Details for: GTPBP8

Gene ID: 29083

Symbol: GTPBP8

Ensembl ID: ENSG00000163607

Description: GTP binding protein 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 120.6080
    Cell Significance Index: -18.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.6791
    Cell Significance Index: -17.4200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 54.2787
    Cell Significance Index: -22.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.0854
    Cell Significance Index: -17.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.0104
    Cell Significance Index: -18.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.7808
    Cell Significance Index: -20.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.7081
    Cell Significance Index: -17.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3674
    Cell Significance Index: -21.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3855
    Cell Significance Index: -13.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5509
    Cell Significance Index: 21.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1691
    Cell Significance Index: 1055.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0516
    Cell Significance Index: 63.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9663
    Cell Significance Index: 105.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9612
    Cell Significance Index: 112.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7052
    Cell Significance Index: 114.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6621
    Cell Significance Index: 34.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5016
    Cell Significance Index: 346.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4937
    Cell Significance Index: 10.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4357
    Cell Significance Index: 19.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4196
    Cell Significance Index: 12.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3082
    Cell Significance Index: 61.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3082
    Cell Significance Index: 21.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2847
    Cell Significance Index: 155.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2796
    Cell Significance Index: 50.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2385
    Cell Significance Index: 45.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2362
    Cell Significance Index: 14.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2235
    Cell Significance Index: 15.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2220
    Cell Significance Index: 30.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2210
    Cell Significance Index: 27.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2191
    Cell Significance Index: 43.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2183
    Cell Significance Index: 4.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2040
    Cell Significance Index: 9.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2009
    Cell Significance Index: 88.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1950
    Cell Significance Index: 19.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1812
    Cell Significance Index: 1.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1809
    Cell Significance Index: 4.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1654
    Cell Significance Index: 19.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1546
    Cell Significance Index: 55.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1336
    Cell Significance Index: 8.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1306
    Cell Significance Index: 3.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1148
    Cell Significance Index: 5.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0992
    Cell Significance Index: 5.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0959
    Cell Significance Index: 7.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0843
    Cell Significance Index: 2.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0643
    Cell Significance Index: 3.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0468
    Cell Significance Index: 3.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0436
    Cell Significance Index: 5.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0275
    Cell Significance Index: 42.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0183
    Cell Significance Index: 2.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0122
    Cell Significance Index: 16.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0098
    Cell Significance Index: 18.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0065
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0063
    Cell Significance Index: 11.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0056
    Cell Significance Index: 0.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0078
    Cell Significance Index: -4.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0127
    Cell Significance Index: -9.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0185
    Cell Significance Index: -8.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0199
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0231
    Cell Significance Index: -17.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0258
    Cell Significance Index: -0.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0264
    Cell Significance Index: -3.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0286
    Cell Significance Index: -4.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0355
    Cell Significance Index: -20.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0379
    Cell Significance Index: -3.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0390
    Cell Significance Index: -24.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0547
    Cell Significance Index: -1.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0570
    Cell Significance Index: -3.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0574
    Cell Significance Index: -16.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0592
    Cell Significance Index: -0.9900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0627
    Cell Significance Index: -1.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0822
    Cell Significance Index: -2.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0889
    Cell Significance Index: -2.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0968
    Cell Significance Index: -4.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0983
    Cell Significance Index: -2.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1004
    Cell Significance Index: -2.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1125
    Cell Significance Index: -23.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1177
    Cell Significance Index: -8.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1180
    Cell Significance Index: -13.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1197
    Cell Significance Index: -2.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1199
    Cell Significance Index: -3.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1790
    Cell Significance Index: -6.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1797
    Cell Significance Index: -4.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1936
    Cell Significance Index: -20.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1949
    Cell Significance Index: -15.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2281
    Cell Significance Index: -11.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2418
    Cell Significance Index: -3.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2807
    Cell Significance Index: -4.2300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2881
    Cell Significance Index: -2.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2920
    Cell Significance Index: -17.9000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3266
    Cell Significance Index: -3.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3285
    Cell Significance Index: -8.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3520
    Cell Significance Index: -7.5300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3731
    Cell Significance Index: -5.5900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3927
    Cell Significance Index: -3.2000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3980
    Cell Significance Index: -3.6700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4112
    Cell Significance Index: -9.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4298
    Cell Significance Index: -12.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4334
    Cell Significance Index: -21.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4377
    Cell Significance Index: -12.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GTPBP8 is a putative gene, meaning that its exact function and mechanism of action are not yet fully understood. However, its involvement in various cellular processes suggests that it plays a crucial role in regulating cellular activities. The gene's expression in multiple cell types indicates that it may be involved in tissue-specific functions, such as immune response, development, and maintenance of epithelial barriers. **Pathways and Functions:** GTPBP8 is involved in several key pathways, including: 1. **GTP binding:** GTPBP8 is a GTP-binding protein, which implies that it is involved in the regulation of GTP-dependent cellular processes. GTP binding proteins play crucial roles in signaling pathways, protein degradation, and cellular transport. 2. **Metal ion binding:** GTPBP8 has been shown to bind metal ions, such as zinc, which is essential for various cellular functions, including enzyme activity, protein structure, and DNA replication. 3. **Mitochondrial function:** The gene's expression in mitochondrial cells suggests that it may be involved in regulating mitochondrial function, including energy metabolism and oxidative stress response. 4. **Protein binding:** GTPBP8 has been shown to interact with various proteins, including those involved in signaling pathways, protein degradation, and cellular transport. **Clinical Significance:** GTPBP8's involvement in multiple cellular processes makes it a potential candidate for involvement in various diseases. Some potential clinical implications of GTPBP8 include: 1. **Immune disorders:** GTPBP8's expression in thymic epithelial cells and other immune cells suggests that it may play a role in immune response and regulation. 2. **Neurological disorders:** The gene's expression in cerebral cortex GABAergic interneurons and other neurons suggests that it may be involved in neurological functions, including synaptic transmission and neuronal development. 3. **Cancer:** GTPBP8's involvement in protein binding and mitochondrial function suggests that it may be involved in cancer cell metabolism and survival. 4. **Epithelial barrier dysfunction:** The gene's expression in intestinal epithelial cells and other absorptive cells suggests that it may play a role in maintaining epithelial barriers and preventing disease. In conclusion, GTPBP8 is a gene with far-reaching implications in cellular processes, including immune response, development, and maintenance of epithelial barriers. Further research is needed to fully understand its function and clinical significance, but its involvement in multiple pathways and cell types underscores its potential importance in human health and disease.

Genular Protein ID: 3593727429

Symbol: GTPB8_HUMAN

Name: GTP-binding protein 8

UniProtKB Accession Codes:

Q8N3Z3 A6NE99 A6NN11 A8K0P6 Q5I0Y4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 6 Ensembl 4 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 284
  • Mass: 32147
  • Checksum: 446AF4FFBC1E6E65
  • Sequence:
    • MAAPGLRLGA GRLFEMPAVL ERLSRYNSTS QAFAEVLRLP KQQLRKLLYP LQEVERFLAP 
YGRQDLHLRI FDPSPEDIAR ADNIFTATER NRIDYVSSAV RIDHAPDLPR PEVCFIGRSN 
VGKSSLIKAL FSLAPEVEVR VSKKPGHTKK MNFFKVGKHF TVVDMPGYGF RAPEDFVDMV 
ETYLKERRNL KRTFLLVDSV VGIQKTDNIA IEMCEEFALP YVIVLTKIDK SSKGHLLKQV 
LQIQKFVNMK TQGCFPQLFP VSAVTFSGIH LLRCFIASVT GSLD

Genular Protein ID: 1978155199

Symbol: Q9P025_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9P025 E7EV33

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 PhylomeDB 1 ProteomicsDB 1 RefSeq 1 SUPFAM 1 UCSC 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

Sequence Information:

  • Length: 307
  • Mass: 34893
  • Checksum: B292B75EAEB221B4
  • Sequence:
    • MAAPGLRLGA GRLFEMPAVL ERLSRYNSTS QAFAEVLRLP KQQLRKLLYP LQEVERFLAP 
YGRQDLHLRI FDPSPEDIAR ADNIFTATER NRIDYVSSAV RIDHAPDLPR PEVRGDSTVH 
LRAGVTALPL PGRPARGVFY RQSNVGKSSL IKLYFHWPLR LKSESPKNQD TQENEFFKVG 
KHFTVVDMPG YGFRAPEDFV DMVETYLKER RNLKRTFLLV DSVVGIQKTD NIAIEMCEEF 
ALPYVIVLTK IDKSSKGHLL KQVLQIQKFV NMKTQGCFPQ LFPVSAVTFS GIHLLRCFIA 
SVTGSLD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.