Details for: GTF2B

Gene ID: 2959

Symbol: GTF2B

Ensembl ID: ENSG00000137947

Description: general transcription factor IIB

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.23
    Marker Score: 4714
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.82
    Marker Score: 61766
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.66
    Marker Score: 1298
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.52
    Marker Score: 2242
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.49
    Marker Score: 1254
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.48
    Marker Score: 2430
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.47
    Marker Score: 1574
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.46
    Marker Score: 14470
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.44
    Marker Score: 1734
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.42
    Marker Score: 1498
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.42
    Marker Score: 707
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.41
    Marker Score: 5553
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.39
    Marker Score: 840
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.38
    Marker Score: 16029
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.36
    Marker Score: 985
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.36
    Marker Score: 782
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.36
    Marker Score: 1272
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.34
    Marker Score: 1674.5
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.33
    Marker Score: 545
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.33
    Marker Score: 1135
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.32
    Marker Score: 1302
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.3
    Marker Score: 403
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.28
    Marker Score: 874
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.28
    Marker Score: 67655.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.27
    Marker Score: 1759
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.27
    Marker Score: 1825
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.27
    Marker Score: 365
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.27
    Marker Score: 1274
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.26
    Marker Score: 379
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.26
    Marker Score: 4665
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.24
    Marker Score: 1651
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.24
    Marker Score: 771
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.23
    Marker Score: 1440.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.23
    Marker Score: 434
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.22
    Marker Score: 768.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2
    Marker Score: 286
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.19
    Marker Score: 1299
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.19
    Marker Score: 1148
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.19
    Marker Score: 866
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.19
    Marker Score: 260
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.18
    Marker Score: 567
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.17
    Marker Score: 3296
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.17
    Marker Score: 12118
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.16
    Marker Score: 529
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.16
    Marker Score: 1252
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.16
    Marker Score: 878
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.15
    Marker Score: 905
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.15
    Marker Score: 3120
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.15
    Marker Score: 70477
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.14
    Marker Score: 7317
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.14
    Marker Score: 2019
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.14
    Marker Score: 966.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.14
    Marker Score: 1983
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.13
    Marker Score: 461
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.13
    Marker Score: 39125
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.13
    Marker Score: 506
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.12
    Marker Score: 341
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.12
    Marker Score: 28650
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.12
    Marker Score: 251
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.11
    Marker Score: 387
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.1
    Marker Score: 524
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.1
    Marker Score: 834
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.1
    Marker Score: 1959
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.1
    Marker Score: 1165
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.09
    Marker Score: 1681
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.09
    Marker Score: 2128
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.09
    Marker Score: 1537
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.09
    Marker Score: 268
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.08
    Marker Score: 968
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.08
    Marker Score: 1129
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.06
    Marker Score: 441
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.06
    Marker Score: 516
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.06
    Marker Score: 1061
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.05
    Marker Score: 224
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.05
    Marker Score: 713
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.04
    Marker Score: 477
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.04
    Marker Score: 1086
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.03
    Marker Score: 283
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.03
    Marker Score: 656
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.02
    Marker Score: 3233.5
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.02
    Marker Score: 271
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.02
    Marker Score: 688
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.02
    Marker Score: 228
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.02
    Marker Score: 500
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.02
    Marker Score: 352
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.02
    Marker Score: 2315
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.02
    Marker Score: 250
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.02
    Marker Score: 786
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.01
    Marker Score: 1309
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.01
    Marker Score: 9632
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.01
    Marker Score: 252
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.01
    Marker Score: 220
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.01
    Marker Score: 359
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.01
    Marker Score: 463
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.01
    Marker Score: 1964
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 1.01
    Marker Score: 294
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.01
    Marker Score: 649
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.01
    Marker Score: 3459
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.01
    Marker Score: 203
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1
    Marker Score: 370

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Other Information

**Key characteristics:** * GTF2B is a nuclear protein that is localized to the nucleus. * It is a member of the GTF2 family of transcription factors, which are involved in the regulation of gene expression in a variety of cell types. * GTF2B has been shown to be essential for the transcription of viral genes in some cell types. **Pathways and functions:** * GTF2B is involved in the regulation of gene expression in a variety of cell types. * In immune cells, GTF2B is essential for the transcription of viral genes. * It is also involved in the regulation of cell cycle progression and apoptosis. **Clinical significance:** * Mutations in GTF2B have been linked to the development of a number of human diseases, including cancer and viral infections. * GTF2B inhibitors are being investigated as potential treatments for these diseases. **Additional information:** * GTF2B is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a multi-domain protein that contains a DNA-binding domain and a transactivation domain. * GTF2B is a relatively poorly understood protein, but it is known to play an important role in the regulation of gene expression in immune cells.

Genular Protein ID: 2265295443

Symbol: TF2B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q00403 A8K1A7 Q5JS30

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 9 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 EMDB 34 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 64 PDBsum 44 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 Rhea 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1876184

Title: Cloning of a human gene encoding the general transcription initiation factor IIB.

PubMed ID: 1876184

DOI: 10.1038/352689a0

PubMed ID: 1946368

Title: Sequence of general transcription factor TFIIB and relationships to other initiation factors.

PubMed ID: 1946368

DOI: 10.1073/pnas.88.21.9553

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1517211

Title: Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

PubMed ID: 1517211

DOI: 10.1016/s0021-9258(19)37087-5

PubMed ID: 3818643

Title: Factors involved in specific transcription in mammalian RNA polymerase II. Functional analysis of initiation factors IIA and IID and identification of a new factor operating at sequences downstream of the initiation site.

PubMed ID: 3818643

DOI: 10.1016/s0021-9258(18)61506-6

PubMed ID: 3029109

Title: Factors involved in specific transcription by mammalian RNA polymerase II. Purification and functional analysis of initiation factors IIB and IIE.

PubMed ID: 3029109

DOI: 10.1016/s0021-9258(18)61505-4

PubMed ID: 2247058

Title: Factors involved in specific transcription by mammalian RNA polymerase II: role of transcription factors IIA, IID, and IIB during formation of a transcription-competent complex.

PubMed ID: 2247058

DOI: 10.1128/mcb.10.12.6335-6347.1990

PubMed ID: 8504927

Title: Multiple functional domains of human transcription factor IIB: distinct interactions with two general transcription factors and RNA polymerase II.

PubMed ID: 8504927

DOI: 10.1101/gad.7.6.1021

PubMed ID: 8392607

Title: ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB.

PubMed ID: 8392607

DOI: 10.1128/jvi.67.8.4676-4687.1993

PubMed ID: 8413225

Title: Potential RNA polymerase II-induced interactions of transcription factor TFIIB.

PubMed ID: 8413225

DOI: 10.1128/mcb.13.10.6253-6259.1993

PubMed ID: 8515819

Title: Interaction between an acidic activator and transcription factor TFIIB is required for transcriptional activation.

PubMed ID: 8515819

DOI: 10.1038/363741a0

PubMed ID: 8515820

Title: Functional dissection of TFIIB domains required for TFIIB-TFIID-promoter complex formation and basal transcription activity.

PubMed ID: 8515820

DOI: 10.1038/363744a08316289

PubMed ID: 8516311

Title: Delineation of two functional regions of transcription factor TFIIB.

PubMed ID: 8516311

DOI: 10.1073/pnas.90.12.5628

PubMed ID: 8516312

Title: Functional domains of transcription factor TFIIB.

PubMed ID: 8516312

DOI: 10.1073/pnas.90.12.5633

PubMed ID: 8566795

Title: Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II.

PubMed ID: 8566795

DOI: 10.1016/0378-1119(95)00634-6

PubMed ID: 7601352

Title: Recycling of the general transcription factors during RNA polymerase II transcription.

PubMed ID: 7601352

DOI: 10.1101/gad.9.12.1479

PubMed ID: 7983760

Title: The Epstein-Barr virus nuclear protein 2 acidic domain can interact with TFIIB, TAF40, and RPA70 but not with TATA-binding protein.

PubMed ID: 7983760

DOI: 10.1128/jvi.69.1.585-588.1995

PubMed ID: 8662660

Title: RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding.

PubMed ID: 8662660

DOI: 10.1074/jbc.271.20.11703

PubMed ID: 8800208

Title: The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB.

PubMed ID: 8800208

DOI: 10.1006/jmbi.1996.0485

PubMed ID: 9420329

Title: New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB.

PubMed ID: 9420329

DOI: 10.1101/gad.12.1.34

PubMed ID: 10359081

Title: The HIV-1 Vpr co-activator induces a conformational change in TFIIB.

PubMed ID: 10359081

DOI: 10.1016/s0014-5793(99)00501-3

PubMed ID: 10318856

Title: The role of human TFIIB in transcription start site selection in vitro and in vivo.

PubMed ID: 10318856

DOI: 10.1074/jbc.274.20.14337

PubMed ID: 11005381

Title: Potential targets for HSF1 within the preinitiation complex.

PubMed ID: 11005381

DOI: 10.1379/1466-1268(2000)005<0229:ptfhwt>2.0.co;2

PubMed ID: 12931194

Title: Transcription factor IIB acetylates itself to regulate transcription.

PubMed ID: 12931194

DOI: 10.1038/nature01899

PubMed ID: 16230532

Title: A core promoter element downstream of the TATA box that is recognized by TFIIB.

PubMed ID: 16230532

DOI: 10.1101/gad.342405

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24441171

Title: A new paradigm for transcription factor TFIIB functionality.

PubMed ID: 24441171

DOI: 10.1038/srep03664

PubMed ID: 7671313

Title: Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein.

PubMed ID: 7671313

DOI: 10.1016/0092-8674(95)90483-2

PubMed ID: 7675079

Title: Crystal structure of a TFIIB-TBP-TATA-element ternary complex.

PubMed ID: 7675079

DOI: 10.1038/377119a0

PubMed ID: 9609687

Title: Human general transcription factor TFIIB: conformational variability and interaction with VP16 activation domain.

PubMed ID: 9609687

DOI: 10.1021/bi9801098

PubMed ID: 10619841

Title: Structural basis of preinitiation complex assembly on human pol II promoters.

PubMed ID: 10619841

DOI: 10.1093/emboj/19.1.25

PubMed ID: 11045620

Title: Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription.

PubMed ID: 11045620

DOI: 10.1110/ps.9.9.1743

PubMed ID: 14641108

Title: Probing Zn2+-binding effects on the zinc-ribbon domain of human general transcription factor TFIIB.

PubMed ID: 14641108

DOI: 10.1042/bj20031706

PubMed ID: 15654739

Title: Structural properties of the promiscuous VP16 activation domain.

PubMed ID: 15654739

DOI: 10.1021/bi0482912

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

PubMed ID: 29158257

Title: Structural dissection of an interaction between transcription initiation and termination factors implicated in promoter-terminator cross-talk.

PubMed ID: 29158257

DOI: 10.1074/jbc.m117.811521

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 316
  • Mass: 34833
  • Checksum: 9CC7E102526C2722
  • Sequence:
    • MASTSRLDAL PRVTCPNHPD AILVEDYRAG DMICPECGLV VGDRVIDVGS EWRTFSNDKA 
TKDPSRVGDS QNPLLSDGDL STMIGKGTGA ASFDEFGNSK YQNRRTMSSS DRAMMNAFKE 
ITTMADRINL PRNIVDRTNN LFKQVYEQKS LKGRANDAIA SACLYIACRQ EGVPRTFKEI 
CAVSRISKKE IGRCFKLILK ALETSVDLIT TGDFMSRFCS NLCLPKQVQM AATHIARKAV 
ELDLVPGRSP ISVAAAAIYM ASQASAEKRT QKEIGDIAGV ADVTIRQSYR LIYPRAPDLF 
PTDFKFDTPV DKLPQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.