Gene GSTM3 - ENSG00000134202 | NCBI Gene ID: 2947

Details for: GSTM3

Gene ID: 2947

Symbol: GSTM3

Ensembl ID: ENSG00000134202

Description: glutathione S-transferase mu 3

Associated with

Biological oxidations
(R-HSA-211859)
Glutathione conjugation
(R-HSA-156590)
Metabolism
(R-HSA-1430728)
Phase ii - conjugation of compounds
(R-HSA-156580)
Cellular detoxification of nitrogen compound
(GO:0070458)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Enzyme binding
(GO:0019899)
Establishment of blood-nerve barrier
(GO:0008065)
Extracellular exosome
(GO:0070062)
Glutathione binding
(GO:0043295)
Glutathione metabolic process
(GO:0006749)
Glutathione transferase activity
(GO:0004364)
Identical protein binding
(GO:0042802)
Intercellular bridge
(GO:0045171)
Nitrobenzene metabolic process
(GO:0018916)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Response to estrogen
(GO:0043627)
Sperm fibrous sheath
(GO:0035686)
Xenobiotic catabolic process
(GO:0042178)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.52
Marker Score: 8873
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.84
Marker Score: 7600
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.69
Marker Score: 3810
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.58
Marker Score: 2735
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.35
Marker Score: 2000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.19
Marker Score: 8455
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.15
Marker Score: 3170
Cell Name: theca cell (CL0000503)
Fold Change: 2.14
Marker Score: 1530
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.96
Marker Score: 818
Cell Name: peptic cell (CL0000155)
Fold Change: 1.96
Marker Score: 821
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.95
Marker Score: 25775
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.94
Marker Score: 2091
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.93
Marker Score: 11453.5
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.86
Marker Score: 4219
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.76
Marker Score: 2710
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.74
Marker Score: 4565
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.74
Marker Score: 557
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.72
Marker Score: 429
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.71
Marker Score: 429
Cell Name: malignant cell (CL0001064)
Fold Change: 1.7
Marker Score: 22807
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.69
Marker Score: 331
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.68
Marker Score: 10901
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.67
Marker Score: 391
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.58
Marker Score: 1671
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.57
Marker Score: 1119
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.57
Marker Score: 445
Cell Name: keratocyte (CL0002363)
Fold Change: 1.57
Marker Score: 361
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.55
Marker Score: 1605
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.45
Marker Score: 12490
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.44
Marker Score: 49069
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.42
Marker Score: 1110
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.41
Marker Score: 48924
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.39
Marker Score: 517
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.37
Marker Score: 2277
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.37
Marker Score: 517
Cell Name: oocyte (CL0000023)
Fold Change: 1.36
Marker Score: 336
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.32
Marker Score: 3116
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.32
Marker Score: 1103
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.31
Marker Score: 890
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.31
Marker Score: 441
Cell Name: supporting cell (CL0000630)
Fold Change: 1.3
Marker Score: 2444
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.29
Marker Score: 14550
Cell Name: kidney cell (CL1000497)
Fold Change: 1.27
Marker Score: 850
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.27
Marker Score: 431
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.26
Marker Score: 792.5
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.25
Marker Score: 1196
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.25
Marker Score: 1546
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.25
Marker Score: 2051
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.25
Marker Score: 2633
Cell Name: Unknown (CL0002371)
Fold Change: 1.25
Marker Score: 1324
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.24
Marker Score: 1781
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.22
Marker Score: 671
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.2
Marker Score: 9357.5
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.2
Marker Score: 1342
Cell Name: stem cell (CL0000034)
Fold Change: 1.18
Marker Score: 2806
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.16
Marker Score: 1177
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.14
Marker Score: 749
Cell Name: fibroblast (CL0000057)
Fold Change: 1.11
Marker Score: 1075
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.11
Marker Score: 11193
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.11
Marker Score: 384
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.11
Marker Score: 2251
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.1
Marker Score: 1333
Cell Name: male germ cell (CL0000015)
Fold Change: 1.08
Marker Score: 312
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.08
Marker Score: 1488
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.08
Marker Score: 267
Cell Name: chondrocyte (CL0000138)
Fold Change: 1.06
Marker Score: 476
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.05
Marker Score: 599
Cell Name: acinar cell (CL0000622)
Fold Change: 1.05
Marker Score: 738
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.04
Marker Score: 902
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251701
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.03
Marker Score: 2793
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1.02
Marker Score: 963
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.02
Marker Score: 959
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.02
Marker Score: 2120
Cell Name: Mueller cell (CL0000636)
Fold Change: 1.01
Marker Score: 1407
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.01
Marker Score: 1781
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71720
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47945
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.99
Marker Score: 2408
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30396
Cell Name: muscle cell (CL0000187)
Fold Change: 0.98
Marker Score: 277
Cell Name: decidual cell (CL2000002)
Fold Change: 0.98
Marker Score: 4218
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.98
Marker Score: 521
Cell Name: inflammatory cell (CL0009002)
Fold Change: 0.98
Marker Score: 420
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.97
Marker Score: 391
Cell Name: stromal cell (CL0000499)
Fold Change: 0.96
Marker Score: 1129.5
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.95
Marker Score: 352
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.95
Marker Score: 553
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.95
Marker Score: 1013
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2400
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 0.94
Marker Score: 1229
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 486
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.94
Marker Score: 588
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.93
Marker Score: 296
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 441
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.92
Marker Score: 328
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.92
Marker Score: 423
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5240
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2711
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.9
Marker Score: 2221

Hover over a box to see details here...

**Key characteristics:** * GSTM3 is a single-pass protein that is expressed in the cytoplasm. * It is a highly conserved protein, with a sequence that is found in organisms from yeast to humans. * GSTM3 is a multi-functional protein that can be active as a glutathione S-transferase or as a glutathione reductase. * It is a key regulator of cellular glutathione levels and plays a role in maintaining cellular homeostasis. **Pathways and functions:** * GSTM3 is involved in a number of important biological processes, including detoxification, cell signaling, and immune responses. * In detoxification, GSTM3 helps to remove harmful substances from the body, including toxins, drugs, and other chemicals. * In cell signaling, GSTM3 is involved in the regulation of cell growth, differentiation, and apoptosis. * In immune responses, GSTM3 is a key regulator of the inflammatory response. It helps to protect cells from damage by reactive oxygen species (ROS), which are produced when oxygen levels are high. **Clinical significance:** * Mutations in GSTM3 have been linked to a number of human diseases, including liver disease, kidney disease, and cancer. * GSTM3 inhibitors are being investigated as a treatment for these diseases. * By understanding the role of GSTM3 in health and disease, researchers hope to develop new treatments for these conditions.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Glutathione S-transferase Mu 3

Genular Protein ID: 2115413120

Symbol: GSTM3_HUMAN

Name: Glutathione S-transferase Mu 3

UniProtKB Accession Codes:

P21266 O60550 Q96HA3

Database IDs:

Citations:

PubMed ID: 2345169

Title: A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes.

PubMed ID: 2345169

DOI: 10.1016/s0021-9258(19)38830-1

PubMed ID: 9882431

Title: Distinctive structure of the human GSTM3 gene-inverted orientation relative to the mu class glutathione transferase gene cluster.

PubMed ID: 9882431

DOI: 10.1006/abbi.1998.0964

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8373352

Title: Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript.

PubMed ID: 8373352

DOI: 10.1042/bj2940373

PubMed ID: 8218382

Title: Human Mu-class glutathione S-transferases present in liver, skeletal muscle and testicular tissue.

PubMed ID: 8218382

DOI: 10.1016/0167-4838(93)90047-u

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10587441

Title: An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases.

PubMed ID: 10587441

DOI: 10.1021/bi991714t

Sequence Information:

Length: 225
Mass: 26560
Checksum: 79093161ECEF5396
Sequence:

MSCESSMVLG YWDIRGLAHA IRLLLEFTDT SYEEKRYTCG EAPDYDRSQW LDVKFKLDLD 
FPNLPYLLDG KNKITQSNAI LRYIARKHNM CGETEEEKIR VDIIENQVMD FRTQLIRLCY 
SSDHEKLKPQ YLEELPGQLK QFSMFLGKFS WFAGEKLTFV DFLTYDILDQ NRIFDPKCLD 
EFPNLKAFMC RFEALEKIAA YLQSDQFCKM PINNKMAQWG NKPVC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GSTM3

Associated with

Cells (max top 100)

Other Information

A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes. PubMed ID: 2345169

Distinctive structure of the human GSTM3 gene-inverted orientation relative to the mu class glutathione transferase gene cluster. PubMed ID: 9882431

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript. PubMed ID: 8373352

Human Mu-class glutathione S-transferases present in liver, skeletal muscle and testicular tissue. PubMed ID: 8218382

Initial characterization of the human central proteome. PubMed ID: 21269460

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases. PubMed ID: 10587441