Gene GTF2E2 - ENSG00000197265 | NCBI Gene ID: 2961

Details for: GTF2E2

Gene ID: 2961

Symbol: GTF2E2

Ensembl ID: ENSG00000197265

Description: general transcription factor IIE subunit 2

Associated with

Disease
(R-HSA-1643685)
Gene expression (transcription)
(R-HSA-74160)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription initiation
(R-HSA-167161)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Rna polymerase ii general transcription initiation factor activity
(GO:0016251)
Tfiih-class transcription factor complex binding
(GO:0001097)
Transcription by rna polymerase ii
(GO:0006366)
Transcription factor tfiid complex
(GO:0005669)
Transcription factor tfiie complex
(GO:0005673)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: oogonial cell (CL0000024)
Fold Change: 1.81
Marker Score: 2597
Cell Name: male germ cell (CL0000015)
Fold Change: 1.63
Marker Score: 471
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.57
Marker Score: 1963
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.32
Marker Score: 12544
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.3
Marker Score: 20388
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.3
Marker Score: 3058
Cell Name: neuron (CL0000540)
Fold Change: 1.29
Marker Score: 5268
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.29
Marker Score: 79048
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.26
Marker Score: 47929
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.24
Marker Score: 45787
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.23
Marker Score: 11546
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.23
Marker Score: 21779
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.23
Marker Score: 10537
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.22
Marker Score: 4729
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.22
Marker Score: 9346
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.21
Marker Score: 1278
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.2
Marker Score: 581
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.19
Marker Score: 1202
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.19
Marker Score: 23743
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.19
Marker Score: 17768
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.18
Marker Score: 1820
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.18
Marker Score: 929
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.14
Marker Score: 1986
Cell Name: fat cell (CL0000136)
Fold Change: 1.1
Marker Score: 613
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.1
Marker Score: 1181
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.09
Marker Score: 11297
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.07
Marker Score: 3162
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.05
Marker Score: 440
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.04
Marker Score: 4095
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.04
Marker Score: 6645
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.04
Marker Score: 1150
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.04
Marker Score: 2164
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.02
Marker Score: 4224
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.02
Marker Score: 1229
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.02
Marker Score: 1669.5
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.01
Marker Score: 1484
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1
Marker Score: 1062
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1
Marker Score: 2196
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1
Marker Score: 1695
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71641
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47866
Cell Name: oocyte (CL0000023)
Fold Change: 0.99
Marker Score: 245
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30378
Cell Name: basal cell (CL0000646)
Fold Change: 0.98
Marker Score: 1259
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.97
Marker Score: 12739
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.96
Marker Score: 459
Cell Name: decidual cell (CL2000002)
Fold Change: 0.95
Marker Score: 4105
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.95
Marker Score: 8186
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.95
Marker Score: 5706
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.94
Marker Score: 6022
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2390
Cell Name: enterocyte (CL0000584)
Fold Change: 0.94
Marker Score: 4496
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.93
Marker Score: 2283.5
Cell Name: malignant cell (CL0001064)
Fold Change: 0.92
Marker Score: 12408
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.92
Marker Score: 995
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.92
Marker Score: 475
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.92
Marker Score: 3976
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.92
Marker Score: 536
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.92
Marker Score: 1299
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.92
Marker Score: 2491
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.92
Marker Score: 5957
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.91
Marker Score: 3385
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.91
Marker Score: 431
Cell Name: podocyte (CL0000653)
Fold Change: 0.91
Marker Score: 337
Cell Name: Unknown (CL0002371)
Fold Change: 0.91
Marker Score: 967
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.91
Marker Score: 2226.5
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.9
Marker Score: 19269
Cell Name: Unknown (CL0000548)
Fold Change: 0.9
Marker Score: 656
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2688
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.9
Marker Score: 281
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.89
Marker Score: 422
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 5048
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.88
Marker Score: 537
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.88
Marker Score: 660
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.88
Marker Score: 1011
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.88
Marker Score: 1423
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.87
Marker Score: 5619
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.87
Marker Score: 3004
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5292
Cell Name: centroblast (CL0009112)
Fold Change: 0.87
Marker Score: 427
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.87
Marker Score: 7526
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.86
Marker Score: 791
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 309
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.85
Marker Score: 469.5
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.85
Marker Score: 582
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.85
Marker Score: 29347
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.85
Marker Score: 1787
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.85
Marker Score: 413
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.85
Marker Score: 816
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.84
Marker Score: 230
Cell Name: osteoclast (CL0000092)
Fold Change: 0.84
Marker Score: 419
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.84
Marker Score: 443
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.84
Marker Score: 238
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.84
Marker Score: 411
Cell Name: interneuron (CL0000099)
Fold Change: 0.84
Marker Score: 383
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.84
Marker Score: 595.5
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.83
Marker Score: 1586
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.83
Marker Score: 636
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.83
Marker Score: 777
Cell Name: melanocyte (CL0000148)
Fold Change: 0.82
Marker Score: 333

Hover over a box to see details here...

**Key characteristics:** * GTF2E2 is a protein of approximately 120 kDa. * It is a member of the TFIH family of transcription factors. * It is expressed in a variety of cell types, including oogonial cells, male germ cells, and neurons. * It is involved in the regulation of gene expression. **Pathways and functions:** * GTF2E2 is involved in the initiation of transcription. * It is a key regulator of the expression of genes involved in the early stages of development. * It is also involved in the regulation of the expression of genes involved in cell cycle regulation and apoptosis. **Clinical significance:** * Mutations in GTF2E2 have been linked to a number of human diseases, including immunodeficiency and neurodegenerative diseases. * GTF2E2 is a potential target for the treatment of these diseases. **Additional information:** * GTF2E2 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a well-characterized protein that has been extensively studied in model systems. * It is a promising target for the development of new therapies for a variety of diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription initiation factor IIE subunit beta

Genular Protein ID: 2178773606

Symbol: T2EB_HUMAN

Name: Transcription initiation factor IIE subunit beta

UniProtKB Accession Codes:

P29084 D3DSV2 Q9H2B9

Database IDs:

Citations:

PubMed ID: 1956398

Title: Structure and functional properties of human general transcription factor IIE.

PubMed ID: 1956398

DOI: 10.1038/354369a0

PubMed ID: 1956404

Title: Conserved sequence motifs in the small subunit of human general transcription factor TFIIE.

PubMed ID: 1956404

DOI: 10.1038/354401a0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7651391

Title: The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE.

PubMed ID: 7651391

DOI: 10.1128/mcb.15.9.4735

PubMed ID: 10792464

Title: Functional interaction of general transcription initiation factor TFIIE with general chromatin factor SPT16/CDC68.

PubMed ID: 10792464

DOI: 10.1046/j.1365-2443.2000.00323.x

PubMed ID: 19106100

Title: MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.

PubMed ID: 19106100

DOI: 10.1074/jbc.m807098200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26996949

Title: GTF2E2 mutations destabilize the general transcription factor complex TFIIE in individuals with DNA repair-proficient trichothiodystrophy.

PubMed ID: 26996949

DOI: 10.1016/j.ajhg.2016.02.008

Sequence Information:

Length: 291
Mass: 33044
Checksum: 20F6BDFF2E06E5E7
Sequence:

MDPSLLRERE LFKKRALSTP VVEKRSASSE SSSSSSKKKK TKVEHGGSSG SKQNSDHSNG 
SFNLKALSGS SGYKFGVLAK IVNYMKTRHQ RGDTHPLTLD EILDETQHLD IGLKQKQWLM 
TEALVNNPKI EVIDGKYAFK PKYNVRDKKA LLRLLDQHDQ RGLGGILLED IEEALPNSQK 
AVKALGDQIL FVNRPDKKKI LFFNDKSCQF SVDEEFQKLW RSVTVDSMDE EKIEEYLKRQ 
GISSMQESGP KKVAPIQRRK KPASQKKRRF KTHNEHLAGV LKDYSDITSS K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GTF2E2

Associated with

Cells (max top 100)

Other Information

Structure and functional properties of human general transcription factor IIE. PubMed ID: 1956398

Conserved sequence motifs in the small subunit of human general transcription factor TFIIE. PubMed ID: 1956404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE. PubMed ID: 7651391

Functional interaction of general transcription initiation factor TFIIE with general chromatin factor SPT16/CDC68. PubMed ID: 10792464

MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. PubMed ID: 19106100

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

GTF2E2 mutations destabilize the general transcription factor complex TFIIE in individuals with DNA repair-proficient trichothiodystrophy. PubMed ID: 26996949