Details for: CNOT7
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 291.0408
Cell Significance Index: -45.2700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 147.6482
Cell Significance Index: -37.4500 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 128.9484
Cell Significance Index: -53.1200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 108.8806
Cell Significance Index: -51.4100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 108.3058
Cell Significance Index: -44.0000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 95.9398
Cell Significance Index: -49.3500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 76.9647
Cell Significance Index: -51.6500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 46.4104
Cell Significance Index: -44.3100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 40.0501
Cell Significance Index: -49.3800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.6261
Cell Significance Index: -41.8600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.8382
Cell Significance Index: -50.6600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.5390
Cell Significance Index: -32.3700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.3798
Cell Significance Index: -18.3400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 4.3518
Cell Significance Index: 507.1500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.8805
Cell Significance Index: 268.3600 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 2.3534
Cell Significance Index: 18.1400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.7718
Cell Significance Index: 111.6700 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.6391
Cell Significance Index: 43.1000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.4115
Cell Significance Index: 49.0500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.1499
Cell Significance Index: 141.3900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.1336
Cell Significance Index: 227.4000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.0672
Cell Significance Index: 14.5600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.9749
Cell Significance Index: 114.9700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9689
Cell Significance Index: 174.6600 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.9641
Cell Significance Index: 17.8200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.9003
Cell Significance Index: 491.6600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.8902
Cell Significance Index: 24.2300 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.8667
Cell Significance Index: 6.9200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8522
Cell Significance Index: 169.1200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.8478
Cell Significance Index: 39.5300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.8443
Cell Significance Index: 54.4700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8058
Cell Significance Index: 727.5700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.7978
Cell Significance Index: 16.7000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.7916
Cell Significance Index: 13.5700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.7630
Cell Significance Index: 104.7800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.7624
Cell Significance Index: 53.9200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7426
Cell Significance Index: 328.3200 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.6693
Cell Significance Index: 85.8000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.6319
Cell Significance Index: 29.7000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.6311
Cell Significance Index: 16.8500 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.5942
Cell Significance Index: 6.4600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4998
Cell Significance Index: 26.2400 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.4523
Cell Significance Index: 6.8700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.4515
Cell Significance Index: 13.2600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4322
Cell Significance Index: 155.0100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4292
Cell Significance Index: 31.9900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4135
Cell Significance Index: 44.9800 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.3972
Cell Significance Index: 51.3200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3758
Cell Significance Index: 19.5200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3154
Cell Significance Index: 16.4300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3073
Cell Significance Index: 8.8600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3038
Cell Significance Index: 51.8800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2817
Cell Significance Index: 15.8100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2773
Cell Significance Index: 191.8200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2582
Cell Significance Index: 42.0000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1845
Cell Significance Index: 18.2500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1740
Cell Significance Index: 3.7700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1707
Cell Significance Index: 4.7700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1408
Cell Significance Index: 26.8000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0935
Cell Significance Index: 5.7500 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.0675
Cell Significance Index: 0.8600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0456
Cell Significance Index: 2.0700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0358
Cell Significance Index: 55.0900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0245
Cell Significance Index: 46.0600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0002
Cell Significance Index: 0.1500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0018
Cell Significance Index: -2.4700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0023
Cell Significance Index: -4.2800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0097
Cell Significance Index: -7.1100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0145
Cell Significance Index: -10.7300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0220
Cell Significance Index: -13.9800 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: -0.0250
Cell Significance Index: -0.2200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0272
Cell Significance Index: -16.9800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0350
Cell Significance Index: -0.5900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0399
Cell Significance Index: -0.8500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0461
Cell Significance Index: -26.0200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0515
Cell Significance Index: -5.2600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0770
Cell Significance Index: -34.9500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0900
Cell Significance Index: -18.9600 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1233
Cell Significance Index: -1.4700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1259
Cell Significance Index: -1.4300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1423
Cell Significance Index: -40.9600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1590
Cell Significance Index: -10.6900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1755
Cell Significance Index: -25.5100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2081
Cell Significance Index: -23.8500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2308
Cell Significance Index: -17.7200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2497
Cell Significance Index: -6.3800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2675
Cell Significance Index: -9.4000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2865
Cell Significance Index: -32.7000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3509
Cell Significance Index: -9.3900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3540
Cell Significance Index: -9.1000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4128
Cell Significance Index: -11.0600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.4338
Cell Significance Index: -4.0000 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.4480
Cell Significance Index: -4.7600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4680
Cell Significance Index: -48.7300 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.4858
Cell Significance Index: -7.2800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5037
Cell Significance Index: -39.8900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5063
Cell Significance Index: -16.2200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.5089
Cell Significance Index: -22.5100 - Cell Name: peg cell (CL4033014)
Fold Change: -0.5410
Cell Significance Index: -12.5000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6638
Cell Significance Index: -25.1400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 896877996
Symbol: CNOT7_HUMAN
Name: CCR4-NOT transcription complex subunit 7
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9820826
Title: Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1.
PubMed ID: 9820826
DOI: 10.1042/bj3360471
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15769875
Title: Conservation of the deadenylase activity of proteins of the Caf1 family in human.
PubMed ID: 15769875
DOI: 10.1261/rna.7135305
PubMed ID: 19558367
Title: Human Ccr4-Not complexes contain variable deadenylase subunits.
PubMed ID: 19558367
DOI: 10.1042/bj20090500
PubMed ID: 19605561
Title: The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.
PubMed ID: 19605561
PubMed ID: 20634287
PubMed ID: 20065043
Title: CCR4-NOT deadenylates mRNA associated with complexes in human cells.
PubMed ID: 20065043
DOI: 10.1128/mcb.01481-09
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21336257
Title: Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.
PubMed ID: 21336257
PubMed ID: 23236473
Title: The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
PubMed ID: 23236473
PubMed ID: 25106868
Title: ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.
PubMed ID: 25106868
DOI: 10.1093/nar/gku652
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30520513
Title: TDP-43 accelerates deadenylation of target mRNAs by recruiting Caf1 deadenylase.
PubMed ID: 30520513
PubMed ID: 31439799
Title: Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation.
PubMed ID: 31439799
PubMed ID: 32502391
Title: Homozygous mutations in BTG4 cause zygotic cleavage failure and female infertility.
PubMed ID: 32502391
PubMed ID: 19276069
Title: Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.
PubMed ID: 19276069
PubMed ID: 22977175
Title: The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex.
PubMed ID: 22977175
DOI: 10.1093/nar/gks883
Sequence Information:
- Length: 285
- Mass: 32745
- Checksum: 2AF23ED27E06EFDB
- Sequence:
MPAATVDHSQ RICEVWACNL DEEMKKIRQV IRKYNYVAMD TEFPGVVARP IGEFRSNADY QYQLLRCNVD LLKIIQLGLT FMNEQGEYPP GTSTWQFNFK FNLTEDMYAQ DSIELLTTSG IQFKKHEEEG IETQYFAELL MTSGVVLCEG VKWLSFHSGY DFGYLIKILT NSNLPEEELD FFEILRLFFP VIYDVKYLMK SCKNLKGGLQ EVAEQLELER IGPQHQAGSD SLLTGMAFFK MREMFFEDHI DDAKYCGHLY GLGSGSSYVQ NGTGNAYEEE ANKQS
Genular Protein ID: 3950515971
Symbol: Q96IQ6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 246
- Mass: 28364
- Checksum: C4CE7E77106ECF9F
- Sequence:
MPAATVDHSQ RICEVWACNL DEEMKKIRQV IRKYNYVAMD TEFPGVVARP IGEFRSNADY QYQLLRCNVD LLKIIQLGLT FMNEQGEYPP GTSTWQFNFK FNLTEDMYAQ DSIELLTTSG IQFKKHEEEG IETQYFAELL MISGVVLCEG VKWLSFHSGY DFGYLIKILT NSNLPEEELD FFEILRLFFP VIYDVKYLMK SCKNLKGGLQ EVAEQLELER IGPQHQAGSD SLLTGNAYEE EANKQS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.