Details for: TMEM208

Gene ID: 29100

Symbol: TMEM208

Ensembl ID: ENSG00000168701

Description: transmembrane protein 208

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 244.9448
    Cell Significance Index: -38.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 135.9783
    Cell Significance Index: -34.4900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 96.9298
    Cell Significance Index: -39.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.3624
    Cell Significance Index: -42.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.1215
    Cell Significance Index: -35.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.6764
    Cell Significance Index: -40.4700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 63.0121
    Cell Significance Index: -42.2800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.1045
    Cell Significance Index: -36.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.2778
    Cell Significance Index: -41.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.0648
    Cell Significance Index: -32.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.5878
    Cell Significance Index: -41.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.4646
    Cell Significance Index: -29.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6011
    Cell Significance Index: -10.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.8204
    Cell Significance Index: 131.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8971
    Cell Significance Index: 17.4700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.6651
    Cell Significance Index: 10.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6308
    Cell Significance Index: 44.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4107
    Cell Significance Index: 105.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3558
    Cell Significance Index: 70.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3386
    Cell Significance Index: 731.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3227
    Cell Significance Index: 62.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2223
    Cell Significance Index: 28.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.1226
    Cell Significance Index: 30.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0873
    Cell Significance Index: 196.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0220
    Cell Significance Index: 27.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9013
    Cell Significance Index: 123.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8721
    Cell Significance Index: 107.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7935
    Cell Significance Index: 102.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7389
    Cell Significance Index: 21.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6536
    Cell Significance Index: 288.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6419
    Cell Significance Index: 18.4000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6367
    Cell Significance Index: 9.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6206
    Cell Significance Index: 7.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5594
    Cell Significance Index: 39.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5131
    Cell Significance Index: 33.1100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5095
    Cell Significance Index: 4.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4946
    Cell Significance Index: 63.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4883
    Cell Significance Index: 48.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4671
    Cell Significance Index: 92.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4645
    Cell Significance Index: 419.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4550
    Cell Significance Index: 15.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4233
    Cell Significance Index: 72.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3727
    Cell Significance Index: 19.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3605
    Cell Significance Index: 24.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3541
    Cell Significance Index: 22.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3273
    Cell Significance Index: 9.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2892
    Cell Significance Index: 34.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2738
    Cell Significance Index: 52.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2112
    Cell Significance Index: 11.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1427
    Cell Significance Index: 3.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1240
    Cell Significance Index: 3.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1062
    Cell Significance Index: 80.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1011
    Cell Significance Index: 20.2800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0827
    Cell Significance Index: 0.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0812
    Cell Significance Index: 13.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0751
    Cell Significance Index: 55.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0455
    Cell Significance Index: 1.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0050
    Cell Significance Index: 3.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0018
    Cell Significance Index: -0.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0075
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0092
    Cell Significance Index: -6.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0104
    Cell Significance Index: -19.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0143
    Cell Significance Index: -5.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0146
    Cell Significance Index: -0.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0183
    Cell Significance Index: -1.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0196
    Cell Significance Index: -0.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0199
    Cell Significance Index: -36.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0235
    Cell Significance Index: -36.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0244
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0267
    Cell Significance Index: -16.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0295
    Cell Significance Index: -40.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0404
    Cell Significance Index: -22.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0421
    Cell Significance Index: -26.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0638
    Cell Significance Index: -7.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0693
    Cell Significance Index: -14.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0744
    Cell Significance Index: -33.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0898
    Cell Significance Index: -1.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1063
    Cell Significance Index: -30.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1096
    Cell Significance Index: -12.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2223
    Cell Significance Index: -32.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2273
    Cell Significance Index: -7.2800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2450
    Cell Significance Index: -6.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2583
    Cell Significance Index: -29.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2943
    Cell Significance Index: -18.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3401
    Cell Significance Index: -4.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3648
    Cell Significance Index: -20.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3854
    Cell Significance Index: -17.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3907
    Cell Significance Index: -30.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3982
    Cell Significance Index: -41.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4187
    Cell Significance Index: -9.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4598
    Cell Significance Index: -35.2900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4866
    Cell Significance Index: -2.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5187
    Cell Significance Index: -34.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6338
    Cell Significance Index: -6.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6553
    Cell Significance Index: -16.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6789
    Cell Significance Index: -41.6200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7931
    Cell Significance Index: -23.3600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7954
    Cell Significance Index: -14.0600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.8256
    Cell Significance Index: -5.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8553
    Cell Significance Index: -37.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMEM208 is a transmembrane protein, consisting of a single transmembrane domain, which is characteristic of many membrane-bound proteins. Its expression is widespread, with notable presence in IgA plasma cells, kidney collecting duct intercalated cells, pneumocytes, and myeloid leukocytes. The protein's subcellular localization is not explicitly stated, but its association with various cellular compartments suggests a role in cell-to-cell communication, protein binding, and regulation of cellular processes. **Pathways and Functions:** TMEM208's involvement in autophagy, endoplasmic reticulum membrane, protein binding, vacuolar protein processing, and vacuole formation suggests a complex role in maintaining cellular homeostasis. Autophagy, a process by which cells recycle damaged or dysfunctional components, is essential for cellular survival and immune function. TMEM208's involvement in autophagy may indicate a role in regulating the degradation of protein aggregates, lipid droplets, or other cellular waste. Additionally, its association with the endoplasmic reticulum membrane and vacuoles suggests a potential role in regulating cellular stress responses and maintaining cellular homeostasis. **Clinical Significance:** TMEM208's expression in immune cells, such as IgA plasma cells and myeloid leukocytes, suggests a potential role in immune regulation and function. Dysregulation of TMEM208 may contribute to the development of autoimmune diseases, such as autoimmune hemolytic anemia, or other immunological disorders. Furthermore, TMEM208's involvement in autophagy and cellular homeostasis may have implications for the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's, where autophagy is impaired. In conclusion, TMEM208 is a multifunctional transmembrane protein with far-reaching implications in immunology and beyond. Further research is necessary to fully elucidate its role in maintaining cellular homeostasis, regulating immune function, and its clinical significance in various diseases. **Recommendations for Future Research:** 1. Investigate the functional role of TMEM208 in immune cells and its contribution to autoimmune diseases. 2. Explore the relationship between TMEM208 and autophagy, focusing on its impact on cellular homeostasis and disease. 3. Utilize cellular and molecular biology approaches to further elucidate TMEM208's subcellular localization and interactions with other proteins. 4. Investigate the potential therapeutic applications of TMEM208 in neurodegenerative diseases and other conditions where autophagy is impaired. By addressing these knowledge gaps, researchers can unlock the full potential of TMEM208 and uncover its role in maintaining cellular homeostasis and regulating immune function.

Genular Protein ID: 2874736012

Symbol: TM208_HUMAN

Name: Transmembrane protein 208

UniProtKB Accession Codes:

Q9BTX3 Q05CT0 Q96D25 Q9NZZ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23691174

Title: Transmembrane protein 208: a novel ER-localized protein that regulates autophagy and ER stress.

PubMed ID: 23691174

DOI: 10.1371/journal.pone.0064228

PubMed ID: 25732826

Title: An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.

PubMed ID: 25732826

DOI: 10.1016/j.celrep.2015.01.053

PubMed ID: 38381787

Title: Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability.

PubMed ID: 38381787

DOI: 10.1073/pnas.2322582121

Sequence Information:

  • Length: 173
  • Mass: 19642
  • Checksum: F6AE0798B79967A6
  • Sequence:
    • MAPKGKVGTR GKKQIFEENR ETLKFYLRII LGANAIYCLV TLVFFYSSAS FWAWLALGFS 
LAVYGASYHS MSSMARAAFS EDGALMDGGM DLNMEQGMAE HLKDVILLTA IVQVLSCFSL 
YVWSFWLLAP GRALYLLWVN VLGPWFTADS GTPAPEHNEK RQRRQERRQM KRL

Genular Protein ID: 718383675

Symbol: J3KRY7_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KRY7

Database IDs:

ARBA 9 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 103
  • Mass: 11758
  • Checksum: 5F3E7A76F403829A
  • Sequence:
    • MSSMARAAFS EDGALMDGGM DLNMEQGMAE HLKDVILLTA IVQVLSCFSL YVWSFWLLAP 
GRALYLLWVN VLGPWFTADS GTPAPEHNEK RQRRQERRQM KRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.