Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 230.7367
Cell Significance Index: -35.8900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 138.8169
Cell Significance Index: -35.2100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 100.9109
Cell Significance Index: -41.5700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 88.0969
Cell Significance Index: -35.7900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 85.3698
Cell Significance Index: -40.3100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 77.4711
Cell Significance Index: -39.8500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 60.1769
Cell Significance Index: -40.3800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 37.7274
Cell Significance Index: -36.0200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 30.4999
Cell Significance Index: -37.6100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.1179
Cell Significance Index: -37.8200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.6958
Cell Significance Index: -38.2600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.3368
Cell Significance Index: -11.6800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.3897
Cell Significance Index: 18.9600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.1572
Cell Significance Index: 17.3400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1187
Cell Significance Index: 1010.1000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.9643
Cell Significance Index: 113.7200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9431
Cell Significance Index: 102.5900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9226
Cell Significance Index: 113.4400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.8396
Cell Significance Index: 115.3000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.8215
Cell Significance Index: 17.2000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8080
Cell Significance Index: 145.6700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.7845
Cell Significance Index: 54.2500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.7576
Cell Significance Index: 19.9200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.7195
Cell Significance Index: 37.4800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7169
Cell Significance Index: 391.5400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.6859
Cell Significance Index: 31.9800 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.6663
Cell Significance Index: 12.3200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6379
Cell Significance Index: 63.1000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.6025
Cell Significance Index: 15.0600 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.6012
Cell Significance Index: 6.8300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5994
Cell Significance Index: 102.3500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5978
Cell Significance Index: 118.6300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5695
Cell Significance Index: 251.7900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5033
Cell Significance Index: 100.9700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4901
Cell Significance Index: 31.6200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4410
Cell Significance Index: 22.9100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4220
Cell Significance Index: 12.1600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3965
Cell Significance Index: 28.0400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3844
Cell Significance Index: 20.1800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3235
Cell Significance Index: 61.5600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3144
Cell Significance Index: 8.4300 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.3022
Cell Significance Index: 3.8700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2852
Cell Significance Index: 17.9800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2561
Cell Significance Index: 32.8300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2324
Cell Significance Index: 4.9500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.2221
Cell Significance Index: 5.9300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2219
Cell Significance Index: 16.5400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2133
Cell Significance Index: 5.8100 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.2118
Cell Significance Index: 27.3600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2087
Cell Significance Index: 7.3400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1885
Cell Significance Index: 8.8600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1843
Cell Significance Index: 66.1200 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.1711
Cell Significance Index: 1.8600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1514
Cell Significance Index: 4.8500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0847
Cell Significance Index: 0.7800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0572
Cell Significance Index: 41.9200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0419
Cell Significance Index: 1.1700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0409
Cell Significance Index: 3.1400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0168
Cell Significance Index: 0.7600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0168
Cell Significance Index: 11.6000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0001
Cell Significance Index: 0.0400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0057
Cell Significance Index: -10.7000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0093
Cell Significance Index: -5.8100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0101
Cell Significance Index: -1.0300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0128
Cell Significance Index: -0.2200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0162
Cell Significance Index: -12.0100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0193
Cell Significance Index: -35.5500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0248
Cell Significance Index: -38.2200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0295
Cell Significance Index: -4.8000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0305
Cell Significance Index: -41.5300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0437
Cell Significance Index: -27.7300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0483
Cell Significance Index: -27.2400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0705
Cell Significance Index: -31.9800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0937
Cell Significance Index: -19.7400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1003
Cell Significance Index: -2.9500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1059
Cell Significance Index: -12.3400 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.1096
Cell Significance Index: -0.8800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1099
Cell Significance Index: -31.6300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1406
Cell Significance Index: -4.0300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1520
Cell Significance Index: -17.4100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1721
Cell Significance Index: -19.6400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2120
Cell Significance Index: -13.0300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2234
Cell Significance Index: -32.4800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2432
Cell Significance Index: -16.3500 - Cell Name: peg cell (CL4033014)
Fold Change: -0.2562
Cell Significance Index: -5.9200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2784
Cell Significance Index: -22.0500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3059
Cell Significance Index: -13.5300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3116
Cell Significance Index: -8.3400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3628
Cell Significance Index: -37.7800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3683
Cell Significance Index: -7.9800 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3990
Cell Significance Index: -4.1300 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4353
Cell Significance Index: -11.1200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4712
Cell Significance Index: -26.4400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4759
Cell Significance Index: -18.0200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5054
Cell Significance Index: -30.9900 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.5774
Cell Significance Index: -4.8500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.5825
Cell Significance Index: -20.2400 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.6149
Cell Significance Index: -7.3300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.6253
Cell Significance Index: -37.5400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.6308
Cell Significance Index: -10.8100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1886428332
Symbol: EPN1_HUMAN
Name: Epsin-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10557078
Title: Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis.
PubMed ID: 10557078
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10764745
Title: Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation.
PubMed ID: 10764745
PubMed ID: 10393179
Title: Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors.
PubMed ID: 10393179
PubMed ID: 12775724
Title: RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis.
PubMed ID: 12775724
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16516836
Title: Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.
PubMed ID: 16516836
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 19367720
Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
PubMed ID: 19367720
DOI: 10.1021/pr800500r
PubMed ID: 18199683
Title: The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.
PubMed ID: 18199683
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 34927784
Title: ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.
PubMed ID: 34927784
PubMed ID: 12836669
Title: Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin.
PubMed ID: 12836669
Sequence Information:
- Length: 576
- Mass: 60293
- Checksum: 68DD433F3168E975
- Sequence:
MSTSSLRRQM KNIVHNYSEA EIKVREATSN DPWGPSSSLM SEIADLTYNV VAFSEIMSMI WKRLNDHGKN WRHVYKAMTL MEYLIKTGSE RVSQQCKENM YAVQTLKDFQ YVDRDGKDQG VNVREKAKQL VALLRDEDRL REERAHALKT KEKLAQTATA SSAAVGSGPP PEAEQAWPQS SGEEELQLQL ALAMSKEEAD QPPSCGPEDD AQLQLALSLS REEHDKEERI RRGDDLRLQM AIEESKRETG GKEESSLMDL ADVFTAPAPA PTTDPWGGPA PMAAAVPTAA PTSDPWGGPP VPPAADPWGG PAPTPASGDP WRPAAPAGPS VDPWGGTPAP AAGEGPTPDP WGSSDGGVPV SGPSASDPWT PAPAFSDPWG GSPAKPSTNG TTAAGGFDTE PDEFSDFDRL RTALPTSGSS AGELELLAGE VPARSPGAFD MSGVRGSLAE AVGSPPPAAT PTPTPPTRKT PESFLGPNAA LVDLDSLVSR PGPTPPGAKA SNPFLPGGGP ATGPSVTNPF QPAPPATLTL NQLRLSPVPP VPGAPPTYIS PLGGGPGLPP MMPPGPPAPN TNPFLL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.