Details for: TIMM22

Gene ID: 29928

Symbol: TIMM22

Ensembl ID: ENSG00000177370

Description: translocase of inner mitochondrial membrane 22

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.34
    Marker Score: 5,247
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.24
    Marker Score: 842
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.08
    Marker Score: 1,357
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.07
    Marker Score: 4,151
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.06
    Marker Score: 1,140
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.02
    Marker Score: 3,792
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.01
    Marker Score: 505
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.01
    Marker Score: 13,329
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1
    Marker Score: 1,444
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,705
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,927
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,395
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.97
    Marker Score: 1,287
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,395
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.94
    Marker Score: 266
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.94
    Marker Score: 1,955
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.92
    Marker Score: 975
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.92
    Marker Score: 957
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.91
    Marker Score: 2,135
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,698
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.9
    Marker Score: 845
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.88
    Marker Score: 590
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,987
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.87
    Marker Score: 480
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,228
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.85
    Marker Score: 637
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.84
    Marker Score: 208
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.84
    Marker Score: 1,763
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.83
    Marker Score: 885
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.82
    Marker Score: 915
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.81
    Marker Score: 864
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.8
    Marker Score: 1,367
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.8
    Marker Score: 428
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.78
    Marker Score: 184
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.78
    Marker Score: 2,123
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.78
    Marker Score: 8,785
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.77
    Marker Score: 1,574
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 310
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.77
    Marker Score: 777
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.76
    Marker Score: 718
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.74
    Marker Score: 249
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.74
    Marker Score: 3,184
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.74
    Marker Score: 255
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.73
    Marker Score: 3,005
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.73
    Marker Score: 6,320
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.73
    Marker Score: 461
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.73
    Marker Score: 25,248
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.72
    Marker Score: 1,439
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.72
    Marker Score: 2,135
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.72
    Marker Score: 4,678
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.72
    Marker Score: 1,955
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.71
    Marker Score: 7,118
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.71
    Marker Score: 389
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,895
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.69
    Marker Score: 339
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.68
    Marker Score: 255
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.68
    Marker Score: 1,120
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.67
    Marker Score: 293
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.67
    Marker Score: 423
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.67
    Marker Score: 194
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 608
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.67
    Marker Score: 1,679
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.65
    Marker Score: 584
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.65
    Marker Score: 418
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.64
    Marker Score: 307
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.64
    Marker Score: 162
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.63
    Marker Score: 461
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.63
    Marker Score: 197
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.63
    Marker Score: 123
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.63
    Marker Score: 288
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.63
    Marker Score: 734
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.62
    Marker Score: 292
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.62
    Marker Score: 329
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.62
    Marker Score: 436
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.61
    Marker Score: 208
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 406
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.61
    Marker Score: 2,352
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.61
    Marker Score: 385
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.6
    Marker Score: 250
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6
    Marker Score: 6,152
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.58
    Marker Score: 552
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.58
    Marker Score: 705
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.58
    Marker Score: 6,778
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.58
    Marker Score: 1,323
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.58
    Marker Score: 4,532
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.58
    Marker Score: 283
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.58
    Marker Score: 423
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.57
    Marker Score: 188
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.57
    Marker Score: 279
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.57
    Marker Score: 293
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.57
    Marker Score: 138
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.57
    Marker Score: 1,346
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TIMM22 is a mitochondrial protein that belongs to the Tim family of translocases, which are responsible for the import of proteins into the mitochondrial intermembrane space and the inner mitochondrial membrane. The gene is highly expressed in various cell types, including placental villous trophoblast, proerythroblast, primordial germ cell, neural progenitor cell, Leydig cell, cortical thymic epithelial cell, osteoclast, mesodermal cell, oogonial cell, and cerebral cortex GABAergic interneuron. TIMM22 shares a high degree of sequence similarity with other Tim family members, suggesting a conserved role in mitochondrial function across species. **Pathways and Functions:** TIMM22 is involved in several mitochondrial pathways, including: 1. **Mitochondrial protein import**: TIMM22 facilitates the insertion of proteins into the inner mitochondrial membrane, regulating the import of essential enzymes, such as ATP synthase and cytochrome c oxidase. 2. **Mitochondrial protein degradation**: TIMM22 is also involved in the regulation of mitochondrial protein degradation, ensuring the proper clearance of damaged or misfolded proteins from the mitochondrial intermembrane space. 3. **Mitochondrial protein translocation**: TIMM22 plays a crucial role in the translocation of proteins across the inner mitochondrial membrane, regulating the flow of essential ions and metabolites. **Clinical Significance:** Dysregulation of TIMM22 has been implicated in various disease states, including: 1. **Mitochondrial disorders**: Mutations in the TIMM22 gene have been associated with mitochondrial disorders, such as Kearns-Sayre syndrome and MERRF syndrome, which are characterized by progressive muscle weakness, neuropathy, and cardiac dysfunction. 2. **Neurodegenerative diseases**: TIMM22 has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where mitochondrial dysfunction is a key pathological feature. 3. **Cancer**: TIMM22 has been implicated in cancer, where its dysregulation can contribute to tumorigenesis and metastasis. In conclusion, TIMM22 plays a critical role in maintaining mitochondrial function and integrity. Its dysregulation can have significant consequences for cellular and organismal health, highlighting the importance of further research into the mechanisms and clinical significance of TIMM22 in disease states.

Genular Protein ID: 2804615515

Symbol: TIM22_HUMAN

Name: Mitochondrial import inner membrane translocase subunit Tim22

UniProtKB Accession Codes:

Q9Y584 Q9NWI8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 1 EPD 1 Ensembl 3 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10611480

Title: The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom.

PubMed ID: 10611480

DOI: 10.1016/s0014-5793(99)01665-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14726512

Title: Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria.

PubMed ID: 14726512

DOI: 10.1074/jbc.m312485200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27718247

Title: TIM29 is a subunit of the human carrier translocase required for protein transport.

PubMed ID: 27718247

DOI: 10.1002/1873-3468.12450

PubMed ID: 27265872

Title: The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly.

PubMed ID: 27265872

DOI: 10.1038/srep27484

PubMed ID: 28712724

Title: Acylglycerol kinase mutated in Sengers Syndrome is a subunit of the TIM22 protein translocase in mitochondria.

PubMed ID: 28712724

DOI: 10.1016/j.molcel.2017.06.013

PubMed ID: 28712726

Title: Sengers syndrome-associated mitochondrial acylglycerol kinase is a subunit of the human TIM22 protein import complex.

PubMed ID: 28712726

DOI: 10.1016/j.molcel.2017.06.014

PubMed ID: 30452684

Title: Mutations of the mitochondrial carrier translocase channel subunit TIM22 cause early-onset mitochondrial myopathy.

PubMed ID: 30452684

DOI: 10.1093/hmg/ddy305

Sequence Information:

  • Length: 194
  • Mass: 20031
  • Checksum: A1E6DD9F7F7399D6
  • Sequence:
    • MAAAAPNAGG SAPETAGSAE APLQYSLLLQ YLVGDKRQPR LLEPGSLGGI PSPAKSEEQK 
MIEKAMESCA FKAALACVGG FVLGGAFGVF TAGIDTNVGF DPKDPYRTPT AKEVLKDMGQ 
RGMSYAKNFA IVGAMFSCTE CLIESYRGTS DWKNSVISGC ITGGAIGFRA GLKAGAIGCG 
GFAAFSAAID YYLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.