Details for: GTF2B

Gene ID: 2959

Symbol: GTF2B

Ensembl ID: ENSG00000137947

Description: general transcription factor IIB

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 249.0594
    Cell Significance Index: -38.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 155.7107
    Cell Significance Index: -39.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 107.8778
    Cell Significance Index: -44.4400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 94.5305
    Cell Significance Index: -44.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 92.6691
    Cell Significance Index: -37.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 84.4892
    Cell Significance Index: -43.4600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 66.6446
    Cell Significance Index: -44.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.2779
    Cell Significance Index: -38.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.2639
    Cell Significance Index: -39.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.1731
    Cell Significance Index: -32.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.2467
    Cell Significance Index: -44.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.4125
    Cell Significance Index: -28.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.2597
    Cell Significance Index: -13.7000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.8010
    Cell Significance Index: 61.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.0797
    Cell Significance Index: 212.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.6708
    Cell Significance Index: 311.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.2618
    Cell Significance Index: 367.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4416
    Cell Significance Index: 13.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4201
    Cell Significance Index: 19.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2243
    Cell Significance Index: 35.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1157
    Cell Significance Index: 29.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0254
    Cell Significance Index: 184.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0039
    Cell Significance Index: 201.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9247
    Cell Significance Index: 43.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8880
    Cell Significance Index: 24.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7897
    Cell Significance Index: 97.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7779
    Cell Significance Index: 40.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6622
    Cell Significance Index: 361.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5789
    Cell Significance Index: 16.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5667
    Cell Significance Index: 250.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4881
    Cell Significance Index: 175.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4794
    Cell Significance Index: 65.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4621
    Cell Significance Index: 59.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4505
    Cell Significance Index: 31.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4447
    Cell Significance Index: 88.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4182
    Cell Significance Index: 49.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3742
    Cell Significance Index: 16.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3631
    Cell Significance Index: 16.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2988
    Cell Significance Index: 38.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2884
    Cell Significance Index: 8.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2798
    Cell Significance Index: 18.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2308
    Cell Significance Index: 159.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1662
    Cell Significance Index: 12.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1601
    Cell Significance Index: 15.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1488
    Cell Significance Index: 3.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1487
    Cell Significance Index: 7.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1359
    Cell Significance Index: 25.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1182
    Cell Significance Index: 9.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0842
    Cell Significance Index: 5.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0253
    Cell Significance Index: 1.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0219
    Cell Significance Index: 41.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0040
    Cell Significance Index: -2.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0115
    Cell Significance Index: -0.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0118
    Cell Significance Index: -18.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0124
    Cell Significance Index: -22.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0138
    Cell Significance Index: -2.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0163
    Cell Significance Index: -7.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0184
    Cell Significance Index: -25.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0295
    Cell Significance Index: -21.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0361
    Cell Significance Index: -1.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0376
    Cell Significance Index: -28.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0473
    Cell Significance Index: -35.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0560
    Cell Significance Index: -5.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0631
    Cell Significance Index: -1.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0659
    Cell Significance Index: -37.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0791
    Cell Significance Index: -49.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0855
    Cell Significance Index: -2.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0936
    Cell Significance Index: -2.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1277
    Cell Significance Index: -7.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1290
    Cell Significance Index: -37.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1456
    Cell Significance Index: -21.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2241
    Cell Significance Index: -25.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2251
    Cell Significance Index: -47.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2575
    Cell Significance Index: -4.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2659
    Cell Significance Index: -4.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2796
    Cell Significance Index: -18.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3066
    Cell Significance Index: -7.8800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3201
    Cell Significance Index: -2.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3650
    Cell Significance Index: -11.6900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3727
    Cell Significance Index: -5.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3857
    Cell Significance Index: -17.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3933
    Cell Significance Index: -20.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3956
    Cell Significance Index: -41.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4427
    Cell Significance Index: -8.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4613
    Cell Significance Index: -36.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4698
    Cell Significance Index: -17.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4761
    Cell Significance Index: -10.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5547
    Cell Significance Index: -14.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5805
    Cell Significance Index: -14.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6652
    Cell Significance Index: -17.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6775
    Cell Significance Index: -11.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7198
    Cell Significance Index: -44.1300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7580
    Cell Significance Index: -4.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7878
    Cell Significance Index: -39.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8161
    Cell Significance Index: -17.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8315
    Cell Significance Index: -24.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8367
    Cell Significance Index: -19.3300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8624
    Cell Significance Index: -15.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.9153
    Cell Significance Index: -9.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9307
    Cell Significance Index: -11.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcription Factor Function**: GTF2B acts as a transcription factor, binding to specific DNA sequences and regulating the assembly of the pre-initiation complex (PIC) on the promoter region of target genes. 2. **Chromatin Remodeling**: GTF2B is involved in chromatin remodeling, a process that facilitates the accessibility of DNA to transcription factors and the assembly of the PIC. 3. **Histone Acetylation**: GTF2B is also involved in histone acetylation, a process that regulates chromatin structure and gene expression. 4. **Cell-Type Specific Expression**: GTF2B is significantly expressed in multiple cell types, including pancreatic acinar cells, fibroblasts, and T cells. 5. **Disease Association**: Alterations in GTF2B expression have been associated with various diseases, including cancer and HIV infection. **Pathways and Functions** 1. **Transcription Initiation**: GTF2B plays a crucial role in the transcription initiation process, facilitating the assembly of the PIC on the promoter region of target genes. 2. **Chromatin Remodeling**: GTF2B is involved in chromatin remodeling, a process that facilitates the accessibility of DNA to transcription factors and the assembly of the PIC. 3. **Histone Acetylation**: GTF2B is also involved in histone acetylation, a process that regulates chromatin structure and gene expression. 4. **Cell Division**: GTF2B is involved in cell division, regulating the assembly of the pre-initiation complex and the transcription of genes involved in cell cycle progression. 5. **Chromatin Binding**: GTF2B binds to specific DNA sequences, facilitating the assembly of the PIC and regulating the transcription of target genes. **Clinical Significance** 1. **Cancer Association**: Alterations in GTF2B expression have been associated with various cancers, including pancreatic cancer and breast cancer. 2. **HIV Infection**: GTF2B plays a crucial role in the regulation of HIV transcription, and alterations in GTF2B expression have been associated with HIV infection and disease progression. 3. **Autoimmune Diseases**: GTF2B has been implicated in autoimmune diseases, including rheumatoid arthritis and multiple sclerosis, where alterations in GTF2B expression have been associated with disease pathogenesis. 4. **Gene Therapy**: GTF2B has been identified as a potential target for gene therapy, where alterations in GTF2B expression have been associated with disease pathogenesis. In conclusion, the GTF2B gene plays a crucial role in the regulation of gene expression and transcription initiation, and its dysregulation has been associated with various diseases, including cancer, HIV infection, and autoimmune diseases. Further research is needed to fully understand the mechanisms of GTF2B function and its role in disease pathogenesis.

Genular Protein ID: 2265295443

Symbol: TF2B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q00403 A8K1A7 Q5JS30

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 21 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 EMDB 45 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 55 PDBsum 55 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 Rhea 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1876184

Title: Cloning of a human gene encoding the general transcription initiation factor IIB.

PubMed ID: 1876184

DOI: 10.1038/352689a0

PubMed ID: 1946368

Title: Sequence of general transcription factor TFIIB and relationships to other initiation factors.

PubMed ID: 1946368

DOI: 10.1073/pnas.88.21.9553

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1517211

Title: Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

PubMed ID: 1517211

DOI: 10.1016/s0021-9258(19)37087-5

PubMed ID: 3818643

Title: Factors involved in specific transcription in mammalian RNA polymerase II. Functional analysis of initiation factors IIA and IID and identification of a new factor operating at sequences downstream of the initiation site.

PubMed ID: 3818643

DOI: 10.1016/s0021-9258(18)61506-6

PubMed ID: 3029109

Title: Factors involved in specific transcription by mammalian RNA polymerase II. Purification and functional analysis of initiation factors IIB and IIE.

PubMed ID: 3029109

DOI: 10.1016/s0021-9258(18)61505-4

PubMed ID: 2247058

Title: Factors involved in specific transcription by mammalian RNA polymerase II: role of transcription factors IIA, IID, and IIB during formation of a transcription-competent complex.

PubMed ID: 2247058

DOI: 10.1128/mcb.10.12.6335-6347.1990

PubMed ID: 8504927

Title: Multiple functional domains of human transcription factor IIB: distinct interactions with two general transcription factors and RNA polymerase II.

PubMed ID: 8504927

DOI: 10.1101/gad.7.6.1021

PubMed ID: 8392607

Title: ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB.

PubMed ID: 8392607

DOI: 10.1128/jvi.67.8.4676-4687.1993

PubMed ID: 8413225

Title: Potential RNA polymerase II-induced interactions of transcription factor TFIIB.

PubMed ID: 8413225

DOI: 10.1128/mcb.13.10.6253-6259.1993

PubMed ID: 8515819

Title: Interaction between an acidic activator and transcription factor TFIIB is required for transcriptional activation.

PubMed ID: 8515819

DOI: 10.1038/363741a0

PubMed ID: 8515820

Title: Functional dissection of TFIIB domains required for TFIIB-TFIID-promoter complex formation and basal transcription activity.

PubMed ID: 8515820

DOI: 10.1038/363744a0

PubMed ID: 8516311

Title: Delineation of two functional regions of transcription factor TFIIB.

PubMed ID: 8516311

DOI: 10.1073/pnas.90.12.5628

PubMed ID: 8516312

Title: Functional domains of transcription factor TFIIB.

PubMed ID: 8516312

DOI: 10.1073/pnas.90.12.5633

PubMed ID: 8566795

Title: Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II.

PubMed ID: 8566795

DOI: 10.1016/0378-1119(95)00634-6

PubMed ID: 7601352

Title: Recycling of the general transcription factors during RNA polymerase II transcription.

PubMed ID: 7601352

DOI: 10.1101/gad.9.12.1479

PubMed ID: 7983760

Title: The Epstein-Barr virus nuclear protein 2 acidic domain can interact with TFIIB, TAF40, and RPA70 but not with TATA-binding protein.

PubMed ID: 7983760

DOI: 10.1128/jvi.69.1.585-588.1995

PubMed ID: 8662660

Title: RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding.

PubMed ID: 8662660

DOI: 10.1074/jbc.271.20.11703

PubMed ID: 8800208

Title: The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB.

PubMed ID: 8800208

DOI: 10.1006/jmbi.1996.0485

PubMed ID: 9420329

Title: New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB.

PubMed ID: 9420329

DOI: 10.1101/gad.12.1.34

PubMed ID: 10359081

Title: The HIV-1 Vpr co-activator induces a conformational change in TFIIB.

PubMed ID: 10359081

DOI: 10.1016/s0014-5793(99)00501-3

PubMed ID: 10318856

Title: The role of human TFIIB in transcription start site selection in vitro and in vivo.

PubMed ID: 10318856

DOI: 10.1074/jbc.274.20.14337

PubMed ID: 11005381

Title: Potential targets for HSF1 within the preinitiation complex.

PubMed ID: 11005381

DOI: 10.1379/1466-1268(2000)005<0229:ptfhwt>2.0.co;2

PubMed ID: 12931194

Title: Transcription factor IIB acetylates itself to regulate transcription.

PubMed ID: 12931194

DOI: 10.1038/nature01899

PubMed ID: 16230532

Title: A core promoter element downstream of the TATA box that is recognized by TFIIB.

PubMed ID: 16230532

DOI: 10.1101/gad.342405

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24441171

Title: A new paradigm for transcription factor TFIIB functionality.

PubMed ID: 24441171

DOI: 10.1038/srep03664

PubMed ID: 7671313

Title: Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein.

PubMed ID: 7671313

DOI: 10.1016/0092-8674(95)90483-2

PubMed ID: 7675079

Title: Crystal structure of a TFIIB-TBP-TATA-element ternary complex.

PubMed ID: 7675079

DOI: 10.1038/377119a0

PubMed ID: 9609687

Title: Human general transcription factor TFIIB: conformational variability and interaction with VP16 activation domain.

PubMed ID: 9609687

DOI: 10.1021/bi9801098

PubMed ID: 10619841

Title: Structural basis of preinitiation complex assembly on human pol II promoters.

PubMed ID: 10619841

DOI: 10.1093/emboj/19.1.25

PubMed ID: 11045620

Title: Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription.

PubMed ID: 11045620

DOI: 10.1110/ps.9.9.1743

PubMed ID: 14641108

Title: Probing Zn2+-binding effects on the zinc-ribbon domain of human general transcription factor TFIIB.

PubMed ID: 14641108

DOI: 10.1042/bj20031706

PubMed ID: 15654739

Title: Structural properties of the promiscuous VP16 activation domain.

PubMed ID: 15654739

DOI: 10.1021/bi0482912

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

PubMed ID: 29158257

Title: Structural dissection of an interaction between transcription initiation and termination factors implicated in promoter-terminator cross-talk.

PubMed ID: 29158257

DOI: 10.1074/jbc.m117.811521

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 316
  • Mass: 34833
  • Checksum: 9CC7E102526C2722
  • Sequence:
    • MASTSRLDAL PRVTCPNHPD AILVEDYRAG DMICPECGLV VGDRVIDVGS EWRTFSNDKA 
TKDPSRVGDS QNPLLSDGDL STMIGKGTGA ASFDEFGNSK YQNRRTMSSS DRAMMNAFKE 
ITTMADRINL PRNIVDRTNN LFKQVYEQKS LKGRANDAIA SACLYIACRQ EGVPRTFKEI 
CAVSRISKKE IGRCFKLILK ALETSVDLIT TGDFMSRFCS NLCLPKQVQM AATHIARKAV 
ELDLVPGRSP ISVAAAAIYM ASQASAEKRT QKEIGDIAGV ADVTIRQSYR LIYPRAPDLF 
PTDFKFDTPV DKLPQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.