Details for: GSTA4

Gene ID: 2941

Symbol: GSTA4

Ensembl ID: ENSG00000170899

Description: glutathione S-transferase alpha 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.72
    Marker Score: 83730
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1
    Marker Score: 8246
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.09
    Marker Score: 2347
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.97
    Marker Score: 2127
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.94
    Marker Score: 3114
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.93
    Marker Score: 38330
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.91
    Marker Score: 25164
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.9
    Marker Score: 7908
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.89
    Marker Score: 69545
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.85
    Marker Score: 12050
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.84
    Marker Score: 7615
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.79
    Marker Score: 6913
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.78
    Marker Score: 67566
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.76
    Marker Score: 3571
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.75
    Marker Score: 26189
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.74
    Marker Score: 7095
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.74
    Marker Score: 16333
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.69
    Marker Score: 10048
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.69
    Marker Score: 16036.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.68
    Marker Score: 14515
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.66
    Marker Score: 101984
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.64
    Marker Score: 3434.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.63
    Marker Score: 549
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.63
    Marker Score: 12483.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.59
    Marker Score: 10349
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.58
    Marker Score: 13585
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.57
    Marker Score: 16250
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.57
    Marker Score: 12255.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.55
    Marker Score: 1033
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.53
    Marker Score: 2354
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.52
    Marker Score: 953
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.5
    Marker Score: 708
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.5
    Marker Score: 2305
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.48
    Marker Score: 1586
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.48
    Marker Score: 620
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.47
    Marker Score: 1559
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.45
    Marker Score: 860.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.44
    Marker Score: 1735
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.43
    Marker Score: 1348
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.41
    Marker Score: 6532
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.37
    Marker Score: 5293
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.36
    Marker Score: 3204
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.34
    Marker Score: 739
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.32
    Marker Score: 1387
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.32
    Marker Score: 1243
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.32
    Marker Score: 2238
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.32
    Marker Score: 725
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.31
    Marker Score: 13161
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.25
    Marker Score: 1048
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.23
    Marker Score: 348
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.22
    Marker Score: 310
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.21
    Marker Score: 1563
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2
    Marker Score: 19315
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.14
    Marker Score: 4231
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.14
    Marker Score: 8465
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.1
    Marker Score: 443
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.09
    Marker Score: 1533
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.08
    Marker Score: 1142
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.07
    Marker Score: 4629
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.07
    Marker Score: 4485.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.05
    Marker Score: 754
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.05
    Marker Score: 1300
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.05
    Marker Score: 419
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.01
    Marker Score: 1140
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1
    Marker Score: 820
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71749
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47974
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.99
    Marker Score: 33290
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.93
    Marker Score: 322
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.93
    Marker Score: 1286
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2724
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9
    Marker Score: 14096.5
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.9
    Marker Score: 1109
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.9
    Marker Score: 19125
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.89
    Marker Score: 373
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.89
    Marker Score: 208
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.89
    Marker Score: 1946.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.88
    Marker Score: 975
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.88
    Marker Score: 9868
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.87
    Marker Score: 322
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.87
    Marker Score: 390
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4940.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.86
    Marker Score: 2317
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.84
    Marker Score: 975
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.83
    Marker Score: 2180
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.83
    Marker Score: 1317
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.82
    Marker Score: 439
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.82
    Marker Score: 945
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.82
    Marker Score: 1959
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.81
    Marker Score: 1336
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.81
    Marker Score: 1647
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 612
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.8
    Marker Score: 303

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * GSTA4 is a single-pass membrane protein that is expressed in a variety of cell types. * It is a key enzyme in the glutathione conjugation system, which is responsible for the formation of glutathione, a protective molecule that helps to neutralize harmful reactive oxygen species. * GSTA4 is also involved in the regulation of inflammation. * It is a highly conserved protein, with a similar sequence in mammals and humans. **Pathways and functions:** * GSTA4 is involved in a variety of cellular processes, including detoxification, immune responses, and energy production. * In detoxification, GSTA4 helps to convert harmful chemicals into less harmful forms. * In immune responses, GSTA4 helps to protect cells from damage by reactive oxygen species (ROS). * In energy production, GSTA4 is involved in the formation of NADPH, a molecule that is used in the electron transport chain, which is responsible for generating energy for cells. **Clinical significance:** * Mutations in GSTA4 have been linked to an increased risk of certain diseases, including cancer, liver disease, and kidney disease. * Therefore, GSTA4 is a potential target for the treatment of these diseases. * GSTA4 inhibitors are being investigated as a treatment for cancer and other diseases that are characterized by oxidative stress. **Additional information:** * GSTA4 is a member of the glutathione S-transferase family of enzymes. * The gene encoding GSTA4 is located on chromosome 15q21. * GSTA4 is a highly regulated protein, with its expression being controlled by a variety of factors, including stress, nutrients, and hormones.

Genular Protein ID: 111967739

Symbol: GSTA4_HUMAN

Name: Glutathione S-transferase A4

UniProtKB Accession Codes:

O15217 B2RD15 Q5T7Q8 Q6P4G1 Q9BX18 Q9H414

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 24 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SFLD 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9461507

Title: Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation.

PubMed ID: 9461507

DOI: 10.1042/bj3300175

PubMed ID: 9480897

Title: Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.

PubMed ID: 9480897

DOI: 10.1042/bj3300827

PubMed ID: 9587421

Title: Identification of a novel human glutathione S-transferase using bioinformatics.

PubMed ID: 9587421

DOI: 10.1006/abbi.1998.0608

PubMed ID: 9820822

Title: Genomic organization, 5'-flanking region and chromosomal localization of the human glutathione transferase A4 gene.

PubMed ID: 9820822

DOI: 10.1042/bj3360437

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10329152

Title: Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products.

PubMed ID: 10329152

DOI: 10.1006/jmbi.1999.2697

PubMed ID: 20085333

Title: Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal.

PubMed ID: 20085333

DOI: 10.1021/bi902038u

Sequence Information:

  • Length: 222
  • Mass: 25704
  • Checksum: 1BD98B41E413BB4E
  • Sequence:
    • MAARPKLHYP NGRGRMESVR WVLAAAGVEF DEEFLETKEQ LYKLQDGNHL LFQQVPMVEI 
DGMKLVQTRS ILHYIADKHN LFGKNLKERT LIDMYVEGTL DLLELLIMHP FLKPDDQQKE 
VVNMAQKAII RYFPVFEKIL RGHGQSFLVG NQLSLADVIL LQTILALEEK IPNILSAFPF 
LQEYTVKLSN IPTIKRFLEP GSKKKPPPDE IYVRTVYNIF RP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.