEAAAAA QPEHKQQKLW 
HLFQNSATAV AQLYKDRVCQ QPGLSLWVPF QNAATAVTNL YKESVDTHQR SFDIGIQIGY 
QRRNKDVLAW VKKRRRTIRR EDLISFLCGK VPPPRNSRAP PRLTVVSPNR ATSTETSSSV 
ETDLQPFREA IALHGLSGAM ASISVRSSTP GSPTHVSSGS NASRRRNGLH DVDLNTFISE 
EMALHLDNGG TRKRTSAQCG DVITDSPTHK RNRMI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.