Details for: GPSM2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 170.4327
Cell Significance Index: -26.5100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 111.9879
Cell Significance Index: -28.4100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 71.3268
Cell Significance Index: -33.6800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 65.0081
Cell Significance Index: -26.4100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 27.9499
Cell Significance Index: -26.6900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 26.7244
Cell Significance Index: -32.9500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.7741
Cell Significance Index: -23.5800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 9.0869
Cell Significance Index: -27.9100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.5224
Cell Significance Index: -33.6300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.7546
Cell Significance Index: 46.8500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.6070
Cell Significance Index: 44.9100 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.3967
Cell Significance Index: 27.2600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1085
Cell Significance Index: 1000.8900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.0377
Cell Significance Index: 63.7800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9764
Cell Significance Index: 158.8000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8682
Cell Significance Index: 94.4400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.8431
Cell Significance Index: 47.3100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.8156
Cell Significance Index: 19.5600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7889
Cell Significance Index: 156.5600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6540
Cell Significance Index: 131.2000 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.6479
Cell Significance Index: 4.3900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.6156
Cell Significance Index: 71.7400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5005
Cell Significance Index: 61.5400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4766
Cell Significance Index: 85.9200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.4405
Cell Significance Index: 6.0100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3909
Cell Significance Index: 140.2200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3465
Cell Significance Index: 20.8000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3330
Cell Significance Index: 9.6000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2760
Cell Significance Index: 6.9000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2705
Cell Significance Index: 11.9700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2561
Cell Significance Index: 113.2200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2509
Cell Significance Index: 9.5000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2495
Cell Significance Index: 11.3100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2494
Cell Significance Index: 19.1400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1932
Cell Significance Index: 133.6300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1807
Cell Significance Index: 12.5000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1712
Cell Significance Index: 10.7900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1468
Cell Significance Index: 3.1800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1465
Cell Significance Index: 14.5000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1277
Cell Significance Index: 4.0900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1177
Cell Significance Index: 22.3900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1142
Cell Significance Index: 15.6800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1037
Cell Significance Index: 56.6300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0928
Cell Significance Index: 171.0600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0883
Cell Significance Index: 135.8700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0820
Cell Significance Index: 9.6700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0687
Cell Significance Index: 31.1800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0528
Cell Significance Index: 3.5500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0496
Cell Significance Index: 93.4400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0378
Cell Significance Index: 51.4000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0210
Cell Significance Index: 0.3600 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.0012
Cell Significance Index: 0.0300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0027
Cell Significance Index: -0.1400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0145
Cell Significance Index: -9.2000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0382
Cell Significance Index: -28.0400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0441
Cell Significance Index: -33.3900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0465
Cell Significance Index: -34.4800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0498
Cell Significance Index: -1.0600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0559
Cell Significance Index: -3.9500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0605
Cell Significance Index: -34.1300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0678
Cell Significance Index: -42.3400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0710
Cell Significance Index: -2.5000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0823
Cell Significance Index: -23.6800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1107
Cell Significance Index: -2.9600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1145
Cell Significance Index: -5.7900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1354
Cell Significance Index: -17.3600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1428
Cell Significance Index: -9.2100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1487
Cell Significance Index: -21.6100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1536
Cell Significance Index: -15.6900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1660
Cell Significance Index: -21.4500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1722
Cell Significance Index: -29.4100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1801
Cell Significance Index: -37.9400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1805
Cell Significance Index: -3.0200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2063
Cell Significance Index: -9.6200 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.2244
Cell Significance Index: -1.7300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2659
Cell Significance Index: -27.6900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2666
Cell Significance Index: -30.5400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2842
Cell Significance Index: -21.1800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2844
Cell Significance Index: -7.6200 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.2871
Cell Significance Index: -4.3600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2967
Cell Significance Index: -6.2100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3188
Cell Significance Index: -16.7400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3525
Cell Significance Index: -9.6000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3613
Cell Significance Index: -16.9800 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.3677
Cell Significance Index: -5.2800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3746
Cell Significance Index: -7.9500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3836
Cell Significance Index: -30.3800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4316
Cell Significance Index: -22.4800 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4905
Cell Significance Index: -12.5300 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.5254
Cell Significance Index: -5.4900 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.5371
Cell Significance Index: -7.5100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5520
Cell Significance Index: -33.8400 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.5564
Cell Significance Index: -9.6200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6063
Cell Significance Index: -21.0700 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.6184
Cell Significance Index: -7.6700 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.6367
Cell Significance Index: -7.9400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.6368
Cell Significance Index: -13.2100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.6516
Cell Significance Index: -9.8200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.6649
Cell Significance Index: -19.0600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.6841
Cell Significance Index: -10.2500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2794416226
Symbol: GPSM2_HUMAN
Name: G-protein-signaling modulator 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8973305
Title: Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2.
PubMed ID: 8973305
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11781568
Title: A mammalian partner of inscuteable binds NuMA and regulates mitotic spindle organization.
PubMed ID: 11781568
DOI: 10.1038/ncb1201-1069
PubMed ID: 15632202
Title: Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division.
PubMed ID: 15632202
PubMed ID: 16458856
Title: Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3.
PubMed ID: 16458856
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20602914
Title: Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82.
PubMed ID: 20602914
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21816348
Title: LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Galphai/LGN/NuMA pathways.
PubMed ID: 21816348
PubMed ID: 22578326
Title: GPSM2 mutations cause the brain malformations and hearing loss in Chudley-McCullough syndrome.
PubMed ID: 22578326
PubMed ID: 22327364
Title: Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation.
PubMed ID: 22327364
DOI: 10.1038/ncb2440
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 26766442
Title: SAPCD2 controls spindle orientation and asymmetric divisions by negatively regulating the Galphai-LGN-NuMA ternary complex.
PubMed ID: 26766442
PubMed ID: 27462074
Title: Nuclear mitotic apparatus (NuMA) interacts with and regulates astrin at the mitotic spindle.
PubMed ID: 27462074
PubMed ID: 22074847
Title: Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN).
PubMed ID: 22074847
PubMed ID: 25664792
Title: Structural basis for the recognition of the scaffold protein Frmpd4/Preso1 by the TPR domain of the adaptor protein LGN.
PubMed ID: 25664792
Sequence Information:
- Length: 684
- Mass: 76662
- Checksum: D007A4765F57CB90
- Sequence:
MEENLISMRE DHSFHVRYRM EASCLELALE GERLCKSGDC RAGVSFFEAA VQVGTEDLKT LSAIYSQLGN AYFYLHDYAK ALEYHHHDLT LARTIGDQLG EAKASGNLGN TLKVLGNFDE AIVCCQRHLD ISRELNDKVG EARALYNLGN VYHAKGKSFG CPGPQDVGEF PEEVRDALQA AVDFYEENLS LVTALGDRAA QGRAFGNLGN THYLLGNFRD AVIAHEQRLL IAKEFGDKAA ERRAYSNLGN AYIFLGEFET ASEYYKKTLL LARQLKDRAV EAQSCYSLGN TYTLLQDYEK AIDYHLKHLA IAQELNDRIG EGRACWSLGN AYTALGNHDQ AMHFAEKHLE ISREVGDKSG ELTARLNLSD LQMVLGLSYS TNNSIMSENT EIDSSLNGVR PKLGRRHSME NMELMKLTPE KVQNWNSEIL AKQKPLIAKP SAKLLFVNRL KGKKYKTNSS TKVLQDASNS IDHRIPNSQR KISADTIGDE GFFDLLSRFQ SNRMDDQRCC LQEKNCHTAS TTTSSTPPKM MLKTSSVPVV SPNTDEFLDL LASSQSRRLD DQRASFSNLP GLRLTQNSQS VLSHLMTNDN KEADEDFFDI LVKCQGSRLD DQRCAPPPAT TKGPTVPDED FFSLILRSQG KRMDEQRVLL QRDQNRDTDF GLKDFLQNNA LLEFKNSGKK SADH
Genular Protein ID: 2535217878
Symbol: B4DIF1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 683
- Mass: 76575
- Checksum: E2600531709DCAE5
- Sequence:
MEENLISMRE DHSFHVRYRM EASCLELALE GERLCKSGDC RAGVSFFEAA VQVGTEDLKT LSAIYSQLGN AYFYLHDYAK ALEYHHHDLT LARTIGDQLG EAKASGNLGN TLKVLGNFDE AIVCCQRHLD ISRELNDKVG EARALYNLGN VYHAKGKSFG CPGPQDVGEF PEEVRDALQA AVDFYEENLS LVTALGDRAA QGRAFGNLGN THYLLGNFRD AVIAHEQRLL IAKEFGDKAA ERRAYSNLGN AYIFLGEFET ASEYYKKTLL LARQLKDRAV EAQSCYSLGN TYTLLQDYEK AIDYHLKHLA IAQELNDRIG EGRACWSLGN AYTALGNHDQ AMHFAEKHLE ISREVGDKSG ELTARLNLSD LQMVLGLSYS TNNSIMSENT EIDSSLNGVR PKLGRRHSME NMELMKLTPE KVQNWNSEIL AKQKPLIAKP SAKLLFVNRL KGKKYKTNSS TKVLQDASNS IDHRIPNSQR KISADTIGDE GFFDLLSRFQ SNRMDDQRCC LQEKNCHTAS TTTSTPPKMM LKTSSVPVVS PNTDEFLDLL ASSQSRRLDD QRASFSNLPG LRLTQNSQSV LSHLMTNDNK EADEDFFDIL VKCQGSRLDD QRCAPPPATT KGPTVPDEDF FSLILRSQGK RMDEQRVLLQ RDQNRDTDFG LKDFLQNNAL LEFKNSGKKS ADH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.