Details for: GTF2E2

Gene ID: 2961

Symbol: GTF2E2

Ensembl ID: ENSG00000197265

Description: general transcription factor IIE subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 205.6315
    Cell Significance Index: -31.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.6919
    Cell Significance Index: -31.1200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 74.3372
    Cell Significance Index: -30.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 73.7097
    Cell Significance Index: -34.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 65.9428
    Cell Significance Index: -33.9200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 51.9506
    Cell Significance Index: -34.8600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.6839
    Cell Significance Index: -30.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.7771
    Cell Significance Index: -33.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.2282
    Cell Significance Index: -27.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.8232
    Cell Significance Index: -27.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4084
    Cell Significance Index: -33.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.8390
    Cell Significance Index: 127.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.5579
    Cell Significance Index: 41.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3904
    Cell Significance Index: 18.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3823
    Cell Significance Index: 36.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1553
    Cell Significance Index: 231.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1068
    Cell Significance Index: 219.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9501
    Cell Significance Index: 857.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9341
    Cell Significance Index: 56.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9056
    Cell Significance Index: 19.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6923
    Cell Significance Index: 248.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6163
    Cell Significance Index: 72.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6123
    Cell Significance Index: 423.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5427
    Cell Significance Index: 74.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4884
    Cell Significance Index: 25.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4787
    Cell Significance Index: 47.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4763
    Cell Significance Index: 13.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4686
    Cell Significance Index: 255.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4553
    Cell Significance Index: 20.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4508
    Cell Significance Index: 73.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4279
    Cell Significance Index: 77.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4197
    Cell Significance Index: 51.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4178
    Cell Significance Index: 15.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3650
    Cell Significance Index: 7.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3541
    Cell Significance Index: 9.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3182
    Cell Significance Index: 24.4200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.2708
    Cell Significance Index: 2.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2658
    Cell Significance Index: 6.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2606
    Cell Significance Index: 17.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2595
    Cell Significance Index: 114.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2449
    Cell Significance Index: 11.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2362
    Cell Significance Index: 40.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2094
    Cell Significance Index: 11.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2087
    Cell Significance Index: 9.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2060
    Cell Significance Index: 6.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1768
    Cell Significance Index: 10.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1253
    Cell Significance Index: 8.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1166
    Cell Significance Index: 14.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0878
    Cell Significance Index: 3.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0801
    Cell Significance Index: 10.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0421
    Cell Significance Index: 8.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0391
    Cell Significance Index: 73.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0306
    Cell Significance Index: 13.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0285
    Cell Significance Index: 43.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0203
    Cell Significance Index: 37.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0168
    Cell Significance Index: 0.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0109
    Cell Significance Index: 6.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0095
    Cell Significance Index: 12.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0043
    Cell Significance Index: 0.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0055
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0150
    Cell Significance Index: -9.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0195
    Cell Significance Index: -14.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0232
    Cell Significance Index: -17.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0301
    Cell Significance Index: -2.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0356
    Cell Significance Index: -26.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0363
    Cell Significance Index: -5.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0391
    Cell Significance Index: -22.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0690
    Cell Significance Index: -1.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0703
    Cell Significance Index: -7.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0705
    Cell Significance Index: -1.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0984
    Cell Significance Index: -28.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0995
    Cell Significance Index: -20.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1006
    Cell Significance Index: -5.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1009
    Cell Significance Index: -1.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1082
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1268
    Cell Significance Index: -14.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1526
    Cell Significance Index: -7.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1567
    Cell Significance Index: -5.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1579
    Cell Significance Index: -4.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1681
    Cell Significance Index: -3.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1760
    Cell Significance Index: -20.5100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2156
    Cell Significance Index: -3.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2187
    Cell Significance Index: -6.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2242
    Cell Significance Index: -14.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2652
    Cell Significance Index: -27.6100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3003
    Cell Significance Index: -6.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3338
    Cell Significance Index: -7.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3469
    Cell Significance Index: -9.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3500
    Cell Significance Index: -7.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3518
    Cell Significance Index: -10.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3665
    Cell Significance Index: -3.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3730
    Cell Significance Index: -9.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3953
    Cell Significance Index: -31.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4191
    Cell Significance Index: -10.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4201
    Cell Significance Index: -14.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4472
    Cell Significance Index: -27.4200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4565
    Cell Significance Index: -6.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4597
    Cell Significance Index: -9.7900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5455
    Cell Significance Index: -5.9300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5760
    Cell Significance Index: -3.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of TFIIIE complex**: GTF2E2 is a subunit of the TFIIIE (Transcription Factor IIE) complex, which plays a vital role in regulating gene expression by facilitating the recruitment of RNA polymerase II to specific promoters. 2. **RNA binding and polymerase II activity**: GTF2E2 interacts with RNA polymerase II, a key enzyme involved in transcription, and modulates its activity to regulate gene expression. 3. **Cell-type specificity**: GTF2E2 is expressed in various cell types, including oogonial cells, male germ cells, and specific neuronal populations, suggesting a cell-type-specific role in regulating gene expression. 4. **Disease association**: GTF2E2 has been implicated in various diseases, including HIV infection, highlighting its potential as a therapeutic target. **Pathways and Functions:** 1. **Transcriptional regulation**: GTF2E2 participates in the regulation of gene expression by interacting with RNA polymerase II and facilitating its recruitment to specific promoters. 2. **HIV transcription**: GTF2E2 is essential for the transcription of the HIV genome, making it a potential target for antiviral therapies. 3. **Gene expression in development**: GTF2E2 is involved in the regulation of gene expression during development, particularly in the specification of germ cells and neurons. 4. **Cell cycle regulation**: GTF2E2 has been implicated in the regulation of cell cycle progression, suggesting a role in maintaining cellular homeostasis. **Clinical Significance:** 1. **HIV infection**: GTF2E2 is a potential target for antiviral therapies, as its disruption can impair HIV transcription and replication. 2. **Neurological disorders**: GTF2E2's involvement in neuronal development and function suggests a potential link to neurological disorders, such as autism and schizophrenia. 3. **Cancer**: GTF2E2's role in regulating gene expression and cell cycle progression makes it a potential biomarker for cancer diagnosis and prognosis. 4. **Immunological disorders**: GTF2E2's involvement in immune responses, particularly in the context of HIV infection, highlights its potential as a therapeutic target for immunological disorders. In conclusion, GTF2E2 is a multifunctional protein that plays a crucial role in regulating gene expression, particularly in the context of HIV infection and neuronal development. Further research is necessary to fully elucidate its mechanisms of action and its potential therapeutic applications. As an expert immunologist, I emphasize the importance of continued investigation into the role of GTF2E2 in human health and disease.

Genular Protein ID: 2178773606

Symbol: T2EB_HUMAN

Name: Transcription initiation factor IIE subunit beta

UniProtKB Accession Codes:

P29084 D3DSV2 Q9H2B9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 37 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1956398

Title: Structure and functional properties of human general transcription factor IIE.

PubMed ID: 1956398

DOI: 10.1038/354369a0

PubMed ID: 1956404

Title: Conserved sequence motifs in the small subunit of human general transcription factor TFIIE.

PubMed ID: 1956404

DOI: 10.1038/354401a0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7651391

Title: The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE.

PubMed ID: 7651391

DOI: 10.1128/mcb.15.9.4735

PubMed ID: 10792464

Title: Functional interaction of general transcription initiation factor TFIIE with general chromatin factor SPT16/CDC68.

PubMed ID: 10792464

DOI: 10.1046/j.1365-2443.2000.00323.x

PubMed ID: 19106100

Title: MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.

PubMed ID: 19106100

DOI: 10.1074/jbc.m807098200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26996949

Title: GTF2E2 mutations destabilize the general transcription factor complex TFIIE in individuals with DNA repair-proficient trichothiodystrophy.

PubMed ID: 26996949

DOI: 10.1016/j.ajhg.2016.02.008

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

Sequence Information:

  • Length: 291
  • Mass: 33044
  • Checksum: 20F6BDFF2E06E5E7
  • Sequence:
    • MDPSLLRERE LFKKRALSTP VVEKRSASSE SSSSSSKKKK TKVEHGGSSG SKQNSDHSNG 
SFNLKALSGS SGYKFGVLAK IVNYMKTRHQ RGDTHPLTLD EILDETQHLD IGLKQKQWLM 
TEALVNNPKI EVIDGKYAFK PKYNVRDKKA LLRLLDQHDQ RGLGGILLED IEEALPNSQK 
AVKALGDQIL FVNRPDKKKI LFFNDKSCQF SVDEEFQKLW RSVTVDSMDE EKIEEYLKRQ 
GISSMQESGP KKVAPIQRRK KPASQKKRRF KTHNEHLAGV LKDYSDITSS K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.