Details for: GUCY1B1

Gene ID: 2983

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: GUCY1B1

Ensembl ID: ENSG00000061918

Description: guanylate cyclase 1 soluble subunit beta 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • promyelocyte CL0000836
    CSI 15.51
    rCSI 22.37%
    PRS 89.38
  • OFF-bipolar cell CL0000750
    CSI 14.58
    rCSI 19.93%
    PRS 85.65
  • microcirculation associated smooth muscle cell CL0008035
    CSI 14.53
    rCSI 42.06%
    PRS 84.2
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 13.42
    rCSI 22.53%
    PRS 68.97
  • tracheobronchial smooth muscle cell CL0019019
    CSI 11.62
    rCSI 20.49%
    PRS 88.9
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 10.63
    rCSI 25.82%
    PRS 66.83
  • diffuse bipolar 3a cell CL4033029
    CSI 9.37
    rCSI 63.79%
    PRS 77.1
  • astrocyte of the cerebral cortex CL0002605
    CSI 8.89
    rCSI 19.93%
    PRS 69.91
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 7.5
    rCSI 23.45%
    PRS 72.63
  • hematopoietic precursor cell CL0008001
    CSI 6.81
    rCSI 7%
    PRS 93.4
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 6.81
    rCSI 25.72%
    PRS 69.34
  • interneuron CL0000099
    CSI 6
    rCSI 12.04%
    PRS 76.95
  • cerebral cortex neuron CL0010012
    CSI 5.84
    rCSI 23.78%
    PRS 77.14
  • fallopian tube secretory epithelial cell CL4030006
    CSI 5.44
    rCSI 5.23%
    PRS 84.3
  • fibroblast of lung CL0002553
    CSI 5.43
    rCSI 5.05%
    PRS 86.07
  • ON-bipolar cell CL0000749
    CSI 5.39
    rCSI 8.02%
    PRS 84.63
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 5.37
    rCSI 9.49%
    PRS 68.52
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 5.36
    rCSI 19.3%
    PRS 66.94
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 5.02
    rCSI 12.01%
    PRS 72.83
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 4.89
    rCSI 11.77%
    PRS 94.58
  • rod bipolar cell CL0000751
    CSI 4.71
    rCSI 8.46%
    PRS 79.17
  • retinal bipolar neuron CL0000748
    CSI 4.7
    rCSI 8.81%
    PRS 74.81
  • megakaryocyte CL0000556
    CSI 4.68
    rCSI 20.33%
    PRS 88.47
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 4.42
    rCSI 9.59%
    PRS 73.14
  • platelet CL0000233
    CSI 4.36
    rCSI 18.1%
    PRS 82.08
  • sncg GABAergic cortical interneuron CL4023015
    CSI 4.2
    rCSI 6.76%
    PRS 70.38
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 4.14
    rCSI 24.37%
    PRS 69.48
  • myofibroblast cell CL0000186
    CSI 4
    rCSI 5.54%
    PRS 81.54
  • hepatic stellate cell CL0000632
    CSI 3.94
    rCSI 14.76%
    PRS 78.65
  • dopaminergic neuron CL0000700
    CSI 3.78
    rCSI 21.39%
    PRS 72.32
  • vascular associated smooth muscle cell CL0000359
    CSI 3.73
    rCSI 12.11%
    PRS 83.13
  • parietal epithelial cell CL1000452
    CSI 3.56
    rCSI 9.51%
    PRS 78.02
  • inhibitory interneuron CL0000498
    CSI 3.39
    rCSI 7.82%
    PRS 74.23
  • perivascular cell CL4033054
    CSI 3.34
    rCSI 4.56%
    PRS 89
  • alveolar type 1 fibroblast cell CL4028004
    CSI 3.32
    rCSI 3.63%
    PRS 86.69
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 3.22
    rCSI 4%
    PRS 66.92
  • vascular leptomeningeal cell CL4023051
    CSI 3.21
    rCSI 5.63%
    PRS 79.94
  • lung pericyte CL0009089
    CSI 3.21
    rCSI 8.46%
    PRS 90.23
  • central nervous system neuron CL2000029
    CSI 3.2
    rCSI 23.49%
    PRS 74.01
  • VIP GABAergic cortical interneuron CL4023016
    CSI 3.09
    rCSI 3.69%
    PRS 69.11
  • retinal ganglion cell CL0000740
    CSI 2.95
    rCSI 6.53%
    PRS 72.26
  • neuron CL0000540
    CSI 2.92
    rCSI 7.77%
    PRS 72.45
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.89
    rCSI 3.73%
    PRS 70.2
  • cerebral cortex endothelial cell CL1001602
    CSI 2.79
    rCSI 4.82%
    PRS 77.77
  • interstitial cell of Cajal CL0002088
    CSI 2.78
    rCSI 3.54%
    PRS 89.48
  • myeloid leukocyte CL0000766
    CSI 2.54
    rCSI 2.34%
    PRS 86.39
  • direct pathway medium spiny neuron CL4023026
    CSI 2.48
    rCSI 59.4%
    PRS 66.85
  • mesodermal cell CL0000222
    CSI 2.47
    rCSI 2.97%
    PRS 83.4
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.47
    rCSI 59.68%
    PRS 67.29
  • pancreatic ductal cell CL0002079
    CSI 2.4
    rCSI 4.66%
    PRS 87.78
  • enteric smooth muscle cell CL0002504
    CSI 2.36
    rCSI 3.37%
    PRS 85.7
  • L6b glutamatergic cortical neuron CL4023038
    CSI 2.29
    rCSI 7.16%
    PRS 70.49
  • renal interstitial pericyte CL1001318
    CSI 2.27
    rCSI 6.26%
    PRS 81.1
  • mesenchymal cell CL0008019
    CSI 2.08
    rCSI 5.29%
    PRS 78.95
  • GABAergic neuron CL0000617
    CSI 1.87
    rCSI 6.27%
    PRS 69.84
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 1.65
    rCSI 1.49%
    PRS 83.71
  • mesenchymal lymphangioblast CL0005021
    CSI 1.64
    rCSI 43.15%
    PRS 89.91
  • amacrine cell CL0000561
    CSI 1.6
    rCSI 4.62%
    PRS 75.34
  • medium spiny neuron CL1001474
    CSI 1.58
    rCSI 13.64%
    PRS 74.52
  • glutamatergic neuron CL0000679
    CSI 1.52
    rCSI 3.12%
    PRS 72.43
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 1.36
    rCSI 4.46%
    PRS 71.67
  • glycinergic amacrine cell CL4030028
    CSI 1.32
    rCSI 3.44%
    PRS 79.22
  • contractile cell CL0000183
    CSI 1.22
    rCSI 3.61%
    PRS 84.1
  • diffuse bipolar 1 cell CL4033027
    CSI 0.91
    rCSI 6.85%
    PRS 74.64
  • podocyte CL0000653
    CSI 0.84
    rCSI 3.71%
    PRS 85.87
  • GABAergic amacrine cell CL4030027
    CSI 0.74
    rCSI 2.52%
    PRS 71.39
  • blood vessel smooth muscle cell CL0019018
    CSI 0.59
    rCSI 4.79%
    PRS 80.38
  • cone retinal bipolar cell CL0000752
    CSI 0.4
    rCSI 5.17%
    PRS 83.76

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [GUCY1B1](/details-gene/2983) encodes the beta 1 subunit of the soluble guanylate cyclase (sGC), a critical intracellular receptor for nitric oxide (NO). In partnership with an alpha subunit, it forms a heterodimeric enzyme that, upon NO binding, catalyzes the conversion of GTP to the second messenger cGMP. This function places [GUCY1B1](/details-gene/2983) at the core of the NO/cGMP signaling pathway, which is essential for diverse physiological processes including smooth muscle relaxation, neurotransmission, and platelet aggregation. **Overall** expression data highlight its significant role in a variety of cell types, including hematopoietic precursors like the [promyelocyte](/details-cell/CL0000836), specialized neuronal cells such as the [OFF-bipolar cell](/details-cell/CL0000750), and various smooth muscle cells, underscor-ing its broad importance in vascular, nervous, and developmental systems. Its clinical relevance is highlighted by its association with conditions like Moyamoya disease ([139397](https://omim.org/entry/139397)). ## Cellular Roles and Expression Landscape The expression profile of [GUCY1B1](/details-gene/2983) reveals its fundamental role across multiple physiological systems. * **Vascular and Muscular Systems:** The gene shows high significance in [microcirculation associated smooth muscle cell](/details-cell/CL0008035) (CSI: 14.53) and [tracheobronchial smooth muscle cell](/details-cell/CL0019019) (CSI: 11.62). This is consistent with its canonical function in mediating NO-induced smooth muscle relaxation, a key mechanism for vasodilation and regulation of blood pressure. * **Nervous System:** [GUCY1B1](/details-gene/2983) is a highly significant gene in a diverse range of neural cells. It is particularly prominent in retinal [OFF-bipolar cell](/details-cell/CL0000750) (CSI: 14.58) and various cortical neurons, including [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 13.42) and [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) (CSI: 10.63). Its high significance in glial cells like [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: 8.89) further suggests a broad role in regulating neuronal signaling, synaptic plasticity, and cerebral blood flow. * **Hematopoietic System:** High CSI values in early hematopoietic cells, notably [promyelocyte](/details-cell/CL0000836) (CSI: 15.51) and [hematopoietic precursor cell](/details-cell/CL0008001) (CSI: 6.81), suggest a potential role for NO signaling in the regulation of hematopoiesis, possibly influencing cell differentiation or proliferation within the bone marrow niche. * **Other Tissues:** The gene also shows notable significance in other tissues, such as in [fallopian tube secretory epithelial cell](/details-cell/CL4030006) and [fibroblast of lung](/details-cell/CL0002553), indicating its involvement in a wider array of biological processes beyond its classical roles. ## Pathways and Molecular Function Functionally, [GUCY1B1](/details-gene/2983) is the sensory component of the primary NO receptor. Its molecular functions are centered on its ability to bind key molecules, including [heme](/details-ontology/GO:0020037), [GTP](/details-ontology/GO:0005525), and [nitric oxide](/details-ontology/GO:0070026), which is essential for its enzymatic activity. As part of the soluble [guanylate cyclase complex](/details-ontology/GO:0008074) located in the [cytosol](/details-ontology/GO:0005829), it directly executes [guanylate cyclase activity](/details-ontology/GO:0004383), producing cGMP. This activity is integral to several major biological processes and pathways: * **NO/cGMP Signaling:** The gene is a central component of [cellular response to nitric oxide](/details-ontology/GO:0071732), the [nitric oxide mediated signal transduction](/details-ontology/GO:0007263) pathway, and the Reactome pathway [Nitric oxide stimulates guanylate cyclase](/details-pathway/R-HSA-392154). * **Cardiovascular and Muscular Regulation:** Its function directly impacts [blood circulation](/details-ontology/GO:0008015), [hemostasis](/details-pathway/R-HSA-109582), and [smooth muscle contraction](/details-pathway/R-HSA-445355). This aligns perfectly with its high expression in smooth muscle cells and its established role in vasodilation. * **Platelet Function:** The gene contributes to [platelet homeostasis](/details-pathway/R-HSA-418346), where NO-induced cGMP production leads to the inhibition of platelet aggregation. Studies on the molecular cloning and crystal structure of the human enzyme have provided detailed insights into its function ([Link](https://doi.org/10.1016/0014-5793(92)80594-7), [Link](https://doi.org/10.1371/journal.pone.0057644)). ## Research Directions The widespread and cell-type-specific significance of [GUCY1B1](/details-gene/2983) suggests that its regulation and functional consequences are highly context-dependent, opening several avenues for future research. **Proposed Hypotheses:** 1. Given the high CSI of [GUCY1B1](/details-gene/2983) in [promyelocyte](/details-cell/CL0000836) and other hematopoietic precursors, NO/cGMP signaling may be a critical regulatory axis governing the commitment and differentiation of myeloid lineage cells during hematopoiesis. 2. The distinct and high significance of [GUCY1B1](/details-gene/2983) across diverse neuronal subtypes (e.g., GABAergic, glutamatergic, bipolar) suggests that it acts as a key modulator of neural circuit activity, potentially by fine-tuning neurotransmitter release or postsynaptic sensitivity in a cell-specific manner. **Experimental Approach:** To test the role of [GUCY1B1](/details-gene/2983) in myeloid differentiation (Hypothesis 1), one could utilize an *in vitro* human hematopoietic stem and progenitor cell (HSPC) differentiation model. HSPCs (CD34+) would be cultured under myeloid-promoting conditions. The experimental groups would include: (i) a control group, (ii) a group treated with an sGC inhibitor (e.g., ODQ), and (iii) a group with [GUCY1B1](/details-gene/2983) expression knocked down using lentiviral shRNA. The progression of differentiation could be monitored over time using flow cytometry to quantify myeloid progenitor populations (e.g., CMPs, GMPs) and mature cell types (e.g., neutrophils, monocytes). A significant alteration in the differentiation trajectory in the inhibitor-treated or knockdown groups compared to the control would support the hypothesis. **Therapeutic Potential:** [GUCY1B1](/details-gene/2983), as part of soluble guanylate cyclase, is already a well-established therapeutic target. The therapeutic strategy is **activation**, not inhibition. sGC stimulators (e.g., Riociguat) that enhance the enzyme's sensitivity to endogenous NO are approved for treating pulmonary hypertension. The widespread expression of [GUCY1B1](/details-gene/2983) in the nervous and vascular systems underscores both its potential for treating a range of ischemic and fibrotic diseases and the challenge of achieving tissue-specific targeting to minimize systemic side effects such as hypotension. Future drug development could focus on creating activators with improved selectivity for specific tissues or disease states.

Genular Protein ID: 486369509

Symbol: GCYB1_HUMAN

Name: Soluble guanylate cyclase small subunit

UniProtKB Accession Codes:

Q02153 B7Z426 Q86WY5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 1 EMBL 5 EMDB 10 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1352257

Title: Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain.

PubMed ID: 1352257

DOI: 10.1016/0014-5793(92)80594-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1680753

Title: Heterogeneity in human soluble guanylate cyclase due to alternative splicing.

PubMed ID: 1680753

DOI: 10.1016/0014-5793(91)81248-7

PubMed ID: 23505436

Title: Crystal structures of the catalytic domain of human soluble guanylate cyclase.

PubMed ID: 23505436

DOI: 10.1371/journal.pone.0057644

PubMed ID: 24669844

Title: Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.

PubMed ID: 24669844

DOI: 10.1021/bi500129k

Sequence Information:

  • Length: 619
  • Mass: 70514
  • Checksum: 231E4E660DE02AA1
  • Sequence:
    • MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR IIYDDSKTYD LVAAASKVLN 
LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQN LDALHDHLAT IYPGMRAPSF 
RCTDAEKGKG LILHYYSERE GLQDIVIGII KTVAQQIHGT EIDMKVIQQR NEECDHTQFL 
IEEKESKEED FYEDLDRFEE NGTQESRISP YTFCKAFPFH IIFDRDLVVT QCGNAIYRVL 
PQLQPGNCSL LSVFSLVRPH IDISFHGILS HINTVFVLRS KEGLLDVEKL ECEDELTGTE 
ISCLRLKGQM IYLPEADSIL FLCSPSVMNL DDLTRRGLYL SDIPLHDATR DLVLLGEQFR 
EEYKLTQELE ILTDRLQLTL RALEDEKKKT DTLLYSVLPP SVANELRHKR PVPAKRYDNV 
TILFSGIVGF NAFCSKHASG EGAMKIVNLL NDLYTRFDTL TDSRKNPFVY KVETVGDKYM 
TVSGLPEPCI HHARSICHLA LDMMEIAGQV QVDGESVQIT IGIHTGEVVT GVIGQRMPRY 
CLFGNTVNLT SRTETTGEKG KINVSEYTYR CLMSPENSDP QFHLEHRGPV SMKGKKEPMQ 
VWFLSRKNTG TEETKQDDD

Genular Protein ID: 2439668388

Symbol: B7Z9H9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z9H9

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 4 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 3 RefSeq 2 RuleBase 1 SAM 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 551
  • Mass: 62702
  • Checksum: C98CE3DC51A6F75F
  • Sequence:
    • MFGKMFFVFC QESGYDTILR VLGSNVREFL QNLDALHDHL ATIYPGMRAP SFRCTDAEKG 
KGLILHYYSE REGLQDIVIG IIKTVAQQIH GTEIDMKVIQ QRNEECDHTQ FLIEEKESKE 
EDFYEDLDRF EENGTQESRI SPYTFCKAFP FHIIFDRDLV VTQCGNAIYR VLPQLQPGNC 
SLLSVFSLVR PHIDISFHGI LSHINTVFVL RSKEGLLDVE KLECEDELTG TEISCLRLKG 
QMIYLPEADS ILFLCSPSVM NLDDLTRRGL YLSDIPLHDA TRDLVLLGEQ FREEYKLTQE 
LEILTDRLQL TLRALEDEKK KTDTLLYSVL PPSVANELRH KRPVPAKRYD NVTILFSGIV 
GFNAFCSKHA SGEGAMKIVN LLNDLYTRFD TLTDSRKNPF VYKVETVGDK YMTVSGLPEP 
CIHHARSICH LALDMMEIAG QVQVDGESVQ ITIGIHTGEV VTGVIGQRMP RYCLFGNTVN 
LTSRTETTGE KGKINVSEYT YRCLMSPENS DPQSHLEHRG PVSMKGKKEP MQVWFLSRKN 
TGTEETKQDD D

Genular Protein ID: 4075073316

Symbol: B7Z685_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z685

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 GO 5 Gene3D 4 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 8 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 3 RuleBase 1 SMART 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 551
  • Mass: 62762
  • Checksum: 888CE3DC51BB4184
  • Sequence:
    • MFGKMFFVFC QESGYDTILR VLGSNVREFL QNLDALHDHL ATIYPGMRAP SFRCTDAEKG 
KGLILHYYSE REGLQDIVIG IIKTVAQQIH GTEIDMKVIQ QRNEECDHTQ FLIEEKESKE 
EDFYEDLDRF EENGTQESRI SPYTFCKAFP FHIIFDRDLV VTQCGNAIYR VLPQLQPGNC 
SLLSVFSLVR PHIDISFHGI LSHINTVFVL RSKEGLLDVE KLECEDELTG TEISCLRLKG 
QMIYLPEADS ILFLCSPSVM NLDDLTRRGL YLSDIPLHDA TRDLVLLGEQ FREEYKLTQE 
LEILTDRLQL TLRALEDEKK KTDTLLYSVL PPSVANELRH KRPVPAKRYD NVTILFSGIV 
GFNAFCSKHA SGEGAMKIVN LLNDLYTRFD TLTDSRKNPF VYKVETVGDK YMTVSGLPEP 
CIHHARSICH LALDMMEIAG QVQVDGESVQ ITIGIHTGEV VTGVIGQRMP RYCLFGNTVN 
LTSRTETTGE KGKINVSEYT YRCLMSPENS DPQFHLEHRG PVSMKGKKEP MQVWFLSRKN 
TGTEETKQDD D

Genular Protein ID: 3895510785

Symbol: E9PCN2_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PCN2

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 4 GeneTree 1 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 2 Pfam 3 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 641
  • Mass: 73071
  • Checksum: 86B7CD07039DFAF8
  • Sequence:
    • MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR IIYDDSKTYD LVAAASKVLN 
LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQK NESKHISDLH HCFLGIYLCC 
NNLDALHDHL ATIYPGMRAP SFRCTDAEKG KGLILHYYSE REGLQDIVIG IIKTVAQQIH 
GTEIDMKVIQ QRNEECDHTQ FLIEEKESKE EDFYEDLDRF EENGTQESRI SPYTFCKAFP 
FHIIFDRDLV VTQCGNAIYR VLPQLQPGNC SLLSVFSLVR PHIDISFHGI LSHINTVFVL 
RSKEGLLDVE KLECEDELTG TEISCLRLKG QMIYLPEADS ILFLCSPSVM NLDDLTRRGL 
YLSDIPLHDA TRDLVLLGEQ FREEYKLTQE LEILTDRLQL TLRALEDEKK KTDTLLYSVL 
PPSVANELRH KRPVPAKRYD NVTILFSGIV GFNAFCSKHA SGEGAMKIVN LLNDLYTRFD 
TLTDSRKNPF VYKVETVGDK YMTVSGLPEP CIHHARSICH LALDMMEIAG QVQVDGESVQ 
ITIGIHTGEV VTGVIGQRMP RYCLFGNTVN LTSRTETTGE KGKINVSEYT YRCLMSPENS 
DPQFHLEHRG PVSMKGKKEP MQVWFLSRKN TGTEETKQDD D

Genular Protein ID: 4235682353

Symbol: D6RC99_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6RC99

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 4 GeneTree 1 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 3 RuleBase 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 594
  • Mass: 67519
  • Checksum: 84F64A4B375D8A18
  • Sequence:
    • MFGKMFFVFC QESGYDTILR VLGSNVREFL QNLDALHDHL ATIYPGMRAP SFRCTDAEKG 
KGLILHYYSE REGLQDIVIG IIKTVAQQIH GTEIDMKVIQ QRNEECDHTQ FLIEEKESKE 
EDFYEDLDRF EENGTQESRI SPYTFCKAFP FHIIFDRDLV VTQCGNAIYR VLPQLQPGNC 
SLLSVFSLVR PHIDISFHGI LSHINTVFVL RSKEGLLDVE KLECEDELTG TEISCLRLKG 
QMIYLPEADS ILFLCSPSVM NLDDLTRRGL YLSDIPLHDA TRDLVLLGEQ FREEYKLTQE 
LEILTDRLQL TLRALEDEKK KTDTGCPARI QAFKVQTTLM LCEKDSRSTK GFPSISYSGF 
LLIPLNRLLY SVLPPSVANE LRHKRPVPAK RYDNVTILFS GIVGFNAFCS KHASGEGAMK 
IVNLLNDLYT RFDTLTDSRK NPFVYKVETV GDKYMTVSGL PEPCIHHARS ICHLALDMME 
IAGQVQVDGE SVQITIGIHT GEVVTGVIGQ RMPRYCLFGN TVNLTSRTET TGEKGKINVS 
EYTYRCLMSP ENSDPQFHLE HRGPVSMKGK KEPMQVWFLS RKNTGTEETK QDDD

Genular Protein ID: 151481240

Symbol: B7Z6G8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z6G8

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 4 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 3 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 641
  • Mass: 73058
  • Checksum: 2BE988D59B2E91AC
  • Sequence:
    • MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR ILYDDSKTYD LVAAASKVLN 
LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQK NESKHISDLH HCFLGIYLCC 
NNLDALHDHL ATIYPGMRAP SFRCTDAEKG KGLILHYYSE REGLQDIVIG IIKTVAQQIH 
GTEVDMKVIQ QRNEECDHTQ FLIEEKESKE EDFYEDLDRF EENGTQESRI SPYTFCKAFP 
FHIIFDRDLV VTQCGNAIYR VLPQLQPGNC SLLSVFSLVR PHIDISFHGI LSHINTVFVL 
RSKEGLLDVE KLECEDELTG TEISCLRLKG QMIYLPEADS ILFLCSPSVM NLDDLTRRGL 
YLSDIPLHDA TRDLVLLGEQ FREEYKLTQE LEILTDRLQL TLRALEDEKK KTDTLLYSVL 
PPSVANELRH KRPVPAKRYD NVTILFSGIV GFNAFCSKHA SGEGAMKIVN LLNDLYTRFD 
TLTDSRENPF VYKVETVGDK YMTVSGLPEP CIHHARSICH LALDMMEIAG QVQVDGESVQ 
ITIGIHTGEV VTGVIGQRMP RYCLFGNTVN LTSRTETTGE KGKINVSEYT YRCLMSPENS 
DPQFHLEHRG PVSMKGKKEP MQVWFLSRKN TGTEETKQDD D