Details for: SEC61A1

Gene ID: 29927

Symbol: SEC61A1

Ensembl ID: ENSG00000058262

Description: SEC61 translocon subunit alpha 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 2.46
    Marker Score: 677
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.05
    Marker Score: 4,665
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 2
    Marker Score: 525
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.91
    Marker Score: 1,349
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.9
    Marker Score: 3,051
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.85
    Marker Score: 3,895
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.8
    Marker Score: 669
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.68
    Marker Score: 831
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.64
    Marker Score: 2,186
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.63
    Marker Score: 7,033
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.63
    Marker Score: 10,375
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.62
    Marker Score: 1,377
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.58
    Marker Score: 1,100
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.57
    Marker Score: 989
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.56
    Marker Score: 889
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.54
    Marker Score: 7,573
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.53
    Marker Score: 52,070
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.53
    Marker Score: 6,361
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.51
    Marker Score: 429
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.49
    Marker Score: 16,783
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.47
    Marker Score: 688
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.45
    Marker Score: 586
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.44
    Marker Score: 602
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.42
    Marker Score: 2,086
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.42
    Marker Score: 1,357
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.36
    Marker Score: 908
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.36
    Marker Score: 3,075
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.35
    Marker Score: 472
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.35
    Marker Score: 15,703
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.34
    Marker Score: 536
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.34
    Marker Score: 46,402
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.33
    Marker Score: 776
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.33
    Marker Score: 5,228
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.33
    Marker Score: 1,431
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.32
    Marker Score: 3,542
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.31
    Marker Score: 1,796
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.29
    Marker Score: 2,054
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.28
    Marker Score: 317
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.28
    Marker Score: 8,318
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.27
    Marker Score: 366
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.27
    Marker Score: 2,246
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.26
    Marker Score: 7,662
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.25
    Marker Score: 6,014
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.25
    Marker Score: 3,278
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.24
    Marker Score: 1,458
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.24
    Marker Score: 844
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.23
    Marker Score: 4,562
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.23
    Marker Score: 4,724
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.21
    Marker Score: 4,700
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.2
    Marker Score: 524
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.19
    Marker Score: 304
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.19
    Marker Score: 303
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.19
    Marker Score: 268
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.19
    Marker Score: 284
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.19
    Marker Score: 653
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.18
    Marker Score: 7,695
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.18
    Marker Score: 3,216
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.18
    Marker Score: 443
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.18
    Marker Score: 410
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.17
    Marker Score: 584
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.17
    Marker Score: 854
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.17
    Marker Score: 645
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.17
    Marker Score: 263
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.17
    Marker Score: 2,774
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.17
    Marker Score: 603
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.16
    Marker Score: 1,296
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.16
    Marker Score: 1,201
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.15
    Marker Score: 7,327
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.14
    Marker Score: 1,429
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.14
    Marker Score: 2,865
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.13
    Marker Score: 1,147
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.13
    Marker Score: 18,097
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.13
    Marker Score: 1,061
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.12
    Marker Score: 1,194
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.12
    Marker Score: 356
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.12
    Marker Score: 701
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.12
    Marker Score: 2,047
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.12
    Marker Score: 1,027
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.11
    Marker Score: 11,175
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.11
    Marker Score: 927
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.1
    Marker Score: 578
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.09
    Marker Score: 4,722
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.09
    Marker Score: 8,141
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.09
    Marker Score: 19,390
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.09
    Marker Score: 1,094
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.09
    Marker Score: 5,727
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.09
    Marker Score: 11,245
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.09
    Marker Score: 313
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.08
    Marker Score: 582
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.08
    Marker Score: 408
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.08
    Marker Score: 3,384
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.08
    Marker Score: 682
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.07
    Marker Score: 1,327
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.07
    Marker Score: 552
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.06
    Marker Score: 335
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.06
    Marker Score: 1,236
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.06
    Marker Score: 391
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.06
    Marker Score: 254
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.05
    Marker Score: 58,756
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.04
    Marker Score: 1,478

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Subunit of the SEC61 translocon**: SEC61A1 is a subunit of the SEC61 translocon complex, which is responsible for the translocation of proteins across the ER membrane. 2. **Cotranslational targeting**: The SEC61 translocon complex, including SEC61A1, facilitates the cotranslational targeting of proteins to the ER membrane. 3. **Protein insertion into ER membrane**: SEC61A1 is involved in the insertion of newly synthesized proteins into the ER lumen. 4. **High expression in immune cells**: The SEC61A1 gene is highly expressed in immune cells, such as plasmablasts, IgA-producing cells, and decidual cells, indicating its critical role in the adaptive immune response. **Pathways and Functions** 1. **Adaptive immune system**: SEC61A1 plays a crucial role in the adaptive immune response, particularly in the processing and presentation of antigens to T-cells. 2. **Antigen processing-cross presentation**: The SEC61 translocon complex, including SEC61A1, is involved in the cross-presentation of antigens from dying cells to antigen-presenting cells (APCs). 3. **Calcium channel activity**: SEC61A1 has been implicated in the regulation of calcium channel activity, which is essential for various cellular processes, including immune responses. 4. **Protein binding and translocation**: SEC61A1 interacts with other proteins to facilitate the binding and translocation of proteins across the ER membrane. **Clinical Significance** 1. **Autoimmune diseases**: Abnormalities in the SEC61A1 gene have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, highlighting its potential role in immune dysregulation. 2. **Cancer**: The SEC61 translocon complex, including SEC61A1, has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. 3. **Infectious diseases**: SEC61A1 has been shown to play a role in the immune response to infections, such as tuberculosis and malaria. 4. **Immunodeficiency disorders**: Mutations in the SEC61A1 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, the SEC61A1 gene plays a critical role in the adaptive immune response, antigen processing, and presentation, and has implications in various diseases, including autoimmune disorders, cancer, and infectious diseases. Further research is necessary to fully elucidate the functions and clinical significance of the SEC61A1 gene.

Genular Protein ID: 4060938873

Symbol: S61A1_HUMAN

Name: Protein transport protein Sec61 subunit alpha isoform 1

UniProtKB Accession Codes:

P61619 P38378 P57726 Q5JPF8 Q8N0Z4 Q8N3U3 Q8NC71 Q9BU16 Q9Y2R3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 20 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 11 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 8616892

Title: The cotranslational integration of membrane proteins into the phospholipid bilayer is a multistep process.

PubMed ID: 8616892

DOI: 10.1016/s0092-8674(00)81115-0

PubMed ID: 12475939

Title: Different transmembrane domains associate with distinct endoplasmic reticulum components during membrane integration of a polytopic protein.

PubMed ID: 12475939

DOI: 10.1091/mbc.e02-04-0198

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22375059

Title: Different effects of Sec61alpha, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.

PubMed ID: 22375059

DOI: 10.1242/jcs.096727

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29719251

Title: Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.

PubMed ID: 29719251

DOI: 10.1016/j.celrep.2018.03.122

PubMed ID: 32814900

Title: An intramembrane chaperone complex facilitates membrane protein biogenesis.

PubMed ID: 32814900

DOI: 10.1038/s41586-020-2624-y

PubMed ID: 32820719

Title: An ER translocon for multi-pass membrane protein biogenesis.

PubMed ID: 32820719

DOI: 10.7554/elife.56889

PubMed ID: 27392076

Title: Heterozygous loss-of-function SEC61A1 mutations cause autosomal-dominant tubulo-interstitial and glomerulocystic kidney disease with anemia.

PubMed ID: 27392076

DOI: 10.1016/j.ajhg.2016.05.028

PubMed ID: 28782633

Title: Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1).

PubMed ID: 28782633

DOI: 10.1016/j.jaci.2017.06.042

PubMed ID: 36261522

Title: Substrate-driven assembly of a translocon for multipass membrane proteins.

PubMed ID: 36261522

DOI: 10.1038/s41586-022-05330-8

Sequence Information:

  • Length: 476
  • Mass: 52265
  • Checksum: 44A9B7B37C7C82E4
  • Sequence:
    • MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL FGIMSSDSAD 
PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII EVGDTPKDRA LFNGAQKLFG 
MIITIGQSIV YVMTGMYGDP SEMGAGICLL ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS 
LFIATNICET IVWKAFSPTT VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP 
NLMNLIATIF VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN 
LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES FGSVLEDPVH 
AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV MRGHRETSMV HELNRYIPTA 
AAFGGLCIGA LSVLADFLGA IGSGTGILLA VTIIYQYFEI FVKEQSEVGS MGALLF

Genular Protein ID: 648958828

Symbol: B3KME8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KME8

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 DNASU 1 EMBL 3 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 170
  • Mass: 18176
  • Checksum: A9592F3C68619F26
  • Sequence:
    • MLSARFSGNL LVSLLGTWSD TSSGGPARAY PVGGLCYYLS PPESFGSVLE DPVHAVVYIV 
FMLGSCAFFS KTWIEVSGSS AKDVAKQLKE QQMVMRGHRE TSMVHELNRY IPTAAAFGGL 
CIGALSVLAD FLGAIGSGTG ILLAVTIIYQ YFEIFVKEQS EVGSMGALLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.