Details for: CNIH4

Gene ID: 29097

Symbol: CNIH4

Ensembl ID: ENSG00000143771

Description: cornichon family member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 269.0536
    Cell Significance Index: -41.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 179.5828
    Cell Significance Index: -45.5500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 120.4037
    Cell Significance Index: -49.6000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 107.5992
    Cell Significance Index: -50.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 94.4040
    Cell Significance Index: -48.5600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 75.9289
    Cell Significance Index: -50.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.3631
    Cell Significance Index: -47.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.6555
    Cell Significance Index: -39.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.2097
    Cell Significance Index: -48.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9204
    Cell Significance Index: -30.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.1827
    Cell Significance Index: -15.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5882
    Cell Significance Index: 43.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3325
    Cell Significance Index: 69.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2902
    Cell Significance Index: 704.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1274
    Cell Significance Index: 154.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0531
    Cell Significance Index: 189.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9645
    Cell Significance Index: 68.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9495
    Cell Significance Index: 44.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9451
    Cell Significance Index: 116.2100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.9290
    Cell Significance Index: 14.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9099
    Cell Significance Index: 402.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8046
    Cell Significance Index: 726.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7380
    Cell Significance Index: 95.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6756
    Cell Significance Index: 134.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6554
    Cell Significance Index: 17.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6385
    Cell Significance Index: 17.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6098
    Cell Significance Index: 45.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5787
    Cell Significance Index: 74.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5584
    Cell Significance Index: 10.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5575
    Cell Significance Index: 111.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5000
    Cell Significance Index: 5.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4720
    Cell Significance Index: 46.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4163
    Cell Significance Index: 9.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4107
    Cell Significance Index: 28.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4085
    Cell Significance Index: 11.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3989
    Cell Significance Index: 18.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3645
    Cell Significance Index: 16.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3640
    Cell Significance Index: 7.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3533
    Cell Significance Index: 10.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3450
    Cell Significance Index: 11.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2171
    Cell Significance Index: 13.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2076
    Cell Significance Index: 33.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2059
    Cell Significance Index: 73.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1789
    Cell Significance Index: 135.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1778
    Cell Significance Index: 4.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1629
    Cell Significance Index: 1.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1587
    Cell Significance Index: 30.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1451
    Cell Significance Index: 24.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1257
    Cell Significance Index: 86.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0690
    Cell Significance Index: 8.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0470
    Cell Significance Index: 1.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0219
    Cell Significance Index: 0.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0090
    Cell Significance Index: 16.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0058
    Cell Significance Index: -4.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0129
    Cell Significance Index: -23.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0169
    Cell Significance Index: -26.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0211
    Cell Significance Index: -2.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0215
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0228
    Cell Significance Index: -16.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0291
    Cell Significance Index: -18.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0340
    Cell Significance Index: -46.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0447
    Cell Significance Index: -27.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0674
    Cell Significance Index: -38.0100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0699
    Cell Significance Index: -0.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0736
    Cell Significance Index: -33.4100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1010
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1032
    Cell Significance Index: -11.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1417
    Cell Significance Index: -40.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1475
    Cell Significance Index: -31.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1496
    Cell Significance Index: -9.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1930
    Cell Significance Index: -6.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1978
    Cell Significance Index: -11.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2015
    Cell Significance Index: -5.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2036
    Cell Significance Index: -29.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2219
    Cell Significance Index: -25.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2823
    Cell Significance Index: -21.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3167
    Cell Significance Index: -34.4500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3524
    Cell Significance Index: -5.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3992
    Cell Significance Index: -20.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4010
    Cell Significance Index: -45.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4042
    Cell Significance Index: -10.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4188
    Cell Significance Index: -10.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4355
    Cell Significance Index: -26.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4461
    Cell Significance Index: -46.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5511
    Cell Significance Index: -43.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5755
    Cell Significance Index: -38.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6119
    Cell Significance Index: -16.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6220
    Cell Significance Index: -38.1400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6476
    Cell Significance Index: -7.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6574
    Cell Significance Index: -8.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7687
    Cell Significance Index: -34.0000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7806
    Cell Significance Index: -13.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8241
    Cell Significance Index: -19.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8701
    Cell Significance Index: -43.9700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.9021
    Cell Significance Index: -5.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9149
    Cell Significance Index: -34.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.9226
    Cell Significance Index: -7.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9228
    Cell Significance Index: -27.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9452
    Cell Significance Index: -20.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9709
    Cell Significance Index: -18.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CNIH4 is a member of the cornichon family, a group of proteins involved in the regulation of ion transport and cellular signaling. The CNIH4 protein is characterized by its ability to bind to proteins and regulate their transport within the cell. Its expression is widespread, with significant levels found in embryonic stem cells, pneumocytes, and alveolar macrophages, suggesting a role in maintaining tissue homeostasis and immune function. **Pathways and Functions:** CNIH4 is involved in several cellular pathways, including: 1. **Ccr5 chemokine receptor binding**: CNIH4 interacts with the CCR5 chemokine receptor, regulating its activity and influencing immune cell trafficking. 2. **Copii-coated ER to Golgi transport vesicle**: CNIH4 is involved in the transport of proteins and lipids between the endoplasmic reticulum (ER) and Golgi apparatus, regulating cellular signaling and protein secretion. 3. **Endoplasmic reticulum-golgi intermediate compartment**: CNIH4 regulates the transport of proteins and lipids between the ER and Golgi apparatus through the intermediate compartment. 4. **Protein binding**: CNIH4 binds to various proteins, regulating their activity and localization within the cell. 5. **Protein transport**: CNIH4 regulates the transport of proteins between the ER and Golgi apparatus, influencing cellular signaling and protein secretion. **Clinical Significance:** CNIH4 has been implicated in various diseases and disorders, including: 1. **Autoimmune diseases**: CNIH4 has been shown to regulate immune cell function and inflammation, making it a potential target for the treatment of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: CNIH4 has been implicated in cancer progression and metastasis, with its expression levels correlating with tumor aggressiveness. 3. **Neurological disorders**: CNIH4 has been shown to regulate neuronal signaling and function, making it a potential target for the treatment of neurological disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, CNIH4 is a multifunctional protein involved in various cellular processes, including immune function, cellular signaling, and protein transport. Its significance in disease pathogenesis and potential as a therapeutic target make it an area of active research in the field of immunology.

Genular Protein ID: 813721468

Symbol: CNIH4_HUMAN

Name: Protein cornichon homolog 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24405750

Title: CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum.

PubMed ID: 24405750

DOI: 10.1111/tra.12148

Sequence Information:

  • Length: 139
  • Mass: 16093
  • Checksum: 9452E9BDEC2A8DEF
  • Sequence:
  • MEAVVFVFSL LDCCALIFLS VYFIITLSDL ECDYINARSC CSKLNKWVIP ELIGHTIVTV 
    LLLMSLHWFI FLLNLPVATW NIYRYIMVPS GNMGVFDPTE IHNRGQLKSH MKEAMIKLGF 
    HLLCFFMYLY SMILALIND

Genular Protein ID: 2991060736

Symbol: A6NLH6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 137
  • Mass: 15771
  • Checksum: 174DAF49F8015CC3
  • Sequence:
  • MEAVVFVFSL LDCCALIFLS VYFIITLSDL ECDYINARSC CSKLNKWVIP ELIGHTIVTV 
    LLLMSLHWFI FLLNLPVATW NIYRYIMVPS GNMGVFDPTE IHNRGQLKSH MKEAMIKLGF 
    HLLCFFMYLY SGSNCPC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.