Details for: HOOK2

Gene ID: 29911

Symbol: HOOK2

Ensembl ID: ENSG00000095066

Description: hook microtubule tethering protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 273.0396
    Cell Significance Index: -42.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 157.2286
    Cell Significance Index: -39.8800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 90.9086
    Cell Significance Index: -42.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.0681
    Cell Significance Index: -37.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.5106
    Cell Significance Index: -42.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.4693
    Cell Significance Index: -41.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.8666
    Cell Significance Index: -42.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.4943
    Cell Significance Index: -26.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.2232
    Cell Significance Index: -13.6200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 5.3835
    Cell Significance Index: 67.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.7455
    Cell Significance Index: 259.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.5115
    Cell Significance Index: 47.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.3462
    Cell Significance Index: 93.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.3353
    Cell Significance Index: 90.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.9288
    Cell Significance Index: 224.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.2584
    Cell Significance Index: 102.3700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.2092
    Cell Significance Index: 19.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.0707
    Cell Significance Index: 59.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9524
    Cell Significance Index: 117.2100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.8769
    Cell Significance Index: 11.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8511
    Cell Significance Index: 96.1600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.8233
    Cell Significance Index: 22.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8051
    Cell Significance Index: 84.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6235
    Cell Significance Index: 322.1900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.6234
    Cell Significance Index: 3.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.5363
    Cell Significance Index: 80.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.3786
    Cell Significance Index: 31.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3493
    Cell Significance Index: 270.6700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.2566
    Cell Significance Index: 30.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1746
    Cell Significance Index: 211.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1666
    Cell Significance Index: 54.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1214
    Cell Significance Index: 83.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0633
    Cell Significance Index: 580.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0625
    Cell Significance Index: 15.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0529
    Cell Significance Index: 136.0300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.0513
    Cell Significance Index: 6.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0370
    Cell Significance Index: 127.5100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8937
    Cell Significance Index: 8.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8258
    Cell Significance Index: 22.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7447
    Cell Significance Index: 267.1100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.6386
    Cell Significance Index: 2.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5725
    Cell Significance Index: 40.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4683
    Cell Significance Index: 207.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4664
    Cell Significance Index: 46.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4119
    Cell Significance Index: 52.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3934
    Cell Significance Index: 4.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3886
    Cell Significance Index: 53.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3872
    Cell Significance Index: 267.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3632
    Cell Significance Index: 69.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3453
    Cell Significance Index: 21.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3253
    Cell Significance Index: 11.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2005
    Cell Significance Index: 377.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1520
    Cell Significance Index: 233.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1450
    Cell Significance Index: 92.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1004
    Cell Significance Index: 17.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0949
    Cell Significance Index: 175.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0633
    Cell Significance Index: 86.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0535
    Cell Significance Index: 3.3700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0458
    Cell Significance Index: 0.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0443
    Cell Significance Index: 33.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0419
    Cell Significance Index: 37.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0362
    Cell Significance Index: 0.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0272
    Cell Significance Index: 19.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0150
    Cell Significance Index: 0.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0077
    Cell Significance Index: -3.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0149
    Cell Significance Index: -11.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0167
    Cell Significance Index: -10.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0266
    Cell Significance Index: -1.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0293
    Cell Significance Index: -4.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0305
    Cell Significance Index: -1.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0360
    Cell Significance Index: -5.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0447
    Cell Significance Index: -25.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0562
    Cell Significance Index: -5.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0832
    Cell Significance Index: -3.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0839
    Cell Significance Index: -5.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0922
    Cell Significance Index: -19.4300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0994
    Cell Significance Index: -1.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1164
    Cell Significance Index: -33.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1331
    Cell Significance Index: -15.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1415
    Cell Significance Index: -9.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2211
    Cell Significance Index: -4.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2250
    Cell Significance Index: -25.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2381
    Cell Significance Index: -27.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2498
    Cell Significance Index: -4.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2685
    Cell Significance Index: -7.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2785
    Cell Significance Index: -8.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2859
    Cell Significance Index: -6.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3288
    Cell Significance Index: -34.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3313
    Cell Significance Index: -4.7500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3390
    Cell Significance Index: -5.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3451
    Cell Significance Index: -8.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3660
    Cell Significance Index: -41.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3709
    Cell Significance Index: -12.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3863
    Cell Significance Index: -7.5400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3922
    Cell Significance Index: -4.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4090
    Cell Significance Index: -9.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4318
    Cell Significance Index: -4.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4508
    Cell Significance Index: -11.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4535
    Cell Significance Index: -35.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Microtubule binding**: Hook2 protein binds to microtubules, influencing their organization and dynamics. 2. **Cytoskeleton-dependent transport**: The protein facilitates the transport of cargo along microtubules, regulating endocytosis, exocytosis, and intracellular transport. 3. **Protein localization**: Hook2 protein is localized to the perinuclear region of the cytoplasm, suggesting its role in regulating microtubule organization and cytoskeleton dynamics. 4. **Cell type specificity**: Hook2 is significantly expressed in various cell types, including cardiac myocytes, skeletal muscle fibers, and epithelial cells, indicating its importance in different cellular contexts. **Pathways and Functions** Hook2 is involved in several cellular pathways, including: 1. **Centrosome organization**: The protein plays a role in maintaining centrosome structure and function, which is essential for cell division and cytoskeleton organization. 2. **Cytoskeleton-dependent intracellular transport**: Hook2 facilitates the transport of cargo along microtubules, regulating endocytosis, exocytosis, and intracellular transport. 3. **Early endosome to late endosome transport**: The protein influences the transport of endosomes between early and late endosomes, regulating the sorting and delivery of cargo. 4. **Endosome organization**: Hook2 helps maintain endosome structure and function, ensuring proper sorting and delivery of cargo. 5. **Microtubule organization**: The protein regulates microtubule organization, influencing the dynamics and stability of microtubules. **Clinical Significance** Dysregulation of Hook2 has been implicated in various diseases, including: 1. **Cardiac disease**: Alterations in Hook2 expression have been linked to cardiac dysfunction and arrhythmias. 2. **Neurological disorders**: Hook2 mutations have been associated with neurological disorders, such as autism and schizophrenia. 3. **Cancer**: The protein's role in regulating microtubule organization and cytoskeleton dynamics makes it a potential target for cancer therapy. In conclusion, Hook2 is a critical gene that plays a significant role in regulating microtubule organization, cytoskeleton-dependent transport, and cellular processes such as endocytosis and exocytosis. Understanding the function and regulation of Hook2 can provide insights into the mechanisms underlying various diseases and lead to the development of novel therapeutic strategies.

Genular Protein ID: 3563277733

Symbol: HOOK2_HUMAN

Name: Protein Hook homolog 2

UniProtKB Accession Codes:

Q96ED9 O60562

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9927460

Title: Genetic analysis of hook, a gene required for endocytic trafficking in Drosophila.

PubMed ID: 9927460

DOI: 10.1093/genetics/151.2.675

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11238449

Title: The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins.

PubMed ID: 11238449

DOI: 10.1083/jcb.152.5.923

PubMed ID: 17540036

Title: Hook2 contributes to aggresome formation.

PubMed ID: 17540036

DOI: 10.1186/1471-2121-8-19

PubMed ID: 17140400

Title: Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function.

PubMed ID: 17140400

DOI: 10.1111/j.1600-0854.2006.00511.x

PubMed ID: 18799622

Title: An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.

PubMed ID: 18799622

DOI: 10.1091/mbc.e08-05-0473

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19273536

Title: SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans.

PubMed ID: 19273536

DOI: 10.1093/hmg/ddp099

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32073997

Title: The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.

PubMed ID: 32073997

DOI: 10.1091/mbc.e19-11-0658

Sequence Information:

  • Length: 719
  • Mass: 83207
  • Checksum: FDF5F8A53DEE9DB6
  • Sequence:
    • MSVDKAELCG SLLTWLQTFH VPSPCASPQD LSSGLAVAYV LNQIDPSWFN EAWLQGISED 
PGPNWKLKVS NLKMVLRSLV EYSQDVLAHP VSEEHLPDVS LIGEFSDPAE LGKLLQLVLG 
CAISCEKKQD HIQRIMTLEE SVQHVVMEAI QELMTKDTPD SLSPETYGNF DSQSRRYYFL 
SEEAEEGDEL QQRCLDLERQ LMLLSEEKQS LAQENAGLRE RMGRPEGEGT PGLTAKKLLL 
LQSQLEQLQE ENFRLESGRE DERLRCAELE REVAELQHRN QALTSLAQEA QALKDEMDEL 
RQSSERAGQL EATLTSCRRR LGELRELRRQ VRQLEERNAG HAERTRQLED ELRRAGSLRA 
QLEAQRRQVQ ELQGQRQEEA MKAEKWLFEC RNLEEKYESV TKEKERLLAE RDSLREANEE 
LRCAQLQPRG LTQADPSLDP TSTPVDNLAA EILPAELRET LLRLQLENKR LCRQEAADRE 
RQEELQRHLE DANRARHGLE TQHRLNQQQL SELRAQVEDL QKALQEQGGK TEDAISILLK 
RKLEEHLQKL HEADLELQRK REYIEELEPP TDSSTARRIE ELQHNLQKKD ADLRAMEERY 
RRYVDKARMV MQTMEPKQRP AAGAPPELHS LRTQLRERDV RIRHLEMDFE KSRSQREQEE 
KLLISAWYNM GMALQQRAGE ERAPAHAQSF LAQQRLATNS RRGPLGRLAS LNLRPTDKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.