Details for: GUCY1B1

Gene ID: 2983

Symbol: GUCY1B1

Ensembl ID: ENSG00000061918

Description: guanylate cyclase 1 soluble subunit beta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 63.1755
    Cell Significance Index: -26.0300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 58.0464
    Cell Significance Index: -27.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.8513
    Cell Significance Index: -22.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.6672
    Cell Significance Index: -28.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.9122
    Cell Significance Index: -22.8300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 7.8359
    Cell Significance Index: 65.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.3358
    Cell Significance Index: -19.4600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 4.8353
    Cell Significance Index: 37.2700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 2.1311
    Cell Significance Index: 9.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8883
    Cell Significance Index: 378.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.7205
    Cell Significance Index: 55.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.6547
    Cell Significance Index: 73.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6027
    Cell Significance Index: 83.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5245
    Cell Significance Index: 546.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4181
    Cell Significance Index: 53.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3185
    Cell Significance Index: 28.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.3050
    Cell Significance Index: 80.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.0225
    Cell Significance Index: 29.1800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.9411
    Cell Significance Index: 8.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7170
    Cell Significance Index: 48.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6499
    Cell Significance Index: 34.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5255
    Cell Significance Index: 100.0000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4906
    Cell Significance Index: 6.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4540
    Cell Significance Index: 313.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4330
    Cell Significance Index: 236.4500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3109
    Cell Significance Index: 4.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2930
    Cell Significance Index: 18.0100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2429
    Cell Significance Index: 3.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1733
    Cell Significance Index: 156.4400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1195
    Cell Significance Index: 1.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0783
    Cell Significance Index: 7.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0517
    Cell Significance Index: 8.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0379
    Cell Significance Index: 17.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0234
    Cell Significance Index: 2.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0024
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0108
    Cell Significance Index: -0.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0167
    Cell Significance Index: -30.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0200
    Cell Significance Index: -30.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0216
    Cell Significance Index: -29.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0233
    Cell Significance Index: -0.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0239
    Cell Significance Index: -15.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0290
    Cell Significance Index: -21.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0295
    Cell Significance Index: -21.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0302
    Cell Significance Index: -13.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0317
    Cell Significance Index: -24.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0388
    Cell Significance Index: -21.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0427
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0497
    Cell Significance Index: -31.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0501
    Cell Significance Index: -3.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0574
    Cell Significance Index: -1.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0783
    Cell Significance Index: -22.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0902
    Cell Significance Index: -5.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0984
    Cell Significance Index: -17.7300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0992
    Cell Significance Index: -1.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1009
    Cell Significance Index: -6.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1018
    Cell Significance Index: -17.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1050
    Cell Significance Index: -6.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1078
    Cell Significance Index: -14.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1129
    Cell Significance Index: -12.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1130
    Cell Significance Index: -8.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1257
    Cell Significance Index: -8.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1340
    Cell Significance Index: -26.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1346
    Cell Significance Index: -28.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1347
    Cell Significance Index: -6.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1353
    Cell Significance Index: -17.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1376
    Cell Significance Index: -20.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1573
    Cell Significance Index: -19.3400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1691
    Cell Significance Index: -2.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1798
    Cell Significance Index: -20.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1971
    Cell Significance Index: -25.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2121
    Cell Significance Index: -21.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2346
    Cell Significance Index: -4.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2432
    Cell Significance Index: -25.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2438
    Cell Significance Index: -28.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2518
    Cell Significance Index: -17.8100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2575
    Cell Significance Index: -5.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2588
    Cell Significance Index: -10.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3143
    Cell Significance Index: -24.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3237
    Cell Significance Index: -10.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3401
    Cell Significance Index: -7.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3585
    Cell Significance Index: -10.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3639
    Cell Significance Index: -17.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3722
    Cell Significance Index: -27.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4004
    Cell Significance Index: -10.5300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4021
    Cell Significance Index: -6.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4040
    Cell Significance Index: -8.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4053
    Cell Significance Index: -13.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4067
    Cell Significance Index: -18.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4345
    Cell Significance Index: -11.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4376
    Cell Significance Index: -7.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4515
    Cell Significance Index: -13.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4518
    Cell Significance Index: -23.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4887
    Cell Significance Index: -17.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5139
    Cell Significance Index: -10.9500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5232
    Cell Significance Index: -13.0500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5563
    Cell Significance Index: -11.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5695
    Cell Significance Index: -19.7900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5887
    Cell Significance Index: -8.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6028
    Cell Significance Index: -17.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Nitric Oxide Signaling:** GUCY1B1 is a critical component of the NO-cGMP signaling pathway, which is involved in numerous physiological processes, including vasodilation, neurotransmission, and platelet aggregation. 2. **Soluble Subunit:** The GUCY1B1 gene encodes a soluble subunit of guanylate cyclase, which is distinct from the membrane-bound subunit. This soluble subunit is essential for the activation of guanylate cyclase by NO. 3. **Expression in the Nervous System:** GUCY1B1 is expressed in various neuronal populations, including inhibitory interneurons, near-projecting glutamatergic cortical neurons, and chandelier interneurons, highlighting its role in regulating neuronal excitability and synaptic transmission. 4. **Expression in the Cardiovascular System:** GUCY1B1 is also expressed in the cardiovascular system, including renal interstitial pericytes, platelets, and smooth muscle cells, where it regulates blood pressure, vascular tone, and platelet aggregation. **Pathways and Functions:** 1. **Nitric Oxide-CGMP Signaling Pathway:** GUCY1B1 is a critical component of the NO-cGMP signaling pathway, which regulates various physiological processes, including smooth muscle contraction, platelet aggregation, and neurotransmission. 2. **Vasodilation:** The activation of guanylate cyclase by NO leads to the production of cGMP, which in turn causes relaxation of smooth muscle cells, resulting in vasodilation. 3. **Neurotransmission:** GUCY1B1 is involved in regulating synaptic transmission, particularly in inhibitory interneurons, where it modulates the release of inhibitory neurotransmitters, such as GABA. 4. **Platelet Aggregation:** The NO-cGMP signaling pathway regulates platelet aggregation, which is essential for maintaining blood clotting and preventing excessive bleeding. **Clinical Significance:** 1. **Cardiovascular Diseases:** Alterations in the NO-cGMP signaling pathway, including changes in GUCY1B1 expression, have been implicated in various cardiovascular diseases, such as hypertension, atherosclerosis, and heart failure. 2. **Neurological Diseases:** Dysregulation of the NO-cGMP signaling pathway, including changes in GUCY1B1 expression, has been implicated in various neurological diseases, such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis. 3. **Therapeutic Target:** GUCY1B1 is a potential therapeutic target for the treatment of cardiovascular and neurological diseases, where modulation of the NO-cGMP signaling pathway can help to restore normal physiological function. In conclusion, GUCY1B1 is a critical component of the NO-cGMP signaling pathway, which plays a pivotal role in regulating various physiological processes, including smooth muscle contraction, platelet aggregation, and neurotransmission. Alterations in GUCY1B1 expression have been implicated in various cardiovascular and neurological diseases, highlighting its importance as a therapeutic target for the treatment of these conditions.

Genular Protein ID: 486369509

Symbol: GCYB1_HUMAN

Name: Soluble guanylate cyclase small subunit

UniProtKB Accession Codes:

Q02153 B7Z426 Q86WY5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 1 EMBL 5 EMDB 10 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1352257

Title: Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain.

PubMed ID: 1352257

DOI: 10.1016/0014-5793(92)80594-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1680753

Title: Heterogeneity in human soluble guanylate cyclase due to alternative splicing.

PubMed ID: 1680753

DOI: 10.1016/0014-5793(91)81248-7

PubMed ID: 23505436

Title: Crystal structures of the catalytic domain of human soluble guanylate cyclase.

PubMed ID: 23505436

DOI: 10.1371/journal.pone.0057644

PubMed ID: 24669844

Title: Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.

PubMed ID: 24669844

DOI: 10.1021/bi500129k

Sequence Information:

  • Length: 619
  • Mass: 70514
  • Checksum: 231E4E660DE02AA1
  • Sequence:
    • MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR IIYDDSKTYD LVAAASKVLN 
LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQN LDALHDHLAT IYPGMRAPSF 
RCTDAEKGKG LILHYYSERE GLQDIVIGII KTVAQQIHGT EIDMKVIQQR NEECDHTQFL 
IEEKESKEED FYEDLDRFEE NGTQESRISP YTFCKAFPFH IIFDRDLVVT QCGNAIYRVL 
PQLQPGNCSL LSVFSLVRPH IDISFHGILS HINTVFVLRS KEGLLDVEKL ECEDELTGTE 
ISCLRLKGQM IYLPEADSIL FLCSPSVMNL DDLTRRGLYL SDIPLHDATR DLVLLGEQFR 
EEYKLTQELE ILTDRLQLTL RALEDEKKKT DTLLYSVLPP SVANELRHKR PVPAKRYDNV 
TILFSGIVGF NAFCSKHASG EGAMKIVNLL NDLYTRFDTL TDSRKNPFVY KVETVGDKYM 
TVSGLPEPCI HHARSICHLA LDMMEIAGQV QVDGESVQIT IGIHTGEVVT GVIGQRMPRY 
CLFGNTVNLT SRTETTGEKG KINVSEYTYR CLMSPENSDP QFHLEHRGPV SMKGKKEPMQ 
VWFLSRKNTG TEETKQDDD

Genular Protein ID: 2439668388

Symbol: B7Z9H9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z9H9

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 4 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 3 RefSeq 2 RuleBase 1 SAM 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 551
  • Mass: 62702
  • Checksum: C98CE3DC51A6F75F
  • Sequence:
    • MFGKMFFVFC QESGYDTILR VLGSNVREFL QNLDALHDHL ATIYPGMRAP SFRCTDAEKG 
KGLILHYYSE REGLQDIVIG IIKTVAQQIH GTEIDMKVIQ QRNEECDHTQ FLIEEKESKE 
EDFYEDLDRF EENGTQESRI SPYTFCKAFP FHIIFDRDLV VTQCGNAIYR VLPQLQPGNC 
SLLSVFSLVR PHIDISFHGI LSHINTVFVL RSKEGLLDVE KLECEDELTG TEISCLRLKG 
QMIYLPEADS ILFLCSPSVM NLDDLTRRGL YLSDIPLHDA TRDLVLLGEQ FREEYKLTQE 
LEILTDRLQL TLRALEDEKK KTDTLLYSVL PPSVANELRH KRPVPAKRYD NVTILFSGIV 
GFNAFCSKHA SGEGAMKIVN LLNDLYTRFD TLTDSRKNPF VYKVETVGDK YMTVSGLPEP 
CIHHARSICH LALDMMEIAG QVQVDGESVQ ITIGIHTGEV VTGVIGQRMP RYCLFGNTVN 
LTSRTETTGE KGKINVSEYT YRCLMSPENS DPQSHLEHRG PVSMKGKKEP MQVWFLSRKN 
TGTEETKQDD D

Genular Protein ID: 4075073316

Symbol: B7Z685_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z685

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 GO 5 Gene3D 4 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 8 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 3 RuleBase 1 SMART 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 551
  • Mass: 62762
  • Checksum: 888CE3DC51BB4184
  • Sequence:
    • MFGKMFFVFC QESGYDTILR VLGSNVREFL QNLDALHDHL ATIYPGMRAP SFRCTDAEKG 
KGLILHYYSE REGLQDIVIG IIKTVAQQIH GTEIDMKVIQ QRNEECDHTQ FLIEEKESKE 
EDFYEDLDRF EENGTQESRI SPYTFCKAFP FHIIFDRDLV VTQCGNAIYR VLPQLQPGNC 
SLLSVFSLVR PHIDISFHGI LSHINTVFVL RSKEGLLDVE KLECEDELTG TEISCLRLKG 
QMIYLPEADS ILFLCSPSVM NLDDLTRRGL YLSDIPLHDA TRDLVLLGEQ FREEYKLTQE 
LEILTDRLQL TLRALEDEKK KTDTLLYSVL PPSVANELRH KRPVPAKRYD NVTILFSGIV 
GFNAFCSKHA SGEGAMKIVN LLNDLYTRFD TLTDSRKNPF VYKVETVGDK YMTVSGLPEP 
CIHHARSICH LALDMMEIAG QVQVDGESVQ ITIGIHTGEV VTGVIGQRMP RYCLFGNTVN 
LTSRTETTGE KGKINVSEYT YRCLMSPENS DPQFHLEHRG PVSMKGKKEP MQVWFLSRKN 
TGTEETKQDD D

Genular Protein ID: 3895510785

Symbol: E9PCN2_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PCN2

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 4 GeneTree 1 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 2 Pfam 3 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 641
  • Mass: 73071
  • Checksum: 86B7CD07039DFAF8
  • Sequence:
    • MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR IIYDDSKTYD LVAAASKVLN 
LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQK NESKHISDLH HCFLGIYLCC 
NNLDALHDHL ATIYPGMRAP SFRCTDAEKG KGLILHYYSE REGLQDIVIG IIKTVAQQIH 
GTEIDMKVIQ QRNEECDHTQ FLIEEKESKE EDFYEDLDRF EENGTQESRI SPYTFCKAFP 
FHIIFDRDLV VTQCGNAIYR VLPQLQPGNC SLLSVFSLVR PHIDISFHGI LSHINTVFVL 
RSKEGLLDVE KLECEDELTG TEISCLRLKG QMIYLPEADS ILFLCSPSVM NLDDLTRRGL 
YLSDIPLHDA TRDLVLLGEQ FREEYKLTQE LEILTDRLQL TLRALEDEKK KTDTLLYSVL 
PPSVANELRH KRPVPAKRYD NVTILFSGIV GFNAFCSKHA SGEGAMKIVN LLNDLYTRFD 
TLTDSRKNPF VYKVETVGDK YMTVSGLPEP CIHHARSICH LALDMMEIAG QVQVDGESVQ 
ITIGIHTGEV VTGVIGQRMP RYCLFGNTVN LTSRTETTGE KGKINVSEYT YRCLMSPENS 
DPQFHLEHRG PVSMKGKKEP MQVWFLSRKN TGTEETKQDD D

Genular Protein ID: 4235682353

Symbol: D6RC99_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6RC99

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 4 GeneTree 1 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 3 RuleBase 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 594
  • Mass: 67519
  • Checksum: 84F64A4B375D8A18
  • Sequence:
    • MFGKMFFVFC QESGYDTILR VLGSNVREFL QNLDALHDHL ATIYPGMRAP SFRCTDAEKG 
KGLILHYYSE REGLQDIVIG IIKTVAQQIH GTEIDMKVIQ QRNEECDHTQ FLIEEKESKE 
EDFYEDLDRF EENGTQESRI SPYTFCKAFP FHIIFDRDLV VTQCGNAIYR VLPQLQPGNC 
SLLSVFSLVR PHIDISFHGI LSHINTVFVL RSKEGLLDVE KLECEDELTG TEISCLRLKG 
QMIYLPEADS ILFLCSPSVM NLDDLTRRGL YLSDIPLHDA TRDLVLLGEQ FREEYKLTQE 
LEILTDRLQL TLRALEDEKK KTDTGCPARI QAFKVQTTLM LCEKDSRSTK GFPSISYSGF 
LLIPLNRLLY SVLPPSVANE LRHKRPVPAK RYDNVTILFS GIVGFNAFCS KHASGEGAMK 
IVNLLNDLYT RFDTLTDSRK NPFVYKVETV GDKYMTVSGL PEPCIHHARS ICHLALDMME 
IAGQVQVDGE SVQITIGIHT GEVVTGVIGQ RMPRYCLFGN TVNLTSRTET TGEKGKINVS 
EYTYRCLMSP ENSDPQFHLE HRGPVSMKGK KEPMQVWFLS RKNTGTEETK QDDD

Genular Protein ID: 151481240

Symbol: B7Z6G8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z6G8

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 4 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 3 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 641
  • Mass: 73058
  • Checksum: 2BE988D59B2E91AC
  • Sequence:
    • MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR ILYDDSKTYD LVAAASKVLN 
LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQK NESKHISDLH HCFLGIYLCC 
NNLDALHDHL ATIYPGMRAP SFRCTDAEKG KGLILHYYSE REGLQDIVIG IIKTVAQQIH 
GTEVDMKVIQ QRNEECDHTQ FLIEEKESKE EDFYEDLDRF EENGTQESRI SPYTFCKAFP 
FHIIFDRDLV VTQCGNAIYR VLPQLQPGNC SLLSVFSLVR PHIDISFHGI LSHINTVFVL 
RSKEGLLDVE KLECEDELTG TEISCLRLKG QMIYLPEADS ILFLCSPSVM NLDDLTRRGL 
YLSDIPLHDA TRDLVLLGEQ FREEYKLTQE LEILTDRLQL TLRALEDEKK KTDTLLYSVL 
PPSVANELRH KRPVPAKRYD NVTILFSGIV GFNAFCSKHA SGEGAMKIVN LLNDLYTRFD 
TLTDSRENPF VYKVETVGDK YMTVSGLPEP CIHHARSICH LALDMMEIAG QVQVDGESVQ 
ITIGIHTGEV VTGVIGQRMP RYCLFGNTVN LTSRTETTGE KGKINVSEYT YRCLMSPENS 
DPQFHLEHRG PVSMKGKKEP MQVWFLSRKN TGTEETKQDD D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.