Details for: USP25
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 4.73
Marker Score: 3,888 - Cell Name: renal principal cell (CL0005009)
Fold Change: 2.42
Marker Score: 1,867 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.06
Marker Score: 15,793 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.06
Marker Score: 1,084 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.03
Marker Score: 19,085 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.03
Marker Score: 2,335 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.97
Marker Score: 8,202 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.95
Marker Score: 119,808 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.95
Marker Score: 38,693 - Cell Name: neuron (CL0000540)
Fold Change: 1.93
Marker Score: 7,838 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.9
Marker Score: 2,552 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.89
Marker Score: 17,926 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.89
Marker Score: 71,629 - Cell Name: fat cell (CL0000136)
Fold Change: 1.87
Marker Score: 1,046 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.86
Marker Score: 68,735 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.86
Marker Score: 3,119 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.83
Marker Score: 7,092 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.83
Marker Score: 27,359 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.82
Marker Score: 15,617 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.78
Marker Score: 1,922 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.77
Marker Score: 2,148 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.77
Marker Score: 874 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.77
Marker Score: 3,882 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.75
Marker Score: 6,217 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.73
Marker Score: 1,496 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.69
Marker Score: 7,011 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.68
Marker Score: 7,041 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.66
Marker Score: 604 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.66
Marker Score: 973 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.63
Marker Score: 1,806 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.63
Marker Score: 36,397 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.59
Marker Score: 53,681 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.58
Marker Score: 4,511 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.55
Marker Score: 454 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.55
Marker Score: 446 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.55
Marker Score: 648 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.54
Marker Score: 2,384 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.54
Marker Score: 2,959 - Cell Name: podocyte (CL0000653)
Fold Change: 1.54
Marker Score: 568 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.53
Marker Score: 32,712 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.53
Marker Score: 27,177 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.53
Marker Score: 15,766 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.44
Marker Score: 23,198 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.44
Marker Score: 1,778 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.44
Marker Score: 857 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.43
Marker Score: 5,081 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.43
Marker Score: 710 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.4
Marker Score: 2,038 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.4
Marker Score: 442 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.39
Marker Score: 3,490 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.36
Marker Score: 6,287 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.31
Marker Score: 1,406 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.31
Marker Score: 1,486 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.31
Marker Score: 479 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.29
Marker Score: 899 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.28
Marker Score: 351 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.28
Marker Score: 1,139 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.27
Marker Score: 865 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.26
Marker Score: 8,108 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.26
Marker Score: 470 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.25
Marker Score: 2,947 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.23
Marker Score: 742 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.23
Marker Score: 314 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.23
Marker Score: 1,742 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.22
Marker Score: 683 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.21
Marker Score: 18,879 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.2
Marker Score: 670 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.2
Marker Score: 380 - Cell Name: astrocyte (CL0000127)
Fold Change: 1.2
Marker Score: 1,036 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.19
Marker Score: 2,926 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.16
Marker Score: 1,102 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.16
Marker Score: 4,985 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.15
Marker Score: 442 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.11
Marker Score: 645 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.1
Marker Score: 2,937 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.09
Marker Score: 5,878 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.06
Marker Score: 1,076 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.06
Marker Score: 2,148 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.05
Marker Score: 1,314 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.05
Marker Score: 3,448 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.04
Marker Score: 2,501 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.02
Marker Score: 328 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.01
Marker Score: 380 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.01
Marker Score: 265 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.01
Marker Score: 315 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,673 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47,903 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.98
Marker Score: 399 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,388 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.96
Marker Score: 1,020 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.95
Marker Score: 246 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,396 - Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.94
Marker Score: 717 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.94
Marker Score: 320 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 482 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 438 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.92
Marker Score: 3,630 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.92
Marker Score: 535 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2,703 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.9
Marker Score: 1,465
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1119117052
Symbol: UBP25_HUMAN
Name: Ubiquitin carboxyl-terminal hydrolase 25
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10644437
Title: USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2.
PubMed ID: 10644437
PubMed ID: 10612803
Title: Narrowing of the region of allelic loss in 21q11-21 in squamous non-small cell lung carcinoma and cloning of a novel ubiquitin-specific protease gene from the deleted segment.
PubMed ID: 10612803
DOI: 10.1002/(sici)1098-2264(200002)27:2<153::aid-gcc6>3.3.co;2-1
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11597335
Title: Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25.
PubMed ID: 11597335
PubMed ID: 16501887
Title: The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins.
PubMed ID: 16501887
PubMed ID: 18538659
Title: Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25.
PubMed ID: 18538659
PubMed ID: 19440361
Title: The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition.
PubMed ID: 19440361
PubMed ID: 19909739
Title: Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase.
PubMed ID: 19909739
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
Sequence Information:
- Length: 1055
- Mass: 122218
- Checksum: 0B9CECDCAD619CF2
- Sequence:
MTVEQNVLQQ SAAQKHQQTF LNQLREITGI NDTQILQQAL KDSNGNLELA VAFLTAKNAK TPQQEETTYY QTALPGNDRY ISVGSQADTN VIDLTGDDKD DLQRAIALSL AESNRAFRET GITDEEQAIS RVLEASIAEN KACLKRTPTE VWRDSRNPYD RKRQDKAPVG LKNVGNTCWF SAVIQSLFNL LEFRRLVLNY KPPSNAQDLP RNQKEHRNLP FMRELRYLFA LLVGTKRKYV DPSRAVEILK DAFKSNDSQQ QDVSEFTHKL LDWLEDAFQM KAEEETDEEK PKNPMVELFY GRFLAVGVLE GKKFENTEMF GQYPLQVNGF KDLHECLEAA MIEGEIESLH SENSGKSGQE HWFTELPPVL TFELSRFEFN QALGRPEKIH NKLEFPQVLY LDRYMHRNRE ITRIKREEIK RLKDYLTVLQ QRLERYLSYG SGPKRFPLVD VLQYALEFAS SKPVCTSPVD DIDASSPPSG SIPSQTLPST TEQQGALSSE LPSTSPSSVA AISSRSVIHK PFTQSRIPPD LPMHPAPRHI TEEELSVLES CLHRWRTEIE NDTRDLQESI SRIHRTIELM YSDKSMIQVP YRLHAVLVHE GQANAGHYWA YIFDHRESRW MKYNDIAVTK SSWEELVRDS FGGYRNASAY CLMYINDKAQ FLIQEEFNKE TGQPLVGIET LPPDLRDFVE EDNQRFEKEL EEWDAQLAQK ALQEKLLASQ KLRESETSVT TAQAAGDPEY LEQPSRSDFS KHLKEETIQI ITKASHEHED KSPETVLQSA IKLEYARLVK LAQEDTPPET DYRLHHVVVY FIQNQAPKKI IEKTLLEQFG DRNLSFDERC HNIMKVAQAK LEMIKPEEVN LEEYEEWHQD YRKFRETTMY LIIGLENFQR ESYIDSLLFL ICAYQNNKEL LSKGLYRGHD EELISHYRRE CLLKLNEQAA ELFESGEDRE VNNGLIIMNE FIVPFLPLLL VDEMEEKDIL AVEDMRNRWC SYLGQEMEPH LQEKLTDFLP KLLDCSMEIK SFHEPPKLPS YSTHELCERF ARIMLSLSRT PADGR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.