Details for: EPN1

Gene ID: 29924

Symbol: EPN1

Ensembl ID: ENSG00000063245

Description: epsin 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.25
    Marker Score: 10,803
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.04
    Marker Score: 12,992
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.99
    Marker Score: 6,256
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.99
    Marker Score: 3,060
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.88
    Marker Score: 466
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.86
    Marker Score: 18,749
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.85
    Marker Score: 4,970
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.85
    Marker Score: 2,661
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.84
    Marker Score: 4,632
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.79
    Marker Score: 4,059
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.78
    Marker Score: 4,834
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.74
    Marker Score: 728
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.6
    Marker Score: 89,723
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.6
    Marker Score: 603
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.58
    Marker Score: 2,627
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.57
    Marker Score: 1,671
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.53
    Marker Score: 3,630
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.48
    Marker Score: 1,659
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.46
    Marker Score: 1,764
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.44
    Marker Score: 1,556
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.44
    Marker Score: 2,797
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.43
    Marker Score: 1,375
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.43
    Marker Score: 3,248
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.4
    Marker Score: 9,138
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.39
    Marker Score: 4,130
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.37
    Marker Score: 340
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.35
    Marker Score: 745
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.35
    Marker Score: 8,002
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.33
    Marker Score: 1,257
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.32
    Marker Score: 309
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.31
    Marker Score: 4,663
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.31
    Marker Score: 2,665
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.29
    Marker Score: 1,290
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.29
    Marker Score: 859
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.28
    Marker Score: 1,358
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.27
    Marker Score: 1,289
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.27
    Marker Score: 366
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.27
    Marker Score: 844
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.27
    Marker Score: 2,678
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.25
    Marker Score: 304
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.24
    Marker Score: 1,263
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.24
    Marker Score: 416
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.23
    Marker Score: 1,812
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.22
    Marker Score: 1,291
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.21
    Marker Score: 3,019
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.21
    Marker Score: 1,252
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2
    Marker Score: 41,703
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.19
    Marker Score: 716
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.19
    Marker Score: 993
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.17
    Marker Score: 8,710
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.17
    Marker Score: 2,438
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.16
    Marker Score: 7,065
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.16
    Marker Score: 572
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.16
    Marker Score: 730
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.13
    Marker Score: 623
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.13
    Marker Score: 320
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.13
    Marker Score: 1,020
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.12
    Marker Score: 767
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.12
    Marker Score: 1,589
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.12
    Marker Score: 1,112
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.11
    Marker Score: 1,188
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.11
    Marker Score: 519
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.11
    Marker Score: 9,566
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.09
    Marker Score: 4,052
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.09
    Marker Score: 1,369
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.09
    Marker Score: 769
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.09
    Marker Score: 4,283
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.09
    Marker Score: 245
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.08
    Marker Score: 14,484
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.07
    Marker Score: 260
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.06
    Marker Score: 1,072
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.06
    Marker Score: 2,506
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.06
    Marker Score: 619
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.06
    Marker Score: 1,145
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.06
    Marker Score: 1,733
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.05
    Marker Score: 9,163
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.05
    Marker Score: 2,097
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.04
    Marker Score: 977
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.04
    Marker Score: 13,689
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.03
    Marker Score: 9,077
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.03
    Marker Score: 381
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.03
    Marker Score: 1,637
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.03
    Marker Score: 917
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.02
    Marker Score: 11,499
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.02
    Marker Score: 1,074
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1
    Marker Score: 1,708
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1
    Marker Score: 679
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1
    Marker Score: 354
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1
    Marker Score: 756
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1
    Marker Score: 238
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,603
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.99
    Marker Score: 33,840
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,823
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.99
    Marker Score: 1,278
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.99
    Marker Score: 3,399
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.99
    Marker Score: 484
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.99
    Marker Score: 285
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.98
    Marker Score: 714
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,369
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.97
    Marker Score: 912

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Epsin 1 is a member of the epsin family of proteins, which are known to regulate clathrin-mediated endocytosis. The protein exhibits a unique ability to recognize and interact with clathrin-coated vesicles, facilitating the internalization of cargo molecules. Epsin 1 has been shown to bind to phospholipids and exhibit molecular sequestering activity, allowing it to regulate the activity of clathrin and other proteins involved in endocytosis. The protein also interacts with various signaling molecules, including receptor tyrosine kinases, and has been implicated in the regulation of signaling pathways. **Pathways and Functions:** Epsin 1 plays a critical role in various cellular pathways, including: 1. **Cargo recognition for clathrin-mediated endocytosis**: Epsin 1 recognizes and interacts with clathrin-coated vesicles, facilitating the internalization of cargo molecules. 2. **Clathrin-coated pit formation**: Epsin 1 regulates the formation of clathrin-coated pits, which are essential for the internalization of cargo molecules. 3. **Signal transduction**: Epsin 1 interacts with receptor tyrosine kinases and other signaling molecules, regulating signaling pathways involved in cell growth, differentiation, and survival. 4. **Molecular sequestering activity**: Epsin 1 exhibits molecular sequestering activity, allowing it to regulate the activity of clathrin and other proteins involved in endocytosis. **Clinical Significance:** The dysregulation of Epsin 1 has been implicated in various diseases, including: 1. **Cancer**: Epsin 1 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role in tumor progression. 2. **Neurodegenerative diseases**: Epsin 1 has been implicated in the regulation of endocytosis in neurons, and its dysregulation has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's. 3. **Embryonic development**: Epsin 1 is essential for embryonic development, and its dysregulation has been linked to birth defects and developmental abnormalities. In conclusion, the Epsin 1 gene plays a critical role in regulating clathrin-mediated endocytosis and cellular membrane trafficking. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of Epsin 1 and its potential therapeutic applications.

Genular Protein ID: 1886428332

Symbol: EPN1_HUMAN

Name: Epsin-1

UniProtKB Accession Codes:

Q9Y6I3 Q86ST3 Q9HA18

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 ELM 1 EMBL 5 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 6 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10557078

Title: Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis.

PubMed ID: 10557078

DOI: 10.1038/sj.onc.1202974

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10764745

Title: Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation.

PubMed ID: 10764745

DOI: 10.1074/jbc.m000521200

PubMed ID: 10393179

Title: Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors.

PubMed ID: 10393179

DOI: 10.1093/emboj/18.13.3629

PubMed ID: 12775724

Title: RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.

PubMed ID: 12775724

DOI: 10.1074/jbc.m302191200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16516836

Title: Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.

PubMed ID: 16516836

DOI: 10.1016/j.devcel.2006.01.016

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18199683

Title: The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.

PubMed ID: 18199683

DOI: 10.1091/mbc.e07-08-0775

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 34927784

Title: ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.

PubMed ID: 34927784

DOI: 10.15252/embr.202051182

PubMed ID: 12836669

Title: Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin.

PubMed ID: 12836669

DOI: 10.1023/a:1011397007366

Sequence Information:

  • Length: 576
  • Mass: 60293
  • Checksum: 68DD433F3168E975
  • Sequence:
    • MSTSSLRRQM KNIVHNYSEA EIKVREATSN DPWGPSSSLM SEIADLTYNV VAFSEIMSMI 
WKRLNDHGKN WRHVYKAMTL MEYLIKTGSE RVSQQCKENM YAVQTLKDFQ YVDRDGKDQG 
VNVREKAKQL VALLRDEDRL REERAHALKT KEKLAQTATA SSAAVGSGPP PEAEQAWPQS 
SGEEELQLQL ALAMSKEEAD QPPSCGPEDD AQLQLALSLS REEHDKEERI RRGDDLRLQM 
AIEESKRETG GKEESSLMDL ADVFTAPAPA PTTDPWGGPA PMAAAVPTAA PTSDPWGGPP 
VPPAADPWGG PAPTPASGDP WRPAAPAGPS VDPWGGTPAP AAGEGPTPDP WGSSDGGVPV 
SGPSASDPWT PAPAFSDPWG GSPAKPSTNG TTAAGGFDTE PDEFSDFDRL RTALPTSGSS 
AGELELLAGE VPARSPGAFD MSGVRGSLAE AVGSPPPAAT PTPTPPTRKT PESFLGPNAA 
LVDLDSLVSR PGPTPPGAKA SNPFLPGGGP ATGPSVTNPF QPAPPATLTL NQLRLSPVPP 
VPGAPPTYIS PLGGGPGLPP MMPPGPPAPN TNPFLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.