Details for: USP25

Gene ID: 29761

Symbol: USP25

Ensembl ID: ENSG00000155313

Description: ubiquitin specific peptidase 25

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 4.73
    Marker Score: 3,888
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.42
    Marker Score: 1,867
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.06
    Marker Score: 15,793
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.06
    Marker Score: 1,084
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.03
    Marker Score: 19,085
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.03
    Marker Score: 2,335
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.97
    Marker Score: 8,202
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.95
    Marker Score: 119,808
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.95
    Marker Score: 38,693
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.93
    Marker Score: 7,838
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.9
    Marker Score: 2,552
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.89
    Marker Score: 17,926
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.89
    Marker Score: 71,629
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.87
    Marker Score: 1,046
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.86
    Marker Score: 68,735
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.86
    Marker Score: 3,119
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.83
    Marker Score: 7,092
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.83
    Marker Score: 27,359
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.82
    Marker Score: 15,617
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.78
    Marker Score: 1,922
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.77
    Marker Score: 2,148
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.77
    Marker Score: 874
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.77
    Marker Score: 3,882
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.75
    Marker Score: 6,217
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.73
    Marker Score: 1,496
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.69
    Marker Score: 7,011
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.68
    Marker Score: 7,041
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.66
    Marker Score: 604
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.66
    Marker Score: 973
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.63
    Marker Score: 1,806
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.63
    Marker Score: 36,397
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.59
    Marker Score: 53,681
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.58
    Marker Score: 4,511
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.55
    Marker Score: 454
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.55
    Marker Score: 446
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.55
    Marker Score: 648
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2,384
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.54
    Marker Score: 2,959
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.54
    Marker Score: 568
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.53
    Marker Score: 32,712
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.53
    Marker Score: 27,177
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.53
    Marker Score: 15,766
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.44
    Marker Score: 23,198
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.44
    Marker Score: 1,778
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.44
    Marker Score: 857
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.43
    Marker Score: 5,081
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.43
    Marker Score: 710
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.4
    Marker Score: 2,038
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.4
    Marker Score: 442
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.39
    Marker Score: 3,490
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.36
    Marker Score: 6,287
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.31
    Marker Score: 1,406
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.31
    Marker Score: 1,486
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.31
    Marker Score: 479
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.29
    Marker Score: 899
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.28
    Marker Score: 351
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.28
    Marker Score: 1,139
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.27
    Marker Score: 865
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.26
    Marker Score: 8,108
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.26
    Marker Score: 470
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.25
    Marker Score: 2,947
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.23
    Marker Score: 742
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.23
    Marker Score: 314
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.23
    Marker Score: 1,742
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.22
    Marker Score: 683
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.21
    Marker Score: 18,879
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.2
    Marker Score: 670
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.2
    Marker Score: 380
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.2
    Marker Score: 1,036
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.19
    Marker Score: 2,926
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.16
    Marker Score: 1,102
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.16
    Marker Score: 4,985
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.15
    Marker Score: 442
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.11
    Marker Score: 645
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.1
    Marker Score: 2,937
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.09
    Marker Score: 5,878
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.06
    Marker Score: 1,076
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.06
    Marker Score: 2,148
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.05
    Marker Score: 1,314
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.05
    Marker Score: 3,448
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.04
    Marker Score: 2,501
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.02
    Marker Score: 328
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.01
    Marker Score: 380
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.01
    Marker Score: 265
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.01
    Marker Score: 315
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,673
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,903
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.98
    Marker Score: 399
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,388
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.96
    Marker Score: 1,020
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.95
    Marker Score: 246
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,396
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.94
    Marker Score: 717
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.94
    Marker Score: 320
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.92
    Marker Score: 3,630
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.92
    Marker Score: 535
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,703
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1,465

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** USP25 is a cysteine-type deubiquitinating enzyme that exhibits a high degree of specificity for removing ubiquitin and ubiquitin-like proteins from lysine residues on target proteins. The enzyme is characterized by its ability to recognize and degrade various types of ubiquitin-containing proteins, including protein ubiquitination, sumoylation, and ubiquitin-like protein modifications. USP25 has been shown to be involved in negative regulation of the erad pathway, a process that is critical for maintaining cellular homeostasis and preventing disease. **Pathways and Functions:** USP25 plays a critical role in various cellular pathways, including: 1. **Protein Degradation:** USP25 is involved in the regulation of protein degradation through the removal of ubiquitin and ubiquitin-like proteins from lysine residues on target proteins. 2. **Protein Stability:** USP25 helps to maintain protein stability by removing ubiquitin and ubiquitin-like proteins that can promote protein degradation. 3. **Cell Signaling:** USP25 is involved in various cell signaling pathways, including the regulation of protein activity, localization, and stability. 4. **Metabolism:** USP25 plays a role in regulating metabolic processes, including the degradation of ubiquitin-containing proteins that are involved in energy metabolism. **Clinical Significance:** Dysregulation of USP25 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic disorders. For example: 1. **Cancer:** USP25 has been shown to be overexpressed in certain types of cancer, including breast cancer and colon cancer, where it can contribute to tumorigenesis and metastasis. 2. **Neurodegenerative Disorders:** USP25 has been implicated in the regulation of protein stability and function in neurons, and its dysregulation has been linked to neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. 3. **Metabolic Disorders:** USP25 plays a critical role in regulating metabolic processes, and its dysregulation has been linked to metabolic disorders such as diabetes and obesity. In conclusion, USP25 is a critical regulator of protein stability and function that plays a key role in maintaining cellular homeostasis and regulating various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of USP25 and its role in human disease.

Genular Protein ID: 1119117052

Symbol: UBP25_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 25

UniProtKB Accession Codes:

Q9UHP3 C0LSZ0 Q6DHZ9 Q9H9W1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 17 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 7 PRO 1 PROSITE 4 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10644437

Title: USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2.

PubMed ID: 10644437

DOI: 10.1006/geno.1999.6025

PubMed ID: 10612803

Title: Narrowing of the region of allelic loss in 21q11-21 in squamous non-small cell lung carcinoma and cloning of a novel ubiquitin-specific protease gene from the deleted segment.

PubMed ID: 10612803

DOI: 10.1002/(sici)1098-2264(200002)27:2<153::aid-gcc6>3.3.co;2-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11597335

Title: Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25.

PubMed ID: 11597335

DOI: 10.1186/gb-2001-2-10-research0043

PubMed ID: 16501887

Title: The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins.

PubMed ID: 16501887

DOI: 10.1007/s00018-005-5533-1

PubMed ID: 18538659

Title: Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25.

PubMed ID: 18538659

DOI: 10.1016/j.molcel.2008.03.021

PubMed ID: 19440361

Title: The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition.

PubMed ID: 19440361

DOI: 10.1371/journal.pone.0005571

PubMed ID: 19909739

Title: Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase.

PubMed ID: 19909739

DOI: 10.1016/j.yexcr.2009.10.023

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 1055
  • Mass: 122218
  • Checksum: 0B9CECDCAD619CF2
  • Sequence:
    • MTVEQNVLQQ SAAQKHQQTF LNQLREITGI NDTQILQQAL KDSNGNLELA VAFLTAKNAK 
TPQQEETTYY QTALPGNDRY ISVGSQADTN VIDLTGDDKD DLQRAIALSL AESNRAFRET 
GITDEEQAIS RVLEASIAEN KACLKRTPTE VWRDSRNPYD RKRQDKAPVG LKNVGNTCWF 
SAVIQSLFNL LEFRRLVLNY KPPSNAQDLP RNQKEHRNLP FMRELRYLFA LLVGTKRKYV 
DPSRAVEILK DAFKSNDSQQ QDVSEFTHKL LDWLEDAFQM KAEEETDEEK PKNPMVELFY 
GRFLAVGVLE GKKFENTEMF GQYPLQVNGF KDLHECLEAA MIEGEIESLH SENSGKSGQE 
HWFTELPPVL TFELSRFEFN QALGRPEKIH NKLEFPQVLY LDRYMHRNRE ITRIKREEIK 
RLKDYLTVLQ QRLERYLSYG SGPKRFPLVD VLQYALEFAS SKPVCTSPVD DIDASSPPSG 
SIPSQTLPST TEQQGALSSE LPSTSPSSVA AISSRSVIHK PFTQSRIPPD LPMHPAPRHI 
TEEELSVLES CLHRWRTEIE NDTRDLQESI SRIHRTIELM YSDKSMIQVP YRLHAVLVHE 
GQANAGHYWA YIFDHRESRW MKYNDIAVTK SSWEELVRDS FGGYRNASAY CLMYINDKAQ 
FLIQEEFNKE TGQPLVGIET LPPDLRDFVE EDNQRFEKEL EEWDAQLAQK ALQEKLLASQ 
KLRESETSVT TAQAAGDPEY LEQPSRSDFS KHLKEETIQI ITKASHEHED KSPETVLQSA 
IKLEYARLVK LAQEDTPPET DYRLHHVVVY FIQNQAPKKI IEKTLLEQFG DRNLSFDERC 
HNIMKVAQAK LEMIKPEEVN LEEYEEWHQD YRKFRETTMY LIIGLENFQR ESYIDSLLFL 
ICAYQNNKEL LSKGLYRGHD EELISHYRRE CLLKLNEQAA ELFESGEDRE VNNGLIIMNE 
FIVPFLPLLL VDEMEEKDIL AVEDMRNRWC SYLGQEMEPH LQEKLTDFLP KLLDCSMEIK 
SFHEPPKLPS YSTHELCERF ARIMLSLSRT PADGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.