Details for: CLEC2D

Gene ID: 29121

Symbol: CLEC2D

Ensembl ID: ENSG00000069493

Description: C-type lectin domain family 2 member D

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.56
    Marker Score: 25,949
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.52
    Marker Score: 2,478
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.51
    Marker Score: 7,044
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.49
    Marker Score: 2,096
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.44
    Marker Score: 24,206
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.41
    Marker Score: 3,417
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.34
    Marker Score: 1,373
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.34
    Marker Score: 7,388
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.33
    Marker Score: 1,686
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.27
    Marker Score: 1,644
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.26
    Marker Score: 1,375
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.24
    Marker Score: 3,905
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.15
    Marker Score: 2,008
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.14
    Marker Score: 113,281
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 2.11
    Marker Score: 2,290
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.11
    Marker Score: 1,086
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.06
    Marker Score: 1,030
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.01
    Marker Score: 702
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.96
    Marker Score: 5,337
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.95
    Marker Score: 3,480
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.94
    Marker Score: 1,068
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.93
    Marker Score: 2,080
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.88
    Marker Score: 12,040
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.87
    Marker Score: 580
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.84
    Marker Score: 597
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.77
    Marker Score: 470
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.73
    Marker Score: 5,142
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.72
    Marker Score: 1,658
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.64
    Marker Score: 1,463
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.63
    Marker Score: 804
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.62
    Marker Score: 933
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.62
    Marker Score: 1,422
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.6
    Marker Score: 3,905
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.59
    Marker Score: 5,656
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.59
    Marker Score: 562
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.58
    Marker Score: 3,102
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.58
    Marker Score: 681
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.56
    Marker Score: 355
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.55
    Marker Score: 358
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.55
    Marker Score: 666
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.51
    Marker Score: 3,408
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.51
    Marker Score: 1,182
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.49
    Marker Score: 1,760
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.49
    Marker Score: 6,392
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,487
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.46
    Marker Score: 1,211
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.45
    Marker Score: 734
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.45
    Marker Score: 16,816
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.44
    Marker Score: 2,120
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.44
    Marker Score: 1,087
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.4
    Marker Score: 842
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.31
    Marker Score: 398
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.28
    Marker Score: 788
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.27
    Marker Score: 711
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.26
    Marker Score: 1,742
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.25
    Marker Score: 43,452
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.25
    Marker Score: 1,102
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.25
    Marker Score: 915
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.24
    Marker Score: 1,373
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.22
    Marker Score: 2,093
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.22
    Marker Score: 606
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.21
    Marker Score: 421
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.21
    Marker Score: 883
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.19
    Marker Score: 1,203
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.19
    Marker Score: 786
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.17
    Marker Score: 2,462
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.16
    Marker Score: 405
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.16
    Marker Score: 1,554
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.15
    Marker Score: 274
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.14
    Marker Score: 1,854
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.12
    Marker Score: 1,222
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.12
    Marker Score: 4,697
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.11
    Marker Score: 944
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.1
    Marker Score: 763
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.08
    Marker Score: 374
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.07
    Marker Score: 353
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.06
    Marker Score: 942
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.04
    Marker Score: 929
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.04
    Marker Score: 700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.03
    Marker Score: 666
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.03
    Marker Score: 1,251
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.02
    Marker Score: 615
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.02
    Marker Score: 4,257
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.01
    Marker Score: 768
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1
    Marker Score: 585
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,669
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,893
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,391
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.98
    Marker Score: 352
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.97
    Marker Score: 570
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.97
    Marker Score: 939
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.97
    Marker Score: 393
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.96
    Marker Score: 1,245
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.95
    Marker Score: 905
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,397
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.93
    Marker Score: 1,235
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.93
    Marker Score: 335
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,706

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CLEC2D is a member of the C-type lectin domain family 2, which belongs to the larger family of lectins that bind carbohydrates. This gene is characterized by its expression on the surface of various immune cells, including T cells, B cells, and dendritic cells. The protein structure of CLEC2D consists of a transmembrane domain, a lectin-like domain, and a cytoplasmic tail. The lectin-like domain is responsible for carbohydrate binding, which triggers signaling pathways that regulate immune responses. **Pathways and Functions:** CLEC2D is involved in several signaling pathways that regulate immune responses. The primary pathways include: 1. **Adaptive Immune System:** CLEC2D plays a crucial role in the adaptive immune response, particularly in the activation and proliferation of T cells. The lectin-like domain binds to specific carbohydrates on the surface of antigen-presenting cells, leading to the activation of T cells. 2. **Cell Surface Receptor Signaling Pathway:** CLEC2D is a transmembrane receptor that undergoes clustering and activation upon binding to its ligands. This leads to the activation of downstream signaling pathways, including the MAPK and PI3K/AKT pathways. 3. **Endoplasmic Reticulum and Plasma Membrane:** CLEC2D is also involved in the regulation of endoplasmic reticulum (ER) stress and plasma membrane signaling. The lectin-like domain can interact with ER chaperones, modulating the unfolded protein response. **Signaling Mechanisms:** The signaling mechanisms of CLEC2D involve the binding of specific carbohydrates to its lectin-like domain. This binding event triggers the activation of downstream signaling pathways, including: 1. **MAPK Pathway:** The activation of the MAPK pathway leads to the phosphorylation and activation of downstream transcription factors, such as NF-κB and AP-1. 2. **PI3K/AKT Pathway:** The activation of the PI3K/AKT pathway leads to the phosphorylation and activation of downstream targets, including mTOR and AKT. **Clinical Significance:** CLEC2D has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases:** CLEC2D has been shown to play a role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** CLEC2D has been implicated in the regulation of tumor immune evasion and the development of cancer. 3. **Infectious Diseases:** CLEC2D has been shown to play a role in the regulation of immune responses to infectious diseases, such as tuberculosis and HIV. In conclusion, CLEC2D is a complex gene that plays a crucial role in the regulation of immune responses. Its involvement in various signaling pathways and its implications in immune-related disorders make it an important area of research in the field of immunology. Further studies are needed to fully elucidate the mechanisms of CLEC2D and its role in human health and disease.

Genular Protein ID: 755985033

Symbol: CLC2D_HUMAN

Name: C-type lectin domain family 2 member D

UniProtKB Accession Codes:

Q9UHP7 D6CI39 D6CI40 D6CI41 Q6YID5 Q8WUP7 Q9HD37 Q9HD38

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 6 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 6 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10541800

Title: Cloning of a new lectin-like receptor expressed on human NK cells.

PubMed ID: 10541800

DOI: 10.1007/s002510050679

PubMed ID: 14753741

Title: Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts.

PubMed ID: 14753741

DOI: 10.1359/jbmr.0301215

PubMed ID: 20843815

Title: Characterization of alternatively spliced transcript variants of CLEC2D gene.

PubMed ID: 20843815

DOI: 10.1074/jbc.m110.179622

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15123656

Title: Characterization of sugar binding by osteoclast inhibitory lectin.

PubMed ID: 15123656

DOI: 10.1074/jbc.m312518200

PubMed ID: 15104121

Title: The LLT1 receptor induces IFN-gamma production by human natural killer cells.

PubMed ID: 15104121

DOI: 10.1016/j.molimm.2003.11.024

PubMed ID: 16339513

Title: Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor.

PubMed ID: 16339513

DOI: 10.4049/jimmunol.175.12.7796

PubMed ID: 25760607

Title: Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states.

PubMed ID: 25760607

DOI: 10.1107/s1399004714027928

PubMed ID: 25826155

Title: Crystal structure of extracellular domain of human lectin-like transcript 1 (LLT1), the ligand for natural killer receptor-P1A.

PubMed ID: 25826155

DOI: 10.1002/eji.201545509

Sequence Information:

  • Length: 191
  • Mass: 21849
  • Checksum: E71F3E21DC361F10
  • Sequence:
    • MHDSNNVEKD ITPSELPANP GCLHSKEHSI KATLIWRLFF LIMFLTIIVC GMVAALSAIR 
ANCHQEPSVC LQAACPESWI GFQRKCFYFS DDTKNWTSSQ RFCDSQDADL AQVESFQELN 
FLLRYKGPSD HWIGLSREQG QPWKWINGTE WTRQFPILGA GECAYLNDKG ASSARHYTER 
KWICSKSDIH V

Genular Protein ID: 3350449322

Symbol: W8JXM2_HUMAN

Name: N/A

UniProtKB Accession Codes:

W8JXM2

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 1 Gene3D 1 GenomeRNAi 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 20843815

Title: Characterization of alternatively spliced transcript variants of CLEC2D gene.

PubMed ID: 20843815

DOI: 10.1074/jbc.M110.179622

Sequence Information:

  • Length: 154
  • Mass: 17703
  • Checksum: BF7D57B198B8A7F9
  • Sequence:
    • MHDSNNVEKD ITPSELPANP AIRANCHQEP SVCLQAACPE SWIGFQRKCF YFSDDTKNWT 
SSQRFCDSQD ADLAQVESFQ ELNFLLRYKG PSDHWIGLSR EQGQPWKWIN GTEWTRQFPI 
LGAGECAYLN DKGASSARHY TERKWICSKS DIHV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.