Details for: TIMM22

Gene ID: 29928

Symbol: TIMM22

Ensembl ID: ENSG00000177370

Description: translocase of inner mitochondrial membrane 22

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 113.8576
    Cell Significance Index: -17.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.4335
    Cell Significance Index: -17.8700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 53.8418
    Cell Significance Index: -22.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.0368
    Cell Significance Index: -21.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.4146
    Cell Significance Index: -18.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 40.6116
    Cell Significance Index: -20.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.9025
    Cell Significance Index: -20.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4911
    Cell Significance Index: -14.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4548
    Cell Significance Index: -21.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3825
    Cell Significance Index: 136.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3805
    Cell Significance Index: 224.5200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8996
    Cell Significance Index: 9.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8829
    Cell Significance Index: 18.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8579
    Cell Significance Index: 51.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4714
    Cell Significance Index: 64.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4535
    Cell Significance Index: 31.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4497
    Cell Significance Index: 11.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4071
    Cell Significance Index: 222.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3816
    Cell Significance Index: 45.0000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3774
    Cell Significance Index: 3.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3652
    Cell Significance Index: 12.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3343
    Cell Significance Index: 21.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3161
    Cell Significance Index: 16.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3134
    Cell Significance Index: 14.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3000
    Cell Significance Index: 132.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2982
    Cell Significance Index: 269.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2789
    Cell Significance Index: 12.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2711
    Cell Significance Index: 7.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2677
    Cell Significance Index: 18.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2668
    Cell Significance Index: 5.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2590
    Cell Significance Index: 7.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2553
    Cell Significance Index: 19.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2318
    Cell Significance Index: 10.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2298
    Cell Significance Index: 46.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2145
    Cell Significance Index: 38.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2100
    Cell Significance Index: 10.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2075
    Cell Significance Index: 5.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1857
    Cell Significance Index: 2.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1682
    Cell Significance Index: 21.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1643
    Cell Significance Index: 21.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1583
    Cell Significance Index: 19.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1458
    Cell Significance Index: 4.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1235
    Cell Significance Index: 7.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1235
    Cell Significance Index: 24.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1097
    Cell Significance Index: 39.3600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1063
    Cell Significance Index: 1.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0840
    Cell Significance Index: 4.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0756
    Cell Significance Index: 12.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0605
    Cell Significance Index: 41.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0590
    Cell Significance Index: 11.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0497
    Cell Significance Index: 0.5900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0463
    Cell Significance Index: 0.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0454
    Cell Significance Index: 0.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0092
    Cell Significance Index: 0.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0022
    Cell Significance Index: 4.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0070
    Cell Significance Index: -5.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0076
    Cell Significance Index: -11.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0087
    Cell Significance Index: -16.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0142
    Cell Significance Index: -19.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0183
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0185
    Cell Significance Index: -13.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0189
    Cell Significance Index: -11.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0197
    Cell Significance Index: -1.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0250
    Cell Significance Index: -14.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0337
    Cell Significance Index: -3.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0344
    Cell Significance Index: -0.9600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0349
    Cell Significance Index: -0.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0379
    Cell Significance Index: -17.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0426
    Cell Significance Index: -26.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0450
    Cell Significance Index: -1.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0589
    Cell Significance Index: -16.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0733
    Cell Significance Index: -8.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0737
    Cell Significance Index: -2.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0825
    Cell Significance Index: -2.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0994
    Cell Significance Index: -11.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1015
    Cell Significance Index: -14.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1030
    Cell Significance Index: -5.7800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1053
    Cell Significance Index: -4.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1074
    Cell Significance Index: -3.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1112
    Cell Significance Index: -23.4300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1488
    Cell Significance Index: -1.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1987
    Cell Significance Index: -20.6900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2048
    Cell Significance Index: -1.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2140
    Cell Significance Index: -5.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2168
    Cell Significance Index: -1.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2213
    Cell Significance Index: -17.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2398
    Cell Significance Index: -4.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2526
    Cell Significance Index: -5.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2533
    Cell Significance Index: -7.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3206
    Cell Significance Index: -8.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3274
    Cell Significance Index: -14.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3431
    Cell Significance Index: -17.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3534
    Cell Significance Index: -21.6700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.3546
    Cell Significance Index: -2.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3920
    Cell Significance Index: -3.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3937
    Cell Significance Index: -14.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3950
    Cell Significance Index: -8.6500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.4051
    Cell Significance Index: -5.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4219
    Cell Significance Index: -14.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TIMM22 is a mitochondrial protein that belongs to the Tim family of translocases, which are responsible for the import of proteins into the mitochondrial intermembrane space and the inner mitochondrial membrane. The gene is highly expressed in various cell types, including placental villous trophoblast, proerythroblast, primordial germ cell, neural progenitor cell, Leydig cell, cortical thymic epithelial cell, osteoclast, mesodermal cell, oogonial cell, and cerebral cortex GABAergic interneuron. TIMM22 shares a high degree of sequence similarity with other Tim family members, suggesting a conserved role in mitochondrial function across species. **Pathways and Functions:** TIMM22 is involved in several mitochondrial pathways, including: 1. **Mitochondrial protein import**: TIMM22 facilitates the insertion of proteins into the inner mitochondrial membrane, regulating the import of essential enzymes, such as ATP synthase and cytochrome c oxidase. 2. **Mitochondrial protein degradation**: TIMM22 is also involved in the regulation of mitochondrial protein degradation, ensuring the proper clearance of damaged or misfolded proteins from the mitochondrial intermembrane space. 3. **Mitochondrial protein translocation**: TIMM22 plays a crucial role in the translocation of proteins across the inner mitochondrial membrane, regulating the flow of essential ions and metabolites. **Clinical Significance:** Dysregulation of TIMM22 has been implicated in various disease states, including: 1. **Mitochondrial disorders**: Mutations in the TIMM22 gene have been associated with mitochondrial disorders, such as Kearns-Sayre syndrome and MERRF syndrome, which are characterized by progressive muscle weakness, neuropathy, and cardiac dysfunction. 2. **Neurodegenerative diseases**: TIMM22 has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where mitochondrial dysfunction is a key pathological feature. 3. **Cancer**: TIMM22 has been implicated in cancer, where its dysregulation can contribute to tumorigenesis and metastasis. In conclusion, TIMM22 plays a critical role in maintaining mitochondrial function and integrity. Its dysregulation can have significant consequences for cellular and organismal health, highlighting the importance of further research into the mechanisms and clinical significance of TIMM22 in disease states.

Genular Protein ID: 2804615515

Symbol: TIM22_HUMAN

Name: Mitochondrial import inner membrane translocase subunit Tim22

UniProtKB Accession Codes:

Q9Y584 Q9NWI8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 1 Ensembl 3 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10611480

Title: The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom.

PubMed ID: 10611480

DOI: 10.1016/s0014-5793(99)01665-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14726512

Title: Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria.

PubMed ID: 14726512

DOI: 10.1074/jbc.m312485200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27718247

Title: TIM29 is a subunit of the human carrier translocase required for protein transport.

PubMed ID: 27718247

DOI: 10.1002/1873-3468.12450

PubMed ID: 27265872

Title: The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly.

PubMed ID: 27265872

DOI: 10.1038/srep27484

PubMed ID: 28712724

Title: Acylglycerol kinase mutated in Sengers Syndrome is a subunit of the TIM22 protein translocase in mitochondria.

PubMed ID: 28712724

DOI: 10.1016/j.molcel.2017.06.013

PubMed ID: 28712726

Title: Sengers syndrome-associated mitochondrial acylglycerol kinase is a subunit of the human TIM22 protein import complex.

PubMed ID: 28712726

DOI: 10.1016/j.molcel.2017.06.014

PubMed ID: 30452684

Title: Mutations of the mitochondrial carrier translocase channel subunit TIM22 cause early-onset mitochondrial myopathy.

PubMed ID: 30452684

DOI: 10.1093/hmg/ddy305

Sequence Information:

  • Length: 194
  • Mass: 20031
  • Checksum: A1E6DD9F7F7399D6
  • Sequence:
    • MAAAAPNAGG SAPETAGSAE APLQYSLLLQ YLVGDKRQPR LLEPGSLGGI PSPAKSEEQK 
MIEKAMESCA FKAALACVGG FVLGGAFGVF TAGIDTNVGF DPKDPYRTPT AKEVLKDMGQ 
RGMSYAKNFA IVGAMFSCTE CLIESYRGTS DWKNSVISGC ITGGAIGFRA GLKAGAIGCG 
GFAAFSAAID YYLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.