Details for: CLEC2D

Gene ID: 29121

Symbol: CLEC2D

Ensembl ID: ENSG00000069493

Description: C-type lectin domain family 2 member D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 128.9336
    Cell Significance Index: -20.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 62.8836
    Cell Significance Index: -15.9500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.9748
    Cell Significance Index: -22.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.8457
    Cell Significance Index: -20.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.6501
    Cell Significance Index: -21.1200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.6320
    Cell Significance Index: -20.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4941
    Cell Significance Index: -21.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.3418
    Cell Significance Index: -14.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.1277
    Cell Significance Index: 266.3000
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.8276
    Cell Significance Index: 8.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.8374
    Cell Significance Index: 83.3300
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.8336
    Cell Significance Index: 8.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8058
    Cell Significance Index: 343.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6845
    Cell Significance Index: 198.6500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.3623
    Cell Significance Index: 13.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1701
    Cell Significance Index: 115.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1418
    Cell Significance Index: 64.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0889
    Cell Significance Index: 216.0900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.9901
    Cell Significance Index: 15.8900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.9666
    Cell Significance Index: 8.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9275
    Cell Significance Index: 837.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8209
    Cell Significance Index: 448.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6983
    Cell Significance Index: 53.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6338
    Cell Significance Index: 18.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6050
    Cell Significance Index: 98.4100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.5997
    Cell Significance Index: 3.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5954
    Cell Significance Index: 11.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4502
    Cell Significance Index: 48.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4421
    Cell Significance Index: 9.4200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.3356
    Cell Significance Index: 1.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2987
    Cell Significance Index: 41.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2909
    Cell Significance Index: 7.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2404
    Cell Significance Index: 48.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2396
    Cell Significance Index: 8.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1998
    Cell Significance Index: 13.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1825
    Cell Significance Index: 5.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1645
    Cell Significance Index: 3.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1498
    Cell Significance Index: 17.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1202
    Cell Significance Index: 43.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1078
    Cell Significance Index: 6.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0965
    Cell Significance Index: 17.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0786
    Cell Significance Index: 148.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0750
    Cell Significance Index: 138.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0707
    Cell Significance Index: 108.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0686
    Cell Significance Index: 8.4300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0407
    Cell Significance Index: 4.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0393
    Cell Significance Index: 17.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0269
    Cell Significance Index: 17.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0262
    Cell Significance Index: 3.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0203
    Cell Significance Index: 9.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0085
    Cell Significance Index: -5.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0120
    Cell Significance Index: -0.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0163
    Cell Significance Index: -4.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0163
    Cell Significance Index: -12.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0203
    Cell Significance Index: -15.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0253
    Cell Significance Index: -14.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0272
    Cell Significance Index: -19.9600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0436
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0476
    Cell Significance Index: -10.0300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0626
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0655
    Cell Significance Index: -11.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0668
    Cell Significance Index: -3.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0768
    Cell Significance Index: -11.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0771
    Cell Significance Index: -2.0600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0791
    Cell Significance Index: -0.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0952
    Cell Significance Index: -9.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1022
    Cell Significance Index: -11.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1283
    Cell Significance Index: -8.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1415
    Cell Significance Index: -6.6500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1416
    Cell Significance Index: -2.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1443
    Cell Significance Index: -15.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1529
    Cell Significance Index: -19.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1880
    Cell Significance Index: -4.7000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1955
    Cell Significance Index: -1.7100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1974
    Cell Significance Index: -1.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2012
    Cell Significance Index: -10.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2104
    Cell Significance Index: -9.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2155
    Cell Significance Index: -5.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2185
    Cell Significance Index: -15.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2238
    Cell Significance Index: -16.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2239
    Cell Significance Index: -11.6300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2286
    Cell Significance Index: -2.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2356
    Cell Significance Index: -10.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2602
    Cell Significance Index: -16.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2677
    Cell Significance Index: -5.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2941
    Cell Significance Index: -9.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3005
    Cell Significance Index: -8.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3223
    Cell Significance Index: -25.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3293
    Cell Significance Index: -12.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3309
    Cell Significance Index: -11.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3766
    Cell Significance Index: -9.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3784
    Cell Significance Index: -19.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3791
    Cell Significance Index: -23.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3857
    Cell Significance Index: -8.0000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4014
    Cell Significance Index: -6.2100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4290
    Cell Significance Index: -6.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4330
    Cell Significance Index: -11.1300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4478
    Cell Significance Index: -6.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4693
    Cell Significance Index: -24.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CLEC2D is a member of the C-type lectin domain family 2, which belongs to the larger family of lectins that bind carbohydrates. This gene is characterized by its expression on the surface of various immune cells, including T cells, B cells, and dendritic cells. The protein structure of CLEC2D consists of a transmembrane domain, a lectin-like domain, and a cytoplasmic tail. The lectin-like domain is responsible for carbohydrate binding, which triggers signaling pathways that regulate immune responses. **Pathways and Functions:** CLEC2D is involved in several signaling pathways that regulate immune responses. The primary pathways include: 1. **Adaptive Immune System:** CLEC2D plays a crucial role in the adaptive immune response, particularly in the activation and proliferation of T cells. The lectin-like domain binds to specific carbohydrates on the surface of antigen-presenting cells, leading to the activation of T cells. 2. **Cell Surface Receptor Signaling Pathway:** CLEC2D is a transmembrane receptor that undergoes clustering and activation upon binding to its ligands. This leads to the activation of downstream signaling pathways, including the MAPK and PI3K/AKT pathways. 3. **Endoplasmic Reticulum and Plasma Membrane:** CLEC2D is also involved in the regulation of endoplasmic reticulum (ER) stress and plasma membrane signaling. The lectin-like domain can interact with ER chaperones, modulating the unfolded protein response. **Signaling Mechanisms:** The signaling mechanisms of CLEC2D involve the binding of specific carbohydrates to its lectin-like domain. This binding event triggers the activation of downstream signaling pathways, including: 1. **MAPK Pathway:** The activation of the MAPK pathway leads to the phosphorylation and activation of downstream transcription factors, such as NF-κB and AP-1. 2. **PI3K/AKT Pathway:** The activation of the PI3K/AKT pathway leads to the phosphorylation and activation of downstream targets, including mTOR and AKT. **Clinical Significance:** CLEC2D has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases:** CLEC2D has been shown to play a role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** CLEC2D has been implicated in the regulation of tumor immune evasion and the development of cancer. 3. **Infectious Diseases:** CLEC2D has been shown to play a role in the regulation of immune responses to infectious diseases, such as tuberculosis and HIV. In conclusion, CLEC2D is a complex gene that plays a crucial role in the regulation of immune responses. Its involvement in various signaling pathways and its implications in immune-related disorders make it an important area of research in the field of immunology. Further studies are needed to fully elucidate the mechanisms of CLEC2D and its role in human health and disease.

Genular Protein ID: 755985033

Symbol: CLC2D_HUMAN

Name: C-type lectin domain family 2 member D

UniProtKB Accession Codes:

Q9UHP7 D6CI39 D6CI40 D6CI41 Q6YID5 Q8WUP7 Q9HD37 Q9HD38

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10541800

Title: Cloning of a new lectin-like receptor expressed on human NK cells.

PubMed ID: 10541800

DOI: 10.1007/s002510050679

PubMed ID: 14753741

Title: Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts.

PubMed ID: 14753741

DOI: 10.1359/jbmr.0301215

PubMed ID: 20843815

Title: Characterization of alternatively spliced transcript variants of CLEC2D gene.

PubMed ID: 20843815

DOI: 10.1074/jbc.m110.179622

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15123656

Title: Characterization of sugar binding by osteoclast inhibitory lectin.

PubMed ID: 15123656

DOI: 10.1074/jbc.m312518200

PubMed ID: 15104121

Title: The LLT1 receptor induces IFN-gamma production by human natural killer cells.

PubMed ID: 15104121

DOI: 10.1016/j.molimm.2003.11.024

PubMed ID: 16339513

Title: Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor.

PubMed ID: 16339513

DOI: 10.4049/jimmunol.175.12.7796

PubMed ID: 25760607

Title: Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states.

PubMed ID: 25760607

DOI: 10.1107/s1399004714027928

PubMed ID: 25826155

Title: Crystal structure of extracellular domain of human lectin-like transcript 1 (LLT1), the ligand for natural killer receptor-P1A.

PubMed ID: 25826155

DOI: 10.1002/eji.201545509

Sequence Information:

  • Length: 191
  • Mass: 21849
  • Checksum: E71F3E21DC361F10
  • Sequence:
    • MHDSNNVEKD ITPSELPANP GCLHSKEHSI KATLIWRLFF LIMFLTIIVC GMVAALSAIR 
ANCHQEPSVC LQAACPESWI GFQRKCFYFS DDTKNWTSSQ RFCDSQDADL AQVESFQELN 
FLLRYKGPSD HWIGLSREQG QPWKWINGTE WTRQFPILGA GECAYLNDKG ASSARHYTER 
KWICSKSDIH V

Genular Protein ID: 3350449322

Symbol: W8JXM2_HUMAN

Name: N/A

UniProtKB Accession Codes:

W8JXM2

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 2 Gene3D 1 HOGENOM 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 20843815

Title: Characterization of alternatively spliced transcript variants of CLEC2D gene.

PubMed ID: 20843815

DOI: 10.1074/jbc.M110.179622

Sequence Information:

  • Length: 154
  • Mass: 17703
  • Checksum: BF7D57B198B8A7F9
  • Sequence:
    • MHDSNNVEKD ITPSELPANP AIRANCHQEP SVCLQAACPE SWIGFQRKCF YFSDDTKNWT 
SSQRFCDSQD ADLAQVESFQ ELNFLLRYKG PSDHWIGLSR EQGQPWKWIN GTEWTRQFPI 
LGAGECAYLN DKGASSARHY TERKWICSKS DIHV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.