Details for: EPN1

Gene ID: 29924

Symbol: EPN1

Ensembl ID: ENSG00000063245

Description: epsin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 230.7367
    Cell Significance Index: -35.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 138.8169
    Cell Significance Index: -35.2100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 100.9109
    Cell Significance Index: -41.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.0969
    Cell Significance Index: -35.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 85.3698
    Cell Significance Index: -40.3100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.4711
    Cell Significance Index: -39.8500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.1769
    Cell Significance Index: -40.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.7274
    Cell Significance Index: -36.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.4999
    Cell Significance Index: -37.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.1179
    Cell Significance Index: -37.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6958
    Cell Significance Index: -38.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.3368
    Cell Significance Index: -11.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3897
    Cell Significance Index: 18.9600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1572
    Cell Significance Index: 17.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1187
    Cell Significance Index: 1010.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9643
    Cell Significance Index: 113.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9431
    Cell Significance Index: 102.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9226
    Cell Significance Index: 113.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8396
    Cell Significance Index: 115.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8215
    Cell Significance Index: 17.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8080
    Cell Significance Index: 145.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7845
    Cell Significance Index: 54.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7576
    Cell Significance Index: 19.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7195
    Cell Significance Index: 37.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7169
    Cell Significance Index: 391.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6859
    Cell Significance Index: 31.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6663
    Cell Significance Index: 12.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6379
    Cell Significance Index: 63.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6025
    Cell Significance Index: 15.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6012
    Cell Significance Index: 6.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5994
    Cell Significance Index: 102.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5978
    Cell Significance Index: 118.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5695
    Cell Significance Index: 251.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5033
    Cell Significance Index: 100.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4901
    Cell Significance Index: 31.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4410
    Cell Significance Index: 22.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4220
    Cell Significance Index: 12.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3965
    Cell Significance Index: 28.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3844
    Cell Significance Index: 20.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3235
    Cell Significance Index: 61.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3144
    Cell Significance Index: 8.4300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3022
    Cell Significance Index: 3.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2852
    Cell Significance Index: 17.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2561
    Cell Significance Index: 32.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2324
    Cell Significance Index: 4.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2221
    Cell Significance Index: 5.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2219
    Cell Significance Index: 16.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2133
    Cell Significance Index: 5.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2118
    Cell Significance Index: 27.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2087
    Cell Significance Index: 7.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1885
    Cell Significance Index: 8.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1843
    Cell Significance Index: 66.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1711
    Cell Significance Index: 1.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1514
    Cell Significance Index: 4.8500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0847
    Cell Significance Index: 0.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0572
    Cell Significance Index: 41.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0419
    Cell Significance Index: 1.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0409
    Cell Significance Index: 3.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0168
    Cell Significance Index: 0.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0168
    Cell Significance Index: 11.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0001
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0057
    Cell Significance Index: -10.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0093
    Cell Significance Index: -5.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0101
    Cell Significance Index: -1.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0128
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0162
    Cell Significance Index: -12.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0193
    Cell Significance Index: -35.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0248
    Cell Significance Index: -38.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0295
    Cell Significance Index: -4.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0305
    Cell Significance Index: -41.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0437
    Cell Significance Index: -27.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0483
    Cell Significance Index: -27.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0705
    Cell Significance Index: -31.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0937
    Cell Significance Index: -19.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1003
    Cell Significance Index: -2.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1059
    Cell Significance Index: -12.3400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1096
    Cell Significance Index: -0.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1099
    Cell Significance Index: -31.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1406
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1520
    Cell Significance Index: -17.4100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1721
    Cell Significance Index: -19.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2120
    Cell Significance Index: -13.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2234
    Cell Significance Index: -32.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2432
    Cell Significance Index: -16.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2562
    Cell Significance Index: -5.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2784
    Cell Significance Index: -22.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3059
    Cell Significance Index: -13.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3116
    Cell Significance Index: -8.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3628
    Cell Significance Index: -37.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3683
    Cell Significance Index: -7.9800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3990
    Cell Significance Index: -4.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4353
    Cell Significance Index: -11.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4712
    Cell Significance Index: -26.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4759
    Cell Significance Index: -18.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5054
    Cell Significance Index: -30.9900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5774
    Cell Significance Index: -4.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5825
    Cell Significance Index: -20.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6149
    Cell Significance Index: -7.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6253
    Cell Significance Index: -37.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6308
    Cell Significance Index: -10.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Epsin 1 is a member of the epsin family of proteins, which are known to regulate clathrin-mediated endocytosis. The protein exhibits a unique ability to recognize and interact with clathrin-coated vesicles, facilitating the internalization of cargo molecules. Epsin 1 has been shown to bind to phospholipids and exhibit molecular sequestering activity, allowing it to regulate the activity of clathrin and other proteins involved in endocytosis. The protein also interacts with various signaling molecules, including receptor tyrosine kinases, and has been implicated in the regulation of signaling pathways. **Pathways and Functions:** Epsin 1 plays a critical role in various cellular pathways, including: 1. **Cargo recognition for clathrin-mediated endocytosis**: Epsin 1 recognizes and interacts with clathrin-coated vesicles, facilitating the internalization of cargo molecules. 2. **Clathrin-coated pit formation**: Epsin 1 regulates the formation of clathrin-coated pits, which are essential for the internalization of cargo molecules. 3. **Signal transduction**: Epsin 1 interacts with receptor tyrosine kinases and other signaling molecules, regulating signaling pathways involved in cell growth, differentiation, and survival. 4. **Molecular sequestering activity**: Epsin 1 exhibits molecular sequestering activity, allowing it to regulate the activity of clathrin and other proteins involved in endocytosis. **Clinical Significance:** The dysregulation of Epsin 1 has been implicated in various diseases, including: 1. **Cancer**: Epsin 1 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role in tumor progression. 2. **Neurodegenerative diseases**: Epsin 1 has been implicated in the regulation of endocytosis in neurons, and its dysregulation has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's. 3. **Embryonic development**: Epsin 1 is essential for embryonic development, and its dysregulation has been linked to birth defects and developmental abnormalities. In conclusion, the Epsin 1 gene plays a critical role in regulating clathrin-mediated endocytosis and cellular membrane trafficking. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of Epsin 1 and its potential therapeutic applications.

Genular Protein ID: 1886428332

Symbol: EPN1_HUMAN

Name: Epsin-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10557078

Title: Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis.

PubMed ID: 10557078

DOI: 10.1038/sj.onc.1202974

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10764745

Title: Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation.

PubMed ID: 10764745

DOI: 10.1074/jbc.m000521200

PubMed ID: 10393179

Title: Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors.

PubMed ID: 10393179

DOI: 10.1093/emboj/18.13.3629

PubMed ID: 12775724

Title: RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.

PubMed ID: 12775724

DOI: 10.1074/jbc.m302191200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16516836

Title: Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.

PubMed ID: 16516836

DOI: 10.1016/j.devcel.2006.01.016

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18199683

Title: The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.

PubMed ID: 18199683

DOI: 10.1091/mbc.e07-08-0775

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 34927784

Title: ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.

PubMed ID: 34927784

DOI: 10.15252/embr.202051182

PubMed ID: 12836669

Title: Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin.

PubMed ID: 12836669

DOI: 10.1023/a:1011397007366

Sequence Information:

  • Length: 576
  • Mass: 60293
  • Checksum: 68DD433F3168E975
  • Sequence:
  • MSTSSLRRQM KNIVHNYSEA EIKVREATSN DPWGPSSSLM SEIADLTYNV VAFSEIMSMI 
    WKRLNDHGKN WRHVYKAMTL MEYLIKTGSE RVSQQCKENM YAVQTLKDFQ YVDRDGKDQG 
    VNVREKAKQL VALLRDEDRL REERAHALKT KEKLAQTATA SSAAVGSGPP PEAEQAWPQS 
    SGEEELQLQL ALAMSKEEAD QPPSCGPEDD AQLQLALSLS REEHDKEERI RRGDDLRLQM 
    AIEESKRETG GKEESSLMDL ADVFTAPAPA PTTDPWGGPA PMAAAVPTAA PTSDPWGGPP 
    VPPAADPWGG PAPTPASGDP WRPAAPAGPS VDPWGGTPAP AAGEGPTPDP WGSSDGGVPV 
    SGPSASDPWT PAPAFSDPWG GSPAKPSTNG TTAAGGFDTE PDEFSDFDRL RTALPTSGSS 
    AGELELLAGE VPARSPGAFD MSGVRGSLAE AVGSPPPAAT PTPTPPTRKT PESFLGPNAA 
    LVDLDSLVSR PGPTPPGAKA SNPFLPGGGP ATGPSVTNPF QPAPPATLTL NQLRLSPVPP 
    VPGAPPTYIS PLGGGPGLPP MMPPGPPAPN TNPFLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.