Details for: CNOT7

Gene ID: 29883

Symbol: CNOT7

Ensembl ID: ENSG00000198791

Description: CCR4-NOT transcription complex subunit 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 291.0408
    Cell Significance Index: -45.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 147.6482
    Cell Significance Index: -37.4500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 128.9484
    Cell Significance Index: -53.1200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 108.8806
    Cell Significance Index: -51.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 108.3058
    Cell Significance Index: -44.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 95.9398
    Cell Significance Index: -49.3500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 76.9647
    Cell Significance Index: -51.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.4104
    Cell Significance Index: -44.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.0501
    Cell Significance Index: -49.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.6261
    Cell Significance Index: -41.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.8382
    Cell Significance Index: -50.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.5390
    Cell Significance Index: -32.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.3798
    Cell Significance Index: -18.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.3518
    Cell Significance Index: 507.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.8805
    Cell Significance Index: 268.3600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.3534
    Cell Significance Index: 18.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.7718
    Cell Significance Index: 111.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6391
    Cell Significance Index: 43.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4115
    Cell Significance Index: 49.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1499
    Cell Significance Index: 141.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1336
    Cell Significance Index: 227.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0672
    Cell Significance Index: 14.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9749
    Cell Significance Index: 114.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9689
    Cell Significance Index: 174.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.9641
    Cell Significance Index: 17.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9003
    Cell Significance Index: 491.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8902
    Cell Significance Index: 24.2300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8667
    Cell Significance Index: 6.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8522
    Cell Significance Index: 169.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8478
    Cell Significance Index: 39.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8443
    Cell Significance Index: 54.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8058
    Cell Significance Index: 727.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7978
    Cell Significance Index: 16.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.7916
    Cell Significance Index: 13.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7630
    Cell Significance Index: 104.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7624
    Cell Significance Index: 53.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7426
    Cell Significance Index: 328.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6693
    Cell Significance Index: 85.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6319
    Cell Significance Index: 29.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6311
    Cell Significance Index: 16.8500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5942
    Cell Significance Index: 6.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4998
    Cell Significance Index: 26.2400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.4523
    Cell Significance Index: 6.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4515
    Cell Significance Index: 13.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4322
    Cell Significance Index: 155.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4292
    Cell Significance Index: 31.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4135
    Cell Significance Index: 44.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3972
    Cell Significance Index: 51.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3758
    Cell Significance Index: 19.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3154
    Cell Significance Index: 16.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3073
    Cell Significance Index: 8.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3038
    Cell Significance Index: 51.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2817
    Cell Significance Index: 15.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2773
    Cell Significance Index: 191.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2582
    Cell Significance Index: 42.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1845
    Cell Significance Index: 18.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1740
    Cell Significance Index: 3.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1707
    Cell Significance Index: 4.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1408
    Cell Significance Index: 26.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0935
    Cell Significance Index: 5.7500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0675
    Cell Significance Index: 0.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0456
    Cell Significance Index: 2.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0358
    Cell Significance Index: 55.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0245
    Cell Significance Index: 46.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0002
    Cell Significance Index: 0.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0097
    Cell Significance Index: -7.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0145
    Cell Significance Index: -10.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0220
    Cell Significance Index: -13.9800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0250
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0272
    Cell Significance Index: -16.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0350
    Cell Significance Index: -0.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0399
    Cell Significance Index: -0.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0461
    Cell Significance Index: -26.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0515
    Cell Significance Index: -5.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0770
    Cell Significance Index: -34.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0900
    Cell Significance Index: -18.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1233
    Cell Significance Index: -1.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1259
    Cell Significance Index: -1.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1423
    Cell Significance Index: -40.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1590
    Cell Significance Index: -10.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1755
    Cell Significance Index: -25.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2081
    Cell Significance Index: -23.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2308
    Cell Significance Index: -17.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2497
    Cell Significance Index: -6.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2675
    Cell Significance Index: -9.4000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2865
    Cell Significance Index: -32.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3509
    Cell Significance Index: -9.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3540
    Cell Significance Index: -9.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4128
    Cell Significance Index: -11.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4338
    Cell Significance Index: -4.0000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.4480
    Cell Significance Index: -4.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4680
    Cell Significance Index: -48.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4858
    Cell Significance Index: -7.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5037
    Cell Significance Index: -39.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5063
    Cell Significance Index: -16.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5089
    Cell Significance Index: -22.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5410
    Cell Significance Index: -12.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6638
    Cell Significance Index: -25.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CNOT7 is a 33-kDa protein that belongs to the CCR4-NOT complex, a multi-protein complex involved in mRNA degradation and transcriptional regulation. The CCR4-NOT complex is composed of several subunits, including CNOT7, CNOT8, CNOT9, and CNOT10. CNOT7 is specifically involved in the deadenylation-dependent decapping of nuclear-transcribed mRNA, a process that regulates mRNA stability and translation. The gene is also involved in the regulation of translation and the response to viral infections. **Pathways and Functions** CNOT7 is involved in several cellular pathways, including: 1. **Deadenylation-dependent mRNA decay**: CNOT7 is specifically involved in the deadenylation-dependent decapping of nuclear-transcribed mRNA, a process that regulates mRNA stability and translation. 2. **Transcriptional regulation**: CNOT7 is involved in the regulation of transcription by RNA polymerase II, a key enzyme involved in protein synthesis. 3. **Translation regulation**: CNOT7 is involved in the regulation of translation, a process that involves the assembly of ribosomes and the translation of mRNA into protein. 4. **Response to viral infections**: CNOT7 is involved in the response to viral infections, a process that involves the regulation of mRNA stability and translation. 5. **Cell cycle regulation**: CNOT7 is involved in the regulation of the cell cycle, a process that involves the coordination of cell growth and division. **Clinical Significance** Dysregulation of CNOT7 has been implicated in various diseases, including: 1. **Cancer**: CNOT7 dysregulation has been implicated in the development of various cancers, including breast, lung, and colon cancer. 2. **Neurodegenerative disorders**: CNOT7 dysregulation has been implicated in the development of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. **Immune disorders**: CNOT7 dysregulation has been implicated in the development of immune disorders, including rheumatoid arthritis and multiple sclerosis. In conclusion, CNOT7 is a critical component of the CCR4-NOT complex, involved in various cellular processes, including mRNA degradation, transcriptional regulation, and translation. Dysregulation of CNOT7 has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis.

Genular Protein ID: 896877996

Symbol: CNOT7_HUMAN

Name: CCR4-NOT transcription complex subunit 7

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9820826

Title: Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1.

PubMed ID: 9820826

DOI: 10.1042/bj3360471

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15769875

Title: Conservation of the deadenylase activity of proteins of the Caf1 family in human.

PubMed ID: 15769875

DOI: 10.1261/rna.7135305

PubMed ID: 19558367

Title: Human Ccr4-Not complexes contain variable deadenylase subunits.

PubMed ID: 19558367

DOI: 10.1042/bj20090500

PubMed ID: 19605561

Title: The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.

PubMed ID: 19605561

DOI: 10.1091/mbc.e09-02-0146

PubMed ID: 20634287

Title: Translational repression by deadenylases.

PubMed ID: 20634287

DOI: 10.1074/jbc.m110.150763

PubMed ID: 20065043

Title: CCR4-NOT deadenylates mRNA associated with complexes in human cells.

PubMed ID: 20065043

DOI: 10.1128/mcb.01481-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21336257

Title: Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.

PubMed ID: 21336257

DOI: 10.1038/emboj.2011.37

PubMed ID: 23236473

Title: The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.

PubMed ID: 23236473

DOI: 10.1371/journal.pone.0051331

PubMed ID: 25106868

Title: ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.

PubMed ID: 25106868

DOI: 10.1093/nar/gku652

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30520513

Title: TDP-43 accelerates deadenylation of target mRNAs by recruiting Caf1 deadenylase.

PubMed ID: 30520513

DOI: 10.1002/1873-3468.13310

PubMed ID: 31439799

Title: Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation.

PubMed ID: 31439799

DOI: 10.1126/science.aax4240

PubMed ID: 32502391

Title: Homozygous mutations in BTG4 cause zygotic cleavage failure and female infertility.

PubMed ID: 32502391

DOI: 10.1016/j.ajhg.2020.05.010

PubMed ID: 19276069

Title: Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.

PubMed ID: 19276069

DOI: 10.1074/jbc.m809250200

PubMed ID: 22977175

Title: The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex.

PubMed ID: 22977175

DOI: 10.1093/nar/gks883

Sequence Information:

  • Length: 285
  • Mass: 32745
  • Checksum: 2AF23ED27E06EFDB
  • Sequence:
  • MPAATVDHSQ RICEVWACNL DEEMKKIRQV IRKYNYVAMD TEFPGVVARP IGEFRSNADY 
    QYQLLRCNVD LLKIIQLGLT FMNEQGEYPP GTSTWQFNFK FNLTEDMYAQ DSIELLTTSG 
    IQFKKHEEEG IETQYFAELL MTSGVVLCEG VKWLSFHSGY DFGYLIKILT NSNLPEEELD 
    FFEILRLFFP VIYDVKYLMK SCKNLKGGLQ EVAEQLELER IGPQHQAGSD SLLTGMAFFK 
    MREMFFEDHI DDAKYCGHLY GLGSGSSYVQ NGTGNAYEEE ANKQS

Genular Protein ID: 3950515971

Symbol: Q96IQ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 246
  • Mass: 28364
  • Checksum: C4CE7E77106ECF9F
  • Sequence:
  • MPAATVDHSQ RICEVWACNL DEEMKKIRQV IRKYNYVAMD TEFPGVVARP IGEFRSNADY 
    QYQLLRCNVD LLKIIQLGLT FMNEQGEYPP GTSTWQFNFK FNLTEDMYAQ DSIELLTTSG 
    IQFKKHEEEG IETQYFAELL MISGVVLCEG VKWLSFHSGY DFGYLIKILT NSNLPEEELD 
    FFEILRLFFP VIYDVKYLMK SCKNLKGGLQ EVAEQLELER IGPQHQAGSD SLLTGNAYEE 
    EANKQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.