Details for: HOOK2

Gene ID: 29911

Symbol: HOOK2

Ensembl ID: ENSG00000095066

Description: hook microtubule tethering protein 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.88
    Marker Score: 86,743
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.89
    Marker Score: 1,056
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.4
    Marker Score: 6,003
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.25
    Marker Score: 1,111
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.22
    Marker Score: 1,239
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.17
    Marker Score: 2,455
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.11
    Marker Score: 1,468
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.06
    Marker Score: 1,825
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.96
    Marker Score: 2,369
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.96
    Marker Score: 820
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.9
    Marker Score: 595
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.88
    Marker Score: 9,046
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.87
    Marker Score: 2,262
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.85
    Marker Score: 1,747
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.83
    Marker Score: 2,690
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.78
    Marker Score: 6,321
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.77
    Marker Score: 2,720
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.74
    Marker Score: 15,021
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.72
    Marker Score: 3,040
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.71
    Marker Score: 7,158
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.7
    Marker Score: 548
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.69
    Marker Score: 536
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.69
    Marker Score: 2,178
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.68
    Marker Score: 3,420
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.66
    Marker Score: 3,039
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.64
    Marker Score: 16,970
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.63
    Marker Score: 1,805
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.62
    Marker Score: 949
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.61
    Marker Score: 12,008
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.61
    Marker Score: 6,192
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.61
    Marker Score: 55,624
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.6
    Marker Score: 2,625
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.6
    Marker Score: 2,565
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.59
    Marker Score: 1,676
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.59
    Marker Score: 770
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.57
    Marker Score: 4,931
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.55
    Marker Score: 856
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.55
    Marker Score: 454
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.53
    Marker Score: 1,322
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.53
    Marker Score: 56,429
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.53
    Marker Score: 1,785
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.52
    Marker Score: 416
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.52
    Marker Score: 14,304
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.52
    Marker Score: 5,960
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.51
    Marker Score: 3,559
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.48
    Marker Score: 551
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.48
    Marker Score: 1,986
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.45
    Marker Score: 89,298
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.45
    Marker Score: 5,356
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.44
    Marker Score: 2,220
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.43
    Marker Score: 1,484
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.43
    Marker Score: 3,255
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.42
    Marker Score: 411
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.42
    Marker Score: 22,814
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.42
    Marker Score: 662
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.42
    Marker Score: 5,770
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.41
    Marker Score: 12,151
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.37
    Marker Score: 1,370
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.37
    Marker Score: 1,225
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.35
    Marker Score: 2,752
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.35
    Marker Score: 787
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.35
    Marker Score: 12,807
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.34
    Marker Score: 3,183
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.32
    Marker Score: 554
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.32
    Marker Score: 3,231
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.32
    Marker Score: 318
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.32
    Marker Score: 10,270
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.31
    Marker Score: 8,541
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.31
    Marker Score: 1,329
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.3
    Marker Score: 1,403
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.3
    Marker Score: 5,383
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.29
    Marker Score: 49,056
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19,938
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.26
    Marker Score: 659
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.26
    Marker Score: 332
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.25
    Marker Score: 753
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.24
    Marker Score: 290
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.23
    Marker Score: 4,773
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.23
    Marker Score: 305
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.23
    Marker Score: 461
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2
    Marker Score: 804
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.2
    Marker Score: 6,327
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.2
    Marker Score: 23,794
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.18
    Marker Score: 324
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.18
    Marker Score: 820
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.17
    Marker Score: 230
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.16
    Marker Score: 7,389
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.16
    Marker Score: 366
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.14
    Marker Score: 2,594
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.13
    Marker Score: 943
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.13
    Marker Score: 888
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.13
    Marker Score: 656
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.11
    Marker Score: 23,738
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.1
    Marker Score: 8,466
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.1
    Marker Score: 775
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.09
    Marker Score: 16,295
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.07
    Marker Score: 216
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.06
    Marker Score: 546
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.05
    Marker Score: 256
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.05
    Marker Score: 690

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Microtubule binding**: Hook2 protein binds to microtubules, influencing their organization and dynamics. 2. **Cytoskeleton-dependent transport**: The protein facilitates the transport of cargo along microtubules, regulating endocytosis, exocytosis, and intracellular transport. 3. **Protein localization**: Hook2 protein is localized to the perinuclear region of the cytoplasm, suggesting its role in regulating microtubule organization and cytoskeleton dynamics. 4. **Cell type specificity**: Hook2 is significantly expressed in various cell types, including cardiac myocytes, skeletal muscle fibers, and epithelial cells, indicating its importance in different cellular contexts. **Pathways and Functions** Hook2 is involved in several cellular pathways, including: 1. **Centrosome organization**: The protein plays a role in maintaining centrosome structure and function, which is essential for cell division and cytoskeleton organization. 2. **Cytoskeleton-dependent intracellular transport**: Hook2 facilitates the transport of cargo along microtubules, regulating endocytosis, exocytosis, and intracellular transport. 3. **Early endosome to late endosome transport**: The protein influences the transport of endosomes between early and late endosomes, regulating the sorting and delivery of cargo. 4. **Endosome organization**: Hook2 helps maintain endosome structure and function, ensuring proper sorting and delivery of cargo. 5. **Microtubule organization**: The protein regulates microtubule organization, influencing the dynamics and stability of microtubules. **Clinical Significance** Dysregulation of Hook2 has been implicated in various diseases, including: 1. **Cardiac disease**: Alterations in Hook2 expression have been linked to cardiac dysfunction and arrhythmias. 2. **Neurological disorders**: Hook2 mutations have been associated with neurological disorders, such as autism and schizophrenia. 3. **Cancer**: The protein's role in regulating microtubule organization and cytoskeleton dynamics makes it a potential target for cancer therapy. In conclusion, Hook2 is a critical gene that plays a significant role in regulating microtubule organization, cytoskeleton-dependent transport, and cellular processes such as endocytosis and exocytosis. Understanding the function and regulation of Hook2 can provide insights into the mechanisms underlying various diseases and lead to the development of novel therapeutic strategies.

Genular Protein ID: 3563277733

Symbol: HOOK2_HUMAN

Name: Protein Hook homolog 2

UniProtKB Accession Codes:

Q96ED9 O60562

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9927460

Title: Genetic analysis of hook, a gene required for endocytic trafficking in Drosophila.

PubMed ID: 9927460

DOI: 10.1093/genetics/151.2.675

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11238449

Title: The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins.

PubMed ID: 11238449

DOI: 10.1083/jcb.152.5.923

PubMed ID: 17540036

Title: Hook2 contributes to aggresome formation.

PubMed ID: 17540036

DOI: 10.1186/1471-2121-8-19

PubMed ID: 17140400

Title: Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function.

PubMed ID: 17140400

DOI: 10.1111/j.1600-0854.2006.00511.x

PubMed ID: 18799622

Title: An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.

PubMed ID: 18799622

DOI: 10.1091/mbc.e08-05-0473

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19273536

Title: SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans.

PubMed ID: 19273536

DOI: 10.1093/hmg/ddp099

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32073997

Title: The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.

PubMed ID: 32073997

DOI: 10.1091/mbc.e19-11-0658

Sequence Information:

  • Length: 719
  • Mass: 83207
  • Checksum: FDF5F8A53DEE9DB6
  • Sequence:
    • MSVDKAELCG SLLTWLQTFH VPSPCASPQD LSSGLAVAYV LNQIDPSWFN EAWLQGISED 
PGPNWKLKVS NLKMVLRSLV EYSQDVLAHP VSEEHLPDVS LIGEFSDPAE LGKLLQLVLG 
CAISCEKKQD HIQRIMTLEE SVQHVVMEAI QELMTKDTPD SLSPETYGNF DSQSRRYYFL 
SEEAEEGDEL QQRCLDLERQ LMLLSEEKQS LAQENAGLRE RMGRPEGEGT PGLTAKKLLL 
LQSQLEQLQE ENFRLESGRE DERLRCAELE REVAELQHRN QALTSLAQEA QALKDEMDEL 
RQSSERAGQL EATLTSCRRR LGELRELRRQ VRQLEERNAG HAERTRQLED ELRRAGSLRA 
QLEAQRRQVQ ELQGQRQEEA MKAEKWLFEC RNLEEKYESV TKEKERLLAE RDSLREANEE 
LRCAQLQPRG LTQADPSLDP TSTPVDNLAA EILPAELRET LLRLQLENKR LCRQEAADRE 
RQEELQRHLE DANRARHGLE TQHRLNQQQL SELRAQVEDL QKALQEQGGK TEDAISILLK 
RKLEEHLQKL HEADLELQRK REYIEELEPP TDSSTARRIE ELQHNLQKKD ADLRAMEERY 
RRYVDKARMV MQTMEPKQRP AAGAPPELHS LRTQLRERDV RIRHLEMDFE KSRSQREQEE 
KLLISAWYNM GMALQQRAGE ERAPAHAQSF LAQQRLATNS RRGPLGRLAS LNLRPTDKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.